Vikas Kumar

Vikas Kumar
Chartwell Pharmaceuticals, NY · Quality

PhD

About

222
Publications
148,104
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
2,907
Citations
Citations since 2017
9 Research Items
1288 Citations
2017201820192020202120222023050100150200250
2017201820192020202120222023050100150200250
2017201820192020202120222023050100150200250
2017201820192020202120222023050100150200250
Introduction
Our major research interest is to translate traditionally known medicinal uses of herbs in terms of modern concepts of evidence based medicine. Visited United States, Canada, Germany, France, China, Nepal, Thailand, Singapore, South Africa, Italy and UAE. I am Life Member of several professional associations and also serves as member of Editorial Board of many peer reviewed international journals. I also have scientific collaborations with Dr. Willmar Schwabe GmbH & Co. KG, Germany.
Additional affiliations
December 2016 - September 2017
University of Mississippi
Position
  • Researcher
March 2006 - present
Indian Institute of Technology (Banaras Hindu University) Varanasi
Position
  • Associate Professor of Pharmacology
Description
  • http://www.iitbhu.ac.in/phe/Dr.VK_profile.html
March 2006 - present
Indian Institute of Technology (Banaras Hindu University) Varanasi
Position
  • Associate Professor of Pharmacology
Description
  • I am teaching general pharmacology, neuropharmacology, behavioral pharmacology, molecular and clinical pharmacology, evaluation of drug activities, physiology, toxicology, and alternatives to animal experiments through simulated experiments.
Education
January 1998 - December 2000
July 1995 - August 1997
Gulbarga University
Field of study
  • Pharmacology
July 1991 - July 1995
Gulbarga University
Field of study
  • Pharmacy

Publications

Publications (222)
Article
Full-text available
Background: The objective of the study is to compare stress resistance-promoting effect of triethylene glycol (TEG) and root extract of Ashwagandha (Withaniasomnifera) i.e. withanolide-free root extract of Withaniasomnifera (WFWS). Materials and methods: Mice groups treated orally with 10 mg/kg TEG or WFWS (3.3, 10, 33.3, or 100 mg/kg) for 12 co...
Article
Full-text available
Background: Contents of bioactive substances extractable from different parts of terrestrial plants vary enormously. Aim: To ascertain that parts of Withania somnifera other than its roots can also be used for prevention and cure of unavoidable stress triggered central hypersensitivity to pain. Material and Methods: Groups of male or female mice tr...
Article
Full-text available
Background and Objective: Andrographis paniculata (Burm. F.) Wall. Ex Nees is an Ayurvedic medicinal plant and it has been traditional used for treatment liver disease, diabetes, cold, fever and diarrhoea. Present study investigated the mechanistic activity of standardized extract of Andrographis paniculata (AP) and its isolated pure andrographolid...
Article
Full-text available
The present study has been conducted to assess the anxiolytic activity of chloroform extract of Abies webbiana leaves in rats using different anxiety model viz. Open field exploratory behavior, elevated plus maze [EPM] and elevated zero maze [EZM] tests. Chloroform extract orally at different dose levels once daily x 3days, while lorazepam [LR: 0.5...
Chapter
Curcuma longa (turmeric) and Withania somnifera (ashwagandha) are the two perennial herbs and have been used for many centuries as potential medicine to promote longevity and immunizing the body against various ailments. However, in Indian Ayurvedic system of medicine, rhizomes of C. longa and roots of W. somnifera are often used for the treatment...
Chapter
Full-text available
Ashwagandha (Withania somnifera) extracts and several pharmaceutical formulations containing them are currently often used as tonics useful for prevention and cure of mental health problems, including sleep disturbances, accompanying or caused by diverse slowly progressing chronic diseases. The possibility that W. somnifera could be used for treatm...
Article
Full-text available
Fumaric acid esters, now often used for treatment of psoriasis and multiple sclerosis, have been identified as bioactive constituents of Fumaria indica used in traditionally known system of medicine as a liver tonicor for treatments of diverse inflammatory conditions, itches and pain. Observations made during efforts to quantify their roles in ther...
Article
Full-text available
Withania somnifera is an important Ayurvedic Rasayana herb, the roots of which are often used in traditionally known systems of medicine as tonic or for rejuvenation purposes. Effects of a single and ten daily oral doses (10, 20 and 40 mg/kg) of an analytically well standardized Withania somnifera root extract against foot shock stress triggered tr...
Conference Paper
Full-text available
OBJECTIVE: The aim of the present study was to evaluate the combined protective effects of quercetin and baicalein on isoproterenol induced myocardial infarcted rats. METHODS: Male albino Wistar rats were pretreated with a combination of quercetin (50 mg/kg) and baicalein (50 mg/kg) daily for 14 days. After the pretreatment, rats were injected iso...
Conference Paper
Full-text available
OBJECTIVE: The present review aims to report the pharmacological profile and therapeutic potential of Rosmarinic acid in neurological disorders such as depression, anxiety and Post-Traumatic Stress Disorder associated with cardiovascular diseases. METHODS: A PubMed and Google Scholar database search (from January 1970 to June 2016) using only Rosm...
Chapter
Full-text available
Fermentation of grains is an ancient method which helps increase the nutritional value and digestibility of grains, protects stomach from the harmful pathogens, improving absorption of bioactive molecules and minerals though the intestinal tract synergistically balancing the gut microbiota. Fermentation of grains is crucial for the bread manufactur...
Article
Curcuma longa rhizomes (turmeric) are used as tonic in traditionally known Indian systems of medicine. Aim of this study was to compare stress response suppressing efficacies of a Curcuma longa extract (CLE) enriched in curcuminoids with those of curcumin and turmeric oil (TO). Effects of daily oral treatments with curcumin (5 mg/kg/day) or CLE (5,...
Article
Cardioprotection represents one of the most important and realistic aspects of preventive therapy today. Quercetin, a naturally occurring dietary flavone, has been studied extensively for its antioxidant properties. The objective of present study is to find out the cardioprotective activity and to explore the underlying mechanisms of quercetin pret...
Article
Full-text available
The reported experimental study was conducted to compare the effects of repeated daily oral doses of curcuminoids (CLE) with metformin as potential antidepressants and analgesics. Effects of a single and ten daily oral doses of CLE (5, 20, 80 mg/kg/day) and of 50 mg/kg/day metformin (MET) were compared in mice hot plate test (HPT) for analgesics. O...
Article
Full-text available
Aim: Withania somnifera root (WSR) extracts are often used in traditionally known Indian systems of medicine for prevention and cure of psychosomatic disorders. The reported experiment was designed to test whether low daily oral doses of such extracts are also effective in suppressing marble burying behavior in stressed mice or not. Materials and...
Article
Full-text available
A brief review of the current trends in development of natural skincare and cosmetics.
Conference Paper
Full-text available
Introduction: Triethylene glycol (TEG) is a newly identified fumaric acid (FA) like bioactive constituent of the adaptogenic Withania somnifera extracts often used in Ayurvedic systems of medicine as tonic or rejuvenator. It has been reported that the regular intake of the food additive carboxymethyl cellulose (CMC) could be a risk factor for diabe...
Article
Context Andrographolide containing Andrographis paniculata (Burm. F.) Wall. Ex Nees (Acanthaceae) extracts is often used for treatments of diabetes and other inflammatory disorders commonly accompanying cognitive and other psychiatric disorders.Objective To compare the efficacies of a standardised A. paniculata extract (AP) and pure andrographolide...
Article
The aim of the present study was to prepare atorvastatin calcium (ATR) loaded poly(3-caprolactone) nanoparticles (ALPNs) to enhance the oral bioavailability, efficacy and safety profile of drug. ALPNs were prepared by a nanoprecipitation technique while formulation and process parameters were optimized using a central composite factorial design. Th...
Article
Full-text available
Objectives: To assess the antidiabetic potential of Shilajatvadi Lauha (SL) processed with Daruharidra (modified SL [MSL]) in streptozotocin (STZ)-nicotinamide (NA)-induced diabetic rats. Materials and Methods: Animals were divided into diabetic and nondiabetic groups. Type 2 diabetes in rats was induced with a single dose of STZ (65 mg/kg) NA (11...
Conference Paper
Full-text available
Objective: To compare oral efficacies of different parts of the Ayurvedic Rasayana herb Withania somnifera (Ashwagandha or Indian Ginseng) in a model for obsessive compulsive disorders in stressed mice. Methods: Groups of male mice were treated with stress resistance promoting oral doses (10 mg/kg/day) of a medicinally used Withania somnifera root...
Article
Full-text available
Aim To compare stress resistance increasing and analgesic activities of piperlongumine and a methanolic Piper longum fruit extract (PLE). Methods Efficacies of a single and repeated daily oral doses (1–256 mg/kg/day) of PLE, piperlongumine, and 50 mg/kg/day doxycycline against foot shock stress triggered alteration in body weights and core tempera...
Article
Full-text available
Aim: To compare doxycycline (DOX) such as oral efficacies of piperlongumine (PL) and a Piper longum fruits extract (PLE) as stress resistance inducers. Materials and methods: Efficacies of oral pretreatments with 5 mg/kg PL or PLE or of 50 mg/kg DOX for 10 consecutive days against stress resistance were compared. Mice in treated groups were subj...
Article
Full-text available
Objective: To compare physiological stress response modulating potentials of triethylene glycol and quercetin in mice. Methods: Effects of single and 10 daily oral doses (5, 20, 100 and 400 mg/kg/day) of quercetin and triethylene glycol (TEG) to male mice on foot shock stress induces transient hyperthermia and on basal rectal temperatures and body...
Chapter
Herbs are used for both medicinal and culinary purposes for thousands years. In many delicious cuisines, dietary herbs are used to increase the taste and flavor of foods. Recent years' reports revealed that herbs contribute as dietary nutrients, which are known to possess a number of beneficial health properties. Currently, research is progressing...
Article
Full-text available
Atorvastatin calcium (ATR), a second generation statin drug, was encapsulated in eudragit RSPO-based polymeric nanoparticles. The effect of independent variables (polymer content, stabilizer concentration, volume of chloroform and homogenization speed) on response variables (mean diameter particle size and entrapment efficiency) were investigated b...
Article
Full-text available
Results of the very first experiments conducted to evaluate therapeutic potentials of a fumarate containing Fumaria indica extract and of fairly low daily oral doses of monomethyl fumarate for prevention of chronic unavoidable foot-shock stress-induced gastric ulcers, and possible involvement of diverse neuro-hormonal and oxidative process in their...
Conference Paper
Metformin is the drug of first choice for glycaemic control in obese patients suffering from diverse metabolic and other health problems. The present study was designed to assess its stress response regulating potentials in obese mouse. High fat fed male obese mice treated daily with 20, 40 or 80 mg/kg/day oral doses of metformin were subjected to...
Conference Paper
Full-text available
Comparison of single and repeated daily oral doses of a turmeric extract containing 94.5 % curcuminoids (CLE) with metformin in hot plate test and on stress responses in mice. Analgesics like effects of a single,S, 7, and 10 daily oral doses of CLE (5, 20, 80 mg/kg/day) and of 50 mg/kg/day metformin were compared in mice hot plate test. On the 11th...
Conference Paper
Full-text available
To reaffirm that monomethyl fumarate (MMF) is a chronic stress response suppressing constituents of methanolic Fumaria indica extracts (MFl). Protective efficacies of 21 daily oral doses of pure MMF (1.25, 2.50, and 5.00 mg/kg/day) and a medicinally used MFI (60, 120 and 240 mg/kg/day) against daily one hour unavoidable foot shock stress (2 mA) tri...
Conference Paper
Full-text available
Monomethyl fumarate (MMF) has been reported to be a hepatoprotective constituent of methanolic extracts of the Ayurvedic medicinal plant Fumaria indica. Aim of the present study was to experimentally verify the possibility that it is also a bioactive constituent of methanolic Fumaria indica extracts (MFl) involved in their protective effects agains...
Conference Paper
Full-text available
To compare modulating ability of fumaric acid (FA) and its mono- (MMF) and di-methyl (DMF) esters and a methanolic Fumaria indica extract (MFl) on toll like receptors (TLRs) and cytokine expressions. Effects of non-cytotoxic concentration of MFI (10p9/ml) and those of FA, MMF, and DMF (7.5pM) on Lipopolysaccharide (LPS) induced TLR-4 and Resiquimod...
Article
Full-text available
Aim of this study was to define oral dose range and treatment regimen of a pharmaceutically well-standardized Withania somnifera root extract (WS) potentially useful for treatments of diabetes-associated comorbidities. Normal and diabetic male mice were treated daily with graded oral doses of WS for 10 consecutive days. On the 1st, 5th, 7th, and 10...
Article
Full-text available
Medicinal uses of edible and other plants for prevention and cure of obesity and overweight associated metabolic and mental health problems have since long been known to scholars and practitioners of Ayurvedic and other traditionally known system of medicine. Modernized versions of numerous edible plant derived formulations mentioned in ancient Ayu...
Article
Full-text available
Andrographolide, a labdane diterpenoid, is quantitatively the major bioactive secondary metabolite of Andrographis paniculata, which is now considered to be a promising therapeutic lead for prevention and cure of inflammatory disorders. Although involvements of Toll-like receptors (TLR) and diverse cytokines have been implicated in its modes of act...
Conference Paper
Full-text available
Withania somnifera root is an important Ayurvedic Rasayana herb now often referred to as Indian ginseng. It is often used in traditionally known Ayurvedic formulations as an herbal adaptogen for promoting physical and mental health or for increasing longevity. Materials and Methods: Effects of a single and 5, 7, and 10 daily oral doses (10, 20 and...
Article
Full-text available
Introduction: Dimethyl fumarate (DMF) is medicinally used for treatments of psoriasis and multiple sclerosis, and monomethyl fumarate (MMF) is often considered to be its primary active metabolite. Fumaric acid (FA) and its hydrolysable conjugates have also been identified as anti-inflammatory and analgesic constituents of several herbal extracts of...
Conference Paper
Full-text available
lntroduction: Dimethyl fumarate (DMF) is therapeutically used for treatments of multiple sclerosis and psoriasis. Monomethyl fumarate (MMF) is considered to be an active metabolite of DMF. Fumaric acid (FA) and its hydrolysable conjugates have been identified as anti-inflammatory and analgesic constituents of several herbal extracts widely used for...
Article
Full-text available
Withania somnifera (Ashwagandha) is an important Rasayana herb and widely considered as Indian ginseng in Ayurveda. In traditional system of Indian medicine, it is used as tonic to rejuvenate the body and increase longevity. In Ayurvedic preparations, various parts of the plant have been used to treat variety of ailments that affect the human healt...
Article
Full-text available
Fumaria indica Linn. (Syn: Fumaria parviflora, Fumariaceae) is a wildly grown weed, mentioned and recommended in classical Ayurvedic texts for treatments of variety of ailments including dermatological diseases, topical diseases, cardiovascular complaints, circulatory disease, fever and headache etc. The present pilot study was designed to experime...
Conference Paper
Ascorbic acid, or Vitamin C, is a nutritionally essential food ingredient necessary for proper functioning of almost all bodily and mental functions. Numerous edible and other medicinal plants commonly used as adaptogens or rejuvenating agents in Ayurvedic and other traditionally known systems of medicine are well known natural sources of the acid....
Conference Paper
Full-text available
Aim: To assess the efficacy of a Withania somnifera root extract (WSR) as a stress response-modulating agent with preventive potentials against obsessive compulsive disorders (OCD). Methodology: Groups of mice orally treated with 10, 20 or 40 mg/kg/day WSR, or with its vehicle, were subjected to a stress induced hyperthermia test on the 1st, 5th, 7...
Conference Paper
Full-text available
Abstract: Comparison of anti-stress efficacies of turrneric oil (TO)with those of pure curcumin and curcuminoids enriched Curcuma longa extracts (CLEs). A well validated and pharmacologically characterized mouse bioassay system for identifying stress response modulating agents was used. At first,the efficacies of single and daily oral doses of thre...
Article
Full-text available
Andrographolide is a major bioactive secondary plant metabolite isolated Andrographis paniculata (Burm. F.) Wall. Ex. Nees. (穿心蓮 chuān xīn lián), a well-known traditionally used medicinal herb. The aim of the study was to pharmacologically evaluate the beneficial effect of andrographolide on stress-induced thermoregulatory and other physiological r...
Article
Full-text available
An analytically characterized extract of Andrographis paniculata leaves (AP) and isolated pure andrographolide were evaluated for their analgesic and anti-inflammatory activity in diabetic rodents. AP (100, 200 and 400 mg/kg/day, p.o.), or andrographolide (30, 60 and 120 mg/kg/day, p.o.) was administered for ten consecutive days. Pentazocine and in...
Article
Full-text available
Background and Objectives: Phloroglucinols are secondary metabolites that occur naturally in certain plant species. Microorganisms such as brown algae or bacteria also produce phloroglucinols. Phloroglucinols has potential health effect and it is used as a treatment for gallstones, spasmodic pain and other related gastrointestinal disorders. The ob...
Article
Full-text available
The aim of the study was to compare the protective efficacies of a single and repeated daily oral doses (5, 20, 80, and 320 mg/kg) of a Curcuma longa extract (C. longa) enriched in curcuminoids (95.4%) with those of metformin (100 mg/kg) against intermittent foot shock stress triggered body weight changes and thermoregulatory responses in male and...
Article
Full-text available
Introduction: Diabetes mellitus is one of the important metabolic diseases, and the percentage of affected population is increasing day by day. The search for better medicament is the need of hour. Aim: Poly-herbal formulation (PF) containing fourteen plant materials is studied for anti-hyperglycemic and anti hyperlipidemic effect. Material and met...
Conference Paper
Objective: Terminalia belerica is one of three components of the Ayurvedic formulation “Triphala”, and it was reported as Ayurvedic Rasayana herbs to have an adaptogenic properties. In view of that, the present study on aqueous extract of Terminalia belerica fruits (TB) was designed to investigate its anti-stress activities in normal and diabetic r...
Conference Paper
Objective: Terminalia belerica is one of constituents of Triphala i.e. an Ayurvedic formulation oftenly used as adaptogen. In view of that, the present study on aqueous extract of Terminalia belerica fruits (TB) was designed to investigate its anti-aggressive activities in normal and diabetic rats. Materials and Methods: Diabetes mellitus was induc...
Conference Paper
Full-text available
Objective: Triethylene glycol and quercetin are two antimicrobial and cyto-static agents encountered also in the adaptogenic herb Withania somnifera. Aim of this study was to compare their efficacies in a mouse bioassay for stress response modulating efficacies of test agents. Materials and Methods: Groups of mice were orally treated with graded da...
Conference Paper
Full-text available
Objective: To compare oral efficacies of two benzoic acid derivatives aspirin and 3-hydroxybenzoic acid in a mice screening assay for adaptogens. Materials and Methods: Efficacies of single and repeated daily oral doses of aspirin and 3-hydroxybenzoic acid in a mice foot shock stress triggered hyperthermia test for adaptogens with anxiolytics and a...
Conference Paper
Full-text available
Herbs are natural remedies for the various diseases with higher safety profile and efficacy. Natural phytochemicals isolated from plants used as traditional medicines are considered as good alternatives for Ayurvedic system of medicine. Piper longum Linn. is a native of indo-Malaya region, belongs to the family of Piperaceae. Piperine and piperlong...
Conference Paper
Full-text available
Objective: Fumaria indica Linn. (Fumariaceae) is an Auyrvedic herb, known as pitpapra. Investigations made in recent past in our laboratory suggest its CNS modulating potential including anti-stress, anxiolytic, antidepressant, nootropic, adaptogenic etc. The present study was aimed to evaluate and compare the effect of standardized 50% methanolic...
Conference Paper
Full-text available
Objective: To study the beneficial effects of a standardized Andrographis paniculata extract (AP) and isolated pure andrographolide on cognitive functions, oxidative stress and cholinergic function in diabetic rats. Materials and Methods: Diabetes was induced by a single intra peritoneal (i.p.) injection of 65 mg/kg streptozotocin, followed by 120...
Conference Paper
Full-text available
Objective: Withania somnifera (Ashwagandha) is an important Rasayana herb and widely considered as Indian ginseng in Ayurveda. In traditional system of Indian medicine, it was used as tonic to promote physical and mental health, rejuvenate the body in debilitated conditions and increase longevity. Materials and Methods: The study was designed to co...
Conference Paper
Full-text available
Objective: Curcumin is major bioactive constituent of Ayurvedic medicinal plant Curcuma longa. Although extensive efforts have been made on curcumin but very less efforts have been executed on improved bioavailable and different concentration of curcuminoids containing extracts on its neuropsychopharmacological activity. The reported experiments we...
Conference Paper
Full-text available
Objective: L-Ascorbic acid (AA) is the most abundant water-soluble naturally occurring organic compound with antioxidant properties. It serves as a cofactor for enzymes involved in hormone biosynthesis, and the regeneration of antioxidants. Plants and food rich in AA have been widely used in Ayurveda to treat a variety of common and stress related...
Article
Full-text available
The common co-morbid psychiatric conditions like depression, anxiety, sleep disturbances and other mental health problems have always been treated with herbal remedies since ancient times [1,2]. Ayurveda is one of the oldest known holistic health care systems recommending diverse medicinal uses of edible and other plant derived products for prevent...
Article
Full-text available
Lactic acid is commonly found in sour milk and is often consumed with food, which plays a role in various biochemical processes and used for trauma, surgery, burn injury and as a neuroprotective. Present pilot study was designed to investigate its putative stress response modulating effects in male mice. A battery of behavioural test models viz. st...
Article
Full-text available
Picrorhiza kurroa Royle ex Benth. (Scrophulariaceae) is a traditional Ayurvedic herb known as Kutki. It is used as a remedy for diabetes by tribes of North Eastern Himalayan region of India. Present study was conducted to explore the mechanism of antidiabetic activity of standardized aqueous extract of Picrorhiza kurroa (PkE). PkE (100 and 200 mg/k...
Conference Paper
Full-text available
Hyperlipidemia, a dominant contributing factor in development of atherosclerosis in humans, is a metabolic syndrome characterized by elevated level of serum lipids and afflicts 39% of adult globally. Complications of atherosclerosis resulting into a number of cardiovascular diseases which are leading cause of death worldwide. Rosuvastatin calcium (...