Vikas Jha

GN Khalsa College · national facility for biopharmaceuticals

In the present study, we attempted to provide a comprehensive perspective towards the exploration of essential oil from Bambusa vulgaris plant as an appropriate substitute for already existing synthetic counterparts. GC–MS analysis was performed to identify the individual components present in the essential oil. The antimicrobial activity and antio...

Antibiotic resistance has reduced the value of synthetic drugs, offering up possibilities for the development of new substitutes with significant potential to benefit their host. Probiotics are living microbes that restore the microbiome in the gut. The main purpose of this research is to explore the probiotic potential of Lactic Acid Bacteria and...

A quarter of the world’s population is thought to be latently infected with Mycobacterium tuberculosis, creating a vast pool of possible future illnesses. Combined with the rising prevalence of multi-drug resistant Mycobacterium tuberculosis (Mtb) strains, TB poses one of the biggest challenges for world health, and the TB epidemic can only be erad...

Multidrug-resistant bacteria are now widely recognized as a global threat and a substantial public health concern. Antimicrobial resistance (AMR) is known as a more significant threat to humanity. Multidrug-resistant (MDR)/ Extensively Drug-resistant (XDR) Mycobacterium tuberculosis (M. tb) is a prime example of AMR. Furthermore, treating MDR-TB is...

Mycobacterium tuberculosis being a causative agent of tuberculosis is a powerful pathogen that has evolved to survive within the host. There are certain metabolic pathways that play a vital role in host-pathogen interaction, pathogenicity and virulence which is indicated by the pathophysiology of Mycobacterium tuberculosis (MTB). The pathways invol...

Background & Objectives: An alarming rise in multi-drug resistant bacterial pathogen like Vancomycin-resistant Enterococci (VRE) has culminated in a global health threat in today’s healthcare environment and has caused significant morbidity and mortality in patients. The field of medicinal herbs has developed at an exponential rate in subsequent de...

Background: Plant derived metabolites have served as the foundation of sophisticated systems in traditional medicine that have existed for hundreds of years and continue to supply mankind with novel treatments. Owing to its antibacterial characteristics, Gingergrass (Cymbopogon martinii) has been utilized in aromatherapy as a skin tonic. It's also...

The ever-increasing fatality due to the surge of drug resistance has demanded the development of therapeutic metabolites with novel modes of mechanism. Despite the discovery of new antimicrobials, antibiotic resistance is increasing at an alarming rate. The emergence of novel molecules is necessary for targeting the Multidrug (MDR) and Pan-Drug res...

With the advancement in various molecular diagnostic tools, DNA Barcoding has emerged as a gold standard molecular diagnostic tool across the globe. Since ancient times, medicinal plants have been widely used in Indian Ayurvedic medicine for treating a variety of ailments. Plants of the genus Andrographis have been extensively used for treating dif...

The growing need for probiotics has emerged due to the imbalances in the gut microbiota. Changes in the microflora of the gut lead to various disorders. Hence, the consumption of probiotics is imperative and rewarding. They provide various benefits when consumed, including antagonistic activities against pathogens by lowering pH to inhibit the grow...

Objective: In this study, the M2 protein of influenza A virus was selected as a target for various phytochemical compounds and an attempt was made to determine their inhibitory activity against the target protein using computational biology. Thus, seeking novel therapeutic strategies against the influenza A virus. Methods: With the aid of the compu...

Objective: In this study, the M2 protein of influenza A virus was selected as a target for various phytochemical compounds and an attempt was made to determine their inhibitory activity against the target protein using computational biology. Thus, seeking novel therapeutic strategies against the influenza A virus. Methods: With the aid of the compu...

The Acquired Immunodeficiency Syndrome (AIDS) is a major global pandemic and of paramount public health concern. Over the years, antiretroviral therapy (ART) has emerged as the gold standard of AIDS treatment. However, drug resistance and toxicity, and drug accessibility and compliance issues have blunted its positive impacts. Thirty years into the...

The study investigates the therapeutic potential of the Citrus aurantium var. amara essential oil extracted from the blossoms of the bitter orange plant by examining its chemical composition, thermal stability, and potency against infectious disease-causing pathogens. Initially, the volatile components of the essential oil were evaluated by obtaini...

Hepatitis B virus (HBV) infections are infamous to cause liver damage, hepatocellular carcinoma, and cirrhosis, all of which can be fatal in nature. Nucleotide analogues, which target viral reverse transcriptase, and interferon therapy, which is known to have side effects in recipients, are currently being used to treat such infections. Increasingl...

Background: Most of the plant natural flora contributes significantly to medicinal benefits. To address the shortcoming usage of synthetic drugs, natural products are in demand which offer a broad spectrum of activities with negligible side effects. Pinus succinefera is a fossilized resin from coniferous woods that belongs to the genus Pinus of the...

Plant derived oils have recently been found to be more effective in pharmaceutical sectors than synthetic goods since these plants contain physiologically active chemicals with a wide range of therapeutic effects. Essential oil, also known as essence, volatile oil, etheric oil, or aetheroleum, is a complex mixture of volatile elements biosynthesise...

Background: Mucormycosis, also referred to as black fungus, is a fatal Angio invasive fungal infection caused by a colony of molds known as mucoromycetes. Rhizopus oryzae is a major fungus that is responsible for almost 70% of the total mucormycosis cases. RNA-dependent RNA polymerase (RdRp), is a crucial enzyme in the RNA polymerization mechanism...

Influenza virus infection is highly contagious and difficult to treat, because of the emergence of different strains formed via antigenic variations. Influenza is a causative agent of acute viral respiratory infection with a broad infectious range that includes all age groups and is linked with high mortality during pandemics, epidemics, and sporad...

Tuberculosis (TB) is a curable illness, caused by, Myco-bacterium Tuberculosis (Mtb), is still significant. Technological progress in TB treatment has been limited. The major therapeutic technique to treat the condition is first line anti-tuberculosis drugs (A fixed-dose, single-tablet combination of four drugs: Rifampin, isoniazid, pyrazinamide, a...

Background : Breast cancer being one of the most common cancers in women all around the world is a dominant cause of deaths occurring all around the globe. The available potent drugs for breast cancer show adverse effects and are found ineffective in patients. Furthermore, this acquired resistance that is vulnerable to cancer-related mutations and...

The need for efficient plant-based remedies is becoming acknowledged across the world as the incidence of infectious diseases rises. Essential oils have been actively studied in the research for plant-derived biomolecules that can substitute synthetic medications and, to some extent, eliminate or lessen their side effects. The goal of this study wa...

While tuberculosis is a curable disease, Mycobacterium tuberculosis (M. tb), its etiological agent, remains a major human pathogen. For thousands of years of human life, this pathogen leads to more human deaths than any other infectious agent. Relatively affordable new drugs for the treatment of this lethal disease need to be developed in light of...

Background: In tremendously effective antiretroviral therapy for Human Immunodeficiency Virus 1 (HIV1) infections, integrase inhibitors are essential drugs. Resistance resulting from mutations, on the other hand, poses a threat to the medication's long-term efficacy in HIV-1 infected people. Purpose: The current study utilized in silico techniques,...

The growing food adulteration and increasing antibiotic intake has led to deterioration of gut health in humans. Probiotics are feed supplements in the form of live microorganisms that have a positive impact on the host by improving intestinal microbial balance. They offer a variety of important and documented beneficial effects, including the prev...

Garcinia L. is a pantropically distributed genus with high species richness in South East Asia. It is a tropical evergreen plant with distinct morphological characteristics and has a high degree of endemism. Outstanding features of the Garcinia L. genus are monopodial growth, leafy texture, oil cavities containing yellow or light-colored resins pre...

Even with the advancement in the field of medicine, currently, there are no permanent cures available to combat the Chikungunya virus (CHIKV) infection, and the only therapy being used is symptomatic treatment. Therefore, there is an exigency to find out potential drug candidates against CHIKV infection. Authors administered in silico screening to...