Vikas Ghai

Vikas Ghai
FYR Diagnostics

PhD

About

33
Publications
2,781
Reads
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363
Citations
Additional affiliations
May 2020 - present
FYR Diagnostics
Position
  • Senior Researcher
February 2016 - February 2016
Institute for Systems Biology
Position
  • PostDoc Position
January 2012 - January 2014
Cornell University
Position
  • PostDoc Position
Education
September 2005 - November 2011
The University of Calgary
Field of study
  • Biochemistry and Molecular Biology
September 2001 - April 2005
University of Waterloo
Field of study
  • Biology

Publications

Publications (33)
Article
Full-text available
MicroRNAs (miRNAs) have been shown to be critical mediators of many cellular and developmental processes and have been implicated in different human diseases. Since the observation of extracellular miRNAs present in various biofluids, much attention and excitement have been garnered toward understanding the functional roles of these circulating ext...
Article
Full-text available
Introduction Diabetic nephropathy (DN) is a form of progressive kidney disease that often leads to end-stage renal disease (ESRD). It is initiated by microvascular complications due to diabetes. Although microalbuminuria (MA) is the earliest clinical indication of DN among patients with type 1 diabetes (T1D), it lacks the sensitivity and specificit...
Article
Full-text available
Type 2 Diabetes Mellitus (T2DM) is the most prevalent form of diabetes in the USA, thus, the identification of biomarkers that could be used to predict the progression from prediabetes to T2DM would be greatly beneficial. Recently, circulating RNA including microRNAs (miRNAs) present in various body fluids have emerged as potential biomarkers for v...
Article
Full-text available
Recently, microRNAs (miRNAs) in circulating extracellular vesicles (EVs), have emerged as a source of potential biomarkers for various pathophysiological conditions, including metabolic disorders such as diabetes. Type 2 diabetes mellitus (T2DM), is the most prevalent form of diabetes in the USA, with 30 million diagnosed patients. Identifying miRN...
Article
Full-text available
Blast-related mild traumatic brain injury (mTBI) is considered the ‘signature’ injury of the wars in Iraq and Afghanistan. Identifying biomarkers that could aid in diagnosis and assessment of chronic mTBI is urgently needed, as little progress has been made toward identifying blood-based biomarkers of repetitive mTBI in the chronic state. Addressin...
Article
Full-text available
Objective Cardiac sarcoidosis is difficult to diagnose, often requiring expensive and inconvenient advanced imaging techniques. Circulating exosomes contain genetic material, such as microRNA (miRNA), that are derived from diseased tissues and may serve as potential disease-specific biomarkers. We thus sought to determine whether circulating exosom...
Article
Mounting evidence points to the significance of neurovascular-related dysfunction in veterans with blast-related mTBI, which is also associated with reduced [¹⁸F]-fluorodeoxyglucose (FDG) uptake. The goal of this study was to determine whether plasma VEGF-A is altered in veterans with blast-related mTBI and address whether VEGF-A levels correlate w...
Article
Background Anti PD-1/PD-L1 antibody therapy is a standard treatment for advanced non-small cell lung cancer (NSCLC), and PD-L1 immunohistochemistry is used as a predictive biomarker for therapeutic response. However, because not all NSCLC patients with a high PD-L1 respond, and some patients with low PD-L1 expression show durable benefit, more accu...
Article
The Extracellular RNA Communication Consortium (ERCC) was launched to accelerate progress in the new field of extracellular RNA (exRNA) biology and to establish whether exRNAs and their carriers, including extracellular vesicles (EVs), can mediate intercellular communication and be utilized for clinical applications. Phase 1 of the ERCC focused on...
Chapter
Full-text available
Early detection, diagnosis and stratification are vital for the proper management and treatment of cancer patients, and as such the development of sensitive, specific and informative cancer biomarkers is critical. However, the current diagnostic approach is still based on invasive procedures. For example, tissue biopsy is usually needed to confirm...
Article
Full-text available
Borrelia burgdorferi, a bacterium in the spirochete phylum, is the causative agent of Lyme disease. B. burgdorferi has a linear chromosome with a number of circular and linear plasmids. Bacteria, including B. burgdorferi, release spherical outer membrane vesicles (OMVs) that are known to carry secretory products including metabolites, nucleic acids...
Article
Background: Anti PD-1/PD-L1 antibody is a standard first or second-line treatment for advanced non-small cell lung cancer (NSCLC), and PD-L1 immunohistochemisty is used as a predictive biomarker for therapeutic response. However, because patients with lower PD-L1 expression also show durable response in NSCLC, and the usefulness of PD-L1 immunohist...
Article
Full-text available
Background: Rural areas in the state of New Mexico have been the "ground-zero" for the epidemic of diabetic Chronic Kidney Disease (CKD) in the United States. However, there is limited research about risk factors of diabetic CKD in this area and scarce data regarding the performance of emerging markers of renal filtration and epigenetic biomarkers...
Data
Patient information and demographics.
Data
Extracellular vesicle–specific enrichment in urine samples of patients with type 1 diabetes mellitus.
Data
Average RNA input concentration and read counts for urine, exosome, and exosome-depleted fractions.
Data
Expanded microRNA profiling data for urine, and exosome fractions (≥0.6 log2FC, P ≥ 0.05).
Data
Protein gels from patient urine and extracellular vesicle (EV) fractions. (A) Patient urine samples run on a sodium dodecyl sulfate–polyacrylamide gel electrophoresis stained with Coomassie blue. (B) Corresponding EV fractions run under the same conditions. I, intermittent microalbinuria (MA) status; L, ladder; N, normal; O, overt nephrology; P, pe...
Article
Proper development of a multicellular organism relies on well-coordinated regulation of cell fate specification, cell proliferation and cell differentiation. The C. elegans postembryonic mesoderm provides a useful system for uncovering factors involved in these processes and for further dissecting their regulatory relationships. The single Spalt-li...
Article
Full-text available
The Caenorhabditis elegans pharyngeal glands represent one of five cell types in the pharynx. We have previously shown that the bHLH transcription factor, HLH-6, is required for gland development and for expression of many, but not all, gland genes (Smit et al., 2008). Here, we have identified additional gland-expressed genes and find that transcri...
Article
Full-text available
The acquisition and maintenance of shape is critical for the normal function of most cells. Here we investigate the morphology of the pharyngeal glands of Caenorhabditis elegans. These unicellular glands have long cellular processes that extend discrete lengths through the pharyngeal musculature and terminate at ducts connected to the pharyngeal lu...
Article
Full-text available
The Caenorhabditis elegans gene hlh-6 is expressed specifically in pharyngeal glands, one of five distinct pharyngeal cell types. Expression of hlh-6 is controlled by a discrete set of cis-regulatory elements, including a negative element called HRL1. Here we demonstrate that HRL1 is a functional binding site for LAG-1, the CSL transcriptional effe...

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