Vijay Kumar Panthi

Queensland University of Technology | QUT · Discipline of Pharmacy

The lack of knowledge about the absorption, distribution, metabolism, and excretion (ADME) of vaccines makes biopharmaceutical optimization difficult. This was shown during the COVID-19 immunization campaign, where gradual booster doses were introduced as the initial dose was not offering broad protection against infection. Thus, understanding vacc...

Quercetin is a well-known plant flavanol that exhibits multiple biological activities, including antioxidant, anti-inflammatory and anticancer activities. The role of quercetin in wound healing has been widely explored by a range of researchers in different models. However, the physicochemical properties, such as solubility and permeability, of thi...

Cancer-related death is a significant health and economic burden worldwide, and some conventional chemotherapy is associated with limited effectiveness in completely curing various cancers, severe adverse effects, and destruction of healthy cells. To overcome the complications associated with conventional treatment, metronomic chemotherapy (MCT) is...

The concept behind synbiotics is that prebiotics aid in the survival of probiotics in the intestine. This indeed could help in balancing the gut bacteria, which is considered to be beneficial for the intestine, metabolism, and enhancing the immune systems. In addition, synbiotics are widely reported to possess advantageous effect to prevent, treat,...

Luliconazole (LCZ) is a new antifungal agent containing imidazole moiety which revealed broad-spectrum antifungal activity. The aim of this research was to prepare water-in-oil (w/o) emulsion-based cream formulation of LCZ in addition to the development and validation of an analytical method by reverse-phase high-performance liquid chromatography (...

A formulation of an adapalene nanohydrogel (ADP-NH) using different surfactants and cosurfactants for topical application was developed and characterized. The best formulation was obtained with nanohydrogel (NH) containing Tween-80- (NH-Tween-80-) incorporated carbopol-940 and ethanol, 0.67% and 3.00% w/w, respectively. The optimized formulations o...

A new reverse phase high-performance liquid chromatography (RP-HPLC) method was developed and validated for the simultaneous estimation of pediatric oral powder formulation containing cefixime (CFX) and clavulanic acid (CVA). In this research, an analytical C18 (4.6 mm × 25 cm), 5 μm column was used for chromatographic separation with a mixture of...

Serratiopeptidase (SRP) is a proteolytic enzyme that emerged as one of the most potent anti-inflammatory and analgesic drugs. The purpose of the present study was to formulate and evaluate enteric-coated tablets for SRP and investigate their stability using a simple and validated analytical method by ultraviolet (UV) spectroscopy. The colloidal sil...

Quercetin is the principal flavonoid compound commonly extracted from cranberries, blueberries, apples and onions. It possesses a wide spectrum of bio-pharmacological properties and may offer promising new options for the development of more effective chemo-preventive and chemo-therapeutic strategies owing to its powerful antioxidant and free-radic...

In the present study, an aqueous extract was prepared using calli from the in vitro-derived leaves of Pyrus pyrifolia cultured in Murashige and Skoog medium containing picloram for a plant growth regulator. The major biological components in the callus extract were identified as uridine (1), adenosine (2), and guanosine (3). In terms of the antioxi...

Co-administration of conventional and natural chemotherapeutics offers synergistic anticancer efficacy while minimizing adverse effects. In this study, an oral co-delivery system for pemetrexed (PMX) and quercetin (QCN) was designed based on water-in-oil-in-water nanoemulsion (NE), which is highly absorbable because it enhances the intestinal membr...

Co-administration of conventional and natural chemotherapeutics offers synergistic anticancer efficacy while minimizing adverse effects. In this study, an oral co-delivery system for pemetrexed (PMX) and quercetin (QCN) was designed based on water-in-oil-in-water nanoemulsion (NE), which is highly absorbable because it enhances the intestinal membr...

Objective: The current study sought to design an oral delivery system of pemetrexed (PMX), a multitargeted antifolate antimetabolite, by enhancing its intestinal membrane permeability. Materials and methods: PMX was ionically complexed with a permeation enhancer such as Nα-deoxycholyl-l-lysyl-methylester (DCK) and prepared as an amorphous solid dis...

In this study, we prepared and characterized a callus extract from Citrus junos and assessed its utility as a source of topical anti-aging ingredients. Callus extract was produced by aqueous extraction from Citrus junos grown on Murashige and Skoog medium with picloram as a growth regulator. After measuring the total phenolic and flavonoid contents...

Amisulpride used for easing the symptoms of severe or sudden (acute) and ongoing or long term (chronic) schizophrenia, a sort of mental health condition which affects the way of thinking, feeling, or action. In this formulation frequent problem were high disintegration and low hardness. As per formulation elaborated in formulation chart it is mainl...

Levetiracetam is an antiepileptic drug with favourable pharmacologic characteristics and demonstrated activity in improving seizure control. Core part of tablet is prepared by wet granulation method. After final formulation the tablet is coated by both seal and film coating method with Hydroxy Propyl Methyl Cellulose 5 cps and packed in alu-alu str...

Essential medicines are those that satisfy the priority health care needs of the population. This study was conducted at two primary healthcare providers to the rural areas of Jhapa, Nepal namely Birta Health Post and Haldibari Sub-health Post among patients having infectious diseases from 19 th June 2013 to 18 th July 2013. The aim of the study is...

These investigations compare the effectiveness of antihypertensive agents among hypertensive patients. It was an open label, prospective and comparative study carried out in the Out-patient department at BPKIHS, Dharan, Sunsari, Nepal. Patients of either sex aged between 25-80 years suffering from mild to moderate hypertension were randomly selecte...