Vijay R Chidrawar

SVKM’s NMIMS School of Pharmacy and Technology Management (SPTM) · Pharmacology

Infectious diseases are illnesses caused by pathogenic microorganisms, including viruses, bacteria, fungi, and parasites. These diseases can be transmitted from one individual to another, as well as through contaminated food, water, and insect bites, infectious agents invade the body, multiply, and disrupt normal bodily functions, leading to variou...

Post-operative wound healing can be complicated due to various factors, which may lead to delay in healing and causes further infections with wound dehiscence. The bioactive compounds are considered as safe alternative for synthetic drugs in minimizing wound complications. Thus, Eucalyptus camaldulensis leaves were extracted using a hydroalcoholic...

Diabetes mellitus, a metabolic disorder characterized by impaired insulin activity and/or secretion, has led to a global increase in diabetic patients, highlighting the urgent need for safer, herbal alternatives to synthetic drugs. Costus speciosus, a plant traditionally used for various ailments, has emerged as a promising source of bioactive comp...

Purpose Although the resistance to decomposition is caused by varied conformation and rigidity, lignocellulose is consid- ered a potential feedstock for the development of substitute fuels, chemicals, fabricating pharmaceutical dressing, and food packaging components. Lignocellulose has been regarded as an essential resistance element in the exploi...

Approximately 20 million new instances of cancer and 10 million cancer-related deaths were reported in 2023, making cancer one of the leading causes of mortality globally. The number of deaths due to cancer worldwide is expected to double by 2050 to an estimated 18.5 million, compared to 9.7 million in 2022. Though there are heaps of new advanced t...

The alarming rise of pathogen antibiotic resistance presents a major global health challenge and demands a novel way to control the microbial infections. Simultaneously, nanotechnology has found numerous uses in electrical as well as electronic systems, including timing, filtering, power factor adaptation, and capacitors for energy storage. This wo...

Remediation of organic and inorganic waste contamination is a growing concern in the environmental sector, while biomedical researchers face challenges in targeting drug delivery for specific diseases. Nanotechnology, particularly the use of polymeric nano-sponges (NS), has emerged as a highly competitive and rapidly evolving solution in both drug...

Although adding flocculants is an essential step in wastewater treatment and maintaining the stability of the solid-state in solution to produce a loose cell-like structure, in some instances, polymeric material fails to support this due to specific surface charges. Therefore, the current study aimed to develop a cationic form (CBS) obtained from u...

Cancer presents a formidable challenge, necessitating innovative therapies that maximize effectiveness while minimizing the side effects to healthy normal cells and tissues. Recent development in management of oncology through nano-enable technology through nano-structured objects have significantly impacted its prevalence. Among several nanotechno...

With the increase in the global human population, the adequate supply of resources has become limited. The necessity of the hour is for the development of technology engendering environmental sustainability, rehabilitation and clean energy sources for the long-term development of human society. Nanotechnology has a tremendous impact on the developm...

Physical and psychological stress has an inverse relation with male libido and sperm quality. The present study investigates the potential fertility-enhancing properties of Desmodium gangeticum (DG) root extracts in male Wister rats subjected to immobilization-induced stress (SIMB). DG roots were extracted using n-hexane (HEDG), chloroform (CEDG),...

BACKGROUND India suffers a quarter of the global burden of cervical cancer (CC) but is controllable by taking some precautions. The major issue is the low amount of participation among women in screening and vaccination for disease. The objective of the research is to evaluate knowledge, attitude, and practice (KAP) regarding CC among college going...

Hypothalamus is central to food intake and satiety. Recent data unveiled the expression of N-methyl-D-aspartate receptors (NMDAR) on hypothalamic neurons and their interaction with GABA A and serotoninergic neuronal circuits. However, the precise mechanisms governing energy homeostasis remain elusive. Notably, in females, the consumption of progest...

South Africa, a biodiversity hotspot, is rich in medicinal and aromatic plants covering an extensive area with different environmental conditions. The geographical position of Brazil, its geomorphology, the presence of flora of past geological eras, and the coexistence and interplay of biotic and non-biotic factors have defined it as a region of hi...

Biogenic nanoparticle production is in demand as it is secure, has great promise, and is environmental friendly. This study aimed at green synthesis, characterization, and evaluation of Terminalia arjuna selenium nanoparticles (TA-SeNPs) for their antioxidant, antibacterial, anticancer activities, and their incorporation in gel for biomedical appli...

The main objective of this review is to provide a comprehensive overview of the current evidence regarding the use of chitosan-based hydrogels to manage skin infections. Chitosan, a naturally occurring polysaccharide derived from chitin, possesses inherent antimicrobial properties, making it a promising candidate for treating various dermal infecti...

This study investigated the effect of dechlorophyllization on the phytochemistry, polyphenol contents, and biological activities of Psidium guajava leaf ethanolic extracts with chlorophyll (PGE), chloroform dechlorophyl-lized (PGC), and sedimentation dechlorophyllized (PGS). Phytochemical profiling results demonstrated that PGE, PGC, and PGS extrac...

Contagious wound infection has become one of the most common challenges concomitants with the wounds, causing severe inflammatory responses, and ultimately delaying skin tissue regeneration. Herein, a phenolic-rich Eucalyptus camaldulensis leaf hydrophobic (ECG) and hydrophilic extract (ECY), in varied content was fortified within a hypromellose po...

In the 21st century, melanoma and non-melanoma skin cancers have become an epidemic outbreak worldwide. Therefore, the exploration of all potential preventative and therapeutic measures based on either physical or bio-chemical mechanisms is essential via understanding precise pathophysiological pathways (Mitogen-activated protein kinase, Phosphatid...

Bacterial infection has become one of the most common challenges associated with wound healing, causing severe inflammatory responses, with delayed healing. Herein, a phenolic-rich Psidium guajava leaf ethanolic extract with chlorophyll (PGE), chloroform dechlorophyllized extract (PGC) or sedimentation dechlorophyllized extract (PGS) was fortified...

The plain 5-fluorouracil (5FU) formulations available in the market are associated with adverse effects such as skin irritation, pruritus, redness, blisters, allergy, and dryness on the site of application. The objective of the present study was to develop a liposomal emulgel of 5FU with increased skin permeability and efficacy using clove oil and...

Objective: Extensively drug-resistant tuberculosis (XDR-TB) has raised a great threat to human health globally, especially in developing countries. The objective of the present study is to collate and contrast the proportions of treatment outcome in the previously published XDR-TB articles. Methods: By considering inclusion criteria and search e...

Aims: Multidrug resistant (MDR) bacteria pose a major public health issuer globally. The genes for antibiotic resistance are transferred vertically in the form of genomic DNA and horizontally in the form of plasmids or transposons. Antibiotic are extensively used in animal farming to treat and prevent animal diseases, and at sub-therapeutic doses,...

Aim: The present study was undertaken to investigate the antiepileptic activity of the essential oil of the Oleo-gum-resin obtained from Commiphora Myrrha (CM) resins. Material and Methods: The essential oil from Commiphora Myrrha (EOCM) was isolated using the Clevenger apparatus. The anticonvulsant effect was examined against pentylenetetrazole (P...

In the present study, we have investigated and/or compared the role of glibenclamide, G as cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor, and lubiprostone, L as chloride channel-2 (ClC-2) activator in the 2,4-dinitrobenzene sulfonic acid (DNBS)-induced gastrointestinal inflammation. GI inflammation was induced by intrarectal...

The present study has been undertaken to evaluate the association between serum uric acid levels as a marker of iron overload in Saudi people. A retrospective cohort study was carried out at King Fahad Medical City in the Riyadh-central region of the Kingdom of Saudi Arabia for four months from 1 st November 2018 to the end of February 2019 on the...

Introduction: Obesity is closely associated with various types of illness, primarily caused by more calorie intake than body burn. In adipocytes, Calcium (Ca 2+) is an important second messenger involved in the regulation of many physiological functions which are essential for survival. In the present research, we have investigated the role of Ca 2...

Kidney stones or urolithiasis is a growing global problem. It is a complex phenomenon which results due to physiochemical changes including super saturation, crystallization and retention within the renal tubules. The problem of the stone formation is considered as a medical challenge due to its high rate of recurrence and also due to multifactoria...

bjective: Angiogenesis, the formation of new capillary blood vessels. Wehave compared the effect of two Angiotensin-Converting Enzyme inhibitors(ACEIs) and two Angiotensin Receptor Blockers (ARBs) for its anti-angio-genic property to pinpoint their role in capillary growth. Methods: The anti-angiogenic activity of ACEIs (Lisinopril, Ramipril) and A...

Introduction: Thymus vulgaris (za"atar) is one of the most famous and traditional spices of Arab countries. Extracts of Thymus vulgaris (zatar) found to be useful as traditional medicine. The current studies are aiming to further explore the phytoconstituents of Thymus vulgaris and its biological activity. Methodology: The present study investigate...

Objective: The present study was undertaken to emphasize on medication errors occurs due to prescription errors. Methodology: In this study we evaluated prescription pattern for completeness in 300 prescriptions of the outpatient department in primary care hospitals situated in the Northern region of Saudi Arabia and analyzed for completeness with...

Bone fitness is considered as an important public health problem especially in post-menopausal women. Numerous studies have investigated to understand beneficiary effects of mother milk on the baby but very few studies have been conducted to understand the effect of breastfeeding on the bone health of lactating women. We hypothesized that high calc...

Objective: Angiogenesis is the development of new blood vessels. The ion channels on endothelium play a vital action in cell proliferation and so in the related angiogenesis. We aimed to investigate the anti-angiogenic effects of Mefloquine (Cl− channel blocker) and 4-Aminopyridine (K+ channel blocker). Methods: The anti-angiogenic activities of Me...

Background: Ca²⁺ channels and calcium signalling appears to play a critical role in the differentiation and functions of osteoclasts and osteoblasts and L-types voltage dependent calcium channels (VDCC) are expressed on bone cells. Either activation or blocking of these channels in bone homeostasis is found to be controversial. Based upon this we h...

Objective: The present study was conducted to investigate the effect of two different doses of two calcium channel blockers i.e. verapamil and nifedipine on genesis and control of osteoporosis by considering various biochemical and bone parameters against ovariectomized (OVX) rat model. Methods: We have used total 42 female albino Wistar rats; one...

Many patients may administered medications like captopril (ACE inhibitor) for treatment of chronic diseases and may also take Paracetamol as an Over The Counter (OTC) drug which may interact with captopril. Therefore, the aim of this study is to evaluate of the hepatoprotective effect of captopril on liver toxicity induced by low and high dose of p...

Objective: To evaluate the role of nifedipine (L-type of calcium channel blocker), glibenclamide [cystic fibrosis transmembrane conductance regulator (CFTR) channel blocker], niflumic acid (chloride channels blocker) and 2-aminoethyldiphenyl borate (calcium releaseactivated channels channel blocker) against chemically induced inflammatory bowel dis...

Present study was undertaken to emphasize on medication errors occurs due to prescription errors. In this study we evaluated prescription pattern for completeness in 100 prescriptions of the outpatient department in primary care hospitals across Hyderabad city India and analyzed for completeness with respective to (a) Prescriber information (b) Pat...

The present study aims to investigate the centrally and peripherally acting analgesic activity of the aqueous extract of Solenostemma argel (AESA) in mice by using Eddy’s Hot plate and acetic acid induced writhing model respectively. The extract was administered per orally at dose of 10 ml/kg and 20 ml/kg while diclofenac sodium was used as sta...

Angiogenesis is the growth of new blood vessels. It mostly occurs where Vascular endothelial Growth factors (VEGF) gets triggered and leads to Endothelial Cell proliferation and thus leading to formation of new blood vessels. Inflammation and free radical formation and are the imperative factors for the activation of VEGF and endothelial proliferat...

The present study aims to investigate the centrally and peripherally acting analgesic activity of the aqueous extract of Solenostemma argel (AESA) in mice by using Eddy's Hot plate and acetic acid induced writhing model respectively. The extract was administered per orally at dose of 10 ml/kg and 20 ml/kg while diclofenac sodium was used as standar...

The objective of this study was to determine the knowledge, attitude and practices of the use of vitamin supplements among the people of the Northern Border Region of Saudi Arabia. Total 400 patients were interviewed during the period of January 2015 to April 2015. A pre-tested and structured questionnaire was used to collect information. It consis...

Cataract is an eye disease characterized by a cloudiness of the normally transparent crystalline lens. Diabetes and smoking are the known risk factors for cataract development. It is well known fact that inorganic ions like Na + , K + , Ca ++ and Cl -play an important role for the maintenance of lens hydration and transmittance. Nicotine aggravates...

Objective Anti–obesity activity of alcoholic and methanolic extracts of roots of Clerodendrum phlomidis was evaluated against high fat diet (HFD) induced obesity in C57BL/6J female mice.Methods Obesity was induced by feeding high fat diet for 13 weeks to C57BL/6J female mice and one group was kept on normal chow diet in order to evaluate the effect...

osteoporosis is a multifactorial skeletal disease, characterized by increased porosity of the skeletal resulting from reduced bone mass, the associated structural changes predispose the bone to fracture. A large variety of animal species, including rodents, rabbits, dogs, and primates, have been used as animal models osteoporosis research. Among th...

Pavani Manupati et.al / IJIPSR / 2 (9), Abstract Many medicinal plants constitute a rich source of bioactive chemicals that are largely free from adverse effects and have excellent pharmacological actions they could lead to the development of new classes of possibly safer drugs. Phytochemical studies of leaves of plants reveal that presence of bioa...

The incidence of coronary heart disease has markedly increased in India over the past few years. Ischemic heart disease, the largest cause of morbidity and mortality in the developed and developing countries today is overwhelmingly contributed by atherosclerosis. The main objective of the study is to evaluate the phytochemical screening of the plan...

Objective: The present study was designed to investigate the prophylactic and curative effect of ethanolic extract of Bassia malabarica bark (EBBM) against cisplatin (7 mg/Kg single dose i. p) induced nephrotoxicity in male albino rats of Wistar strain. Materials and Methods: After the treatment schedule for 15 days, the extent of nephrotoxicity wa...

Cardiotoxicity is a condition that occurs during therapy with several cytotoxic drugs and may be the dose limiting factor in the cancer treatment. The use of herbal supplements has become increasingly popular in recent years. Cardiotoxicity appears in several forms, though cardiomyopathy and congestive heart failure are the most important cumulativ...

ARTICLE INFO ABSTRACT Article History: Received 11 th , June, 2014 Received in revised form 21 st , June, 2014 Accepted 11 th , July, 2014 Published online 28 th , July, 2014 Cisplatin is the potent antineoplastic drug with significant nephrotoxic effects. The present study is to evaluate the nephrotoxic effects on varying doses of cisplatin such a...

Objective: The present study was designed to investigate the prophylactic and curative effect of ethanolic extract of Bassia malabarica bark (EBBM) against cisplatin (7 mg/Kg single dose i. p) induced nephrotoxicity in male albino rats of Wistar strain. Materials and Methods: After the treatment schedule for 15 days, the extent of nephrotoxicity wa...

The present study is performed on the whole plant ethanolic extract of Physalis alkekengi (EEPA) and successive ethanolic extract of Physalis alkekengi (SEEPA) to screen the phytochemical compounds and analgesic activity. Analgesic activity is being assessed on mice using acetic acid induced writhings and on rats using Eddy"s hot plate method.. The...

Hepatocytes are the predominant liver cells which are responsible for the multifold functions of the liver and are susceptibleto injury by the drugs like paracetamol. Herbal drugs play an important role in the cure of liver diseases. Aloe vera (Aloebarbadensis) has been used for many centuries for it’s curative and therapeutic properties, and healt...

Diabetes mellitus is a complex metabolic disorder arising from lack of insulin production or insulin resistance. It is a leading cause of morbidity and mortality in the developed world, particularly from diabetic complications. Activation of polyol pathway under chronic hyperglycemic conditions by accumulation of sorbitol is the major pathway respo...

Objectives: To study the protective potential of polysaccharides of Aloe vera against experimentally induced liver injury."Methods: Polysaccharides of Aloe vera were identified and isolated by alcohol precipitation method. Hepatotoxicity was induced with ccl 4 (0.25ml/100gm). The effect of Aloe vera fractions on ccl 4 induced liver injury was studi...

Objectives: To study the protective potential of polysaccharides of Aloe vera against experimentally induced liver injury. " Methods: Polysaccharides of Aloe vera were identified and isolated by alcohol precipitation method. Hepatotoxicity was induced with ccl 4 (0.25ml/100gm). The effect of Aloe vera fractions on ccl 4 induced liver injury was stu...

The adverse drug responses are an important post marketing public health issue and thus "toxicology" which deals with understanding such responses has gained importance since many decades. The research scientists have uncovered the genetic code and the foundation of most fundamental building blocks for molecular activity that supports biological st...

Pharmacovigilance defined by the World Health Organization as ‗The science and activities relating to the detection, assessment, understanding and prevention of adverse effects or any other drug-related problem' plays a key role in ensuring that patients receive safe drugs. Pharmacovigilance has been regarded as a type of continual monitoring of un...