Vignesh Muthuvijayan

Vignesh Muthuvijayan
Indian Institute of Technology Madras | IIT Madras · Department of Biotechnology

PhD

About

47
Publications
8,486
Reads
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615
Citations
Citations since 2016
39 Research Items
561 Citations
2016201720182019202020212022020406080100120140
2016201720182019202020212022020406080100120140
2016201720182019202020212022020406080100120140
2016201720182019202020212022020406080100120140
Introduction
Vignesh Muthuvijayan is a Chemical Engineer by training. He received his BTech in Chemical Engineering from A. C. Tech, Anna University, Chennai. He went on to pursue his Master's degree in Chemical and Biochemical Engineering at the University of Maryland, Baltimore County, and his Ph.D. in Chemical Engineering at Oklahoma State University. He also worked as a post-doc at Johns Hopkins University. After spending about 8 years in the United States, he moved back to India to join the Department of Biotechnology at IIT Madras in October 2011. His research interests are in the area of biomaterials and their applications. He has published more than 15 articles in the top peer-reviewed journals in his field. He has also presented his work at many international and national conferences.

Publications

Publications (47)
Article
In this research, biomimetic deposition of “bone-like” apatite by novel Gram-positive bacterium Bacillus tequilensis was investigated. Hydroxyapatite (HA) was produced by Bacillus tequilensis using defined biomineralization media and dried. Calcination was carried out at different temperatures (100 °C–900 °C) and HA nanopowder was analysed for its...
Article
Chronic wounds require suitable treatment and management strategies for proper healing. Among other causes, infection delays the healing of wounds and increases the risk of wound-related complications. In this study, an inherently antibacterial and biocompatible wound dressing is developed to enhance the healing. Chemical modification of a natural...
Article
Full-text available
Liposomal drug formulations often utilise passive drug-loading methods to encapsulate drugs into the liposome. These formulations require an additional processing step to remove the unencapsulated drug, using techniques like ultracentrifugation, ultrafiltration, column chromatography, dialysis, etc. However, these methods suffer from downsides like...
Chapter
The repairing procedure in the nervous system is intricate and brings significant difficulties to investigators. The complication of the structure and function of the nervous system, and its slow rate of regeneration, make it further challenging to treat in comparison to other human tissues when damage takes place. Furthermore, the existing therape...
Article
A rationally designed amphiphilic poly(aryl ether)-based dendrimer self-assembles into nanomicelles and exhibits tunable morphology upon varying the hydrophilic chain length. The self-assembled 30 nm-sized dendrimer nanomicelles successfully entrapped doxorubicin, demonstrated...
Article
Full-text available
Endophytic fungi with the ability to produce plant based secondary metabolites are a potential alternative for producing the host plant metabolite and to prevent natural plants from extinction. To isolate a high metabolite yielding endophytic strain from plants, hundreds of endophytic strains are screened and tested for product yield separately und...
Chapter
Soft tissues connect, support, or surround other structures and organs of the body, including skeletal muscles, tendon vessels, and nerves supplying these components. Also, organs such as the heart, brain, liver, and kidney are considered as soft tissues. Acute and chronic injury may cause transient or permanent damage to organs and soft tissues. I...
Article
Full-text available
Bacterial adhesion and colonization on stainless steel (SS) based surgical instruments, hospital equipments, orthopedic implants, water purification and food processing units are a major problem. Imparting rechargeable antibacterial properties to SS offers the prospect of a reusable and clean surface. In this study, SS surface was functionalized wi...
Article
Full-text available
In recent years, there has been an increasing focus on inorganic nanomaterials for various applications, such as catalysis, thermal energy storage, biomedical imaging, drug delivery, and tissue engineering. Amongst these, Mesoporous Silica Nanoparticles (MSNs) possess an orderly mesoporous structure, large surface area, and pore volume. Hence, MSNs...
Article
Full-text available
Fabrication of a surface engineered electrospun scaffold having biomimetic properties like the extracellular matrix (ECM) is essential for neural tissue engineering. In this regard an electroconductive and elastomeric scaffold with aligned fibers acting as substrate has a great impact on directional outgrowth of neurites. In consideration to that,...
Article
Full-text available
Nitric oxide (NO) is an important signalling molecule involved in haemostasis. NO, present as endogenous S-nitrosothiols, is released by cysteine through a transnitrosation reaction. To exploit this mechanism, cysteine was immobilised onto the different carboxylated polyethylene terephthalate (PET) surfaces using 1-step EDC (1-ethyl-3-(3-dimethylam...
Article
The increased threat of bacterial resistance against conventional antibiotics has warranted the need for the development of membrane targeting antibacterial agents. Several self-assembled cationic amphiphiles with different supramolecular structures have been reported in recent years for potent antibacterial activity with increased specificity. In...
Article
Bacterial infection is one of the major complications occurs in biomedical implants. Bacterial adhesion on the implant surfaces can form a biofilm, which leads to infection and failure at an earlier phase of implantation. So the surface properties of the implant such as surface topography, surface energy, and chemistry play a crucial role in bacter...
Article
Fluorophores are used for sensing biologically relevant ions, toxic metals or pathogenic markers. However, the mode of entry of such fluorophores into the cell greatly depends on their size, shape, surface charge, functional groups, and hydrophobicity. In particular, the influence of hydrophobicity on the intracellular uptake of fluorophores is poo...
Article
Poor haemocompatibility of material surfaces is a serious limitation that can lead to failure of blood-contact devices and implants. In this work, we have improved the haemocompatibility of polyethylene terephthalate (PET) surfaces by immobilizing apyrase/ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) on to the carboxylated PET. NTPDase...
Article
Hyaluronic acid from metabolically engineered Lactococcus lactis (HAL) was characterized for its biocompatibility and immobilized on the polyethylene terephthalate (PET) surface. HAL was chemically crosslinked on hydrolyzed PET (hPET) surface to form HAL-coated PET (hPET-HAL). The unmodified and modified PET were characterized by Fourier-transform...
Article
A novel method of preparing chitosan gels using in situ generated negatively-charged colloidal salts of a variety of metal ions is described. Their potential as scaffolds for tissue-engineering and as...
Article
Full-text available
Tissue engineering combines cells, scaffolds and signalling molecules to synthesize tissues in vitro. However, the lack of a functioning vascular network severely limits the effective size of a tissue-engineered construct. In this work, we have assessed the potential of reduced graphene oxide (rGO), a non-protein pro-angiogenic moiety, for enhancin...
Article
Treatment of chronic non-healing wounds in diabetes is still a major clinical challenge. Here, we have developed reduced graphene oxide (rGO) loaded isabgol nanocomposite scaffolds (Isab + rGO) to treat normal and diabetic wounds. rGO was synthesized by rapid reduction of graphene oxide (GO) under focused solar radiation. Then, rGO was uniformly di...
Article
We have developed a novel hydrogel composed of konjac glucomannan (KGM), human hair proteins (KER), and an ethanolic extract of Avena sativa (OAT) and evaluated its potential as a dressing material for diabetic wounds. KGM is an excellent biocompatible gelling agent that stimulates fibroblast proliferation and immunomodulation. Human hair proteins...
Article
Full-text available
Chronic wounds cost several billion dollars of public healthcare spending annually and continue to be a persistent threat globally. Several treatment methods have been explored, and all of them involve covering up the wound with therapeutic dressings that reduce inflammation and accelerate the healing process. In this present study, morin (MOR) was...
Article
Full-text available
We have developed L-glutamic acid (LG) loaded chitosan (CS) hydrogels to treat diabetic wounds. Although literature reports wound healing effects of poly(glutamic acid)-based materials, there are no studies on the potential of L-glutamic acid in treating diabetic wounds. As LG is a direct precursor for proline synthesis, which is crucial for collag...
Article
Surface functionalization of polymers is crucial for improving biocompatibility and haemocompatibility, which correlates to improved performance of medical devices. Here, we have evaluated the effect of four PET surface carboxylation techniques on the antifouling property, haemocompatibility, and endothelialization. Surface carboxylation was achiev...
Patent
Full-text available
Non-leaching bacterial and platelet anti-adhesive bioactive surface are a dire need for biocompatibility of implants. A single step method was developed for surface modification of a medical implant having at least one surface exposed to tissue and/or blood. Herein we describe a technique to apply thin layer of graphene oxide (GO) over polyurethane...
Article
Herein, we describe the design, synthesis, and drug release kinetics of a low molecular weight gel based on aryl ether molecule, under in vitro conditions. The first generation dendron self-assemble and form gels, resulting in a robust three dimensional fibrous network, to facilitate controlled release of molecules. While aryl ether dendrons are kn...
Conference Paper
Full-text available
Polyurethanes a widely accepted polymeric biomaterial for biomedical applications are mostly used for cardiovascular devices. Blood compatibility (haemocompatibility), is a crucial property for such materials to be used in blood contacting applications like, vascular grafts, so many researchers have explored to enhance the blood compatibility of bi...
Article
Composite 3D scaffolds using a natural, carbohydrate polymer, isabgol (Isab) and silk fibroin (SF) were prepared by a freeze drying method. 2 wt% solutions of both Isab and SF were blended in four different ratios to obtain the 3D scaffolds. ATR-FTIR results showed the presence of amide bonds and β sheet conformation in Isab/SF scaffolds. SEM micro...
Article
The aim of this article was to develop silk protein (SF) and l-proline (LP) loaded chitosan-(CS) based hydrogels via physical cross linking for tissue engineering and wound healing applications. Silk fibroin, a biodegradable and biocompatible protein, and l-proline, an important imino acid that is required for collagen synthesis, were added to chit...
Article
This study explores the potential of gallic acid incorporated chitosan (CS/GA) 3D scaffolds for tissue engineering applications. Scaffolds were prepared by freezing and lyophilization technique and characterized. FTIR spectra confirmed the presence of GA in chitosan (CS) gel. DSC and TGA analysis revealed that the structure of chitosan was not alte...
Conference Paper
Full-text available
Functional restoration of human body is assisted by implantation of long term simple or sophisticated medical devices which closely involves use of biomaterials. Biomaterials, in such a scenario attract lots of bacteria which colonize and infect the surrounding healthy tissue leading to severe failure and rejection of the device. Bacterial infectio...
Article
Full-text available
In this article, we report the development of graphene oxide (GO) reinforced electrospun poly(carbonate urethane) (PCU) nanocomposite membranes intended for biomedical applications. In this study, we aimed to improve the mechanical properties of PCU fibroporous electrospun membranes through fiber alignment and GO incorporation. Membranes with 1, 1....
Article
Full-text available
A single step method for encapsulation of clinically relevant proteins viz., Bovine Serum Albumin (BSA), Lysozyme and Insulin molecules, inside core-sheath structured polymer fibres using coaxial electrospinning technique, is described. Transmission electron microscopic pictures show the formation of core-sheath structure. The secondary structure o...
Article
Polyethylene terephthalate (PET) was functionalized to introduce carboxyl groups onto its surface by a carboxylation technique. Surface and bulk properties, such as possible surface deterioration, surface roughness and the mechanical strength of the carboxylated polymers, were studied and compared with those of aminolyzed and hydrolyzed PET. Atomic...
Article
Proteome analysis was used to compare global protein expression changes in Escherichia coli fermentation between exponential and glucose-limited fed-batch phase. Two-dimensional gel electrophoresis and MALDI-TOF mass spectrometry were used to separate and identify 49 proteins showing >2-fold difference in expression. Proteins upregulated during exp...
Article
We report here probable nutrient-sensing signal transduction pathways in Aspergillus nidulans, a model filamentous fungus, based on sequence homology studies with known Saccharomyces cerevisiae and Schizosaccharomyces pombe proteins. Specifically, we identified A. nidulans homologs for yeast proteins involved in (1) filamentation-invasion, (2) cAMP...

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Projects (3)
Project
Functionalize and improve dispersion of graphene in polymeric matrix to fabricate polymeric nanocomposite membranes with improved mechanical properties. Surface engineering of polyurethane to have differential adhesion of bacterial cells, platelets and mammalian cells. Fabricate biomimetic scaffolds for neural tissue engineering.