
Victoria Vega AgapitoUniversity of Valladolid | UVA · Departamento de Didáctica de las Ciencias Experimentales, Sociales y de la Matemática
Victoria Vega Agapito
Doctor of Pharmacy
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24
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Introduction
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February 2016 - August 2016
Publications
Publications (24)
We have reported previously that peroxynitrite stimulates l-arginine release from astrocytes, but the mechanism responsible for such an effect remains elusive. To explore this issue,
we studied the regulation ofl-[3H]arginine transport by either exogenous or endogenous peroxynitrite in glial cells. A 2-fold peroxynitrite-mediated stimulation
of l-a...
La enseñanza de Ciencias de la Naturaleza en centros con Programa Educativo Bilingüe continúa siendo una labor exigente para los docentes que imparten esta materia en inglés. Bajo este pretexto, el British Council nos solicitó realizar un estudio para analizar la autoevaluación de los docentes de Natural Sciences sobre sus propias competencias prof...
Este estudio aborda las actitudes hacia la ciencia y los factores que influyen en ella en una muestra de 303 estudiantes españoles de sexto curso de Educación Primaria. Se utiliza un cuestionario preexistente cuya confiabilidad y validez se evalúan. Los hallazgos demuestran la fiabilidad y validez psicométrica de la herramienta constituida por tres...
The aim of this study is to assess the application of inquiry as a teaching strategy during the practicum of a pre-service teacher and to verify the acquisition of scientific skills by her students. The importance of this study is the application of inquiry as a teaching strategy at lower levels of basic education to contribute to scientific skills...
Se analiza una experiencia innovadora centrada en desarrollar la excelencia en la formación inicial de maestros. Consiste
en la inclusión, mediada por las TIC, de profesionales en activo
en el proceso de evaluación de los estudiantes. La experiencia
docente se analiza desde una metodología de Investigación-Acción con dos ciclos de investigación. La...
The present work is focused on the formative proposal “La Semana de la Ciencia” (Science Week) based on Project Based Learning (PBL) and the assessment of this experience.
Thirty-one undergraduate students have taken part carry on nine workshops about different themes of sciences for 240 young children within 3 and 5 years old and his nine forms...
In this work, the inclusion of a professional vision of an early childhood education teacher in the assessment of a formative experience of Project Oriented Learning in University Teaching is analyzed. After some initial considerations on the features, possibilities, and limitations of out-door science learning, we discuss the experience developmen...
Obstructive sleep apnea syndrome (OSAS) is described as repetitive obstructions of the upper airways during sleep, causing concomitant episodes of systemic hypoxia and associated cardiovascular and metabolic pathologies. The mechanisms generating these pathologies are controversial. Since recurrent hypoxia is the element of inadequate respiration t...
Ventilatory effects of chronic cigarette smoke (CS) alone or associated to chronic hypoxia (CH), as frequently occurs in chronic obstructive pulmonary disease (COPD), remain unknown. We have addressed this problem using whole-body plethysmography in guinea-pigs, common models to study harmful effects of CS on the respiratory system. Breathing frequ...
Obstructive sleep apnea is a frequent medical condition consisting in repetitive sleep-related episodes of upper airways obstruction and concurrent events of arterial blood hypoxia. There is a frequent association of cardiovascular diseases and other pathologies to this condition conforming the obstructive sleep apnea syndrome (OSAS). Laboratory mo...
Cigarette smoke (CS) and chronic hypoxia (CH) can produce pulmonary hypertension. Similarities and differences between both exposures and their interaction have not been explored. The aim of the present study was to investigate the effects of CS and CH, as single factors or in combination, on the pulmonary circulation in the guinea pig.
51 guinea p...
Moderate intake of alcoholic beverages decreases the incidence of cardiovascular pathologies, but it is in dispute if cardioprotective effects are due to ethanol, to polyphenolic compounds present in beverages or to a combination of both. In humans, effects of high, moderate, and low doses of alcoholic beverages are widely studied, but effects of p...
Abstract Obstructive sleep apnoea syndrome (OSAS) is a disorder characterized by repetitive episodes of complete (apnoea) or partial (hypopnoea) obstruction of airflow during sleep. The severity of OSAS is defined by the apnoea hypopnoea index (AHI) or number of obstructive episodes. An AHI greater than 30 is considered severe, but it can reach val...
Cardiovascular (CV) diseases are a leading cause of mortality and they are frequent in patients with the obstructive sleep apnea syndrome (OSAS).
In this study we investigated if OSAS influences CV function independently of other CV risk factors frequently present in these patients (e.g. obesity, high blood pressure).
We compared plasma markers of...
Superoxide anion is the most important reactive oxygen species (ROS) primarily generated in cells. The main cellular constituents with capabilities to generate superoxide anion are NADPH oxidases and mitochondrial respiratory chain. The emphasis of our article is centered in critically examining hypotheses proposing that ROS generated by NADPH oxid...
En el cerebro, la arginina se localiza predominantemente en astrocitos,
mientras que la concentración en neuronas es muy baja, siendo limitante
para la actividad de la oxido nítrico sintasa neuronal (nNOS). A continuación
subóptimas de arginina se generan anión superóxido y óxido nítrico por
la NOS. Ambos radicales libres reaccionan rápidamente ori...
Abstract : The biosynthesis of the physiological messenger nitric oxide (•NO) in neuronal cells is thought to depend on a glial-derived supply of the •NO synthase substrate arginine. To expand our knowledge of the mechanism responsible for this glial-neuronal interaction, we studied the possible roles of peroxynitrite anion (ONOO-), superoxide anio...