Víctor Edmundo Valdespino-Castillo

Víctor Edmundo Valdespino-Castillo
Mexican Institute of Social Security | IMSS · Cirugia general

Dr.

About

36
Publications
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Introduction
Víctor Edmundo Valdespino-Castillo currently works at the Cirugia general, Mexican Institute of Social Security. Víctor does research in Surgery, Pathology and Oncology. Their current project is 'Cancer cell signaling pathways'.
Additional affiliations
June 2021 - present
Mexican Institute of Social Security
Position
  • Research Director
Description
  • ONCOLOGY, SURGERY,
Education
March 1998 - February 2006

Publications

Publications (36)
Article
Full-text available
OBJETIVO: Describir las características clínicas e histopatológicas de los casos de teratoma maduro con transformación maligna, su tratamiento y supervivencia. MATERIALES Y MÉTODOS: Estudio retrospectivo, transversal y observacional efectuado entre enero de 2014 y diciembre de 2018 en un servicio de oncología ginecológica. Parámetros de estudio: e...
Article
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ANTECEDENTES: Las malformaciones müllerianas aparecen en 0.5-5%, incluso más, de la población de estudio, y el cáncer endometrioide representa 10% de todos los tumores malignos del ovario. CASO CLÍNICO: Paciente de 45 años, con dolor abdominal-pélvico crónico, asociado con elevadas concentraciones de Ca-125 (94 U). En los estudios de extensión, la...
Article
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Myofibroblastoma is a rare benign mesenchymal tumor of the breast. This tumor has been preiously described in the pathological and surgical literature, but the are limited reports on the women. It tends to be more prevalent in the male breast. A spindle cell lesions of the breast are rare, when encountered on core biopsy, it can be challenging to d...
Article
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OBJETIVO: Identificar micrometástasis ganglionares en neoplasias malignas ginecológicas, y las características histopatológicas y clínicas asociadas con los hallazgos. MATERIALES Y MÉTODOS: Estudio observacional, descriptivo y retrospectivo efectuado en pacientes con uno o más ganglios con micrometástasis identificados en cirugías primarias etapif...
Article
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Antecedentes: La linfadenectomía retroperitoneal y pélvica es parte del proceso quirúrgico de etapificación del cáncer de endometrio y ovario. La asignación de etapa y tratamiento de pacientes con cáncer cervicouterino es clínica; con radioterapia y quimioterapia concomitante, sin conocer factores pronósticos de la enfermedad local, ni el estado de...
Article
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Bone lipomas are infrequently in the current dairy medical practice, those tumor represent 0.1% of all bone tumors. Aetiology is unknown and surgery is the best treatment. In this tumors is necessary to do a relation physical - radiological and histopatological and, in this way is necessary to known a prognosis about them tumors. The bone tumors do...
Article
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BACKGROUND: 80% of the cases of epithelial ovarian cancer are diagnosed in stages III and IV, locoregional recurrence is a frequent feature of this malignant neoplasm. Associated mortality is one of the most important of all malignant neoplasms in women, all over the world. OBJECTIVE: To document the metastasis of ovarian cancer to skin, incidence,...
Article
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At least four main groups of intracellular signaling pathways or submodules concur in the cell division and proliferation module: those for the control of the cell cycle, those for the metabolism programming, those for cytoskeleton remodeling, and those for DNA replication and repair. Precise signaling pathways that control cell proliferation modul...
Article
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ANTECEDENTES: en 80% de las ocasiones el cáncer de ovario epitelial se diagnostica en etapas III y IV, la recurrencia locorregional es una característica frecuente en esta neoplasia maligna. La mortalidad asociada es una de las más importantes de todas las neoplasias malignas en la mujer, en todo el mundo. OBJETIVO: documentar las metástasis de cá...
Article
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More than 200 cancer susceptibility syndromes (CSS) have been recognized through performing classic epidemiologic studies and genetic linkage analysis. In most CSSs clinical conditions of the patients have been identified as well as their hereditary patterns and the predisponent genes to cancer development. Cancer hereditary identification is a use...
Article
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Nowadays cellular physiology is best understood by analyzing their interacting molecular components. Proteins are the major components of the cells. Different proteins are organized in form of functional clusters, pathways or networks. These molecules are ordered in clusters of receptor molecules of extracellular signals, transductors, sensors and...
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Regenerative medicine is a medical multidisciplinary area with the aim of morphologic and functional restoration of tissues or organs in order to re-establish normal function. The main bases of regenerative medicine are the use of autologous stem or progenitor cells and the ex vivo construction of physical-mechanical tissue structuring organization...
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The cellular differentiation process involves complex genetic, epigenetic and signaling pathways systems. The analysis of a specific model of cellular differentiation may contribute to understand the global mechanisms. The cellular differentiation process based on the experimental reprogramming of somatic cells (terminally differentiated cells) to...
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Biological processes in human health and disease can be studied by macroscopic, microscopic and nanoscopic scales.Human Genome, HapMap and 1000 Genomas Projects have advanced in the structural analysis of the human genome. Recently the Encyclopedia of DNA Elements Project has initiated the analysis of the main human genome functional components, ex...
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In this review, we provide an overview of the physiological and pathophysiological epigenetic changes of normal cells and cancer cells, and emphasize the achievements and the perspectives of cancer epigenetic therapy. Cancer epigenetic alterations correspond foremost to hypermethylation of tumor suppressor genes promotors, global DNA hypomethylatio...
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Cancer cells take no notice of basic environment human tissues. The products of oncogenes and tumor suppressor genes expression alter the physiological intracellular signaling pathways, and deregulating proliferation, differentiation, apoptosis, adhesion/mobility cell programs, etc. In cancer as other complex diseases, the intracellular signaling p...
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A wide number of genetic and epigenetic changes are required 10 drive normal cells towards malignancy. These changes participate in oncogenic intracellular pathways that allow tumor cells proliferation and dissemination. Hanahan and Weinberg(1) in their seminal paper "The hallmarks of cancer" described the classic cell hallmarks acquired in cancer...
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A wide number of genetic and epigenetic changes are required to drive normal cells towards malignancy. These changes participate in oncogenic intracellular pathways that allow tumor cells proliferation and dissemination. Hanahan and Weinberg' in their seminal paper "The hallmarks of cancer" described the classic cell hallmarks acquired in cancer de...
Article
The genomic and proteomic research in cancer provide us new functional levels of information and analysis of tumor molecular alterations. Macroscopic and microscopic informational functional levels of cancer patients study have been improved gradual and significantly in the last decades. Cancer is a polygenic disease caused by genetic, epigenetic a...
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Transitions from normal cell to neoplastic malignant cell type require multiple alterations in cell signalling pathways. Transduction and transmission of these signalling pathways are dependent on integrated molecular circuits. A paramount aspect in cancer development is the concept that the cell loses its ability to detect and respond to extracell...
Article
Full-text available
Transitions from normal cell to neoplastic malignant cell type require multiple alterations in cell signalling pathways. Transduction and transmission of these signalling pathways are dependent on integrated molecular circuits. A paramount aspect in cancer development is the concept that the cell loses its ability to detect and respond to extracell...
Article
Full-text available
Renal cell carcinoma (RCC) represents approximately 3% of malignant tumors in adults and occurs in a M:F ratio of 1.5:1.0. Although in most cases it occurs in persons 50 to 70 years of age, there are also reports in children. Clear cell carcinoma is the most frequent histological type, and 30% of renal carcinomas have metastasized at the time of di...
Article
Recent advances and insights into the molecular pathogenesis of cancer provide unprecedented opportunities for discovery and development of molecularly target-therapeutic (MTT) strategies. Cancer is a complex process due to accumulation of multiple mutations and alterations in the genoma. Tumor cells seem to rely heavily on the continued deregulati...
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The global incidence of emergencies and urgent medical?surgical conditions in cancer patients has not been well described. The aim of the study was to identify the main symptoms and diagnoses in patients seen for consultation at the Urgent Care Service in a Mexican Comprehensive Cancer Center. This was a retrospective observational study. The infor...
Article
Metastases in the vertebrae of patients with cervical cancer (CeCa) can be difficult to diagnose, and the treatment is palliative in many cases. The aim of this study was to assess the ti-me required for diagnosis, the lesion's locoregional extent and the therapeutic schemes applied, in a retrospective series of 58 patients with CeCa and with lumba...
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Cervical cancer is a Public Health problem among women worldwide, especially in the developing world. The understanding of the HPV association with the high-grade squamous intraepithelial lesions and cervical cancer and the knowledge of the pre-invasive lesions natural history have strengthened the justification of different means of cancer prevent...
Article
Full-text available
Summary Transitions from normal cell to neoplastic malignant cell type require multiple alterations in cell signalling pathways. Transduction and transmission of these signalling pathways are dependent on integrated molecular circuits. A paramount aspect in cancer development is the concept that the cell loses its ability to detect and respond to e...

Questions

Question (1)
Question
In ovarian dysgerminoma, retroperitoneal lyphadenectomy is very important foto a precise pathological stage, ower group suggests avoiding pelvic lyphadenectomy in case, no growing pelvic nodes, puré dysgerminoma and no evidencie of peritoneal invasion

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