Victor Tseng

Victor Tseng
Emory University | EU · Division of Pulmonary, Allergy and Critical Care Medicine

Doctor of Medicine

About

27
Publications
2,208
Reads
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84
Citations
Citations since 2016
22 Research Items
78 Citations
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201620172018201920202021202205101520
Education
July 2015 - August 2018
National Jewish Health
Field of study
  • Pulmonary Sciences and Critical Care Medicine
July 2015 - August 2018
University of Colorado
Field of study
  • Pulmonary Sciences and Critical Care Medicine
July 2012 - June 2015
Emory University
Field of study
  • Internal Medicine

Publications

Publications (27)
Article
Full-text available
SIGNIFICANCE: Peroxisome proliferator-activated receptor-γ (PPARγ) maintains pulmonary vascular health through coordination of antioxidant defense systems, inflammation, and cellular metabolism. Insufficient PPARγ contributes to pulmonary hypertension (PH) pathogenesis, whereas therapeutic restoration of PPARγ activity attenuates PH in preclinical...
Article
Pulmonary hypertension (PH) comprises a diverse group of disorders that share a common pathway of pulmonary vascular remodeling leading to right ventricular failure. Development of anti-remodeling strategies is an emerging frontier in PH therapeutics that requires a greater understanding of the interactions between vascular wall cells and their ext...
Article
Pulmonary hypertension (PH) is a complex condition that arises due to pulmonary vascular disease, heart disease, lung disease, chronic thromboembolism, or several rare causes. Regardless of underlying cause, PH increases mortality, yet there are no directed treatments for the most common forms of PH due to left heart or lung disease. Because metabo...
Article
Full-text available
Chronic hypoxia leads to pathologic remodeling of the pulmonary vasculature and pulmonary hypertension (PH). The antioxidant enzyme extracellular superoxide dismutase (SOD3) protects against hypoxia-induced PH. Hyaluronan (HA), a ubiquitous glycosaminoglycan of the lung extracellular matrix, is rapidly recycled at sites of vessel injury and repair....
Article
Full-text available
Background: Several inflammatory lung diseases display abundant presence of hyaluronic acid (HA) bound to heavy chains (HC) of serum protein inter-alpha-inhibitor (IαI) in the extracellular matrix. The HC-HA modification is critical to neutrophil sequestration in liver sinusoids and to survival during experimental lipopolysaccharide (LPS)-induced...
Conference Paper
Full-text available
Rationale: Dysregulated hyaluronan (HA) turnover is a newly recognized feature in multiple subgroups of pulmonary hypertension, including PH owing to chronic hypoxia. Extracellular superoxide dismutase (SOD3) protects against hypoxic PH. We hypothesized that hypoxia and vascular SOD3 availability determine the structure of pulmonary HA through regu...
Poster
Full-text available
Rationale: Hyaluronic acid (HA) is released into the extracellular fluid in human sepsis and acute respiratory distress syndrome. Higher concentrations of free HA in the circulation and alveolar fluid predict increased mortality in these conditions. We studied the kinetics of HA release and clearance in the plasma and alveolar compartments in three...
Presentation
Full-text available
Background and synoptic overview of current work concerning the the role of extracellular superoxide dismutase in regulating hyaluronan turnover during hypoxia
Poster
Full-text available
RATIONALE: Loss of extracellular superoxide dismutase (SOD3) contributes to chronic hypoxic pulmonary hypertension (PH) and injurious vascular remodeling. SOD3 preserves the structural integrity of lung matrix components, including glycans such as hyaluronan (HA). Fragments of HA are perceived in situ as inflammatory danger signals. We hypothesized...
Presentation
Review of ”Piezo2 senses airway stretch and mediates lung inflation-induced apnoea” by K. Nonomura et al. in Nature. 2017 Jan 12;541(7636):176-181
Article
Full-text available
Background Chronic alcohol ingestion induces the expression of transforming growth factor beta-1(TGFβ1), inhibits nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-mediated activation of the antioxidant response element (ARE), depletes alveolar glutathione pools, and potentiates acute lung injury. In this study, we examined the mechanistic relatio...
Article
Full-text available
Background: Peripheral smear review is a critical, but labor intensive adjunct for evaluation of lymphocytosis. Standard practice based on consensus guidelines is to review cases with absolute lymphocyte count (ALC) >5×109/L. We hypothesize that identifying cases for review by applying appropriately adjusted ALC and age discriminators will decreas...

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Projects

Projects (5)
Project
To understand the formation, chemistry, and bioactivity of oxidized hyaluronic acid generated in acute and chronic lung diseases. Major methods used include mouse models of lung disease (bleomycin, hypoxia) and detection of reactive hyaluronan species in vivo with electron paramagnetic resonance spectroscopy.
Project
Understanding the effects of hyaluronan on the outcomes of acute lung Injury and sepsis