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Citations since 2017
10 Research Items
January 2018 - present
Universidad Autonoma de Bucaramanga
- Docente titular
The absence or damage of a tissue is the main cause of most acute or chronic diseases and are one of the appealing challenges that novel therapeutic alternatives have, in order to recover lost functions through tissue regeneration. Chronic cutaneous lesions are the most frequent cause of wounds, being a massive area of regenerative medicine and tis...
Diabetic foot ulcer morbidity and mortality are dramatically increasing worldwide, reinforcing the urgency to propose more effective interventions to treat such a devastating condition. Previously, using a diabetic mouse model, we demonstrated that administration of bone marrow mesenchymal stem cells derivatives is more effective than the use of bo...
Non-healing chronic skin ulcers are considered a major biological, psychological, and financial burden for both patients and health systems. Multidisciplinary endeavors are required to address this refractory disease, in order to find definitive solutions that lead to improved living conditions. Diabetes, venous stasis, arterial insufficiency, pres...
Oral squamous cell carcinoma is the fifth most common epithelial cancer in the world, and its current clinical treatment has both low efficiency and poor selectivity. Cationic amphipathic peptides have been proposed as new drugs for the treatment of different types of cancer. The main goal of the present work was to determine the potential of Lfcin...
In vitro cytotoxic effect of LfcinB (20–25)4 HET-1A cell line. Structural damage caused by LfcinB (20–25)4 was assessed via transmission electron microscope. Images show sections of HET-1A cells pre- and post-treatments. (TIF)
Follow-up antitumoral effect of LfcinB peptides in OSCC hamster model. Tumor macroscopic characteristics were evaluated after five weeks of peptide or vehicle administration. Representative images of tumor size of the buccal pouch for different doses. Representative data of n = 7 animals for vehicle group and n = 5 animals for others groups. (TIF)
In vitro cytotoxic effect of LfcinB (20–25)4 on CAL27 cell line. Structural damage caused by LfcinB (20–25)4 was assessed via transmission electron microscope. Images show sections of CAL27 pre- and post- treatments. (TIF)
Several short linear peptides derived from cyclic bovine lactoferricin were synthesized and tested for their cytotoxic effect against the oral cavity squamous-cell carcinoma (OSCC) cell lines CAL27 and SCC15. As a control, an immortalized and nontumorigenic cell line, Het-1A, was used. Linear peptides based on the RRWQWR core sequence showed a mode...
Supplementary Material shows photomicrographs of the OSCC cell lines at different culture confluence; expression of epithelial and mesenchymal markers in both SCC15 cell subpopulations; inhibition of apoptosis by the caspases inhibitor Z-VAD-FMK; evaluation of the hemolytic effect of LfcinB25 derived peptides, and the effect of a second addition of...
Which type of controls could be used to induce necrosis in vitro, in carcinoma cell line?. Thanks.
Based on your experience, do you consider that there are considerable differences between male or female hamster in DMBA-Induced Hamster Buccal Pouch Carcinomas?
Thanks a lot