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Víctor García-López

Víctor García-López
ETH Zurich | ETH Zürich · Department of Chemistry and Applied Biosciences

Ph.D.

About

25
Publications
3,340
Reads
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664
Citations
Additional affiliations
May 2016 - present
ETH Zurich
Position
  • PostDoc Position
August 2011 - May 2016
Rice University
Position
  • PhD Student

Publications

Publications (25)
Article
With the desire to synthesize surface-rolling molecular machines that can be translated and rotated with extreme precision and speed, we have synthesized a series of five nanocars. Each structure features a permanent dipole moment, generated by an N,N-dimethylamino- moiety on one end of the car coupled with a nitro group on the other end. These car...
Article
Resorcin[4]arene cavitands, equipped with diverse quinone (Q) and [Ru(bpy)2dppz]2+ (bpy=2,2′‐bipyridine, dppz=dipyrido[3,2‐a:2′,3′‐c]phenazine) photosensitizing walls in different configurations, were synthesized. Upon visible‐light irradiation at 420 nm, electron transfer from the [Ru(bpy)2dppz]2+ to the Q generates the semiquinone (SQ) radical an...
Article
Resorcin[4]arene cavitands can be switched between a kite conformation, adopted in the dark, and a vase conformation, generated under visible light irradiation. The switching is triggered by the formation of a semiquinone radical anion through a photosensitizing process. The large conformational rearrangement of the cavitands resembles the mechanic...
Article
Full-text available
Light-activated molecular nanomachines (MNMs) can be used to drill holes into prokaryotic (bacterial) cell walls and the membrane of eukaryotic cells, including mammalian cancer cells, by their fast-rotational movement, leading to cell death. We examined how these MNMs function in multi-cellular organisms and investigated their use for treatment an...
Article
Molecular motors are at the heart of cellular machinery, and they are involved in converting chemical and light energy inputs into efficient mechanical work. From a synthetic perspective, the most advanced molecular motors are rotators that are activated by light wherein a molecular subcomponent rotates unidirectionally around an axis. The mechanic...
Article
Full-text available
The orientation of molecules is crucial in many chemical processes. Here, we report how single dipolar molecules can be oriented with maximum precision using the electric field of a scanning tunneling microscope. Rotation is found to occur around a fixed pivot point that is caused by the specific interaction of an oxygen atom in the molecule with t...
Article
Using two-photon excitation (2PE), molecular nanomachines (MNMs) are able to drill through cell membranes and kill the cells. This avoids the use of the more damaging ultraviolet (UV) light that has been used formerly to induce this nanomechanical cell-killing effect. Since 2PE is inherently confocal, enormous precision can be realized. The MNMs ca...
Article
Single molecule fluorescence microscopy at air-solid interface severely suffers from photobleaching. In this study, we evaluated using triplet state quencher cyclooctatetraene (COT) group to enhance the photostability of cy5 attached molecular machines. For single dye modified nanocars, the photobleaching lifetime of the dye was extended by 2.1 tim...
Article
A light-actuated resorcin[4]arene cavitand equipped with two quinone (Q) and two opposite Ru(II)-based photosensitizing walls was synthesized and investigated. The cavitand is capable of switching from an open to a contracted conformation upon reduction of the two Q to the corresponding SQ radical anions by intramolecular photoinduced electron tran...
Article
At room temperature, four-adamantane-wheeled nanocars thermally diffuse on an air-glass interface. A line-scan imaging method was developed to improve the time resolution in tracking their surface movement. The fast imaging technique disclosed that the 4-wheeled nanocars diffuse on glass surfaces in a quasi-random 2D diffusion manner. That is, they...
Article
Full-text available
A four-step synthesis of substituted 5,11-dicyano-6,12-diaryltetracenes was developed, starting from readily available para-substituted benzophenones. The key step of this straightforward route is the complex cascade reaction between tetraaryl[3]cumulenes and tetracyanoethene (TCNE) resulting in 5,5,11,11-tetracyano-5,11-dihydrotetracenes. The mech...
Article
Beyond the more common chemical delivery strategies, several physical techniques are used to open the lipid bilayers of cellular membranes. These include using electric and magnetic fields, temperature, ultrasound or light to introduce compounds into cells, to release molecular species from cells or to selectively induce programmed cell death (apop...
Article
The first NanoCar Race was an opportunity to see how far we have come in manipulating single molecules. As the team with the fastest molecule in this race, we share the synthetic challenges to building a fast nanocar and the experimental approach needed for rapid translation across a surface.
Article
The design and synthesis of a fluorescent light-driven motorized nanocar with a linear geometry is described. Due to its structural design, the nanocar is present as a mixture of two photo-interconvertible diastereomers. An extensive and detailed NMR study allowed the full assignment of the chemical shifts of the two diastereomers in the mixture. T...
Article
Single molecule fluorescence microscopy (SMFM) is a powerful technique in monitoring single molecular machine actions at ambient conditions. To improve the fluorescence intensity and photo-stability, one strategy is to attach multiple dyes to the same single molecular machine. However, it is unclear how the fluorescence property of the dyes will ch...
Article
Molecular machines are a key component in the vision of molecular nanotechnology, and have the potential to transport molecular species and cargo on surfaces. The motion of such machines should be triggered remotely, ultimately allowing a large number of molecules to be propelled by a single source, with light being an attractive stimulus. Here, we...
Article
Motivated by "driving" nanoscopic nanocars on solid substrate surfaces at ambient conditions, we studied the moving kinetics of nanocars on differently modified surfaces. Single molecule fluorescence imaging was used to track the nanocar movement so that the molecules were minimally perturbed. On freshly cleaned, hydroxylated glass surfaces, nanoca...
Article
The synthesis and photophysical properties of a series of photostable unimolecular submersible nanomachines (USNs) are reported as a first step toward the analysis of their trajectories in solution. The USNs have a light-driven rotatory motor for propulsion in solution and photostable cy5-COT fluorophores for their tracking. These cy5-COT fluoropho...
Article
Unimolecular submersible nanomachines (USNs) bearing light-driven motors and fluorophores are synthesized. NMR experiments demonstrate that the rotation of the motor is not quenched by the fluorophore and that the motor behaves in the same manner as the corresponding motor without attached fluorophores. No photo- or thermal-decomposition is observe...
Article
The design and synthesis of a 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY)-based motorized nanocar and two control molecules for single-molecule fluorescence microscopy studies (SMFM) is described. The nanocar incorporates a fast rotatory light-driven motor (3 MHz at 25 °C) that is expected to move in circles. In addition, two control molecu...
Article
The synthesis of a Ru-based olefin metathesis catalyst dye-tagged at the N-heterocyclic carbene ligand is reported. Its catalytic activity toward ring-opening metathesis polymerization (ROMP) of 1,5-cyclooctadiene was found to be similar to that of its parent second-generation Hoveyda-Grubbs catalyst. The quantum yield of fluorescence (ΦF = 0.22) m...

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Projects

Project (1)
Project
The ongoing quest for miniaturization of technology inspired the conceptualization of molecular machines, as molecular analogues of macroscopic objects with the ability to convert external energy inputs into molecular motion. The objective of this project is the development of molecular actuators and grippers that controllably expand and contract in response to physical (electrical or electromagnetic) stimuli. As a result, molecular grippers can reversibly encapsulate smaller molecules, enabling their prospective application as nanoscale switches, sensors, receptors, delivery systems, or elements in nanorobotics. Our collaborative interdisciplinary research approach focuses predominantly on functionalized resorcin[4]arene cavitands as platforms for voltage or light-induced actuation and gripping.