Verónica Miró Pina

Centre for Genomic Regulation | CRG · Bioinformatics and Genomics

Plasmids are extra-chromosomal genetic elements that encode a wide variety of phenotypes and can be maintained in bacterial populations through vertical and horizontal transmission, thus increasing bacterial adaptation to hostile environmental conditions like those imposed by antimicrobial substances. To circumvent the segregational instability res...

Plasmids are extra-chromosomal genetic elements that encode a wide variety of phenotypes and can be maintained in bacterial populations through vertical and horizontal transmission, thus increasing bacterial adaptation to hostile environmental conditions like those imposed by antimicrobial substances. To circumvent the segregational instability res...

Preventive and modeling approaches to address the COVID-19 pandemic have been primarily based on the age or occupation, and often disregard the importance of heterogeneity in population contact structure and individual connectivity. To address this gap, we developed models based on Erdős-Rényi and a power law degree distribution that first incorpor...

In this work, we study general Dirichlet coalescents, which are a family of Ξ-coalecents constructed from i.i.d mass partitions, and are an extension of the symmetric coalescent. This class of models is motivated by population models with recurrent demographic bottlenecks. We study the short time behavior of the multidimensional block counting proc...

Plasmids are extra-chromosomal genetic elements that encode a wide variety of phenotypes and can be maintained in bacterial populations through vertical and horizontal transmission, thus increasing bacterial adaptation to hostile environmental conditions like those imposed by antimicrobial substances. To circumvent the segregational instability res...

After admixture, recombination breaks down genomic blocks of contiguous ancestry. The breakdown of these blocks forms a new ‘molecular clock’, that ticks at a much faster rate than the mutation clock, enabling accurate dating of admixture events in the recent past. However, existing theory on the break down of these blocks, or the accumulation of d...

Background Preventive and modelling approaches to address the COVID-19 pandemic have been primarily based on the age or occupation, and often disregard the importance of the population contact structure and individual connectivity. Methods We developed models that first incorporate the role of heterogeneity and connectivity and then can be expande...

After admixture, recombination breaks down genomic blocks of contiguous ancestry. The break down of these blocks forms a new 'molecular' clock, that ticks at a much faster rate than the mutation clock, enabling accurate dating of admixture events in the recent past. However, existing theory on the break down of these blocks, or the accumulation of...

In this article, we propose a Wright-Fisher model with two types of individuals: the inefficient individuals, those who need more resources to reproduce and can have a higher growth rate, and the efficient individuals. In this model, the total amount of resource N is fixed, and the population size varies randomly depending on the number of efficien...

In populations competing for resources, it is natural to ask whether consuming more or less resources provides any selective advantage. To answer this question, we propose a Wright-Fisher model with two types of individuals: the inefficient individuals, those who need more resources to reproduce and can have a higher growth rate, and the efficient...

We define a new class of Ξ-coalescents characterized by a possibly infinite measure over the non negative integers. We call them symmetric coalescents since they are the unique family of exchangeable coalescents satisfying a symmetry property on their coagula-tion rates: they are invariant under any transformation that consists in moving one elemen...

This thesis presents two different models to study how recombination and migration shuffle genetic diversity. In the first model, recombination is the only evolutionary force. At time 0, each individual has her unique chromosome painted in a distinct color. By the blending effect of recombination, the genomes of the descending individuals look like...

We consider a Moran model with recombination in a haploid population of size $N$. At each birth event, with probability $1-\rho_N$ the offspring copies one parent's chromosome, and with probability $\rho_N$ she inherits a chromosome that is a mosaic of both parental chromosomes. We assume that at time $0$ each individual has her chromosome painted...

Geographic structure can affect patterns of genetic differentiation and speciation rates. In this article, we investigate the dynamics of genetic distances in a geographically structured metapopulation. We model the metapopulation as a weighted directed graph, with N vertices corresponding to N homogeneous subpopulations. The dynamics of the geneti...