Verónica Miró Pina

Verónica Miró Pina
Centre for Genomic Regulation | CRG · Bioinformatics and Genomics

PhD

About

16
Publications
1,161
Reads
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18
Citations
Citations since 2017
16 Research Items
18 Citations
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Introduction
My research area is probability applied to population genetics. I have been working on how different phenomena such as recombination or demographic bottlenecks shape the evolution of populations and the genealogies. Currently I am working on Cancer evolution, trying to understand the interplay between tumor heterogeneity and selection. For more information: http://www.normalesup.org/~miropina/

Publications

Publications (16)
Article
Full-text available
Plasmids are extra-chromosomal genetic elements that encode a wide variety of phenotypes and can be maintained in bacterial populations through vertical and horizontal transmission, thus increasing bacterial adaptation to hostile environmental conditions like those imposed by antimicrobial substances. To circumvent the segregational instability res...
Preprint
Plasmids are extra-chromosomal genetic elements that encode a wide variety of phenotypes and can be maintained in bacterial populations through vertical and horizontal transmission, thus increasing bacterial adaptation to hostile environmental conditions like those imposed by antimicrobial substances. To circumvent the segregational instability res...
Article
Full-text available
Preventive and modeling approaches to address the COVID-19 pandemic have been primarily based on the age or occupation, and often disregard the importance of heterogeneity in population contact structure and individual connectivity. To address this gap, we developed models based on Erdős-Rényi and a power law degree distribution that first incorpor...
Preprint
Full-text available
In this work, we study general Dirichlet coalescents, which are a family of Ξ-coalecents constructed from i.i.d mass partitions, and are an extension of the symmetric coalescent. This class of models is motivated by population models with recurrent demographic bottlenecks. We study the short time behavior of the multidimensional block counting proc...
Preprint
Full-text available
Plasmids are extra-chromosomal genetic elements that encode a wide variety of phenotypes and can be maintained in bacterial populations through vertical and horizontal transmission, thus increasing bacterial adaptation to hostile environmental conditions like those imposed by antimicrobial substances. To circumvent the segregational instability res...
Article
Full-text available
After admixture, recombination breaks down genomic blocks of contiguous ancestry. The breakdown of these blocks forms a new ‘molecular clock’, that ticks at a much faster rate than the mutation clock, enabling accurate dating of admixture events in the recent past. However, existing theory on the break down of these blocks, or the accumulation of d...
Preprint
Full-text available
Background Preventive and modelling approaches to address the COVID-19 pandemic have been primarily based on the age or occupation, and often disregard the importance of the population contact structure and individual connectivity. Methods We developed models that first incorporate the role of heterogeneity and connectivity and then can be expande...
Preprint
Full-text available
After admixture, recombination breaks down genomic blocks of contiguous ancestry. The break down of these blocks forms a new 'molecular' clock, that ticks at a much faster rate than the mutation clock, enabling accurate dating of admixture events in the recent past. However, existing theory on the break down of these blocks, or the accumulation of...
Article
In this article, we propose a Wright-Fisher model with two types of individuals: the inefficient individuals, those who need more resources to reproduce and can have a higher growth rate, and the efficient individuals. In this model, the total amount of resource N is fixed, and the population size varies randomly depending on the number of efficien...
Preprint
Full-text available
In populations competing for resources, it is natural to ask whether consuming more or less resources provides any selective advantage. To answer this question, we propose a Wright-Fisher model with two types of individuals: the inefficient individuals, those who need more resources to reproduce and can have a higher growth rate, and the efficient...
Preprint
Full-text available
We define a new class of Ξ-coalescents characterized by a possibly infinite measure over the non negative integers. We call them symmetric coalescents since they are the unique family of exchangeable coalescents satisfying a symmetry property on their coagula-tion rates: they are invariant under any transformation that consists in moving one elemen...
Thesis
Full-text available
This thesis presents two different models to study how recombination and migration shuffle genetic diversity. In the first model, recombination is the only evolutionary force. At time 0, each individual has her unique chromosome painted in a distinct color. By the blending effect of recombination, the genomes of the descending individuals look like...
Preprint
Full-text available
We consider a Moran model with recombination in a haploid population of size $N$. At each birth event, with probability $1-\rho_N$ the offspring copies one parent's chromosome, and with probability $\rho_N$ she inherits a chromosome that is a mosaic of both parental chromosomes. We assume that at time $0$ each individual has her chromosome painted...
Article
Full-text available
Geographic structure can affect patterns of genetic differentiation and speciation rates. In this article, we investigate the dynamics of genetic distances in a geographically structured metapopulation. We model the metapopulation as a weighted directed graph, with N vertices corresponding to N homogeneous subpopulations. The dynamics of the geneti...

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