Vera Mitrophanovna Kodentsova

Scientific-Research Institute of Nutrition

Coenzyme Q (CoQ) plays a key role in cell bioenergetics; it is not only supplied with food, but also synthesized in the body. Endogenous CoQ synthesis decreases with age, with statin use, with cardiovascular, neurodegenerative, and other diseases. In this regard, specialized food products (SFP) enriched with CoQ are being developed. Aim of the revi...

Review was carried out using the RSCI, Google Scholar, Pubmed, and ReserchGate databases. When biologically active substances (BAS) are used as functional ingredients in the composition of specialized food products (SPP) of dietary therapeutic and dietary preventive nutrition, the problems of choosing their dose arise. There are epidemiological dat...

Natural food sources of carotenoids are colored vegetables and fruits, eggs, milk. Total carotenoid intake varies from 1 to 22 mg/day in European countries and from 5 to 16 mg/day in the USA. The average daily intake of lycopene in Europe ranges from 5 to 7 mg/day, in the USA – from 5.7 to 10.5 mg/day. Carotenoids are used in the production of fort...

Exclusive breastfeeding for the first six months of life provides many short and long term health benefits. A woman’s awareness of the concept of breastfeeding as a unique biological phenomenon that has not only nutritional, but also psychological significance, which has a powerful positive effect on the neuropsychic development of the child, is an...

Background. Against the backdrop of stagnation in most industries, the production of semi-finished meat products is expanding, which is due to an increase in demand and, accordingly, an increase in consumption. This trend is also observed in the nutrition of the Baikal regions population, however, the micronutrient value of meat semi-finished produ...

Monitoring the actual nutrition of various groups of the population of the Russian Federation indicates the presence of pronounced deficiencies of essential micronutrients, and above all vitamins and biologically active compounds. Deficiency of many micronutrients is a risk factor for the development of a number of conditions (anxiety, depression,...

The lack of vitamins D, B group, calcium and magnesium is common for the diet of the Russian population. It has been previously demonstrated that that the elimination of B vitamin deficiency is a necessary condition for the implementation of vitamin D biological functions. The aim of the research was to assess the effect of a combined deficiency of...

A review of the existing literature on the problem in recent years was carried out using the RSCI, CyberLeninka, Pubmed, and ReserchGate databases. Structurally, βglucans are complex natural polysaccharides consisting of monomeric βD-glucose units covalently linked by glycosidic bonds in various positions. βGlucans are found in bacteria, algae, edi...

Despite the existence of sufficiently effective drug therapy, interest in additional dietary interventions that improve the clinical condition of patients with the most common alimentary diseases is constantly growing; as well as the inclusion of biologically active compounds (BAC) of plant origin as functional ingredients in foods for special diet...

Due to the versatility of its functions and participation in all types of metabolism, magnesium can be considered the main cation in the human organism. Equally important is the role of the main intracellular ion - potassium, which is a synergist of magnesium, especially with regard to the effect on cardiovascular system function. In Russia, there...

Taurine is a sulfur-containing amino acid. Taurine is necessary for the conjugation of bile acids, has antioxidant, anti-inflammatory properties, acts as an anti-apoptotic factor; cell membrane stabilizer; regulator of Ca2+ signaling, fluid homeostasis in cells, retinal photoreceptor activity; contributes to osmoregulation and conduction in the ner...

The insufficient provision of micronutrients (vitamins A, D, E, C, and B-group, the minerals zinc, iron, selenium, magnesium, copper, and phosphorus) weakens the immune response, which can increase the risk of infection, contribute to disease severity and COVID-19 complications. The population of Russia, both adults and children, has deficiencies o...

Vitamin D, including all its vitamers, being a food substance, does not belong to drugs, it can specifically cure those diseases that were caused by its deficiency in the diet. Vitamin D may be officially registered as a dietary supplement or medicine. In both cases, it is intended for the prevention of vitamin D deficiency as well as for the treat...

The presented review of scientific findings is devoted to various aspects of influence of vegetarian diets on a growing organism. Following a vegetarian diet means excluding animal products from the diet. Experts are particularly concerned about the use of vegetarian diets in children due to nutritional deficiencies in children can lead to various...

Calcium as an essential mineral is involved in many processes in the body, being the main one in the mineral matrix of bones and teeth. It is necessary for conducting nerve impulses, blood coagulation, muscle contraction, regulation of the transport of various ions through the cell membrane, glycogenolysis and gluconeogenesis, and the activity of m...

Insufficient vitamin content in the diet is a risk factor for the development of various diseases and their progression, and drug therapy can also contribute to the development of a deficiency of these micronutrients. Data on vitamin sufficiency of patients with type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN) are needed to develop mea...

Currently, the Russian Federation has several methodological and clinical recommendations, programs and guidelines developed by the communities of nutritionists, pediatricians and obstetricians-gynecologists. All of them are of informational and methodological nature and are designed for practical use. The aim of the study is to compare the current...

The available scientific literature, domestic and international regulatory codes of normative documents concerning the fortification of various types of food products have been analyzed. The groups of food products of conventional and regular consumption included into the diets of all categories of consumers, recommended for fortification with esse...

The purpose of the review is to analyze the results of the use of vitamin-mineral supplements (MMS) during pregnancy using the databases of the RSCI, CyberLeninka, pubMed. The detection of micronutrient deficiency in a significant part of pregnant women requires its unconditional correction by taking vitamin-mineral supplements. In recent years, th...

A significant part of pregnant and lactating women have a lack of several micronutrients at once (vitamin D, group B, iodine, iron, etc.). The secretion of vitamins A, E, D, C, B1, B2, B6, B12, iodine and selenium into breast milk decreases with their insufficient consumption and insufficient provision of the nursing mother. The content of folates,...

The composition of the lipid component of consumed foods affects the consumers' health. Fats are not only a source of essential fatty acids, but also participate in the formation of the organoleptic and rheological properties of foodstuffs. At the same time, fats are sources of saturated and trans-isomeric fatty acids, which excessive consumption i...

The search for original publications on fundamental and clinical medicine that would produce results of the highest scientific quality represents an urgent need for every medical researcher. Such publications are essential, in particular, for the development of reliable treatment standards. The Englishlanguage resources PUBMED and EMBASE are essent...

Deficiency of vitamins is a risk factor for the development of various diseases of the gastrointestinal tract (GIT), and, on the contrary, diseases serve as the cause of the deficiency of these micronutrients. Data on the actual vitamin status of gastrointestinal patients are necessary to develop measures for its improvement. Material and methods ....

Despite the presence of combined deficiency of vitamins D and group B among the population of Russia, the intake of cholecalciferol is often recommended without correcting the supply with B group vitamins, which are involved in ensuring the biological functions of vitamin D. The aim of the study was to compare the effectiveness of vitamin D deficit...

The diet of the majority of the population of Russia is characterized by an insufficient content of a number of micronutrients, including macro- and micronutrients. The aim of the study is to characterize in a rat model experiment the effect of combined nutritional deficiency of calcium, magnesium and iodine on the availability of other mineral sub...

1 ФГБУН «Федеральный исследовательский центр питания, биотехнологии и безопасности пищи», Москва, Россия; 2 ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова», Москва, Россия; 3 ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова» Минздрава России, Москва, Р...

The aim of this review is to assess the possibility of the optimization of breast milk vitamin composition and the vitamin provision for infant based on the enrichment of a nursing woman’s diet. The search for literature was carried out using PubMed, Google Scholar, ResearchGate, RSCI, CyberLeninka systems. The concentration of vitamins (A, E, D, C...

Due to the prevalence of multiple deficiency of vitamins and some minerals among the population, as well as the role of micronutrients in maintaining cognitive functions, the aim of the research was to study the effect of combined deficit of vitamins and/or calcium, magnesium and iodine in the diet of growing Wistar male weaning rats on the manifes...

commendations for using vitamin-mineral complexes (composition, forms, vitamin doses, duration and regimen of intake) that would make it possible to improve the vitamin status of the body are given. Vitamin doses corresponding to 50% of the recommended consumption norms, taken for 2 months, cannot eliminate vitamin deficiency. Doses that correspond...

The authors have analyzed evidence about the effect of consumption of PUFAs and dietary fibers on the provision of the body with vitamins. Despite the controversial data, a conclusion might be made that diet enrichment with the ω-3 family PUFAs (fish oil, linseed oil) in doses exceeding the adequate level of consumption, and with soluble and insolu...

Lack of several vitamins, calcium, magnesium, zinc, iodine and other minerals in the diet now is typical for the majority of the adult and childrens population of Russia, regardless of where they live, throughout the year. In addition, population groups that are additionally at risk of developing micronutrient deficiencies exist. Children 23 years...

Background. Inadequate supply with vitamins is a risk factor for the development of many nutritionally-related diseases and their progression. Data on the actual vitamin status of patients are necessary to develop measures for its improvement. Aim. To characterize the supply of persons with non-communicable diseases with vitamins A, E, C, B2 and -c...

Introduction. The English-language databases PubMed/MEDLINE and Embase are valuable information resources for finding original publications in basic and clinical medicine. Currently, there are no artificial intelligence systems to evaluate the quality of these publications.Aim. Development and testing of a system for sentiment analysis (i.e. analys...

Multiple micronutrient deficiency (simultaneous insufficient supply of the organism with several vitamins at once (vitamin D, B group), as well as calcium, magnesium, zinc and iodine, and not an isolated deficiency of any one micronutrient is characteristic of a significant part of the Russian population throughout the year, regardless of places of...

Objective: to study the vitamins level in athletes of various sports. Materials and methods: during the training process, 400 athletes of various sports and specializations were examined: martial artists, game sport athletes, cyclic, complex coordination sports. We assessed the dietery intake of vitamins A, C, B1, B2 and PP and the blood serum leve...

One of the essential parts of fundamental research in Nutrition Science is the determination of the physiological requirements of humans for energy and food substances. Research that has been carried out in this area over the past 90 years, consistently develops and improves the norms of physiological requirements for energy and nutrients for vario...

A statistical analysis of the data on the sufficiency with vitamins of certain groups of the Russian adults and children from 1987 to 2017 revealed certain patterns. At first, the presence of multiple micronutrient deficiency (vitamins D, B group, as well as a number of minerals) is still a characteristic feature. At second, vitamin D deficit is th...

Fruits and berries are the most important sources of a wide range of biologically active substances, including vitamin C, carotenoids, flavonoids, anthocyanins. In order to replenish and update data on the content of food and biologically active substances in the tables of the chemical composition of food products, a study of the content of mono- a...

Introduction. The lack of micronutrients in the diet of the Russian population continues to arouse the interest of the scientific community in the development of fortified foods. The range of enriched products on the domestic market remains quite poor. Bouillon cubes are popular in home cooking and catering. The data of the scientific and technical...

BACKGROUND: Synchronously optimized concentrations of vitamins C, E, A, carotenoids and their ratios in blood plasma help to prevent or slow down the development of many alimentary-dependent diseases and their complications. AIMS: to characterize the vitamin status of obese patients from the standpoint of the risk of progression of existing and de...

Insufficient intake of vitamins of group B and vitamin D is typical for the population of Russia. Data on disturb of mineral status and redistribution of trace elements in rat organs and tissues under deficiency of B vitamins had been appeared. The aim of the study was to characterize the effect of multiple vitamin deficiency in growing rats on the...

Bakery products based on spelled whole-grain flour with the addition of vegetable ingredients and a vitamin-mineral premix containing 5 vitamins, iron and calcium have been developed. Vitamin and iron fortification has been achieved to the level of 18–37% of the recommended daily intake in 150 g. The increased nutritional value of the developed vit...

Studies assessing the availability of vitamins with biochemical methods after the end of a long Orthodox Lent are practically absent. Aim: to assess the sufficiency with vitamins C, B2, A, E and β-carotene by measuring their level in blood serum, as well as vitamins C, B1, B2 and B6 by measuring urine excretion of their main metabolites in people w...

Multiple alimentary deficiency of micronutrients (all vitamins, calcium, magnesium and iodine) in growing rats (51.4±0.5 g) was caused by a 2-fold decrease in the content of calcium, magnesium and iodine in the mineral mixture and 5-fold of all vitamins in the vitamin mixture in the semi-synthetic diet. It was accompanied by a decrease of the brain...

The nutrition of adult and children population of Russia is characterized by multiple micronutrient deficiency due to the simultaneous insufficient content of vitamins, calcium, magnesium, zinc, iodine and other mineral elements in the diet. A lack of several micronutrients can occur as a result of the use of various diets, medication, the developm...

Vitamin D deficiency found in 50-90 % of the adult and children's population in Russia (I.N. Zakharova et al., 2015; V.M. Kodentsova et al., 2017, 2018) and caused by inadequate intake and reduced endogenous synthesis in the skin due to insufficient solar irradiation, is associated with many chronic diseases and makes an important problem (A. Hosse...

Inadequate intake of vitamins, noted in children with obesity, reduces the immune system activity, contributes to the metabolic disorders aggravation and may result in comorbidity. The aim of the work was to study sufficiency with vitamins and carotenoids of children with obesity. Material and methods. Examination of vitamin D, B2, C, A, E and β-ca...

Objective: assessment of the vitamin content in the basic and supplementary diets of highly qualified athletes in the pre-competition period of sports activities. Materials and methods: 159 highly skilled athletes of both sexes participated in the study (92 men, mean age 21.7 ± 0.8 years, 67 women, 23.1 ± 1.5 years). Studies were carried out on the...

Aim. To compare the calculated data of A, B2, D vitamins and beta-carotene consumption with diets and biomarkers of vitamin status of 178 residents of Tazovsky and Gyda settlements of Yamal-Nenets Autonomous Area. Materials and Methods. The actual nutrition was studied by frequency (according to the frequency of food consumption for the previous mo...

Aim - analysis of data on the role of vitamin and carotenoid deficiency in the development of metabolic syndrome (MS), the consumption of individual vitamins and vitamin supplements, as well as estimation of the effectiveness of the use of vitamins in patients with MS. A review of the existing literature has been carried out in the databases of RIN...

The objective. To assess the incidence of insufficient supply of water-soluble vitamins in vegetarian children using non-invasive methods (excretion with the urine), depending on the intake of the vitamin-mineral complex. In the winter-autumn period we examined 38 preschool and school-aged vegetarian children (3–16 years old) living in Moscow and b...

Aim. To assess the availability of patients with type 2 diabetes mellitus (DM-2) and obesity with vitamins C, A, E, D, B2, B6, niacin and betacarotene. Material and methods. We assess vitamin status of 40 patients with DM-2 (14 men and 26 women) aged 42-80 years was 60,2±1,3 (Me=60,5) with concomitant obesity and a body mass index from 31,2 to 57,4...

Vitamin A (retinoids) is a hormonal growth factor for which there are corresponding receptors (retinoid receptors) and which is fundamentally necessary for the growth and the differentiation of the cells of the placenta and the fetus. During pregnancy, the need for the vitamin A increases thus requiring a balanced approach to the dosage of the vita...

Background. Vitamins and minerals are significant components of the diet of a person of any age. Nowadays, when there is a focus on the ‘Western’ type of food, it is impossible to get the necessary amount of all vitamins and minerals with a normal diet, which explains the high prevalence of hypovitaminosis in children. It is known that children wit...

Background. About 22% of the surveyed adult population in Russia has a combined deficiency of vitamins (mostly D, B 2 and beta-carotene). The purpose of the study was to search for effective ways to optimize the consumption of vitamins by the population. Material and methods. A review of the literature was carried out using the databases Russian...

Alterations in mineral element status have been assessed under the combined nutritional deficiency of B1, B2, and B6 vitamins in rat and murine in vivo models. Female Wistar (W) and hybrids of the 1st generation of Dark Agouti and Wistar (DA×W) strains, as well as female BALB/c and DBCB tetrahybrid mice were used. Animals were fed with a balanced d...

Background. Children of preschool and school age are at risk of developing vitamin deficiency. Screening of the vitamin provision of children remains an urgent problem of pediatrics. Objective. Our aim was to determine the prevalence of low excretion of water-soluble vitamins among healthy preschool and school-age children. Methods. The study was c...

The subnormal vitamin deficiency form poses a threat to the normal growth and development of the child. Reduced supply of vitamins A, PP, B6, B12, E is associated with decreased immunity, and increases the risk of physical development delay and the formation of functional diseases. According to 2015--2017 data, the vitamin provision pattern for pre...

The objective. To assess vitamin status and possibilities of its improvement in patients with newly diagnosed clinical forms of lung tuberculosis with the help of a vitamin-mineral complex (VMC), containing prophylactic doses of vitamins, calcium, iron, selenium, and iodine. Patients and methods. In an uncontrolled study of vitamin (А, Е, D, В2, ca...

Students are at risk for vitamin deficiency; however, a number of vitamin status investigations dealing with the simultaneous determination of the blood level of just several vitamins are scarce. Objective - to assess the provision of vitamins in the students of Northern State Medical University (Arkhangelsk). Subject and methods. The cross-section...

Consumption of diets that are inadequate in energy value to the actual energy expenditure can lead to the development of metabolic syndrome (MS), which has consequences such as type 2 diabetes mellitus, non-Alcoholic steatohepatosis, atherosclerosis, gout, allergic diseases. Experimental models of MS are needed to develop new approaches to its diet...

Individuals who adhere to a vegetarian diet are at risk for vitamin B12 and D deficiencies. Objective - to assess the actual nutrition and metabolic status of vegetarians and to investigate provision with vitamins A, E, C, D, B2, B12, folic acid, and carotenoids from their plasma levels and dietary intakes. Material and methods. Forty-six clinicall...

The provision of vitamins A, E, D, B1, B2, B6, B12, C, folates, and carotenoids simultaneously was investigated in 2015-2017 in separate population groups (students, pregnant women, athletes, people employed in hazardous working conditions, patients with nutrition-dependent and infectious diseases) (a total of 1200 people) living in different regio...

The molecular docking method was used to study the structural characteristics determining the competitive transport in the blood, and also the subsequent binding with enzymes of tocopherols and their metabolites to yield a specific biological activity. The target proteins were a-tocopherol-transport protein (α-TTP), tocopherol-associated protein 1...

Biochemical, vitamin, trace element and immunological changes were searched for the combined nutritional deficiency of vitamins B1 B2, B6 on in vivo models in rats and mice. Female rats of Wistar (W) strain and hybrids of the 1st generation of Dark Aguti and Wistar (DA∗W) strains, female mice of BALB/c strain and DBCB tetrahybrids were used in expe...

In a review in order to characterize the dynamics of vitamin status for the period from 1987 to the present, the results of 16 surveys (conducted in 2015-2017) of the sufficiency with vitamins C,A,E, B2 and Be of adult men and women of working age (about 1200people) living in different regions of the Russian Federation, were compared with the frequ...

The objective. To assess the effect of intake of a complex with an incomplete set of vitamins on the water-soluble vitamin status in children of preschool and school age. Patients and methods. A prospective open non-randomized study included 40 practically healthy children (20 boys and 20 girls) aged 4 to 14 years (mean age 8.6 ± 0.5 years). All ch...