Vera Faustino

Vera Faustino
University of Minho · Centro de Tecnologias Mecânicas e de Materiais (CT2M)

Doctor of Engineering

About

28
Publications
5,870
Reads
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614
Citations
Citations since 2016
16 Research Items
569 Citations
2016201720182019202020212022020406080100
2016201720182019202020212022020406080100
2016201720182019202020212022020406080100
2016201720182019202020212022020406080100
Introduction
Microfluidic systems Separation and deformation of blood cells
Additional affiliations
May 2019 - present
International Iberian Nanotechnology Laboratory
Position
  • Associated research
Education
March 2015 - June 2020
University of Minho
Field of study
  • Microfluidics
September 2009 - October 2011
Instituto Politécnico de Bragança
Field of study
  • Biomedical Engineering
September 2005 - December 2009
Instituto Politécnico de Leiria
Field of study
  • Biomechanics

Publications

Publications (28)
Article
Full-text available
Fluids containing colloidal suspensions of nanometer-sized particles (nanofluids) have been extensively investigated in recent decades with promising results. Driven by the increase in the thermal conductivity of these new thermofluids, this topic has been growing in order to improve the thermal capacity of a series of applications in the thermal a...
Article
Full-text available
The efficient separation of blood components using microfluidic systems can help to improve the detection and diagnosis of several diseases, such as malaria and diabetes. Therefore, a novel multi-step microfluidic device, based on passive crossflow filters was developed. Three different designs were proposed, fabricated and tested in order to evalu...
Article
The increasing interest to establish significant correlations between blood cell mechanical measurements and blood diseases, has led to the promotion of microfluidic devices as attractive clinical tools for potential use in diagnosis. In this paper, it is presented a multi-step microfluidic device able to separate red and white blood cells (RBCs an...
Article
The analysis of the thermal conductivity of nanofluids (NFs) is extremely important to better understand the heat transfer mechanisms involved in the performance and efficiency of several thermal devices. In this work, two different NFs were tested using distilled water (DI-Water) as the base fluid. The first was a traditional NF formed by Al2O3 na...
Article
Full-text available
: Fluids containing nanometer-sized particles (nanofluids, NFs) are potential candidates to improve the performance and efficiency of several thermal devices at micro- and macro-scale levels. However, the problem of sedimentation and instability of these colloidal dispersions has been the biggest obstacle for industrial-scale applications. In this...
Chapter
Biomedical microfluidic devices are fabricated using different fabrication technologies. The most popular method is the soft-lithography manly due their main attraction, its high resolution capabilities and low material cost. However, usually, the fabrication of the moulds to produce microfluidic devices, is performed in a cleanroom environment and...
Article
Full-text available
The loss of the red blood cells (RBCs) deformability is related with many human diseases, such as malaria, hereditary spherocytosis, sickle cell disease, or renal diseases. Hence, during the last years, a variety of technologies have been proposed to gain insights into the factors affecting the RBCs deformability and their possible direct associati...
Article
Full-text available
Microfluidic devices have been widely used as a valuable research tool for diagnostic applications. Particularly, they have been related to the successful detection of different diseases and conditions by assessing the mechanical properties of red blood cells (RBCs). Detecting deformability changes in the cells and being able to separate those cell...
Article
Full-text available
Blood analogues have long been a topic of interest in biofluid mechanics due to the safety and ethical issues involved in the collection and handling of blood samples. Although the current blood analogue fluids can adequately mimic the rheological properties of blood from a macroscopic point of view, at the microscopic level blood analogues need fu...
Article
Full-text available
Malaria is one of the leading causes of death in underdeveloped regions. Thus, the development of rapid, efficient, and competitive diagnostic techniques is essential. This work reports a study of the deformability and velocity assessment of healthy and artificially impaired red blood cells (RBCs), with the purpose of potentially mimicking malaria...
Article
Full-text available
Techniques, such as micropipette aspiration and optical tweezers, are widely used to measure cell mechanical properties, but are generally labor-intensive and time-consuming, typically involving a difficult process of manipulation. In the past two decades, a large number of microfluidic devices have been developed due to the advantages they offer o...
Article
Full-text available
The soft-lithography is the most popular microfabrication technique to manufacture microfluidic devices for biomedical applications. However, the sophisticated equipment, high costs and time-consuming involved in the soft-lithography are slowing down the interest of the industrial community to commercialize microfluidic devices for engineering and...
Conference Paper
Red blood cells (RBCs) deformability is a high relevant mechanical property, whose variations are associated with some diseases, such as diabetes and malaria. Therefore, the present study aims to compare different image processing methods for assessing the RBCs deformability in a continuous flow, measured in a polydimethylsiloxane (PDMS) microchann...
Article
The cell-free layer (CFL) is a hemodynamic phenomenon that has an important contribution to the rheological properties of blood flowing in microvessels. The present work aims to find the closest function describing RBCs flowing around the cell depleted layer in a polydimethysiloxane (PDMS) microchannel with a diverging and a converging bifurcation....
Article
One of the most popular methods to fabricate biomedical microfluidic devices is by using a soft-lithography technique. However, the fabrication of the moulds to produce microfluidic devices, such as SU-8 moulds, usually requires a cleanroom environment that can be quite costly. Therefore, many efforts have been made to develop low-cost alternatives...
Article
The behavior of suspensions of individual blood cells, such as red blood cells (RBCs), flowing through microvessels and microfluidic systems depend strongly on the hematocrit (Hct), microvessel topology and cell properties. Although it is well known that blood rheological properties are temperature dependent, to the best of our knowledge no work ha...
Article
Full-text available
Blood flow presents several interesting phenomena in microcirculation that can be used to develop microfluidic devices capable to promote blood cells separation and analysis in continuous flow. In the last decade there have been numerous microfluidic studies focused on the deformation of red blood cells (RBCs) flowing through geometries mimicking m...
Data
Trajectories of both RBC and PBMC flowing around the cross-flow pillars. RBCs deform and pass through the pillars into the branch channel whereas a PBMC rolls along the pillars in the direction of the primary flow.
Article
Full-text available
Microfluidic devices are electrical/mechanical systems that offer the ability to work with minimal sample volumes, short reactions times, and have the possibility to perform massive parallel operations. An important application of microfluidics is blood rheology in microdevices, which has played a key role in recent developments of lab-on-chip devi...
Conference Paper
Studies of in vitro blood flow behaviour in stenosis are essential not only as an attempt to understand this phenomenon, but also to develop microfluidic devices, as an alternative clinical methodology to detect blood diseases. Regarding a better understanding of the role that rigid Red Blood Cells (rRBCs) play in the blood flow behaviour, we have...
Article
Red blood cell (RBC) deformability has become one of the important factors to assess blood and cardiovascular diseases. The interest on blood studies have promoted a development of various microfluidic devices that treat and analyse blood cells. Recent years, besides the RBC deformability assessment, these devices are often applied to cancer cell d...
Article
Full-text available
Red blood cell (RBC) deformability has become one of the important factors to assess blood and cardiovascular diseases. The interest on blood studies have promoted a development of various microfluidic devices that treat and analyse blood cells. Recent years, besides the RBC deformability assessment, these devices are often applied to cancer cell d...
Chapter
Full-text available
The present study uses a hyperbolic microchannel with a low aspect ratio (AR) to investigate how the red blood cells (RBCs) deform under conditions of both extensional and shear induced flows. The deformability is presented by the degree of the deformation index (DI) of the flowing RBCs throughout the microchannel at its centerline. A suitable imag...
Article
A separação e a identificação de células são essenciais em várias aplicações biomédicas, incluindo a biologia celular e os métodos de diagnóstico e terapêuticos. O sangue é um fluido não-Newtoniano contendo inúmeras informações preciosas sobre o estado fisiológico e patológico do corpo humano. No entanto, devido à sua complexidade, existem actualme...

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Projects

Projects (3)
Project
MalariaChip is under development at CMEMS and ICVS, both from University of Minho, aiming an accurate malaria diagnosis tool, which is critical for the disease control and elimination. The project focus on developing a novel non-invasive device integrating optical and acoustic systems to efficiently detect, in few seconds, the presence of the malaria parasite measured directly in patient’s skin. Taking advantage of the malaria parasite particular features in infected blood (red blood cells deformability and hemozoin formation), the main innovation herein disclosed is the on-chip acoustic detection of red blood cells misshape combined with optical detection of parasitic hemozoin (reflectance spectroscopy). Development of such microdevice will meet the growing clinical demands for reliable, rapid and quantitative diagnosis, suitable for field use at the patient's side. Because is a non-invasive device, besides being patient’s favored (without the need of needles incision or skin puncture), it will meet ecologic matters with no disposable parts and, consequently, no costs associated.
Project
Combine new optimization tecniques in scheduling and robotics areas.