Venkateswaramurthy .N

Venkateswaramurthy .N
JKK Nataraja College of Pharmacy | JKKNCP · Department of Pharmacy Practice

M.Pharm, Ph.D.,

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66
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288
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Publications

Publications (66)
Article
The aim of this study was to develop controlled release mucoadhesive microspheres of amoxicillin trihydrate for the treatment of peptic ulcer disease caused by Helicobacter pylori (H. pylori). Microspheres were prepared by solvent evaporation technique using carbopol 974P, hydroxypropyl methyl cellulose K4M (HPMC K4M) and Eudragit RS 100. The prepa...
Article
The purpose of this research was to formulate and systematically evaluate in vitro performances of mucoadhesive Furazolidone microspheres for the potential use of treating gastric and duodenal ulcers, which were associated with Helicobacter pylori. Furazolidone mucoadhesive microspheres were prepared by simple emulsification phase separation techni...
Article
It is well documented that Helicobacter pylori infection can use chronic peptic ulceration and can increase the risk of gastric denocarcinoma. The wide use of antibiotic therapies for H. pylori infection has also increased the number of therapeutic failures. Recent data show a decreasing efficacy of these therapies worldwide. One reason for the inc...
Article
Helicobacter pylori (H. pylori) infection has a strong association with chronic active gastritis and duodenal ulcer (DU). H. pylori infection can be detected in 90% of patients with DU and 70% of those with gastric ulcers. The most successful and universal treatment is triple therapy, three drugs twice a day for 1 week (proton pump inhibitor [PPI],...
Article
The primary aim of this study was to assess the relation between treatment satisfaction and medication adherence in hypertensive patients. Secondary objective of the study was to provide patient counselling and developing the levels of treatment satisfaction and medication adherence. A total of 200 patients were selected in the study period of 6 mo...
Article
Introduction Hypertension is a leading cause of cardiovascular disease and chronic kidney disease resulting in premature death and disability. The Renin-Angiotensin-Aldosterone system (RAAS) blockers including Angiotensin Converting Enzyme (ACE) Inhibitors or Angiotensin Receptor Blockers (ARBs) are used as first-line antihypertensive therapy to tr...
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The COVID-19 outbreak, caused by the severe acute respiratory syndrome coronavirus 2, has been detected in December 2019 in Wuhan, China, and is accompanied by significant degrees of morbidity and mortality. Antibiotic resistance (AMR) threatens to wreak havoc on healthcare system and the impact of globalization, and COVID-19 is intended to keep it...
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Tapentadol is a synthetic opioid analgesic that has been on the market in India since 2011. According to international studies, there is a low danger of abuse and diversion. Prescription opioid pain reliever abuse remains a major public health concern. Tapentadol, a prescription painkiller, differs from opioids such as oxycodone and morphine in tha...
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Globally, the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) had infected over 3 million individuals and claimed many lives producing a global epidemic that necessitates the rapid development of therapeutic solutions. The ideal technique for quickly deploying well-characterized medicines against novel infections is known as drug repur...
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Guillain-Barré syndrome (GBS) is an immune-mediated disease that affects peripheral nerves and can lead to life-threatening consequences. It affects around 10000 people per year worldwide. Since the outbreak of acute respiratory syndrome coronavirus-2 (sar-cov-2) the incidence of GBS has been increased with a fatality rate of 4-7%. The exact associ...
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Sleep apnea occurs when the upper airway repeatedly becomes blocked during sleep, reducing or entirely blocking airflow. This is referred to as obstructive sleep apnea. If the brain fails to provide the necessary impulses for breathing, the disease is known as central sleep apnea. Sleep apnea and other sleep breathing problems are a leading cause o...
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Background: The deadly arrival of novel coronavirus (COVID-19) in late December 2019, caused by the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) has emerged worldwide causing a pandemic. The World Health Organization (WHO) has proved ineffectiveness against existing medications this influenced the prompt identification of Monoclonal...
Article
Wound infection has always been a major complication of surgery and trauma. The aim of our study was to determine the bacteriology of wound infections and to study the antibiotic susceptibility pattern of the isolates. The study was conducted in tertiary care hospital, Erode. The design of the study was a prospective type. Pus swabs / specimens wer...
Article
GestationalDiabetesMellitus(GDM) is an irregular glucose tolerance condition that developsfirst and is recognized during pregnancy.The Oral Glucose Tolerance Test (OGTT) is the gold standard for the diagnosis of this disorder from 24 to 28 weeks. A number of adverse results, including gestational hypertension, cardiovascular disease and preeclampsi...
Article
The study was aimed to analyse the pattern of medication errors and drug interaction induced adverse drug reactions in the psychiatry department of a tertiary care hospital. A Prospective observational study being conducted in the inpatient and outpatient department of psychiatry in a tertiary care hospital, Erode, Tamil Nadu for over six months. A...
Article
Childhood asthma is the common chronic illness among school going children. It was a syndrome characterized by airflow obstruction that differs strikingly. There were very few school based studies on the prevalence of asthma in Indian children. We aimed to estimate the prevalence of asthma in children between 12 -15 years of age group at Komarapala...
Article
Epithelial-to-mesenchymal transition (EMT) is an orchestrated event where epithelial cells progressively undergo biochemical changes and transition into mesenchymal-like cells by gradually losing their epithelial characteristics. EMT plays a crucial pathologic role in renal abnormalities, especially renal fibrosis. A number of bench studies suggest...
Article
The activation of peroxisome proliferator-activated receptor α (PPARα) is a key pharmacological drug target for dyslipidemic management. Dyslipidemia is associated with abnormal serum lipid profiles viz. elevated total cholesterol, high triglyceride, elevated low-density lipoprotein cholesterol, and reduced high-density lipoprotein cholesterol leve...
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The world is running out of antibiotics. Between 1940 and 1962, more than 20 new classes of antibiotics were marketed. Since then, only two new classes of antibiotics were marketed. Now, not enough analogues are reaching the market to stem the tide of antibiotic resistance, particularly among gram-negative bacteria which indicates the need of novel...
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Chloroquine is a prototype antimalarial drug used to prevent and treat malaria, amebiasis and other autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. The drug acts as an autophagy inhibitor were autophagy is a self-destructive process which is needed to balance sources of energy at developmental process and in resp...
Article
The prevalence of diabetes has increased to a greater extend over the past few decades and is estimated to increase over few years. According to the World Health Organization, India has the unique distinction of being the country with the largest number of diabetic patients in the world. In 1995, prevalence of diabetes was 19.4 million and is proje...
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Background: In the past few decades the issue of overweight and obesity has become a serious public health concern throughout the world. In India, 5% of the population is obese. Obesity is not an immediately fatal disease by itself, but is a risk factor for wide range of serious non communicable diseases in Indian population. Aims: This study was a...
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Irrational drug prescription leads to ineffective treatment, occurrence of adverse effects, prolonged duration of illness and suffering to patient, and an increased economic burden to society. Since children are more vulnerable than adults, it is crucial that principles of rational prescription are strictly adhered to. The main objective is to stud...
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p> Objective: To assess the incidence and pattern of potential drug-drug interaction (pDDI) in hospitalized stroke patients. Methods: A retrospective study was carried out in a medical record from a tertiary care teaching hospital for a 4 mo period from November 2015-February 2016. The total of 200 prescriptions was analyzed during the study perio...
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Statins are most effective in reducing the plasma cholesterol level by inhibiting hydroxyl methyl glutaryl coenzyme A reductase. Emerging evidence suggest that statins exert other mechanism of action called Pleiotropic effects; which are plaque stability, endothelial function modification, thrombus formation etc. Therefore therapeutic potential of...
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Impact of pharmacist offered patient counseling was studied on asthmatic patients. Patient education plays a vital role in enhancing quality of life of asthma patients. In this study an overall of 173 asthma patients were chosen and counseling provided by using patient education leaflet, videos and pictorial aid. Impact of patient counseling was st...
Article
To study the antihypertensive drug utilization pattern among Hypertensive patients in a rural tertiary care teaching Hospital at Salem, Tamilnadu, India. A prospective study of 9 month duration was conducted at the tertiary care hospital. The prescriptions containing antihypertensives were collected from the patients attending the outpatient depart...
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Purpose: To evaluate in vivo H. pylori clearance efficacy of formulated mucoadhesive microspheres of amoxicillin trihydrate and clarithromycin.Methods: Amoxicillin trihydrate and clarithromycin mucoadhesive microspheres were prepared by solvent evaporation method using Carbopol 974P, HPMC K4M and Eudragit RS 100. In vivo clearance efficacy of the m...
Article
Objective: The pattern of drug utilization in pediatric patients in a tertiary care hospital in erode dist was studied. Methods: The study was conducted in the two pediatric clinics in erode dist, during which prescription and case records were reviewed. Results: A total of 286 patient's prescriptions were analyzed. In that 156(54.5%) patients were...
Article
Pre-eclampsia is a multi-organ system disorder that occurs after the 20th week of gestation in pregnancy and is characterized by hypertension and proteinuria with or without edema. It is a major cause of morbidity and mortality for the woman and her child. The aim of this study was to investigate the efficiency of the short-term treatment with anti...
Article
The aim of this study was to develop controlled release mucoadhesive microspheres of clarithromycin for the treatment of peptic ulcer disease caused by Helicobacter pylori (H. pylori). Clarithromycin mucoadhesive microspheres were prepared by using carbopol 974P and Hydroxypropyl methyl cellulose K4M (HPMC K4M) and Eudragit RS 100. The prepared mic...
Article
Objective: To investigate the management of hypertension in patients with diabetes mellitus. Method: An observational study was conducted in outpatient department of a cardiology hospital. Patients with either diagnosed hypertension or high blood pressure who attended the clinic were eligible for inclusion in the present study. Result and Conclusio...
Article
The aim of this study is to investigate the antitumour and antioxidant activities of the ethanol extract of Scutia myrtina (EESM) against Ehrlich's ascites carcinoma (EAC) in mice. Twenty-four hours after tumour inoculation, EESM was administered at doses 100, 200 and 300 mg kg⁻¹ bodyweight/mice/day for 21 days. EESM caused a significant (p < 0.01)...
Article
Background: In this study an attempt was made to evaluate the prevalence of Diabetes mellitus and Arterial hypertension in patients with ocular disorders such as Cataract, Glaucoma and Retinopathy. Materials and methods: It was a six month prospective study. The study was conducted in eye hospital. Patients with disorders of Cataract, Glaucoma and...
Article
Oral administration of unfractionated heparin enhances gastric ulcer healing without affecting the coagulation function. In order to localize the heparin at site on the gastric epithelium for improving the efficacy of anti-ulcer activity a mucoadhesive microspheres composed of Carbopol 934P and Ethyl Cellulose have been developed. Heparin microsphe...
Article
The hepatoprotective effect and antioxidant role of ethanol extract of Scutia myrtina (EESM) was evaluated against paracetamol induced liver damage in rats. The degree of protection was measured by using biochemical parameters such as serum transaminase (SGPT and SGOT), alkaline phosphatase (ALP), bilirubin, total protein and uric acid. Further, th...
Article
Non-ionic surfactant vesicles containing cefpodoxime proxetil were prepared using drug, sorbitan ester and cholesterol in the ratios (by weight) of 1:3:1, 1:6:1, and 1:9:1. The prepared vesicles were characterized for the shape, size, entrapment efficiency, and in-vitro drug release and stability studies. The particle size distributions were carrie...
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Abstract Aim of study: This study examines the in vitro antioxidant activity of the ethanol extract of Symplocos racemosa (EESR) Roxb bark. Material and methods: The coarse powdered materials of Symplocos racemosa was extracted with ethanol (95%v/v) by using soxhlet apparatus. The ethanol extract was concentrated in vacuo and kept in a vacuum desic...
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Cancer prevention and treatment using traditional medicines have attracted increasing interest. The present study is designed to evaluate the cytotoxicity of ethanolic extract of Pseudarthria viscida (EEPV) Linn by MTT assay on HT29 (human colorectal cancer cell line), C2C12 (mouse muscle cell line) and 3T3 L1 (mouse, embryo fibro blast) cell lines...
Article
During the past two decades, there has been a steady increase in both the number of antiretroviral medications and the number of possible regimens available to manage human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS). But still, regimen fails due to some reasons such as toxicity, adverse effects, and consequent diffi...
Article
Helicobacter pylori (H. pylori) is a Gram-negative bacterium that causes one of the most common chronic infections in humans. The infection produces chronic gastritis and predisposes to the development of peptic ulcer disease. Although triple therapy protocols used at present in the clinics have resulted in significant benefits to the patients, the...
Article
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Mucoadhesive microspheres include microparticles and microcapsules (having a core of the drug) of 1-1000μm in diameter and consisting either entirely of a mucoadhesive polymer or having an outer coating of it, respectively. Amoxicillin microspheres were formulated by using solvent evaporation technique. Using Eudragit RS 100 as matrix polymer. Eval...
Book
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Biopharmaceutics and Pharmacokinetics A Practical Manual
Article
The present study was carried out to evaluate the hepatoprotective and antioxidant effect of the methanol extract of Caesalpinia bonducella (MECB) (Family: Caesalpiniaceae) in Wistar albino rats. The different groups of animals were administered with carbon tetrachloride (CCl 4) (30 % CCl 4, 1 ml/kg b. wt. in liquid paraffin 3 doses (i.p.) at 72 h...
Article
Full-text available
The aim of the present study is to investigate the anti-inflammatory and antimicrobial activity of petroleum ether and ethanol extracts of Scutia myrtina (Family: Rhamnaceae). In anti-inflammatory activity carrageenan and histamine induced paw oedema and cotton pellet induced granuloma for acute and chronic inflammatory models were studied in Wiste...
Article
Full-text available
The methanol extract of stem barks of Careya arborea Roxb. (MECA) (Family-Myrtaceae) was evaluated for antitumor activity and antioxidant status against Ehrlich's Ascites Carcinoma (EAC) bearing Swiss albino mice. After 24 h of tumor inoculation the MECA was administered at the doses of 50, 100 and 200 mg/kg body weight/mice/day for 14 days. After...
Article
Full-text available
The aim of the present study is to investigate central nervous system (CNS) activity of the methanol extract of barks of Careya arborea (Myrtaceae) in Swiss albino mice and Wistar albino rats. General behavior, exploratory behavior, muscle relaxant activity and phenobarbitone sodium–induced sleeping time were studied. The results revealed that the...
Article
Full-text available
The aim of the present study is to investigate the anti-inflammatory and antimicrobial activity of petroleum ether and ethanol extracts of Scutia myrtina (Family: Rhamnaceae). In anti-inflammatory activity carrageenan and histamine induced paw oedema and cotton pellet induced granuloma for acute and chronic inflammatory models were studied in Wiste...

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