Vellapandian Chitra

SRM Institute of Science and Technology | SRM · Department of Pharmacology

Background: This study investigates the antiarthritic potential of a polyherbal formulation (PHF) comprising extracts from Tinospora cordifolia, Rosa damescena, and Acacia leucoploea in a rat model of rheumatoid arthritis (RA). RA is a chronic autoimmune disorder with debilitating consequences. PHF's impact on joint inflammation, bone degradation,...

Burkholderia cepacia complex (BCC) is a Gram-negative, non-spore-forming bacterium with more than 20 opportunistic pathogenic species, most commonly found in soil and water. Due to their rapid mutation rates, these organisms are adaptable and possess high genomic plasticity. BCC can cause life-threatening infections in immunocompromised individuals...

Polycystic ovary syndrome (PCOS) is a common endocrinopathy characterized by excess androgen and infertility due to anovulatory failure. A significant fraction of the world's population is affected by the infertility condition known as PCOS. Due to the disease's complicated nature and overlapping symptoms, diagnosis of the condition is frequently c...

Cancer prevalence and resistance issues in cancer treatment are a significant public health concern globally. Among the existing strategies in cancer therapy, targeting cyclin-dependent kinases (CDKs), especially CDK-6 is found to be one of the most promising targets, as this enzyme plays a pivotal role in cell cycle stages and cell proliferation....

Prostatis prevalence more in aged males and amidst disputes of severe therapeutic measures, both physicians and patients resort to alternative and non-traditional measures. The aim of this study is to investigate the effect of Musa paradisiaca (lyophilized juice) and Punica granatum (peel powder) suspension by carrageenan-induced method for prostat...

Obesity is a complex disease caused by various factors, and synthetic drugs used to treat it can have side effects. Natural compounds, such as olivetol, could be a promising alternative. Olivetol is a substance found in certain lichen species and has anti-inflammatory and anti-cancer properties. In this study, researchers conducted in-silico molecu...

Aim: Determining the in-vivo assessment of Naringenin’s nephroprotective efficacy against Autosomal dominant polycystic kidney disease (ADPKD) and Madin-Darby canine kidney (MDCK) derived cysts. Method: Our research on the molecular mechanism of naringenin, a flavonoid present in plants and berries that has been shown to limit cell growth and prote...

Advanced economic development and technologies cause worldwide plastic waste to increase many folds, leaving policymakers with the dilemma of managing it. Synthetic solid particles or polymeric matrices of plastics with...

Objective: The objective of this study was to investigate the influence of Decalepis hamiltonii (D. hamiltonii), a traditional plant used in herbal medicine, on the intestinal absorption and pharmacokinetics of fexofenadine, a substrate of P-glycoprotein (P-gp), in rats. Methods: In situ intestinal perfusion tests were conducted to assess the intes...

Background Impaired wound healing is the most common and significant complication of Diabetes. While most other complications of Diabetes have better treatment options, diabetic wounds remain a burden as they can cause pain and suffering in patients. Wound closure and repair are orchestrated by a sequence of events aided by the release of pro-infla...

The aim of this study was to investigate the influence of excipients on retaining the particle size of methotrexate (MTX) loaded chitosan nanocarriers (CsNP) during lyophilization, which relates to the ability to enlarge the particle size and target specific areas. The nanocarriers were prepared using the ionic gelation technique with tripolyphosph...

The valued studies of alternative psoriasis treatment options are in a much higher need among the Scientific Community. This study aimed to evaluate the anti-psoriatic activity of ursolic acid cream in imiquimod-induced psoriasis in BALB/c mice. The creams containing ursolic acid, a pentacyclic triterpenoid at percentages of 0.1 and 0.2% were formu...

The growing prevalence of diabetic patients in recent times has been increasing globally and is also attributed as the most common metabolic disease. As a result of its lack in the control and management of disease condition seems to be still far from achieving success, especially due to the safety limitations of currently available medicines. Toxi...

This study was carried out to study the effect of anethole rich fraction on the Diabetic Nephropathy (DN) rats, and explore the mechanisms.

Migraine is a chronic illness with a high economic burden. Recognizing the aetiology of migraine is crucial both from a public health and a medical point of view. Regardless of the fact that the actual cause of migraines is unidentified, trigeminal nerve fibres encompassing meningeal arteries have indeed been linked to migraine path biology. Pollut...

The pharmacological healing for inflammatory bowel diseases continues to be uncertain and requires immediate therapeutic interventions. A poly-herbal formulation obtained from a traditional and authentic classic text of Ayurveda was assessed for its effect against IBD (inflammatory bowel disease) in this study. The formulated poly-herbal suspension...

The purpose of this review is to discuss and summarize the prospects of combinatorial approach involving immunogenic cell death induction and immunosuppressive adenosine A2A receptor pathway inhibition in enhancing anti-tumor immunity. Majority of chemotherapeutic agents can elicit antitumor immunity and modulate the composition, density, function,...

Aim: The aim of the present study was to evaluate the anti-arthritic and anti-inflammatory effects of stigmasterol and β-sitosterol. Method: The CAM test was used to investigate the anti-arthritic and anti-inflammatory properties of stigmasterol and -sitosterol, which were obtained commercially. The anti-oxidant activity of the 2, 2'-Azino-Bis-3-Et...

Background COVID19 (coronavirus disease of 2019) occurs due to the highly contagious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It uses angiotensin-converting enzyme-2 (ACE-2) as its primary receptor to enter the host cell. Recent reports suggest that this pathogen also has a large impact on the CNS alongside other organs. Variou...

The study evaluated the nephroprotective activity of hydroalcoholic extracts of Trachyspermum ammi leaves and Citrus paradisi fruits against prednisolone-induced ADPKD in experimental rats. The hydroalcoholic extracts were given orally at 100 and 200 mg/kg for a period of 28 days. Kidney function was evaluated by measuring serum and urine creatinin...

Background Neurological complications are most likely to be fatal and cause loss of ability to function or care for self. These include Alzheimer’s disease and cognitive impairment. The main aim of the review is to determine the effects of various drugs and their cognitive risk with the need to opt for herbal therapy as an adjuvant in treating neur...

Background The aim of this systematic review is to ponder the possible mechanism of action of anthocyanin in Alzheimer’s disease (AD), to prompt the development of anthocyanin-based dietary supplementation or therapeutic intervention for AD and to explore the natural sources of anthocyanins. Methods Electronic bibliographic databases such as PubMe...

Multiple sclerosis (MS) is an autoimmune disease affecting 2.5 million individuals globally. MS majorly affects younger adults, especially women, than males having an incidence ratio of 3:1. MS conditions are characterized by demyelination, axonal deterioration, gliosis, heterogeneous lesions, and lymphocytes entrance infiltrates into the CNS by br...

The aim of the study was to evaluate the pharmacological effect of stigmasterol and β-sitosterol using anti-inflammatory and anti-arthritic in-vitro and ex-vivo methods. Stigmasterol and β-sitosterol was obtained commercially and the CAM assay was done to determine the anti-arthritic and anti-inflammatory effects. The DPPH (2,2-diphenyl-1-picrylhyd...

The chapter focuses on an up-to-date insight into the role of neuroinflammatory responses which are seen after the occurrence of TBI. TBI is a heterogeneous disorder with the injury differing on the basis of cause of the injury or its mechanism. The pathophysiology of TBI is very unique and involves two phases. The initial phase is the primary phas...

The polycystic ovarian syndrome is one of the most frequent gynecological disorders among reproductive-age women (PCOS). The polycystic ovarian disease is also known as Stein Leventhal syndrome or high androgen anovulation syndrome. It is a common endocrine illness marked by polycystic ovaries, chronic anovulation, and hyperandrogenism, which cause...

Nephrolithiasis appear to be a major health crisis among the population with serious medical related consequences throughout the lifetime of patient. The aim of the study was to evaluate the preventive effect of the hydro-alcoholic extract of A. lanata roots on Urolithiasis rats. Thirty adults male wistar Albino rats weighing 200 – 250 g were divid...

Background Parkinson’s disease (PD) exhibits the extra pyramidal symptoms caused due to the dopaminergic neuronal degeneration in the substantia nigra of the brain and depletion of aldehyde dehydrogenase (ALDH) enzyme. Objective This study was designed to enlighten the importance of Aldehyde dehydrogenase enzyme in protecting the dopamine levels i...

Osteoporosis is the multifactorial skeletal disease that leads to fracture risk in individuals. It is characterized by a decrease in bone mineral density leading to increased fracture risk. It is often silent and only known when fractures occur in the elderly leading to death. The reason is that the disease is always underdiagnosed and not treated...

Introduction: Homoeopathy, one of the most commonly employed alternative medicines globally, has a wide range of role in the management of diabetes. Screening of the action of homoeopathic medicines in diabetes on animal model not only helps in validating their antidiabetic potential but also aids in understanding their effect on living systems and...

In the experimental models of Parkinson's disease (PD), a well-known neurotoxin 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine or MPTP, pesticides like benomyl, paraquat,etc. are successfully used to induce a Parkinson's disease in human and nonhuman primates, which can be reversed by the drugs such as L-DOPA. A review on the alternative methods a...

Ethnopharmacological relevance Prosopis cineraria (L.) Druce is a plant that is widely found in dry parts of India. The unripe fruit pod has a very specific traditional claim of treating male infertility and increasing sperm volume and count. Aim The present work was endeavored to investigate the long-standing traditional claim of P. cineraria on...

Recent studies have suggested that environmental factors have a crucial role in triggering and/ or propagating the pathological changes in Parkinson’s disease (PD). Although many studies have been and being performed by utilizing MPTP like chemicals to study the effectiveness of new extracts and compounds in PD, a little focus was made on the role...

Osteoporosis is a metabolic bone disorder which causes bone loss in course of time leading to increasing the fracture risk. The disease is often silent and known only when fractures occur. Both men and women are equally affected. But women are more susceptible to osteoporosis. The main cause of fragility fractures in women is due to the estrogen de...

Objective: The objective of this study was to evaluate the protective effect of Hemidesmus indicus against 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mice model. Methods: A total of 18 male Swiss Albino mice were divided into three groups (n=6). Hydroalcoholic concentrate of H. indicus (HAHI) at 200 and 400 mg/kg dosages, 30 min be...

The aim of the present study is to evaluate the anti-angiogenic effect of Tanacetum pathenium (Feverfew) herb formulation and Amlodipine Concentration. This study is also done to compare and contrast the anti-angiogenic score of Tanacetum parthenium (Feverfew) to that of Amlodipine taking Amlodipine as control. The anti-angiogenic activity of Amlod...

Objective: The objective of this study was to evaluate the anti-inflammatory and antiarthritic potential of Parmelia perlata. Methods: The relative study is based on in vitro anti-inflammatory and antiarthritic activity using hydroalcoholic extract of P. perlata (HAEPP). The preliminary phytochemical tests showed the presence of various phytochemic...

Objective: The objective of this study was to evaluate the anti-inflammatory and antiarthritic potential of Parmelia perlata. Methods: The relative study is based on in vitro anti-inflammatory and antiarthritic activity using hydroalcoholic extract of P. perlata (HAEPP). The preliminary phytochemical tests showed the presence of various phytochemic...

Objective: Garcinia atroviridis belongs to the family Clusiaceae. The whole plant was dried, extracted to obtain a xanthone-rich extract. Phytochemical studies of extract showed the presence of phenols, alkaloids, steroids, resins, and saponins. Alzheimer’s disease (AD) the most common form of dementia, a brain disorder which has been affecting the...

Aim: The study deals with the evaluation of neuroprotective effect of charantin. Charantin was isolated from Momordica charantia (MC) L. (Bitter gourd) and characterized by performing infrared (IR), nuclear magnetic resonance (NMR). As it was earlier proved that amyloid beta deposition and cognition are inter-related, neuroblastoma cell lines SH-SY...

Objective: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced parkinsonism is a widely accepted animal model for screening the drugs used in Parkinson’s disease (PD). In the present study, the neuroprotective effects of methanolic extract of Canscora decussata (MECD) were evaluated, which was already known for its monoamine oxidase inhibit...

The present study was designed to evaluate antiosteoporotic activity of the fresh juice mixtures obtained from Actinidia deliciosa and Garcinia mangostana as well as the pericarp extract of Garcinia mangostana on postmenopausal osteoporosis. 3-month-old female Wistar rats were ovariectiomized and the treatment began 14 days after ovariectomy and co...

The stimulation or suppression of the immune response may modulate disease free state. Herbal medicine paved way for immunmodulation role in many mmunological disorder. The present study was aimed to prove the traditional claim on the theimmunomodulatory activity ofAvicenniaofficinalisagainst autoimmune diseases. TheAvicenniaofficinalis leaves was...

Objective: Prolonged usage of neuroleptics in psychotic disorders such as schizophrenia provokes extrapyramidal symptoms that are also seen in Parkinson’s disease. An attempt has been made to study the neuroprotective role of Achyranthes aspera hydroalcoholic (HA) extract on haloperidol-induced Parkinson’s symptoms in Wistar rats.Methods: The prese...

Objective: Felodipine, a BCS class II calcium channel blocker, is used in the management of hypertension and angina pectoris. Due to the poor solubility and low bioavailability of the drug, there is a necessity to design an alternative route to achieve a constant plasma concentration of felodipine for its maximum therapeutic utility and can be achi...

Spectral Analysis of Sargassum ilicifolium (Turner) C. Agardh and in vitro Anti-proliferative Study of its Ethanolic Extract and Chloroform Fraction Against Colon Cancer (HT-29) and Lung Cancer (A549) Cell Lines. Current research in drug discovery from medicinal plants involves the identification of safe and inexpensive lead molecule towards diseas...

Oxidative stress is implicated as one of the primary factor that contributes to the neurodegerative disease, brain damage, stroke, hypoxia etc. The aim and objective of the present study is to investigate the neuroprotective effect of hydrolcoholic seed extract of Langenaria siceraria on hypoxic neurotoxicity induced in wistar rats. The animals wer...

Syzygium cumini is a folklore plant traditionally indicated to treat various inflammatory disorders. In this study anti rheumatic activity of oral administration of petroleum ether extract of Syzygium cumini stem bark at the doses of 50,500,750,1000, mg/kg on complete Freund's complete adjuvant induced arthritis has been studies in rats. The treatm...

Objective: Mimusops elengi Linn, is one such important medicinal plant whose bark, leaves and flowers have proved to have several pharmacological properties. In the present study, hydroalcoholic extract of flowers is used to study the protective role in Alzhiemer’s disease. Materials and Methods:Rats were divided into 5 groups and treated with Colc...

Use of antipsycotics like haloperidol in the treatment of schizophrenia and other affective disorders are known to produce extra pyramidal symptoms which are seen in Parkinson’s disease. In the present study, an attempt has been made to evaluate the neuroprotective effect of methanolic extract of Canscora decussata on haloperidol (2mg/kg-intraperit...

Chronic renal failure (CRF) is a rapidly growing global health problem and it causes anaemia and cognitive impairment. Recombinant Human erythropoietin (rHu-Epo) has been a promising role in the management of anaemia in CRF subjects and it is well documented. It also shown as a remarkable neuroprotection in both cell cultures and in animal models....

The present work is carried out to study the effect of Asystasia gangetica T. Adams (Acanthaceae) on blood glucose levels and antioxidant enzymes levels in Alloxan induced diabetic rats. Alloxan (120 mg/kg, i.p) induced diabetic rats were treated with Asystasia gangetica leaf methanolic and n-hexane extract for 21 days. Glucose level was measured i...

Ulcers are the most common form of GI disorder that is often caused by either inflammation or infection that certainly affected 10% of the population at risk. Among all types of ulcers, peptic ulcer is the more catastrophic one. This point made an exemption objective to conduct an investigation for antiulcer activity of alcoholic extract of Garuga...

The Immune System is the most complex biological systems in the body. The present study was aimed to investigate the immunomodulatory activity of the ethanolic extract of leaves of Glycosmis pentaphylla in swiss albino mice. The effect of humoral antibody response was evaluated by Haemagglutination antibody titre method. Cellular immunity was evalu...

Objective: The purpose of the present study was to determine the Pharmacodynamic interaction of the garlic homogenate with Atorvastatin on Doxorubicin induced myocardial damage in Albino rats. Methods: Myocardial damage was induced by intraperitoneal Doxorubicin (15mg/kg) administration.Garlic homogenate at different doses of 125 and 250mg/kg orall...

A new, simple, specific, accurate and precise reversed phase-high performance liquid chromatography (RP-HPLC) method was developed for the determination of levofloxacin in rat plasma and saliva was developed. An HPLC system based on a Phenomenex Luna C18 Column (250 × 4.6 mm) and a UV detector (λ = 296 nm) were used. A mixture of Acetonitrile: wate...

Several studies have suggested that antioxidants retard the process of cataractogenesis by scavenging free oxygen radicals. The present study assessed the efficacy of erdosteine in preventing experimental cataractogenesis in an experimental setting. In the in vitro phase of the study, goat lenses were used and lenses were subjected for photographic...

Aim: The present study was aimed to investigate the cellular and molecular mechanisms of protective effects of allylmercaptocaptopril (AMC) against liver carcinoma induced by Aflatoxin B1, a potent inducer of liver cancer. Method: In this study we determined the protective effect of AMC on liver tissue, as well as on enzymatic liver functions by es...

Chlorophytum arundinaeceum is a plant possessing various medicinal properties. The aim of present study was to investigate the immunomodulatory activity of the hydroalcoholic extract (HRC) obtained from the root of the plant at the dose of 100 mg kg-1 and 200 mg kg-1. To evaluate the immunomodulatory activity of the hydroalcoholic root extract of C...