Vasudeva Murthy

• M.Pharm., Ph.D (Kakatiya University, Warangal , India)
• Professor at Jayamukhi College of Pharmacy

A retrospective observational study aimed to assess blood calcium levels in children with lower respiratory tract infections (LRTIs) from September 2023 to February 2024. A total of 225 eligible records were evaluated. Calcium deficiency was observed in 44.8% of children, hyperchloremia in 42.6%, and hyperkalemia in 36.8% on admission. The mean age...

Background: Drug-resistant tuberculosis is a burgeoning threat to public health requiring novel strategies to combat the infection. Although national tuberculosis elimination programs focus on improving health services, challenges in eradicating tuberculosis still exist. Factors attributing to unfavorable outcomes are unknown in Warangal district o...

Abstract Background: Drug-resistant tuberculosis is a burgeoning threat to public health requiring novel strategies to combat the infection. Although national tuberculosis elimination programs focus on improving health services, challenges in eradicating tuberculosis still exist. Factors attributing to unfavorable outcomes are unknown in Warangal d...

Background and aims Non-alcoholic fatty liver disease (NAFLD) is one of the leading causes of chronic liver disease in type-2 diabetics. The quality of life among those patients was not explored well. Hence, the present study aimed to correlate the determinants with the quality of life (QoL) among the study subjects. Methods A hospital-based case–...

Rational use of antimicrobials including antimicrobial stewardship program. •The emergence of antibiotic resistance. • Antimicrobial stewardship program. • Antibiotic stewardship program activities in India. • Hospital antibiotic stewardship programs

Withania somnifera (ashwagandha) has been used traditionally as a remedy for insomnia and to enhance cognitive function. The effects of ashwagandha extract (AE, 35% withanolide glycosides, ShodenⓇ) on the expression levels of γ-aminobutyric acid (GABA)Aρ1 and histamine H3 receptors in Rattus norvegicus glioblastoma (C6) cell lines were studied usin...

Withania somnifera (ashwagandha) has been used traditionally as a remedy for insomnia and to enhance cog-nitive function. The effects of ashwagandha extract (AE, 35% withanolide glycosides, Shoden Ⓡ) on the expression levels of γ-aminobutyric acid (GABA)Aρ1 and histamine H3 receptors in Rattus norvegicus glioblastoma (C6) cell lines were studied us...

Background Scarcity of data in relationship between hyperuricemia and nonalcoholic fatty liver disease (NAFLD) in Type 2 diabetics (T2DM), particularly in terms of gender differences. Hence, the study was aimed to investigate the gender difference in association between hyperuricemia, and NAFLD in the Indian population. Methodology A cross-section...

Aim: To monitor the nature and incidences adverse effects of both antipsychotics and antidepressants medicines in the psychiatry outpatient department. Objectives: Reporting the incidences of adverse effects and to establish the frequency of a specific class of drug. Identifying the system affected and the assessment of the management of the advers...

Background: Ashwagandha (Withania somnifera), a known traditional medicine used in Ayurveda system of medicine, native to the India. Poor quality sleep always looked as serious complaint as it disrupts sleep. The natural phytoconstituents present in the ashwagandha believed to be adaptogen that helps the body to adapt stress by normalizing or corre...

Objective Out-of-Hospital Cardiac Arrest (OHCA) is a global public health problem. There is inadequate data on OHCA in India. The Warangal Area out-of-hospital Cardiac Arrest Registry (WACAR) was planned to understand OHCA in a regional setting in India. Methods WACAR is a prospective one-year observational cohort study of OHCA in the Warangal are...

The aim of the study was to investigate the incidence and factors linked with nonalcoholic fatty liver disease (NAFLD) among type-2 diabetes mellitus (T2DM) patients in Warangal, Telangana, India. It was an observational, cohort cross- sectional study; a target sample of 100 T2DM patients was recruited from a single study site of Warangal. Detaile...

Background: Neurologic manifestations caused by the major electrolyte abnormalities in neurologic conditions. The clinical significance of electrolytes in clinical practice and their abnormalities are developing in any of the neurological manifestations and along with other complications. Objectives: The neurological manifestation requires effectiv...

Background: Newspapers in India often report incidents of cardiac arrest. Media reports are a source for raising awareness of cardiac arrest and cardiopulmonary resuscitation (CPR) among the public. This study is aimed at evaluating the reports of cardiac arrest published in Indian newspapers. Materials and Methods: This is an observational study o...

Context: Recording of neurophysiological properties in a rodent model by stereotaxic surgery is well known, while the non-invasive method used to investigate the neurophysiological effects of studied using carbamazepine (CBZ). Aims: The effects of CBZ electrical activity of the brain recorded using a non-invasive technique and validated by an exper...

This paper describes about the new non-invasive method to measure brain waves from the scalp of the rats. The method allows to record good quality Electroencephalogram (EEG) from freely moving rats in the cage. Methods: This experiment targeting rodents used simple adhesive patch containing conductive gel placed on the scalp of the rats has a poten...

The present study is designed to evaluate the cardioprotective effect of Rosa damascena petals called rose on isoproterenol-induced myocardial infarction in experimental rats. The experimental rats were divided into 4 groups, each consisting of 6 animals. Group 1 rats received standard diet and drinking water ad libitum for 45 days and will serve a...

The objective of this study is to appraise the cardioprotective properties of Gomphrena globosa flowers on isoproterenol-induced myocardial infarction in albino rats. The experimental rats were divided into four groups with six rats in all the groups. Group 1 and group 2 animals were treated with standard diet for 45 days and will serve as a normal...

Background: Newspapers in India often report incidents of cardiac arrest. Media reports are a source for raising awareness of cardiac arrest and cardiopulmonary resuscitation (CPR) among the public. This study is aimed at evaluating the reports of cardiac arrest published in Indian newspapers. Materials and Methods: This is an observational study o...

Objective: Cardiovascular diseases are the major cause of morbidity and mortality in the modern era. Myocardial infarction is a condition where there is a significant decrease or block in the blood (oxygen) supply to the part of heart, leading to degeneration of a portion of the myocardium which triggers a cascade of cellular, inflammatory and bioc...

The objective of the present work was to formulate and to characterize controlled release matrix tablets of losartan potassium in order to improve bioavailability and to minimize the frequency of administration and increase the patient compliance. Losartan potassium controlled release matrix tablets were prepared by direct compression technique by...

The objective of the present study was to develop Cefixime gastroretentive floating matrix tablets for prolonged gastric retention time and thereby increased drug bioavailability. Cefixime is a third generation Cephalosporins antibiotic which is slowly and incompletely absorbed from the GIT, which resulting into the poor bioavailability 40- 50%.The...

We report a library consisting of some novel Hantzsch dihydropyridines of biological interest as well as their synthesis and analysis. The important steps in the synthetic part were found to be Hantzsch reactions. The synthesized compounds were screened for their in vitro antibacterial activity against two gram-positive bacteria: Staphylococcus aur...

The pleural fluid was aspirated from the tuberculous patients both untreated and under treatment with three months anti-tuberculosis therapy. The amount of malondialdehyde, lactate dehydrogenase, and total protein content in pleural fluid of untreated tuberculous patients were found to be significantly higher when compared with under treatment grou...

Antioxidant activities of some antitubercular drugs were evaluated by using a simple, accurate and reproducible method. Ascorbic acid was used as a control in the study. The antioxidant activities of antitubercular drugs were less as compared to ascorbic acid.

Severe oxidative stress has been reported in leprosy patients because of malnutrition and poor immunity. The purpose of this study was to investigate the serum lipid peroxidation products, serum LDH and important free radical scavenging enzymes, i.e. superoxide dismutase (SOD), and catalase and anti-oxidant glutathione levels and total anti-oxidant...