Vanessa Poth

Vanessa Poth
Universität des Saarlandes | UKS · Fachbereich Biophysik

Master of Science

About

6
Publications
705
Reads
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53
Citations
Citations since 2017
6 Research Items
53 Citations
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201720182019202020212022202305101520
201720182019202020212022202305101520

Publications

Publications (6)
Article
Full-text available
Alternative splicing is a potent modifier of protein function. Stromal interaction molecule 1 (Stim1) is the essential activator of store-operated Ca2+ entry (SOCE) triggering activation of transcription factors. Here, we characterize Stim1A, a splice variant with an additional 31 amino acid domain inserted in frame within its cytosolic domain. Pro...
Article
Full-text available
Store-operated Ca2+-entry (SOCE) regulates basal and receptor-triggered Ca2+ signaling with STIM proteins sensing the endoplasmic reticulum (ER) Ca2+ content and triggering Ca2+ entry by gating Orai channels. Although crucial for immune cells, STIM1’s role in neuronal Ca2+ homeostasis is controversial. Here, we characterize a splice variant, STIM1B...
Article
The endoplasmic reticulum (ER) is a vast intracellular organelle important to maintain proteome, lipid and calcium homeostasis to ensure cellular functionality. Stromal Interaction Molecule (STIM) proteins are sensors that can respond to changes in ER Ca²⁺ concentration with conformational change, oligomerization and relocalization to ER–plasma mem...
Article
Full-text available
Store-operated Ca2+-entry (SOCE) regulates basal and receptor-triggered Ca2+ signaling with STIM proteins sensing the endoplasmic reticulum (ER) Ca2+ content and triggering Ca2+ entry by gating Orai channels. Although crucial for immune cells, STIM1’s role in neuronal Ca2+ homeostasis is controversial. Here, we characterize a splice variant, STIM1B...
Article
Full-text available
Adjusting intracellular calcium signaling is an important feature in the regulation of immune cell function and survival. Here we show that miR-34a-5p, a small non-coding RNA that is deregulated in many common diseases, is a regulator of store-operated Ca2+ entry (SOCE) and calcineurin signaling. Upon miR-34a-5p overexpression, we observed both a d...

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