Valiollah Dabidi Roshan

University of Mazandaran | UMZ · Department of Physiology and Sport Biomechanics

Physical Inactivity caused by internet addiction (IA) in adolescents is one of the world’s most serious health issues and technology-based intervention and exercise training methods are being developed to control it. This study sought to examine the potential influences of 2- and 4-week-virtual-reality (VR) training program with/without interval No...

Background: Both coding and long non-coding RNAs (lncRNAs) have emerged as vital regulators in almost every cellular process, and their expression can be modulated by external stimuli, such as physical exercise. Objectives: The current research aimed to investigate the effects of different volumes of TABATA-high-intensity interval training (HIIT) e...

Although the use of biofeedback devices is beyond measure, they are widely applied only for clinical purposes. Therefore, this study evaluated whether biofeedback devices could be applied to estimate heart rate variability (HRV) among healthy populations. 60 individuals (46 ± 5 years; 30 women) performed maximal exercise protocol (MEP). At pre- and...

Objectives: This study aimed to investigate the responses of AT1R mRNA expression, cortisol, and cardiovascular stress to high- versus moderate-intensity training (HIT vs. MIT) among women and men. Methods: 144 participants were allocated to the exercise training groups for both sexes. Right after the HIT and MIT running were performed on a treadmi...

Tabata exercise has been proposed as an extremely time-efficient high-intensity interval training (HIIT) method to achieve health benefits, but direct comparisons between the low-volume-HIIT (LV-HIIT), moderate-volume-HIIT (MV-HIIT) with and without nano-curcumin (NaC) supplement for 8-week on cardiovascular hemodynamic, respiratory function, muscu...

This study compared the capacity of two different models of HIIT [high‐(HC) and low‐(LC) compression], with or without the use of berberine (BBR), on NOD‐like receptor pyrin domain‐containing protein‐3 (NLRP3), H19, interleukin (IL)‐1β, high‐sensitivity C‐reactive protein (hs‐CRP), and insulin resistance markers. Fifty‐four middle‐aged men with ove...

Background and Purpose: Heart failure patients with reduced left ventricular ejection fraction (HFrEF) have cardiac autonomic dysfunction that cause mortality. Poor heart rate (HR) and rate-pressure product (RPP) recovery immediately after a cardiopulmonary exercise test (CPET) is due in part to a reduction in vagal tone. There are limited studies...

Background: Being sedentary due to internet addiction is a common public health problem that causes overweight and obesity. Novel methods are needed for weight control behaviors. This study aimed to determine effects of short-term (two weeks) and moderate-term (four weeks) of virtual reality (VR) exercise program with and without interval Nordic wa...

Nanocurcumin (NaC) and high-intensity interval training (HIIT) play crucial role in weight and inflammation control. The purpose of the current study was to evaluate the separate and combined effects of 8 weeks of Tabata-HIIT and NaC supplementation on the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, long non-coding RNA...

Background: Following the SARS-CoV-2 pandemic in 2019, medical face masks were widely recommended for large numbers of people and for long periods of time. The effect of wearing surgical and N95 face masks during long-term high-intensity interval training on the cardiac autonomic system has not been reported. Methods: Eighteen healthy men were rand...

Purpose: As consequences of industrial processes, air pollution has led to increased cardiovascular diseases resulting in mortality. However, there are few pieces of evidence expressing physical fitness and gender impacts in such environments. Regarding long-term exposure to air pollution, this study aimed to determine the effect of physical fitne...

Background and purpose: Wearing face masks has become popular during the COVID-19 pandemic as a measure to prevent the spread of the virus. Some studies have pointed out the intervening role of these masks in the effect of exercise on the cardiovascular system. This study aimed at examining and comparing the effects of masking (N95 respirators and...

BACKGROUNDː Wearing a facemask affects physiological responses to exercise. We explored how exercising with a facemask affects the expression of SARS-CoV-2 entry receptor (angiotensin-converting enzyme 2, ACE2,) and some associated genes (angiotensin type-1 receptors, AT1R; Mas receptor, MasR; hypoxia inducible factor 1α, HIF-1α; endothelial nitric...

Objectives: Cardiorespiratory function is negatively affected by aging while being, to a great extent, depends on exercise intensity and mode. Here we investigated the effects of age and exercise mode on cardiorespiratory function across ages among healthy men. Equipment and methods: Thirty-six men were divided into three groups of 12: children, m...

Background: cardiac rehabilitation is a structured program to prevent secondary cardiovascular diseases. Objective: to investigate and compare the effectiveness of home-based cardiac rehabilitation program (HBCRP) on improving cardiovascular stress indices in men and women who had experienced myocardial infarction (MI). Methods: in this randomize...

Objectives: We investigated how wearing a mask - and its modality (surgical vs. N95) - affect hemodynamic and hematologic function in males and females across two exercise intensities (submaximal (SUB) and maximal (MAX)). Methods: 144 individuals participated in the present study and were randomly allocated to three mask groups of 48 (N95, SURGI...

Introduction: Air pollution is the main factor and modulation of cardiovascular diseases in urban societies. The potentially harmful effects of acute and chronic air pollution exposure have serious consequences on disease and mortality. This study amid to investigate the correlation between cardiovascular hemodynamic parameters of perimenopausal wo...

Background: Cardiorespiratory Fitness (CRF) and its associated modifiable and non-modifiable health risk factors are very important in clinical studies. Objectives: This study aimed to compare health risk factors affecting CRF between Iranian and Italian male and female exercise science students. The correlation between VO2max and these factors was...

Background: Asthma and obesity are becoming increasingly common among children. Such conditions are known to negatively affect both cardiac autonomic function and oxidative stress. We therefore investigated the heart rate variability (HRV) and oxidative (malondialdehyde, MDA) response to exercise within a high humidity environment (~65%) in obese...

Abstract Background: The risk of cardiovascular diseases increases in relation with age and physical inactivity. However, there is limited data about the importance of each factor. Thus, the present study has examined the association of physical activity level (PA) and age with chest pain signs and blood pressures in patients with heart failure. Ma...

Introduction: Pedometer feedback home-based cardiac rehabilitation (PFHCR) programs have been effective in augmenting exercise tolerance. Our aim was to investigate the effects of PFHCR on cardiovascular functional capacity in patients with myocardial infarction (MI).Methods: Forty MI patients were divided into two intervention and two control grou...

Background and aim: Indices of lifestyle (ie, physical health, exercise-fitness, nutrition, prevention of diseases, mental health, spiritual health, social health, avoid of drugs and narcotics, prevention of events and environmental health), blood pressure and cardiorespiratory fitness associated with coronary artery disease. However, there is limi...

Abstract Background and purpose: One of the main issues in cancer treatment is to reduce the side effects of drugs on healthy tissues. The aim of this study was to investigate the preventative effects of continuous aerobic exercise on apoptosis ratio and liver fibrosis induced by doxorubicin in aging rats. Materials and methods: In this experimenta...

Background: In the last decade, cancer incidence increases progressively with age and older patients cannot participate in treatment programs due to the special physical condition and side effects of anti-tumor drugs. Therefore, the aim of this study was to examine the effect of six-week voluntary wheel running exercise on doxorubicin (DOX)-induced...

Introduction: Myocardial infarction (MI) is a leading cause of morbidity and mortality. Taurine, an essential amino acid, plays a critical role in cardiovascular function. The present study was accomplished to investigate the beneficial role of taurine on atherogenesis and atherothrombosis indexes in patients with MI. Materials & Methods: In this...

Background: Cardiovascular diseases are the leading cause of human mortality worldwide. Myocardial ischemia is a type of cardiovascular disease that increases with age spread. Therefore, the purpose of this study was to compare non-invasive myocardial ischemia in patients with heart problems in different age groups. Methods: This study is a causal-...

Introduction: Angina pectoris is the usual clinical manifestation of transient myocardial ischemia, which, in turn, is a condition of myocardial suffering occurring when coronary blood flow is insufficient to meet oxygen requirements by myocardial cells necessary to carry out their contractile function. It is suggested that physical activity is mos...

The aims of the current study were to investigate the oxidant and antioxidant status of liver tissue challenged by Doxorubicin and to examine the possible protective effects of aerobic exercise on Doxorubicin-induced oxidative stress. Seventy-two rats were divided into three age groups (Young, Adult, and Elderly) with three treatment subgroups cons...

Background and purpose: Maximum Oxygen Consumption (Vo2max) is a measurement for assessing cardiorespiratory fitness. Its direct measurement is an aggressive method that is technically and operationally difficult. This study investigated the correlation between this variable and the variables obtained from non-invasive methods of evaluation of body...

Background: Different training methods have been presented to reduce the side effects of doxorubicin and it seems that according to patient’s condition, the time to start exercises, and the duration and stress of exercise should be considered. This study aimed to investigate the preventive effect of voluntary exercise on liver apoptosis induced by...

Background: Waterpipe (WP) smoking has been linked to reduced birth weight, genetic damage, and respiratory and cardiovascular disease, possibly via enhanced exposure to carbon monoxide and volatile aldehydes. Objective: The effect of long-term WP smoking on cardiac autonomic function at rest and following exercise was investigated. Methods: Twenty...

Background: Cardiovascular diseases are the leading cause of human mortality worldwide. Myocardial ischemia is a type of cardiovascular disease that increases with age spread. Therefore, the purpose of this study was to compare non-invasive myocardial ischemia in patients with heart problems in different age groups. Methods: This study is a causal-...

We tested the hypothesis that aerobic exercise training (AET) would modulate doxorubicin-induced cardiotoxicity in rats of various ages. Wistar male rats (n = 72) were assigned to three groups (young, adult, and elderly) with 3 subgroups for each age: doxorubicin (DG, n = 8), AET+ doxorubicin (AETDG, n = 8), AET + Saline (AETSG, n = 8). Following t...

Objective(s): Oxidative stress and apoptosis are the major side effects of doxorubicin (DOX) and the advantages accruing fromexercise and some medicinal herbs in mitigation of these toxic side effects is well documented. But so far, the effects of exercise in combination with medicinal nanoparticles on oxidative stress and apoptosis signaling simul...

Background: The purpose of this study was to examine the anti-atherogenic and anti-inflammatory effect of supplemental taurine prior to and following incremental exercise in patients with heart failure (HF). Methods: Patients with HF and left ventricle ejection fraction less than 50%, and placed in functional class II or III according to the New...

Objectives: The purpose of this study was to examine the anti-atherogenic and anti-inflammatory effect of taurine prior to and following incremental exercise in patients with heart failure (HF). Methods: Patients with HF and left ventricle ejection fraction less than 50%, and placed in functional class II or III according to New York Heart Associat...

Background: Doxorubicin (DOX) is a commonly used chemotherapeutic agent that causes hepatotoxicity via depletion of anti-oxidants and activation of apoptosis. Present study was aimed to investigate the Interactive effects of two forced treadmill running and voluntary wheel running exercise training method and Nanocurcumin supplement on hepatic dama...

Introduction: The aim of this study was to investigate the pretreatment effects of time courses of training and Different doses of medication in multiple organs (liver and heart) of rats treated with doxorubicin. Materials and Methods: Seventy-two Wistar male rats were randomly assigned to control and training groups with three subgroups: DOX10mg/...

Background: Taurine is an abundant amino acid found in very high concentrations in the heart and it is assumed that the taurine contributes in several physiological functions in mammalian cells such as osmoregulation, anti-inflammation, membrane stabilization, ion transport modulation, and regulation of oxidative stress and mitochondrial protein sy...

Background and Objective: Doxorubicin (DOX) is an effective anticancer drug. It has been shown that a short-term exercise performed prior to DOX-treatment has no effect on cardiotoxicity in young rats. In the present study, old and young rats were evaluated to determine the protective effects of pre-treatment with short-term exercise on DOX-induced...

Abstract Background & Aims: Previous studies have confirmed the sidelong effects of Doxorubicin (DOX) on healthy tissues, but pretreatment effect of regular Aerobic exercise in restrain of hepatotoxicity induced by various dosages of doxorubicin is not clear. The aim of this study was to determine the pretreatment effect of six weeks aerobic exerci...

Background and Aim: The aim of this study was to evaluate the effects of active recoveries in and out of the water with and without creatine monohydrate consumption on some inflammatory markers and physical performance after six bouts of maximum intermittent swimming in young women. Materials and Methods: Sixteen healthy non-elite swimmers in a sem...

Background: Breast neoplasms has known as the most common cancer among the women worldwide, and relationship between obesity, metabolic syndrome, inflammation and cancer has been recognized since many years ago. Objectives: The aim of this study was to determine the individual and concomitant effect of 6-weeks water-based exercise and oral ginge...

Purpose: The aim of study was to determine the relationship between time-span of heart rate recovery (HRR) and selected body composition factors following two type of exercise among male with different ages. Methods: Thirty-six healthy male were assigned to three groups: children, adult and elderly and performed a continuous incremental exercise on...

Aim. Asthmatic obese children experience changes in functional capacity and autonomic control. Previous heart rate variability (HRV) studies were based on 24-hour recordings, little research has been conducted on the shortterm HRV in asthmatic obese children, primarily during physical effort indifferent environmental humidity conditions. The aim of...

This study examined the effect of various modes of exercise on parasympathetic reactivation in children. Twelve healthy boys volunteered for this study. Time domain measurement of heart rate variability in 5 and 10 min and heart rate recovery (HRR) in 1 (HRR1) and 2 min (HRR2) were measured during recovery after incremental exercise tests by a 12-l...

The aim of this study was to compare the behavior of heart rate variability at rest, midtest, immediately, 5 and 10 min of recovery following the exhaustive arm crank and cycle ergometer protocols in healthy children, middle--aged and elderly subjects. Thirty--six healthy men volunteered to participate in this study and were assigned to three group...

Purpose This investigation was carried out to study the relationship between resting heart rate variability (HRV) and heart rate recovery (HRR) after upper body exercise test (arm cranking) in some healthy men with different ages. Methods Thirty-six healthy men (children n = 12, adult n = 12, elderly n = 12) performed an incremental upper body exer...

Aim: Asthmatic obese children experience changes in functional capacity and autonomic control. Previous HRV studies were based on 24-hour recordings, little research has been conducted on the short-term heart rate variability (HRV) in asthmatic obese children, primarily during physical effort indifferent environmental humidity conditions. The aim...

Background: We have investigated the effect of 8 weeks aerobic training (AT) and Ferula gummosis supplement (FG) on apelin and apelin receptor (APJ), nitric oxide (NO) and angiotensin converting enzyme (ACE) of hypertensive rats. Materials and Methods: In a experimental study, 50 adult male wistar rats were classified into five groups; 1- AT, 2- F...

Purpose: The ability of the human organism to recover its autonomic balance soon after physical exercise cessation has an important impact on the individual's health status. Heart rate variability widely used as a non-invasive technique at rest, during and after exercise for the assessment of the autonomic nervous system activity on the heart a...

Aims: To examine the pretreatment effects of regular aerobic training on the IGF system (IGF-I, IGFBP-3 and IGF/IGFBP) and doxorubicin(DOX) induced hepatotoxicity in rats. Materials and methods: Forty-eight male rats were divided into groups:(1) control+placebo (2)control+DOX10 mg.kg-1 (3)control+DOX20 mg.kg-1 (4) training+placebo (5) training+D...

Objective: Elevated amino acid homocysteine (Hcy) levels and insufficient physical activity are the risk factors in Alzheimer disease (AD) development. The effect of intermittent aerobic training on memory retention test and Thiobarbituric Acid Reactive Substances (TBARS) and superoxide dismutase (SOD) levels in the dorsal hippocampus of rats which...

We evaluated the effect of Creatine (Cr) supplementation on muscle fatigue and physiological indices after intermittent swimming bouts in trained swimmers. Sixteen healthy non-elite swimmers (19±4 years, 75±12 kg) were randomly assigned into two groups of either Cr supplementation or placebo and performed six repeated sprints swimming bouts of 50-m...

Background: Breast cancer is one of the most frequent diseases in women today. Little information exists on modifiable lifestyle factors including effects of ginger supplements (as an anti-oxidant and anti-inflammatory herbal) and water-based exercise on biomarkers related to oxidative stress such as malondialdehyde (MDA), nitric oxide (NO) and gl...

Background: Doxorubicin is an anthracycline antibiotic commonly used to treat a variety of cancers as a most effective antitumor. However, its clinical use is associated with the toxic effects in numerous healthy tissues. Here we investigated the pretreatment effect of regular aerobic exercise on oxidative stress in rats acutely exposed to DOX-ind...

After intraperitoneal injection of 20 mg/kg lead acetate, rats received 8 weeks of treadmill exercise (15-22 m/min, 25-64 minutes) and/or treadmill exercise at 1.6 km/h until exhaustion. The markers related to neurotoxicity were measured by enzyme-linked immunosorbent assay method. 8 weeks of treadmill exercise significantly increased brain-derived...

Lead is a highly neurotoxic agent that particularly affects the developing central nervous system. In the current study we investigated the neuroprotective effects of exercise training and/or diferuloyl methane (DM) supplement, which is known as curcumin, on lead acetate-induced neurotoxicity in the rat hippocampus. Sixty rats were randomly divided...

The purpose of this study was to determine the effects of endurance and/ or weight training in normal and/ or moderate heat environments on heat shock protein (HSP72) response in active young females. Forty-five healthy active female (21±3 year, 61.4±10.2 kg, VO2max 37.2±5.3 mL/kg/min) were randomLy assigned into five groups; endurance training+nor...

Abstract We have investigated responses of hippocampus Brain Derived Neurotherophic Factor (BDNF) and oxidative biomarkers such as; Total Antioxidant Capacity (TAC) and Malondialdehyde (MDA) to acute treadmill exercise and it’s adaptations to chronic exercise in rats exposed to lead acetate. Forty rats were randomly divided into 5 groups: (1) lead...

Abstract Context: For many years it has been known that lead is life-threatening, not only as an air pollutant but also because of it has been associated with several conditions including neurodegenerative disease. Curcumin (the principal curcuminoid found in turmeric) has demonstrated potent antioxidant properties. Objective: We investigated neuro...

Abstract Introduction: In recent years, by understanding the free radical mechanism of Adriamycin(ADR)-induced cardiac stress, it has become possible to develop effective strategies to prevent or modify expected damage. Several strategies for detecting and preventing cardiac stress have been developed, including physical activity or limiting cumula...

Aim. Exercise increases oxygen free radicals that cause oxidative stress. Metallothioneins (MTs) are increased in states of oxidative stress and ameliorate the damaging effects of free radicals. Methods. We measured MT levels and oxidative markers in heart tissue of rats exposed to acute training (2 days) or chronic (8 weeks) aerobic training. Thir...

Objective: The purpose of this study was to determine pretreatment effects of moderate-term endurance training before the various dosages (10 and 20 mg.kg(-1)) of DOX on a heat shock protein (HSP70 kda) and cardiotoxicity in heart tissue. Methods: Forty-eight male rats were randomly assigned to nontraining (NT) and training (T) groups and three...

This study evaluates the effect of treadmill exercise and Ferula gummosa (FG) on heat shock protein (HSP72), biomarkers related to vascular function, and oxidant/antioxidant system in the heart tissue of spontaneously hypertensive rats treated with N(ω)-nitro-l-arginine-methyl ester (l-NAME). Fifty adult male Wistar rats are randomly classified int...

Background and objective: Cardiotoxicity and oxidative stress is a life-threatening side effect of doxorubicin (DOX). We investigate the effects of short-term exercise as therapeutic tool for improvement of cardioprotection against DOX-induced cardiotoxicity in the rat. Methods: Wistar males (weighing 257 ± 28 g) were divided into six groups: (1...

The effect of aerobic training and Ferula gummosa supplementation (90 mg/kg) on apelinergic system and markers of cardiac stress in hypertensive rats were studied. Chronically administered l-NAME resulted in an increased level of angiotensin-converting enzyme (ACE), malondialdehyde (MDA), and high-sensitive C-reactive protein (hs-CRP), and also red...

Background and Objective: Studies show that the moderate intensity exercise reduces the oxidative stress and increases the neurotrophin levels in brain, but less attention was given to the examination of exercise-induced neuroprotection after administration of lead acetate. The purpose of this study was to investigate the effects of 8 week enduranc...

Effects of exercise training and curcumin supplementation, alone or combined on cardioprotective markers in left ventricle were investigated in rats during chronic exposure to lead acetate. Forty (40) male rats were randomly assigned to; sham (Sh), training + lead (TL), curcumin + lead (CL), training + curcumin + lead (TCL), and lead (L) groups. He...

Doxorubicin (DOX) is an anthracycline antibiotic that is widely used as an anticancer agent. However, the clinical use of DOX is limited due to its cardiotoxic side effects. Few studies have assessed pretreatment effects of chronically exercise against doxorubicin-induced cardiotoxicity. The aim of this study was to determine cardioprotective effec...

The effects of exercise training on heart have been widely explored. However, less understood are the effects of dehydration and rehydration on electrocardiographic (ECG) and echocardiographic (Echo) parameters in wrestlers. The aim of this study was to determine the effect of dehydration and rehydration on some ECG and Echo parameters. Fourteen he...

Responses of the left ventricle oxidant/antioxidant markers such as glutathione peroxidase (GPx), superoxide dismutase (SOD), malondialdehyde (MDA) and protein carbonyls (PCs) induced by lifestyle modification, including turmeric supplementation and exercise training, were investigated in rats during chronic exposure to lead acetate. Forty male rat...

Objective: Many studies evaluated the efficacy of exercise on some depression indices, but the effect of physical exercise in exhilarating milieu on urine 3-Methoxy-4-Hydroxyphenylglycol (MHPG) sulfate-the main metabolite of norepinephrine is not clear. The purpose of this research was to study the effect of a six-week intermittent walking in the w...

We have investigated the cardioprotective effects of exercise training and/or curcumin on lead acetate-induced myocardial damage. Forty rats were randomly divided into 5 groups: (1) lead acetate, (2) curcumin, (3) endurance training, (4) training + curcumin, (5) sham groups. The rats in groups 3 and 4 experienced the treadmill running of 15 to 22 m...

Taurine (2-aminoethanesulfonic acid) is a semi-essential amino acid found in mammalian tissues that is not involved in protein synthesis. The function of taurine is not completely understood. Some studies have demonstrated that taurine supplementation reduces death rate in rabbits with heart failure (HF) and diminishes HF severity in human models o...

The present study aims to evaluate Cardioprotection effects of exercise training and curcumin on myocardial damage induced by lead acetate. Forty-eight rats were randomly divided into six groups of the base, sham, lead, exercise, curcumin and exercise+curcumin (EC). The rats in the exercise and (EC) groups performed the progressive treadmill runnin...

The neuroprotective effects of prolonged exercise training on levels of lead acetate-induced brain-derived neurotrophic factor (BDNF) were investigated. Forty rats were randomly divided into 4 groups: (1) basic, (2) sham, (3) lead acetate + training and (4) lead acetate groups. The rats of groups 3 and 4 experienced treadmill running of 15 to 22 m/...