Valia Rodriguez

• MD, PhD
• Aston University

Physical and cognitive decline at an older age is preceded by changes that accumulate over time until they become clinically evident difficulties. These changes, frequently overlooked by patients and health professionals, may respond better than fully established conditions to strategies designed to prevent disabilities and dependence in later life...

Objective: To assess and compare the functional state of the autonomic nervous system in healthy individuals with patients in coma using measures of heart rate variability (HRV), and to evaluate its efficiency in predicting mortality. Methods: Time, informational, and frequency domain HRV indices were calculated from 7 minutes of free of artefacts...

Nonconvulsive epileptic seizures (NCSz) and nonconvulsive status epilepticus (NCSE) are two neurological entities associated with increment in morbidity and mortality in critically ill patients. In a previous work, we introduced a method which accurately detected NCSz in EEG data (referred here as 'Batch method'). However, this approach was less ef...

When the above article was published online and in print, the section ‘Very high-frequency oscillations of patients in coma’ on page 511 contained errors. The corrected portion of that section is listed below: The frequency of the appearance of peaks in the VHF range, considered from 0.4 to 1.0 Hz, was reported by other authors in 9 recordings of 6...

Nonconvulsive status epilepticus (NCSE) is a condition where the patient is exposed to abnormally prolonged nonconvulsive epileptic seizures (NCES)(epileptic seizures without evident physical symptoms). Hence, the diagnosis can only be stated by means of EEG monitoring. NCSE and NCES are associated with severe irreversible brain damage and poor out...

Primary objective: The objective of this study is to assess the functional state of the autonomic nervous system in healthy individuals and in individuals in coma using measures of heart rate variability (HRV) and to evaluate its efficiency in predicting mortality. Design and methods: Retrospective group comparison study of patients in coma clas...

Objective: To assess and compare the functional state of the autonomic nervous system in healthy individuals with patients in coma using measures of heart rate variability (HRV), and to evaluate its efficiency in predicting mortality. Methods: Time, informational, and frequency domain HRV indices were calculated from 7 minutes of free of artefacts...

Objective: To assess and compare the functional state of the autonomic nervous system in healthy individuals with patients in coma using measures of heart rate variability (HRV), and to evaluate its efficiency in predicting mortality. Methods: Time, informational, and frequency domain HRV indices were calculated from 7 minutes of free of artefacts...

The paper assesses the functional state of the autonomic nervous system in healthy individuals and with patients in coma using measures of heart rate variability (HRV), in predicting mortality. Stepwise multiple regression logistic analysis (SMRLA), followed by ROC curve analysis were applied to evaluate predictions. HRV reduction with a progressiv...

Summary of the calculations related with the adjustment procedure used in this study to cope with the effect of different confounding factors. Abbreviations of HRV indices are the same described in Material and Methods; F(m,n), F-Statistic for m,n respective degrees of freedom; P, associated probability to the corresponding F-Statistic values; K, V...

Introduction In this study we explore the reorganization of brain functional connectivity in patients with refractory mesial temporal lobe epilepsy that underwent surgery. We carried out a resting-state EEG functional connectivity analysis in a baseline period before and two years after the surgical intervention. Methods Changes in synchronization...

Nonconvulsive status epilepticus is a condition where the patient is exposed to abnormally prolonged epileptic seizures without evident physical symptoms. Since these continuous seizures may cause permanent brain damage, it constitutes a medical emergency. This paper proposes a method to detect nonconvulsive seizures for a further nonconvulsive sta...

Objective To present a monitor developed to solve continuous EEG monitoring in Cuban ICUs. Material and methods We review the state of the art and needs of the technology. Results Our monitor was developed on windows platform using the commercial 32 channel digital electroencephalographer Medicid-V – Neuronic SA. The monitor incorporates all requ...

Presented during poster session at the annual meeting of OHBM, Switzerland. https://ww5.aievolution.com/hbm1601/index.cfm?do=abs.viewAbs&abs=4463

The ictal-interictal continuum (IIC) is characterized by periodic and/or rhythmic EEG patterns that occur with relative high frequency in critically ill patients. Several studies have reported that some patterns seen within the continuum are independently associated with poor outcome. However there is no consensus regarding when to treat them or ho...

Abstract submitted for presentation at the 2016 ACNS meeting.

Abstract to be presented at the 2016 meeting of ACNS

Aminoglycosides are efficient antimicrobials commonly used in clinical practice. Their effects on the cells of the organ of Corti and the spiral ganglion neurons have been extensively studied. However, there are only a few reports concerning aminoglycoside-induced morphological changes on the stria vascularis. The purpose of this study was to descr...

In this study, we explored the neural correlates of perceptual awareness during a masked face detection task. To assess awareness more precisely than in previous studies, participants employed a 4-point scale to rate subjective visibility. An event-related fMRI and a high-density ERP study were carried out. Imaging data showed that conscious face d...

The purpose of this study is to better characterize the hematological, biochemical, respiratory, cardiovascular and electroneurophysiological parameters in young adult Cercopithecus aethiops sabaeus of both sexes. The rhesus and cynomolgus monkeys are widely used as experimental primate models. However, only few articles have been published testing...

Amyotrophic lateral sclerosis (ALS) is a disease of the central nervous system characterized by loss of spinal motor neurons, for which no effective treatment exists. Epidermal growth factor (EGF) and growth hormone releasing peptide-6 (GHRP-6) have been considered as good candidates for the treatment of this disease, due to their well documented e...

Scenes are so rich in information that the visual system cannot process all inputs simultaneously. Visual attention is the process that allows us to select the information that is relevant to our current behavior from the multiple inputs available at any given moment. Previous chapters have focused on the role of spatial and feature-based attention...

Two objects are presented simultaneously, defined by shape and color, which suffer some mutations in certain local features, to measure the attentional blink’s (AB) effect, which is evident in case of different-object transitions. Results proof that the attentional transitions established between two features of a single object are easier than t...

Many fMRI experiments have examined the neural substrate of conscious visual perception. Though activity in both ventral stream and frontoparietal areas is linked to consciousness, there is still no consensus on their different roles. In this study we explored the neural correlates of perceptual awareness during a masked-face detection task. Improv...

Neural correlates of face processing have been largely studied, but more emphasis has been done in the identification of a particular face. Here we study the neural correlates of the N170 peak corresponding to the correct and incorrect detection of faces through the use of the Bayesian Model Averaging procedure. Moreover, different components of el...

Deafness is one of the most widespread disabilities in the world. Its most frequent cause is death of cochlear hair cells (located in the organ of Corti), which induces degeneration of spiral ganglion neurons and their peripheral processes innervating the organ of Corti. In a previous light microscopy study using a rat model of ototoxicity, a loss...

Nimotuzumab (h-R3) is a humanized anti-epidermal growth factor receptor monoclonal antibody (mAb) registered for treating head and neck tumours. The present study was designed to evaluate the systemic and skin toxicity of chronic intravenous administration of the h-R3 in a relevant species demonstrated by comparing the h-R3 binding affinity constan...

In the visual system, early atomized representations are grouped into higher-level entities through processes of perceptual organization. Here we present neurophysiological evidence that a representation of a simple object, a surface defined by color and motion, can be the unit of attentional selection at an early stage of visual processing. Monkey...

La sordera es una de las discapacidades más comunes mundialmente, con una incidencia en Cuba de 2,1 por cada 1 000 habitantes. La mayoría de las sorderas son de origen sensorineural, debido a la muerte de las células ciliadas cocleares, localizadas en el órgano de Corti, lo que conduce a la degeneración de las neuronas del ganglio espiral. En un tr...

No existe un consenso en la descripción de la distribución topográfica de la respuesta cortical P40 del potencial evocado somatosensorial por la estimulación del nervio tibial. Se han reportado diferencias de distribución con máxima respuesta en línea media. Otros autores, sin embargo, la refieren en la región centro-parietal ipsilateral al estímul...

During transparent motion, attention to changes in the direction of one illusory surface will impede recognition of a similar event affecting the other surface if both are close together in time. This is a form of object-based attentional blink (AB). Here, we show that this AB is related to a smaller N200 response to the change in direction and tha...

Resumen Introducci ón : En este trabajo se estudian las células tipo I del ganglio espiral (GE) de la cóclea. Adem ás de ser las m ás susceptibles al dañ o, constituyen el 95% de la población celular, por lo que son decisivas en la aplicación de los implantes cocleares. En un estudio previo al microscopio óptico, desde la segunda semana de sordera...

Damage induced by ototoxic therapeutic drugs is among the main causes of auditive losses in humans. The objective of this work was to explore the temporal dynamics of an ototoxic treatment with kanamycin and furosemide on the cytoarchitecture of the organ of Corti and the spiral ganglion in adult rats. Cochlear sections from deaf rats (removed at 2...

In this study, we explored the influence of an irrelevant translational event on the automatic capture of attention to one of two superimposed surfaces defined by transparent motion. The results showed that an irrelevant translation on one surface did not automatically capture the subjects' attention if the attentional resources have been endogenou...

The h-R3 is a humanized growth factor receptor monoclonal antibody (mAb) in development for the treatment of head and neck tumours in which malignant cells overexpress the Epidermal Growth Factor receptor. The present study was designed to evaluate the toxicity of repeated intravenous doses of the h-R3 mAb in a relevant species demonstrated by the...

Many studies have examined the neural mechanisms of visual attention by recording event-related potentials (ERPs). In most of these studies, objects are abruptly presented to the observer, often in a rapid succession of events. Similar stimuli are used in the psychophysical technique known as rapid serial visual presentation (RSVP). We argue that i...

Attending to objects implies the concurrent process of features that are analyzed in different visual subsystems or domains. Previous works have shown that attention cannot be simultaneously directed to the components of motion present in two transparent surfaces [M. Valdés et al., Cognition 66 (1998) B13-B23], even though they occupy overlapping r...

Information processing in the visual cortex depends on complex and context sensitive patterns of interactions between neuronal groups in many different cortical areas. Methods used to date for disentangling this functional connectivity presuppose either linearity or instantaneous interactions, assumptions that are not necessarily valid. In this pap...

A visual scene is rapidly segmented into the regions that are occupied by different objects and background. Segmentation may be initiated from the detection of boundaries, followed by the filling-in of the surfaces between these boundaries to render them visible. Alternatively, segmentation may be based on grouping of surface elements that are simi...

Although psychophysical evidence for object-based attention has been reported, corresponding studies with event-related potentials (ERPs) are scarce. Here subjects were presented with perceptual fields containing two superimposed objects (transparent surfaces generated by two sets of dots in rigid rotation around fixation, each set of a different c...

Abstract

A pesar de la comprobada ototoxicidad de los aminoglucósidos, éstos continúan empleándose frecuentemente en la clínica por su alta efectividad bactericida [1-3]. El dominio de modelos de ototoxicidad constituye un arma potente para las investigaciones que se imponen ante el desarrollo de nuevos enfoques para aliviar o resolver la sordera. El objeti...