Valery Victorovich Tuchin

Valery Victorovich Tuchin
Saratov State University · Department of Optics and Biophotonics

PhD, Dr.Sc., Professor

About

1,510
Publications
285,276
Reads
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22,176
Citations
Additional affiliations
August 2011 - present
University of Oulu
Position
  • FiDiPro Professor (Finland Distinguished Professor), 2011-2014
Description
  • Biophotonics group http://www.oulu.fi/eeng/oemlab/research%20groups/biophotonics
January 2009 - present
University of Limerick
Position
  • Professor (Associate)
January 1999 - present
Huazhong University of Science and Technology
Position
  • Professor

Publications

Publications (1,510)
Article
Full-text available
By advances in the treatments of diabetes in the last few decades, diabetic foot problems, wounds and ulcerations continue to be a major global burden for patients and the health care systems. For monitoring wound healing, it is essential to use an accurate wound measurement method, which is able to detect small changes in the wound size. The terah...
Article
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This special issue collects 20 excellent papers, spanning NIR II imaging, high-speed imaging, adaptive wavefront shaping, label-free imaging, ultrasensitive detection, polarization optics, photodynamic therapy, and preclinical applications.
Article
Commentaries on the section “Biophotonics of molecules and nanoparticles” of the 9th Congress of the Russian Photobiological Society are presented. Presentations are briefly introduced along with the main conclusions made by their authors. This section included a plenary lecture, oral presentations, and posters with interesting talks and follow-up...
Article
In this study, the optical properties of glycated (HbA1c) and non-glycated (Hb) hemoglobin are compared using Surface-enhanced Raman spectroscopy (SERS), spectrofluorimetry, and refractometry. Analysis of the spectral shift of SERS spectra showed good discrimination between two hemoglobins indicating differences in their molecular structure. The fl...
Article
Objectives The development of compact diagnostic probes and instruments with an ability to direct access to organs and tissues and integration of these instruments into surgical workflows is an important task of modern physics and medicine. The need for such tools is essential for surgical oncology, where intraoperative visualization and demarcatio...
Article
Continuously tunable middle-infrared bandpass filters have been developed based on gradient metal-hole arrays with two distinct geometries. The rotation filter relies on an array of metal holes with gradually changing periods and hole sizes in the azimuthal direction, while the translation filter exploits a metal-hole array with a linear gradient....
Article
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The estimation of the spectral absorption coefficient of biological tissues provides valuable information that can be used in diagnostic procedures. Such estimation can be made using direct calculations from invasive spectral measurements or though machine learning algorithms based on noninvasive or minimally invasive spectral measurements. Since i...
Article
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The heating degree of the inner layers of tumor tissue is an important parameter required to optimize plasmonic photothermal therapy (PPT). This study reports the optical properties of tissue layers of transplanted cholangiocarcinoma and covering tissues in rats without treatment (control group) and after PPT using gold nanorods (experimental group...
Article
Full-text available
Unique effects of terahertz (THz)-wave–matter interaction push rapid progress in THz optoelectronics aimed at bridging the problematic THz gap. However, majority of modern methods of THz spectroscopy and imaging are still hampered by low spatial resolution. Common lens/mirror-based THz optics fails to overcome the Abbe barrier and usually provides...
Article
Optical clearing of adipose tissue has not been studied enough, although it can be promising in medical applications, including surgery and cosmetology, for example, to visualize blood vessels or increase the permeability of tissues to laser beams. The main objective of this work is to develop technology for optical clearing of abdominal adipose ti...
Article
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The pancreas is a highly important organ, since it produces insulin and prevents the occurrence of diabetes. Although rare, pancreatic cancer is highly lethal, with a small life expectancy after being diagnosed. The pancreas is one of the organs less studied in the field of biophotonics. With the objective of acquiring information that can be used...
Article
Full-text available
Cancer remains one of the leading causes of death in the world. For a number of neoplasms, the efficiency of conventional chemo- and radiation therapies is insufficient because of drug resistance and marked toxicity. Plasmonic photothermal therapy (PPT) using local hyperthermia induced by gold nanoparticles (AuNPs) has recently been extensively exp...
Chapter
This chapter discusses the optical clearing (OC) of adipose tissue ex vivo and in vivo, which has not yet been described but can be useful in optical diagnostics, therapy, and surgery when the site where it is necessary to carry out light exposure is covered by adipose tissue, which is typical in the case of many important internal organs. The chap...
Article
Multimodality registration of optical and magnetic resonance (MR) images in the same tissue volume in vivo may be enabled by MR contrast agents with optical clearing (OC) effect. The goals of this study were to a) investigate the effects of clinical MR contrast agent gadobutrol (GB) and its combinations as potential OC agent assisting in fluorescen...
Article
Full-text available
The effect of low-dose photodynamic therapy on in vivo wound healing with topical application of 5-aminolevulinic acid and methylene blue was investigated using an animal model for two laser radiation doses (1 and 4 J/cm2). A second-harmonic-generation-to-auto-fluorescence aging index of the dermis (SAAID) was analyzed by two-photon microscopy. SAA...
Article
Full-text available
Adhesion of the spike protein of the SARS-CoV-2 virus is studied by vibrational spectroscopy using terahertz metamaterials. The features of metastructure absorption upon the deposition of histidine, albumin, and the receptor-binding domain of the spike protein films are investigated. An original technique for quantitative assessment of the efficien...
Article
Предложено комбинированное использование иммерсионного агента с низкоинтенсивным лазерным облучением для оптического просветления кожи перед проведением процедуры плазмонной фототермической терапии (ПФТТ). Представлены пилотные результаты исследования влияния иммерсионных агентов на оптические параметры кожи, подкожной соединительной ткани и модель...
Article
The effect of tissue optical clearing (TOC) to increase the probing depth and observe in-depth structure of the ex vivo porcine dura mater was studied by confocal Raman microspectroscopy. Raman intensities were significantly increased at the depth of 250 μm for all collagen bands after treatment with glycerol. The influence of glycerol on collagen...
Chapter
The application of optical clearing agents on skin allows the optical properties of skin to be controlled and thus the enhancement of optical probing depth. However, optical clearing agents can affect skin hydration, which is an important parameter critical for maintaining healthy skin conditions. This chapter aims to review recent progress in the...
Chapter
The potential of terahertz (THz) technology is beyond doubt, with water being a key endogenous marker of pathological processes in tissue in the THz medical diagnosis. The content and state (free or bound) of tissue water can reflect biochemical changes in normal tissues, as well as the presence and severity of pathological changes. At the same tim...
Article
Full-text available
Regretfully, because of her sudden demise, Assoc. Prof. Ekaterina Borisova is no longer amongst us. COVID-19 pulled away a brilliant scientist during the peak of her scientific career (see Fig. 1). All authors would like to express deepest condolences and sincere support to her family, friends, relatives and colleagues! We, therefore, rightfully co...
Article
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This Commentary describes a call for submissions for the upcoming Special Issue focused on the science presented at the 9th Congress of The Russian Photobiological Society entitled “Actual Problems in Photobiology.”
Article
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Solid Immersion (SI) microscopy is a modern imaging modality that overcomes the Abbe diffraction limit and offers novel applications in various branches of visible, infrared, terahertz, and millimeter-wave optics. Despite the widespread use, SI microscopy usually results in qualitative imaging. Indeed, it presents only the raw distributions (in the...
Article
This review presents principles and novelties in the field of tissue optical clearing (TOC) technology, as well as application for optical monitoring of drug delivery and effective antimicrobial phototherapy. TOC is based on altering the optical properties of tissue through the introduction of immersion optical cleaning agents (OCA), which impregna...
Article
Full-text available
Interaction of iohexol (Omnipaque), an X-Ray contrast agent, with a mimetic peptide of collagen (GPH) 3 as one of the main components of biological tissues has been studied with the use of methods of classical molecular dynamics (GROMACS). Complex molecular modeling of the post-diffusion stage of optical clearing allowed to evaluate such parameters...
Article
The influence of ischemia–reperfusion (I/R) action on pancreatic blood flow (PBF) and the development of acute pancreatitis (AP) in laboratory rats is evaluated in vivo by using the laser speckle contrast imaging (LSCI). Additionally, the optical properties in norm and under condition of AP in rats were assessed using a modified integrating sphere...
Article
Full-text available
Photodynamic inactivation of microorganisms known as antibacterial photodynamic therapy (APDT) is one of the most promising and innovative approaches for the destruction of pathogenic microorganisms. Among the photosensitizers (PSs), compounds based on cationic porphyrins/metalloporphyrins are most successfully used to inactivate microorganisms. Se...
Article
Full-text available
Significance: An increasing interest in the area of biological effects at exposure of tissues and cells to the terahertz (THz) radiation is driven by a rapid progress in THz biophotonics, observed during the past decades. Despite the attractiveness of THz technology for medical diagnosis and therapy, there is still quite limited knowledge about sa...
Article
Full-text available
Complex study of glycerol effects on the skin tissue was performed. The change in optical, weight and geometrical parameters of the rat skin under the action of the glycerol solutions was studied ex vivo. Possible mechanisms of the skin optical clearing under the action of glycerol solutions of different concentrations were discussed. The results c...
Article
Full-text available
In this paper we present three studies that demonstrate the applicability of spectroscopy methods and optical clearing treatments in pathology identification and monitoring. In the first study, by obtaining the absorption spectra of human healthy and pathological (adenocarcinoma) colorectal mucosa tissues, it was possible to identify a higher conte...
Article
Full-text available
A spatially resolved multimodal spectroscopic device was used on a two-layered “hybrid” model made of ex vivo skin and fluorescent gel to investigate the effect of skin optical clearing on the depth sensitivity of optical spectroscopy. Time kinetics of fluorescence and diffuse reflectance spectra were acquired in four experimental conditions: with...
Article
The current work is focused on the study of optical clearing of skeletal muscles under local compression. The experiments were performed on in vitro bovine skeletal muscle. The time dependence of optical clearing was studied by monitoring the luminescence intensity of NaYF 4 :Er,Yb upconverting particles located under tissue layers. This study show...
Article
Full-text available
Citation: Gonçalves, T.M.; Martins, I.S.; Silva, H.F.; Tuchin, V.V.; Oliveira, L.M. Spectral Optical Properties of Rabbit Brain Cortex between 200 and 1000 nm. Photochem 2021, 1, 190-208.
Article
Skin cancer is one of the most frequent cancers worldwide. Recently, it has been shown that the tumor proliferation rate in skin and its dynamics can be changed by an osmotic pressure. However, these findings are rather unstructured. A weak pressure can slow down the tumor growth, while a very high pressure can, on the contrary, lead to accelerated...
Article
In this paper, we describe the combination of ultraviolet (UV) spectroscopy with the optical clearing technique to induce new tissue windows, evaluate their efficiency, study the diffusion properties of agents and discriminate cancer. The use of highly concentrated glycerol solutions has induced high efficiency clearing effects in the UV, both in h...
Article
Full-text available
Terahertz (THz) technology holds strong potential for the intraoperative label-free diagnosis of brain gliomas, aimed at ensuring their gross-total resection. Nevertheless, it is still far from clinical applications due to the limited knowledge about the THz-wave–brain tissue interactions. In this work, rat glioma model 101.8 was studied ex vivo us...
Article
In this paper, we describe the study of the kinetics and efficiency of the refractive index matching mechanism created by highly concentrated glycerol solutions in human normal and pathological colorectal mucosa tissues. Considering the wavelength range between 200 and 1000 nm, higher efficiency was obtained for the pathological mucosa, which shows...
Research Proposal
Full-text available
The main goal of SFM’21 is to present and discuss recent developments and applications of optical and laser technologies in biology and medicine, precise mechanics and control of tissues and cells, coherent optics of random and ordered media, material and environmental sciences, nonlinear dynamics of laser systems, laser physics, spectroscopy and m...
Preprint
Full-text available
The knowledge of the optical properties of biological tissues in a wide spectral range is highly important for the development of noninvasive diagnostic or treatment procedures. The absorption coefficient is one of those properties, from which various information about tissue components can be retrieved. Using transmittance and reflectance spectral...
Article
Full-text available
Optical coherence tomography (OCT) has become widespread in clinical applications in which precise three-dimensional functional imaging of living organs is required. Nevertheless, the kidney is inaccessible for the high resolution OCT imaging due to a high light attenuation coefficient of skin and soft tissues that significantly limits the penetrat...
Article
Full-text available
Confocal Raman microspectroscopy (CRM) with 633- and 785-nm excitation wavelengths combined with optical clearing (OC) technique was used for ex-vivo study of porcine skin in the Raman fingerprint region. The optical clearing has been performed on the skin samples by applying a mixture of glycerol and distilled water and a mixture of glycerol, dist...
Article
Full-text available
Abstract. Modern studies of the penetration of light into biological tissues is becoming very important in various medical applications. This is an important factor for determining the optical dose in many diagnostic and therapeutic procedures. The absorption and scattering properties of the tissue under study determine how deeply the light will pe...
Article
Full-text available
ABSTRACT The light source-based medical techniques for brain imaging, diagnosis, and treatment are very common clinical tools. However, applying these techniques is limited due to the high attenuation of light in the scalp and skull. Such optical attenuation reduces the achievable spatial resolution and precludes the visualization of small features...
Article
In this study, we used machine learning techniques to reconstruct the wavelength dependence of the absorption coefficient of human normal and pathological colorectal mucosa tissues. Using only diffuse reflectance spectra from the ex vivo mucosa tissues as input to algorithms, several approaches were tried before obtaining good matching between the...
Chapter
Here, we demonstrate the therapeutic effects of transcranial photobiomodulation (tPBM, 1267 nm, 32 J/cm², a 9-day course) in mice with the injected model of Alzheimer’s disease (AD) associated with accumulation of beta-amyloid (Aβ) in the brain resulting in neurocognitive deficit vs. the control group (CG) (the neurological severity score (NNS), AD...
Chapter
The blood-brain barrier (BBB) poses a significant challenge for drug delivery to the brain. The limitations of our knowledge about the nature of BBB explain the slow progress in the therapy of brain diseases and absence of methods for drug delivery to the brain in clinical practice. Here, we show that the BBB opens for high-molecular-weight compoun...
Article
Full-text available
Current biophotonics methods cover the entire optical spectrum from the deep ultraviolet to the terahertz. To optimize such methods for diagnostic and therapeutic applications, the need to obtain the wideband dispersion of tissues is high. The pancreas is a very important organ in the human body, since it produces insulin and its malfunction may in...