Valery Ivanjvich Petukhov

Valery Ivanjvich Petukhov
Latvian Institute of Organic Synthesis | Latvian IOS

Professor

About

47
Publications
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53
Citations

Publications

Publications (47)
Article
Full-text available
The authors analyze the results of atomic emission spectrometry of hair samples for Al, Cd, Fe, Cr, Cu, Li, Pb, V, and Zn in 952 healthy subjects and 952 liquidators of the Chernobyl nuclear power plant accident. Using correlation analysis (Pearson) of the obtained data, the authors have found pair correlations between metal concentration values. A...
Article
Full-text available
We have found out in our previous studies that results of quantitative spectrometry of electrogenic metals (Ca, K, Na) in epidermal cells (hair) of healthy people and the Chernobyl liquidators (chronic oxidative/nitrosative stress) are conjugated. The nature of this «conjugation», like many intimate mechanisms of the metal-ligand homeostasis in the...
Article
Using atomic emission spectrometry and EPR analysis metal-ligand homeostasis (MLH) has been studied in epidermal cells of 954 liquidators of the Chernobyl accident and 947 healthy individuals. A possible association of the redox status with the quantitative changes in the MLH, which could be used as discriminators of oxidative/nitrosative stress, a...
Article
Full-text available
The article presents the results of the study of metal-ligand homeostasis (MLH) in the cells of the epidermis at 954 liquidators of accident at Chernobyl NPP and 947 practically healthy persons by means of atomic-emission spectrometry and EPR-analysis. Possible connection of redox status with the quantitative shifts in MLH is caused special interes...
Article
Quantitative assay of nitric oxide (NO) and iron (Fe) was carried out by the electron paramagnetic resonance (EPR) method in epidermal derivative (hair) of 45 liquidators of the Chernobyl accident, 30 employees of radiological institutions having contact with radiation, and 50 students of Vladimir State University, most of which were diagnosed with...
Article
Full-text available
The present article is an attempt to reveal the connection (Pearson) between potassium (K) and sodium (Na), K and zinc (Zn) levels on the basis of analytical determination of elemental content in human scalp hair (atomic emission spectrometry in 954 Chernobyl accident liquidators and 947 healthy persons). The negative K-Zn correlation and also the...
Article
Measurements of nitrogen oxide and copper in the blood of 57 patients with chronic viral hepatitis C was carried out before antiviral therapy by electron paramagnetic resonance on a Radiopan EPR spectrometer. The results indicate elevated levels of nitrogen oxide and copper in the blood of these patients in comparison with normal subjects. Comparis...
Article
Plasma NO-binding activity was studied in patients with various forms of hematological malignancies. The method used in the study quantitatively evaluated the plasma capacity to bind NO, which reflects the intensity of NO production and the degree of patient's stress resistance. Plasma NO-binding activity significantly decreases in patients with he...
Article
The results of serum ferritin (SF) and iron (Fe) assays in 49 pregnant women, 11 newborns and 40 healthy controls were quantitavely compared in diagnosis of iron deficiency. The SF serum levei as a laboratory criterion of iron deficiency was found to be much more informative than the Fe assay. Therefore, its application in diagnosis of iron deficie...
Article
Full-text available
Whether iron (Fe) and selenium (Se) deficiency in pregnant women of Russia and Latvia influences a demographic situation in these countries was investigated in the study of 100 pregnant women at different terms of gestation with Fe deficiency (iron deficiency anemia or latent iron deficiency). The women were examined for lipid peroxidation intensit...
Article
Twelve patients with polycythemia vera (PV) were observed and assigned to two groups: group 1 had duration of the disease up to 3 years (mean duration 2.1 years); group 2 - more than 10 years (mean duration 14.6 years). 50 healthy volunteers served control. Content of haemoglobin (Hb) was determined in blood and red blood cells (RBC). Activities of...
Article
Polymerase chain reaction (PCR) was used to study bcr-abl transcripts in 36 CML patients. 13 of them have received recombinant or natural alpla-interferon, 15 were treated with myelosan or hydroxyurea and 8 - combination of cytostatics. Rearrangement types b3a2, b2a2 and e1a2 occurred in 22, 5 and 5 out of 36 patients, respectively. Two patients di...
Article
Aim. To study the activity of antioxidant enzymes and lipid peroxidation in red blood cells of patients with depressed antioxidant system after a course of an interval normobaric hypoxia (INH). Methods. Venous blood samples from fourteen women suffering from different diseases were drawn before, in the middle, and after an INH course. Activities of...
Article
The effect of superoxide dismutase (SOD) and selenium on the blood level of ferritin and transferrin in patients with hemoblastosis was studied. Two-month treatment with SOD and selenium had no effect on the level of ferritin but reduced the concentration of malonic dialdehyde (MDA) in the native erythrocytes in patients with chronic lymphoid leuke...
Article
Concentration of malonic dialdehyde (MDA) and activity of antioxidant enzymes G-6-PD, glutation peroxidase (GP), glutation reductase, catalase, superoxide dismutase were measured in red cells of patients with polycythemia vera. Plasmic ions Fe3+ were estimated by means of electron-paramagnetic resonance. MDA concentration and antioxidant enzymes (e...
Article
Concentration of malonic dialdehyde (MDA) and activity of antioxidant enzymes G-6-PD, glutation peroxidase (GP), glutation reductase, catalase, superoxide dismutase were measured in red cells of patients with polycythemia vera. Plasmic ions Fe3+ were estimated by means of electron-paramagnetic resonance. MDA concentration and antioxidant enzymes (e...
Article
Blood and erythrocytes of 50 healthy volunteers and 105 patients with different forms of hemoblastoses were investigated. 54 patients had acute phase, 51 patients--remission stage of disease. Essential differences in the activity of antioxidant enzymes (SOD, CAT, GSH-Px) were detected and compared with content of MDA and degree of anaemia. Acute ph...
Article
The authors present results of chronic myeloid leukemia (CML) treatment with recombinant and leukocytic interferon in monotherapy and in combination with myelosan. The best responses (72% of complete hematological remissions) were obtained in patients pretreated with myelosan (one course of 1-1.5 months) in combination with natural antioxidants.
Article
A trial has been conducted of recombinant alpha 2-interferon (reaferon) used in 32 patients with Ph'[correction of Rh']-positive chronic myeloid leukemia (CML). A chronic stage was in 3, transient in 3 and blast in 1 patients. 25 CML patients were newly diagnosed. The treatment lasted from 2 months to 3 years. Clinicohematological remission was con...
Article
The prognostic significance of the clinicohematological and kinetic characteristics was analyzed in patients suffering from chronic myeloleukemia with the aid of computerized methods of linear and nonlinear regression (Cox's model). New predictors not previously used in patients with chronic myeloleukemia are offered: the ratio of variation of the...
Article
The effects of a synthetic prostaglandin E1 (PGE1) analog on colony-forming activity in agar cultures of peripheral blood and bone marrow was studied in 28 patients with chronic myeloid leukemia and 9 hematologically healthy subjects. Addition of PGE1 to normal bone marrow culture was followed by a significant drop in the number of colonies per dis...
Article
The authors report the results of the clinical, cytochemical, cytogenetic and kinetic studies (3H-thymidine autoradiography and scanning integrating cytospectrophotometry of DNA) in a male patient with chronic myeloleukemia with blast infiltration of the lymph nodes. Analysis of the karyotype and kinetic aspects of leukemic cells obtained from the...

Projects

Project (1)
Project
Our previous studies have found that results of quantitative spectrometry of electrogenic metals (Ca, K, Na) in epidermal cells (hair) from healthy individuals and the liquidators of the Chernobyl accident (chronic oxidative / nitrosative stress) are conjugated. The nature of this «conjugation», like many intimate mechanisms of the metal-ligand homeostasis in the epidermis, remains unsolved. However transmembrane traffic electrogenic metals (and especially the ion Na+) are directly related to cell bioenergetics. Therefore intracellular bioenergetics processes in the membrane and in the mitochondrial respiratory chain, can determine homeostasis electrogenic metals. It has been shown that in the cell, which is an open dynamic system, there are signs of self-organized criticality (SC). This allows classifying electrogenic metal homeostasis among the SC-phenomena.