Valeriy Novochadov

• Doctor of Medicine
• Volgograd State University

Introduction. Very few works have studied the spatial distribution of proteoglycans of the articular cartilage of femoral condyles (FCs) and the tibial plateau (TP) in normal and experimental osteoarthritis (OA). The aim of the paper was to analyze the spatial distribution of lubricin and aggrecan in the articular cartilage of FCs and the TP in nor...

Osteoarthritis is a common degenerative joint disease. The use of clustering algorithms in studies of both articular cartilage and other tissues can increase the accuracy and objectivity of experimental results. Therefore, the aim of this work was to conduct a pilot study on the use of cluster analysis to identify tissue structures of articular car...

Proteins synthesized by cells of various tissues may have common functions, but at the same time have a heterologous structure. Previously, it was experimentally confirmed that lung suffractant proteins can be synthesized by chondrocytes of articular cartilage. Articular cartilage proteoglycans, such as lubricin (PRG4) and aggrecan (ACAN), have par...

The presence of large areas of anthropogenic transformation of plant communities with a potentially negative impact on adjacent territories makes it relevant to develop various methods for automated monitoring and modeling of processes occurring in these ecosystems. Based on the results of previous studies of phytocoenoses, the authors selected fou...

The paper is devoted to simulation modelling of the arid plant communities (APC) behaviour. Such systems belong to the class of agroecological systems and include a large number of interacting natural factors that contribute to the system’s degradation. We propose a model of APC behaviour based on a weighted oriented graph. The values of weights an...

In this study, biocompatibility of plasma-sprayed 3D CP Ti-coated wire implants has been evaluated. Plasma-sprayed 3D CP Ti coatings have a porous structure consisting of ridges and cavities whose height is equal to that of the thickness of the coating. The porosity of plasma-sprayed 3D CP Ti coatings was found to be higher in cavities and it made...

Acta Materialia

The review analyzes cellular and molecular aspects of the participation of intestinal microflora and related features of luminal metabolism in the occurrence and subsequent development of colon tumors, primarily colorectal cancer. The article describes the problems of increasing frequency of this disease in recent years, the participation of geneti...

We evaluated the efficiency of a lubricant based on a pulmonary surfactant in experimental knee osteoarthritis in rats induced by intraarticular injection of abrasive material that reduces the lubricative properties of the synovial fluid. Experimental substance containing proteins of the pulmonary surfactant exhibiting natural lubricative propertie...

The study is devoted to the study of the effectiveness of a lubricant based on a pulmonary surfactant in experimental osteoarthritis of the knee joint in rats. Experimental osteoarthritis was caused by intraarticular injection of abrasive material that reduces the lubricative properties of synovial fluid. As a lubricant, an experimental substance c...

The algorithm of the virtual database screening for the detection of proteins with the practical significance for the pharmaceutical and biotechnological industries has been developed. The Pythom programming language v. 3.6.5 in Notepad++ framework was used to develop the algorithm. The UniProt database served as a source of the information about t...

The use of modern bioinformatic approaches for the solution of environmentally oriented tasks provides new data that can be used for spot control anthropogenic ecosystems and ecosystem rebuilding of their violation obtained from adverse factors of natural and antropogenical genesis. This work aims at demonstrating and identifying metal binding prot...

The use of modern bioinformatic approaches for the solution of environmentally oriented tasks provides new data that can be used for spot control anthropogenic ecosystems and ecosystem rebuilding of their violation obtained from adverse factors of natural and antropogenical genesis. This work aims at demonstrating and identifying nickel and cobalt...

The paper demonstrates relationship between morphological characteristics of articular cartilage and its functional properties in osteoarthritis. An automated analysis of the sections of the rat articular cartilage has revealed these mutual dependences. An algorithm for assessing the functional properties of cartilage by certain characteristics of...

The study presents the results of defining some physico-chemical properties (viscosity and sliding friction coefficient) and four biochemical indices of oral fluid in 146 patients after installation of fixed dentures relying on intraosseous implants. On the basis of clinical examination, the prosthetic patients were divided in two clinical groups w...

The use of modern eco-oriented approaches in agriculture ensures not only the conservation of natural resources and the restoration of damaged ecosystems, but also the growth of agrocenoses productivity, increasing the tolerance of artificial ecosystems to unfavorable factors of natural and anthropic origin. The identification of consortia relation...

A software for processing sets of full-color images of biological tissue histological sections is developed. We used histological sections obtained by the method of high-precision layer-by-layer grinding of frozen biological tissues. The software allows restoring the image of the tissue for an arbitrary cross-section of the tissue sample. Thus, our...

A software for processing sets of full-color images of biological tissue histological sections is developed. We used histological sections obtained by the method of high-precision layer-by-layer grinding of frozen biological tissues. The software allows restoring the image of the tissue for an arbitrary cross-section of the tissue sample. Thus, our...

In the article features of phytosanitary situation in the agrarian sector of industry in the South of Russia are considered. The mechanisms and degree of influence of economic and environmental factors on the state of farmland, their infection with insect pests are revealed. The structure and dynamics of entomo-communities in arid agrocenoses of th...

The objective of the study was to investigate the genetic basis of general non-specific reactivity of an organism. Systematic search in PubMedCentral, PDB, KEGG and SNP databases identified a set of genes and their polymorphisms that can determine pain sensitivity and therefore the level of general non-specific reactivity of the human organism. Six...

The objective of the study was to investigate the genetic basis of general non-specific reactivity of an organism. Systematic search in PubMedCentral, PDB, KEGG and SNP databases identified a set of genes and their polymorphisms that can determine pain sensitivity and therefore the level of general non-specific reactivity of the human organism. Six...

The article describes a production method of substance containing great amount of phospolipids (up to 36 %) and surfactant proteins (up to 2 %) in terms of lyophilisate composition. Basic physical and chemical characteristics of the substance (density, viscosity, surface tension and the coefficient of sliding friction) indicate a high lubricant cap...

Four types of three-dimensional plasma capillary-porous titanium coatings for model intraosseous implants are developed. By means of pulsed microplasma oxidation in solutions or plasma spraying of powders, additional bioactive coatings on the basis of calcium phosphates are deposited on the Ti coating surface. Shear strength values of the interface...

Experiments were carried out on 22 albino male Wistar rats to study the morphological peculiarities of osseointegration of titanium grafts with bioactive surface stimulated additionally with bone plastic material "Gamalant-paste-FORTE Plus" containing recombinant human bone morphogenetic protein-2 (rhBMP-2). In 9 rats the implants were placed into...

Four types of the three-dimensional plasma capillary-porous titanium coatings for model intraosseous implants were developed. By means of pulsed microplasma oxidation in solutions or plasma spraying of powders, the additional bioactive coatings on the base of calcium phosphates have been deposited on the Ti coating surface. Shear strength values of...

The article has a goal to demonstrate capabilities of layer-by-layer overlapping method for 3D-reconstruction of knee joint. The model object was chosen for this research to provide the base for new methods in diagnostics and treatment of human orthopedic diseases. We used the original technology of high-precision grinding and compared the ability...

We compared cellular and tissue reactions of the lungs in Wistar rats after inhalation of LPS from E. coli 0128: B12 in the form of ultradispersion in water-salt phase and lipid phase. The estimated dose of the toxin was 200 mg/kg in both series. The content of LPS and TNF-α in lung homogenates, bronchoalveolar fluid, and blood serum was determined...

As a result of a bioinformatic search using resources of NCBI PubMed Central, PDB, KEGG, and SNP authors have developed a database of genes associated with phenotypic manifestations of general non-specific reactivity level (GNRL). Out of 164 genes primarily relevant by search criteria for a detailed analysis there are selected 23 genes, divided int...

Why Scientific Papers are Read and Used [Editor’s Foreword]

To study the heterogenecity of hyaline cartilage we have analyzed the tissues of elbow joint received from six intact Chinchilla rabbits. Classic histological assays, step-by-step scanning, and quantitative morphological analysis were performed. The revealed phenomenon at least concluded in an available of mosaic plots (microclusters), different fr...

To reveal and study the structural changes of clusters (mosaic) organization of hyaline cartilage in case of osteoarthritis we carried out experiments on its modeling using bilateral transection of anterior cruciate ligaments in 28 knee joints of 14 white rats. The autopsy material at 4, 8 and 12 weeks after ligament transaction, and 12 samples fro...

A remodelling of articular cartilage due to damage or pathological state development is characterized by an alteration in cartilage homeostasis including distribution of the chondrocytes. Said alteration can be determined by cellular response changes during cartilage regeneration and remodelling. However, features of cellular distrubution in native...

The purpose of the study - to determine the effectiveness of using PRP in the treatment of patients with stage III knee arthritis. Material for the study - 81 patients , two clinical groups with unilateral ( 9 patients - 15%) or bilateral ( 51 patients - 85%) with stage III knee arthritis. The first group of patients in an amount of 40 people were...

The article is an attempt to explain the renewal of the articular cartilage in normalcy and osteoarthritis development by principles of mathematical modeling. Such models help to develop advanced methods of prevention, detection and treatment of osteoarthritis including molecular biotechnologies based on tissue engineering conception. We used histo...

The effect of the radiofrequency ablation on the healing of experimental mechanical damage, formed in the synovium, menisci, and fat body in the rat knee joints was analyzed in this paper. To generate a cold plasma the bipolar radiofrequency electrode “CoVac 50 Wand” of apparatus ‘Atlas’ (ArthroCare, USA), applied in modes 3 (150 V, 68 W) and 6 (22...

The application of chitosan on bioactive surface of the screw titanium implants was shown to improve the morphological characteristics of osseointegration after implantation into the rat femoral bone. The additional osteoconductive effect of the fine-dispersed chitosan appeared in more intensive and rapid osteogenesis around implants, and the more...

The article presents a systematic review of literature analyzing the prevalence, base technologies, and perspective directions of growth factor usage in cartilage tissue engineering. The main attention is given to problems of combinations of growth factors in modern scaffolds for cellular settlement and options for mechanical and physical-chemical...

Incomplete varying obstruction of the urinary tract was reproduced by injecting artificial stomatological material into the rat bladder. Inflammatory changes and nephrosclerosis were detected in the renal tissue on days 14 and 21 of the experiment. Urinary concentration of total protein and activity of γ-glutamylaminotransferase increased. A direct...

Resulting from the generalisation of existing approaches to an estimation of the human requirements the universal technique was developed. It allows to define separatelly the quantitative expressivenesses of physiological requirements, requirements for safety, reproductive, social, requirements for education, requirements for self-realisation, unit...

The general nonspecific reactivity level of the organism (GNRLO) as the factor of individual stress resistance of the person was characterized during an experimental research. Based on the analysis of cardiovascular system activity, formation mechanisms of adaptable reactions, indicators of lipid's peroxidation it was defined that individuals with...

Morphological changes in the ovaries and levels of sex hormones were studied in rats with chronic endotoxicosis. Long-term endogenous intoxication was associated with the development of sclerocystic ovary syndrome paralleled by hormone imbalance.

The study was aimed at assessing the relationship between the activity (including the inflammatory one) of the atherosclerotic process in the zone ofarterial reconstruction in patients under-going surgery on the aortoiliac arterial segment and long-term thrombotic reocclusions. The study comprised a total offorty-nine patients, with the postoperati...

Dynamic studies on rats with chronic endogenous intoxication showed involvement of the thyroid hormones in modulation of liver injury. Thyroid modulation is realized as more intense induction of TNF apoptosis in the cells and stimulation of microcirculatory disorders at the expense of nitroxide synthase expression. The modulation is quantitative, a...

Traumatic stomatitis oforalmucosa in rabbits has been studied. Stimulatory effect ofmagnesium-containing "Polykatan” gel on thermal burn in comparison with "Polykatan" solution has been revealed. "Polykatan" solution based on solution of clean bischofite mineral is used in the therapeutic dentistry.

Chronic endotoxicosis leads to pronounced structural changes in the thyroid gland and hypothyrosis characterized by reduced weight and activity of the thyroid parenchyma.

We studied expression of endothelial and neuronal NO synthase isoforms and severity of ischemia/reperfusion-induced damage to neurons in different brain compartments in albino rats. The peculiarities of distribution of NO synthase isoforms in the cerebral cortex and medulla oblongata were determined by different sensitivity of these compartments to...

Using the results of instrumental and numerical investigations of structure — activity relationships among derivatives and structural analogs of cinnamic acid, we predicted and then experimentally proved the protective action of the new bile-expelling drug cycvalon (a cyclohexanone derivative) in rats under the conditions of model endotoxicosis. Th...

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