Valerio Voliani

Valerio Voliani
Istituto Italiano di Tecnologia | IIT · Center for Nanotechnology Innovation

Researcher

About

78
Publications
10,754
Reads
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1,468
Citations
Citations since 2017
49 Research Items
1159 Citations
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2017201820192020202120222023050100150200250300
2017201820192020202120222023050100150200250300
Introduction
My efforts are devoted in filling the gap between inorganic nanomaterials and clinical applications
Additional affiliations
June 2014 - present
Istituto Italiano di Tecnologia
Position
  • PostDoc Position
Description
  • The object of this research line is the development of innovative nano-architectures for theranostics and catalysis.
February 2012 - May 2013
University of Valencia
Position
  • PostDoc Position
September 2007 - April 2012
Scuola Normale Superiore di Pisa
Position
  • PhD Student

Publications

Publications (78)
Article
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Skin burns are debilitating injuries with significant morbidity and mortality associated to infections and sepsis, especially in immunocompromised patients. In this context, nanotechnology can provide pioneering approaches for the topical...
Article
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Head and neck squamous cell carcinomas (HNSCCs) are a complex group of malignancies that affect different body sites pertaining to the oral cavity, pharynx and larynx. Current chemotherapy relies on platinum complexes, the major exponent being cisplatin, which exert severe side effects that can negatively affect prognosis. For this reason, other me...
Article
Angiogenesis and metastasis are two interdependent cancer hallmarks, the latter of which is the key cause of treatment failure. Thus, establishing effective antiangiogenesis/antimetastasis agents is the final frontier in cancer research. Gold nanoparticles (GNPs) may provide disruptive advancements in this regard due to their intrinsic physical and...
Article
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The selective and localized delivery of active agents to neoplasms is crucial to enhance the chemotherapeutic efficacy while reducing the associated side effects. The encapsulation of chemotherapeutics in nanoparticles decorated with targeting agents is a strategy of special interest to improve drug delivery. However, serum protein adsorption often...
Article
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The intranasal administration of drugs allows an effective and noninvasive therapeutic action on the respiratory tract. In an era of rapidly increasing antimicrobial resistance, new approaches to the treatment of communicable diseases, especially lung infections, are urgently needed. Metal nanoparticles are recognized as a potential last-line defen...
Article
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Considering the dismal survival rate, novel therapeutic strategies are warranted to improve the outcome of pancreatic ductal adenocarcinoma (PDAC). Combining nanotechnology for delivery of chemotherapeutics—preferably radiosensitizing agents—is a promising approach to enhance the therapeutic efficacy of chemoradiation. We assessed the effect of bio...
Article
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Many efforts have recently concentrated on constructing and developing nanoparticles (NPs) as promising thermal agent for optical hyperthermia and photothermal therapy. However, thermal energy transfer in biological tissue is a complex process involving different mechanisms such as conduction, convection, radiation. Therefore, having information ab...
Article
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With the aim of preparing hybrid hydrogels suitable for use as patches for the local treatment of squamous cell carcinoma (SCC)-affected areas, curcumin (CUR) was loaded onto graphene oxide (GO) nanosheets, which were then blended into an alginate hydrogel that was crosslinked by means of calcium ions. The homogeneous incorporation of GO within the...
Article
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The European Society for Medical Oncology (ESMO) suggests the use of chemotherapy as neoadjuvant, adjuvant, and concomitant to surgery and radiotherapy for the treatment of oral carcinoma by depending on the cancer stage. The usual drug of choice belongs to the platinum compounds. In this context, the evaluation of the cancer behavior associated to...
Article
Gold nanomaterials have been recognized as considerably active and effective catalysts toward several industrial and environmentally relevant reactions, among which are hydrocarbon selective oxidation, CO oxidation and propylene epoxidation. Engineered nanomaterials may be able to suppress some of the more severe issues that block their industrial...
Article
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Surgical site infection (SSI) substantially contributes each year to patients’ morbidity and mortality, accounting for about 15% of all nosocomial infections. SSI drastically increases the rehab stint and expenses while jeopardizing health outcomes. Besides prevention, the treatment regime relies on an adequate antibiotic therapy. On the other hand...
Article
This paper presents a novel chemical sensor that combines an organic, floating gate field‐effect transistor and a functional graphene electrode, aimed at realizing the basic building block for novel biomedical sensor systems. A non‐covalent functionalization of graphene with sensing peptides bearing a pyrene moiety is described as a way to provide...
Article
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Preclinical cancer research increasingly demands sophisticated models for the development and translation of efficient and safe cancer treatments to clinical practice. In this regard, tumor-grafted chorioallantoic membrane (CAM) models are biological platforms that account for the dynamic roles of the tumor microenvironment and cancer physiopatholo...
Article
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The constant advent of major health threats such as antibacterial resistance or highly communicable viruses, together with a declining antimicrobial discovery, urgently requires the exploration of innovative therapeutic approaches. Nowadays, strategies based on metal nanoparticle technology have demonstrated interesting outcomes due to their intrin...
Article
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Diffuse Intrinsic Pontine Gliomas (DIPGs) are highly aggressive paediatric brain tumours. Currently, irradiation is the only standard treatment, but is palliative in nature and most patients die within 12 months of diagnosis. Novel therapeutic approaches are urgently needed for the treatment of this devastating disease. We have developed non-persis...
Article
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Introduction: Advancements in cancer management and treatment are associated with strong preclinical research data, in which reliable cancer models are demanded. Indeed, inconsistent preclinical findings and stringent regulations following the 3Rs principle of reduction, refinement, and replacement of conventional animal models currently pose chall...
Article
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Catalysts are involved in a number of established and emerging chemical processes as well as in environmental remediation and energy conversion. Nanoparticles (NPs) can offer several advantages over some conventional catalysts, such as higher efficiency and selectivity. Nowadays, versatile and scalable nanocatalysts that combine activity and stabil...
Article
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DIPGs are the most aggressive pediatric brain tumors. Currently, the only treatment is irradiation but due to its palliative nature patients die within 12 months. Effective delivery of chemotherapy across the blood-brain barrier (BBB) has been a key challenge for the eradication of this disease. We have developed a novel gold nanoparticle functiona...
Article
Current chemotherapy for head and neck squamous cell carcinomas (HNSCCs) are based on cisplatin, which is usually associated to severe side effects. In general, the exploration for metal-based alternatives to cisplatin has resulted in the development of a series of ruthenium complexes that are able to produce a safe therapeutic action against some...
Article
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The effective exploitation of the intriguing theranostic features of noble metal nanoparticles for therapeutic applications is far from being a routine practice due to the persistence issue. In this regard, passion fruit-like nano-architectures (NAs), biodegradable and excretable all-in-one, nature-inspired platforms which jointly combine these cha...
Article
Synergistic combined treatments are currently practiced in clinics for the management of several neoplasms. While surgery, radiotherapy, and chemotherapy remain as the standards of care for monomodal and co-treatments, emerging modalities like hyperthermia (HT) demonstrate promising features as (neo)adjuvant, particularly for recurrent cancers. How...
Article
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Among the organism’s entry portals, the respiratory tract is one of the most promising routes for a non-invasive administration of therapeutics for local and systemic delivery. On the other hand, it is the subtlest to preserve from environment pollution and microbial occurrences. Here, the biokinetics, distribution, and clearance trends of gold ult...
Article
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As a first approach, standard 2D cell culture techniques are usually employed for the screening of drugs and nanomaterials. Despite the easy -handling, findings achieved on 2D cultures are often not efficiently translatable to in vivo preclinical investigations. Furthermore, although animal models are pivotal in preclinical studies, more strict dir...
Article
Three-dimensional tumor models are becoming extensively employed in cancer research due to their accessibility and close representation of physiological tumor conditions. Hence, novel oncological diagnostic, therapeutic and combined theranostic platforms, including nanomaterial-based systems, are increasingly evaluated at preclinical stage by means...
Article
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Negative or positive HPV-associated Head and Neck Squamous Cell Carcinomas (HNSCCs) are high recurrence neoplasms usually resulting in a poor prognosis, mainly due to metastasis formation. Despite the low overall patient survival rate and the severe side effects, the treatment of choice is still cisplatin-based chemotherapy. Here, we report a strai...
Article
Effective excretion of nanostructured noble metals is still one of the most challenging bottle-neck for their employment in clinical practice. Beside the persistence issue, the clinical translation of inorganic nanomaterials is also affected by a bewildering lack of investigations regarding their quantitative biokinetics. Here, we have quantitative...
Article
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Photothermal therapy (PTT) is a promising (co)treatment with translation potentiality in oncology. Nowadays, the plasmonic nanoparticle-mediated photothermal effect (PT) relies on two well established NIR-responsive platforms: gold nanorods and nanoshells. Nonetheless, these nanostructures are affected by: (i) re-shaping after irradiation that prev...
Article
The persistence of metals in the body after the designed theranostic action has hampered the clinical translation of noble metal nanoparticles (NPs) to clinics. Therefore, the appealing behaviors of NPs for healthcare applications are still on the bench‐side. Here, quantitative evaluation in healthy murine models show that gold comprised in passion...
Article
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Although conceptually obvious, the effective delivery of proteins in therapeutic applications is far from being a routine practice. The major limitation is the conservation of protein physicochemical identity during the transport to the target site. In this regard, nanoparticle-based systems offer new intriguing possibilities, provided that (i) the...
Article
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Nanomaterials have attracted increasing interest for their potentiality to revolutionize the diagnosis and treatment of many diseases, especially neoplasms. Interestingly, there is a huge imbalance between the number of proposed nanoplatforms and the few ones approved for clinical applications. This disequilibrium affects in particular noble metal...
Article
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Several nanomaterials rely on the passive accumulation in the neoplasm target because of enhanced permeability and retention effect. On the other hand, directing nanomaterials to the target by employing the targeting agents may lead to a pivotal improvement in the efficacy of the treatment for a number of cancers. However, targeting moieties often...
Article
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Passion fruit-like nano-architectures (NAs) are all-in-one platforms of increasing interest for the translation of metal nanoparticles into clinics. NAs are nature-inspired disassembling inorganic theranostics, which jointly combine most of the appealing behaviors of noble metal nanoparticles with their potential organism excretion. Despite their u...
Chapter
This chapter contains sections titled: Physical Properties of Nanomaterials Nanomaterials: An Overview
Chapter
This chapter contains sections titled: Ultrasmall‐in‐Nano Approach Porphyrin‐Based Nanomaterials
Chapter
This chapter contains sections titled: Diagnostics Therapy
Chapter
This chapter contains sections titled: Approval Pipeline (FDA and EMA) Nanotherapeutics Nanodiagnostics
Chapter
This chapter contains sections titled: Cellular Level (in vitro) Body Level (in vivo)
Article
Ultrasound (US) imaging is a well-established diagnostic technique to image soft tissues in real time, while photoacoustic (PA) is an emerging imaging technique employed to collect molecular information. Integration of PA and US imaging provides complementary information enhancing diagnostic accuracy without employing ionizing radiations. The devel...
Article
Catalytic properties of materials are of dramatic significance in many technological sectors, among which automotive, chemical industry, and environment remediation. Nanotechnology has revolutionized this field due to the rational design of catalysts at the nanometer scale that improve the catalytic efficiency and selectivity of materials. Due to t...
Article
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Currently, nanomaterials are of widespread use in daily commercial products. However, the most promising and potentially impacting application is in the medical field. In particular, nano-sized noble metals hold the promise to shift the current medical paradigms for the detection and therapy of neoplasms thanks to the: i) localized surface plasmon...
Article
PhotoAcoustic Imaging (PAI) is a promising non-invasive technique for molecular and cellular characterization of cancer. Cancer detection by PAI is an area of active research, and the recent advent of contrast agents based on near infrared (NIR)-absorbing dyes or organic/inorganic nanoparticles tremendously improved the specificity and the signal c...
Article
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Noble metal nanostructures have demonstrated a number of intriguing features for both medicine and catalysis. However, accumulation issues have prevented their clinical translation, while their use in catalysis has shown serious efficiency and stability hurdles. Here we introduce a simple and robust synthetic protocol for passion fruit-like nano-ar...
Article
Stealth agents are extensively investigated as means to prolong nanostructures residence time in the bloodstream by avoiding uptake by the reticuloendothelial system. Unfortunately, commonly used agents such as poly(ethylene glycol) can adversely impact on targeting efficiency and promote immune reaction by the host organism. Therefore, there is an...
Article
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The transferrin receptor (TfR) is a promising target in cancer therapy owing to its overexpression in most solid tumors and on the blood brain barrier. Nanostructures chemically derivatized with transferrin are employed in TfR targeting but often lose their functionality upon injection in the bloodstream. As an alternative strategy, we rationally d...
Article
The clinical translation of inorganic nanoparticles (NPs) requires combining the feasibility of body clearance typical for ultrasmall NPs with the physical behavior of bigger NPs. On page 818, V. Voliani and co-workers present passion fruit-like nano-architectures: this novel approach to the synthesis of nanoparticles results in nanocapsules that d...
Article
Accumulation of inorganic nanostructures in the excretory system organs increases their likelihood of toxicity and interference with common medical diagnoses. Thus, one of the major concerns regarding their clinical translation is related to their persistence in organisms. Here the authors demonstrate that nano-architectures composed by hollow sili...
Article
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By exhibiting a measurable bandgap and exotic valley physics, atomically-thick tungsten disulfide (WS2) offers exciting prospects for optoelectronic applications. The synthesis of continuous WS2 films on other two-dimensional (2D) materials would greatly facilitate the implementation of novel all-2D photoactive devices. In this work we demonstrate...
Article
One of the major concerns regarding the clinical translation of metal nanoparticles is related to the question of their persistence in organisms that can increase the likelihood of toxicity and the interaction/interference with common medical diagnoses. In order to overcome these issues we have recently introduced a versatile 90 nm nano-architectur...
Poster
Full-text available
The transferrin receptor (TfR) is a promising target in cancer therapy owing to its overexpression in most solid tumors. Nanostructures chemically derivatized with transferrin are employed in TfR targeting but often lose their functionality upon injection in the bloodstream.[1] As an alternative strategy, we evaluated a coating composed of binding...
Article
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In a recent study by Voliani et al. (Small 7, 3271 (2011)), the electromagnetic field enhancement in the vicinity of gold nanoparticle surface has been exploited to achieve photocontrolled release of a molecular cargo conjugated to the nanoparticle via 1,2,3-triazole, a photocleavable moiety. The aim of the present study is to investigate the mecha...
Article
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We introduce biodegradable hollow silica nanocapsules embedding arrays of 3-nm gold nanoparticles. The silica shell degrades in full serum in few hours, potentially allowing the clearance of the capsules and their contents by the efficient renal pathway, and therefore overcoming accumulation issues typical of metallic nanoparticles.
Article
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The most exciting promise of cell micro-bioreactors is their expected ability to reproduce specific aspects of physiological environments in vitro, singularly or in combination, and to perform advanced biological studies to unravel novel interaction mechanisms; but this challenge is formidable. Moreover, the use of microfluidics is limited by the d...
Article
Texture and phase recognition analysis (TPRA) based on electron nanodiffraction technique is used to characterize the geometry of up-conversion nanocrystals (UCNCs) synthesized by the common thermal-decomposition protocol in the presence of a stoichiometric amount of NH4F. Here, we confirmed experimentally that despite the apparently different shap...
Article
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We report the preparation of water-dispersible, ca. 30 nm-sized nanohybrids containing NaYF4:Er3+, Yb3+ up-conversion nanoparticles (UCNPs), capped with a polyethylene glycol (PEG) derivative and highly loaded with a singlet oxygen photosensitizer, specifically a diiodo-substituted Bodipy (IBDP). The photosensitizer, bearing a carboxylic group, was...
Data
Full-text available
We report the preparation of water-dispersible, ca. 30 nm-sized nanohybrids containing NaYF4:Er3+, Yb3+ up-conversion nanoparticles (UCNPs), capped with a polyethylene glycol (PEG) derivative and highly loaded with a singlet oxygen photosensitizer, specifically a diiodo-substituted Bodipy (IBDP). The photosensitizer, bearing a carboxylic group, was...
Article
Full-text available
Background: Catechin-dextran conjugates have recently attracted a lot of attention due to their anticancer activity against a range of cancer cells. Magnetic nanoparticles have the ability to concentrate therapeutically important drugs due to their magnetic-spatial control and provide opportunities for targeted drug delivery. Purpose: Enhancemen...
Article
Nanomaterials engineered in novel multi-modular systems in which every component works in a synergistic way with others could potentially lead to a completely new type of tools for nanomedicine. The development of nanostructures able to release drugs directly within the target after a stimulus can drastically improve the therapeutics efficiency by...
Article
A simple and straightforward method for the orthogonal functionalisation of upconverting NaYF4 nanocrystals (UCNCs)-doped withYb(3+) and Er(3+) -based on N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide/N-hydroxysuccinimide (EDC/NHS) selective reactions between two dyes and two different reactive groups present at the periphery of the upconverting na...
Article
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Doxorubicin is a widely used but toxic cancer chemotherapeutic agent. In order to localize its therapeutic action and minimize side effects, it was covalently conjugated to peptide-encapsulated gold nanospheres by click-chemistry and then photo-released in a controlled fashion by a multiphoton process. Selective treatment of a chosen region in a 2D...
Article
Full-text available
Doxorubicin is a widely used but toxic cancer chemotherapeutic agent. In order to localize its therapeutic action and minimize side effects, it was covalently conjugated to peptide-encapsulated gold nanospheres by click-chemistry and then photo-released in a controlled fashion by a multiphoton process. Selective treatment of a chosen region in a 2D...
Article
Lanthanides (or rare-earth elements) usually appear as an appendage of the periodic table, but in recent years they are being used in an evergrowing variety of applications in modern nanotechnology and nanomedicine. In particular, lanthanide-doped solids show unconventional anti-Stokes emissions, due to their ability to convert near infrared (NIR)...
Article
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A single-step method to coat and trifunctionalize water-dispersed gold nanospheres (AuNss) with carboxylic acids, amines, and alkynes is reported. The coating is based on a mix of two hexa-peptides, differing only in the C-terminal amino acid. The process yields AuNss that are non-cytotoxic, stable in physiological environments, and which present t...
Article
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Discoveries in the field of nanotechnology are triggering a revolution in medicine, by providing a profusion of potential and actual applications of nanosized objects in the diagnosis and treatment of several diseases. This trend is also evident in the increasing number of patents recorded annually. In particular, nanoparticles able to find a targe...
Article
Yellow-green controlled photorelease: probes click-linked to peptide-coated gold nanospheres by a triazole ring can be released in living cells under a focused 561 nm laser at low power. Photocleaving follows a three-photon event stimulated by the excitation of the localized surface plasmon resonance.
Article
The image shows an illustration of the modular nanosystem developed for the controlled photorelease of molecular payloads, induced by yellow-green laserlight. Peptide-coated 30-nm gold nanospheres are covalently conjugated to molecular payloads by standard click chemistry, via a 1,2,3-triazole-ring linker. The photorelease of payloads is triggered...