Valerie Marien

Valerie Marien
KU Leuven | ku leuven · Department of Biology

Master of Science

About

5
Publications
347
Reads
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16
Citations
Citations since 2016
5 Research Items
16 Citations
20162017201820192020202120220246810
20162017201820192020202120220246810
20162017201820192020202120220246810
20162017201820192020202120220246810

Publications

Publications (5)
Preprint
This perfusion protocol is essential for preserving tissue morphology in order to perform good quality immunohistochemical stainings. Here, we show you how we perform our perfusions on the African turquoise killifish. This protocol was already used in the following publications: Aging impairs the essential contributions of non-glial progenitors to...
Article
Full-text available
The aging central nervous system (CNS) of mammals displays progressive limited regenerative abilities. Recovery after loss of neurons is extremely restricted in the aged brain. Many research models fall short in recapitulating mammalian aging hallmarks or have an impractically long lifespan. We established a traumatic brain injury model in the Afri...
Preprint
Full-text available
The African turquoise killifish uniquely combines a short lifespan with vertebrate-specific features, including age-dependent loss of neuroregenerative capacity, that are missing from the currently used model organisms. In this study, we investigate the cellular landscape that shapes adult neuro- and gliogenesis using single-cell sequencing. Our an...
Article
Full-text available
Aging increases the risk for neurodegenerative disease and brain trauma, both leading to irreversible and multifaceted deficits that impose a clear societal and economic burden onto the growing world population. Despite tremendous research efforts, there are still no treatments available that can fully restore brain function, which would imply neur...
Preprint
Full-text available
The aging central nervous system (CNS) of mammals displays progressive limited regenerative abilities. Recovery after loss of neurons is extremely restricted in the aged brain. Many research models fall short in recapitulating mammalian aging hallmarks or have an impractically long lifespan. We established a traumatic brain injury model in the Afri...

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