Valerie Sitterle

• Georgia Tech Research Institute

Validating artificial intelligence systems is challenging. Systems continuing to learn new behaviors in the field are particularly difficult, because the designer does not know what the functions need proving. This article reports on a research project using the Toulmin augmentation method to structure validation test plans and validation testing f...

System assurance is the justified confidence that a system functions as intended and is free of exploitable vulnerabilities, either intentionally or unintentionally designed or inserted as part of the system at any time during the life cycle. The computation and communication backbone of cyber-physical systems (CPS), coupled with readily available...

Dynamically transforming mission contexts in conjunction with ever-increasing budgetary constraints provides great impetus for the Department of Defense (DoD) to identify resilient systems early in the design process. The engineered resilient systems (ERS) community of interest (COI) research efforts focus on identifying and quantifying methods to...

Engineered Resilient Systems (ERS) is a Department of Defense (DoD) program focusing on the effective and efficient design and development of complex engineered systems across their lifecycle. An important area of focus is the evaluation of early-stage design alternatives in terms of their modeled operational performance and characteristics. The wo...

Engineered Resilient Systems (ERS) is a Department of Defense (DoD) program focusing on the effective and efficient design and development of complex engineered systems across their lifecycle. An important area of focus is the evaluation of early-stage design alternatives in terms of their modeled operational performance and characteristics. The wo...

Engineered Resilient Systems (ERS) is a Department of Defense (DoD) program focusing on the effective and efficient design and development of complex engineered systems across their lifecycle. An important area of focus is the evaluation of early-stage design alternatives in terms of their modeled operational performance and characteristics. This w...

Socio-Cultural Analysis (SCA) has evolved rapidly over the past decade as conflicts in Afghanistan and Iraq have forced the DOD to reappraise the techniques used to collect information about the populations in conflict zones. As these two major conflicts wind down, the DOD must recognize that SCA must evolve again due the changing responsibilities...

Complex system development, especially in the context of large-scale military acquisition programs, requires integrated systems engineering tools to enable effective exploration of the design alternative tradespace. The prototype development described herein offers a capability framework through which tradespace analyses of materiel solutions may b...

As technology continues to advance and increasingly permeate society, generating violence that makes a societal group feel vulnerable is not difficult. Generating the desired interpretation of that violence is hard, however, and is critical to the coupling we need between future U.S. counterterrorism (CT) and information operations (IO) strategy. T...

This chapter discusses the process of Knowledge Exchange and the challenges associated with Knowledge Transfer both within a multi-disciplinary academic research team and across the research team to the customer stakeholders. Specifically addressing socio-technical complex adaptive systems, Knowledge Exchange provides a vital cornerstone to both su...

A series of water-insoluble, biologically compatible dyes, meso-tetraphenylchlorin, meso-tetraphenylporphyrin and chlorophyll-a, were successfully incorporated into beads composed of linear polystyrene (PS) via a tunable combined swelling-diffusion process. Dyed PS beads were prepared by the addition of a dye solution in tetrahydrofuran to an aqueo...

We report on a combined swelling−heteroaggregation (CSH) method for preparation of highly scattering, metal nanoparticle(NP)-coated polystyrene (PS) latex beads. This methodology is a facile and relatively benign single-step process for preparation of metal-coated dielectrics for applications in biomedical imaging, sensors, photonics, electronics,...

Noble-metal coated polymer composite microspheres and nanoshells have attracted intense interest due to applications in electronics, photonics, medical imaging, drug delivery, surface-enhanced Raman scattering (SERS) and catalysis. By incorporating nanoparticles (NPs) exhibiting preferential scattering characteristics on a polymeric bead surface, t...

The objective of this study was to evaluate photochemical bonding as an approach for adhering live cartilage tissues across a repair interface in a manner that may lead to enhanced integration. Photochemical bonding of both meniscal fibrocartilage and articular cartilage was explored using an anionic, hydrophilic phthalocyanine photosensitizer. Var...

We report on the facile preparation of highly scattering metal-coated polystyrene (PS) latex beads by using solvent-controlled heterocoagulation. Starting with an aqueous dispersion of PS beads and poly(vinyl pyrrolidone)-capped metal nanoparticles (NPs), homogeneous and dense metal coatings were obtained by the controlled addition and removal of t...

Effective attachment to relevant anatomical surfaces has long been a critical issue for tissue replacement or repair. This is especially true for cartilage repair where adequate, reliable initial fixation to surrounding tissue and joint surfaces has been a dominant factor affecting clinical outcomes. Due to ease of application and ability to replic...

The present study investigates whether photoactivated attachment of cartilage can provide a viable method for more effective repair of damaged articular surfaces by providing an alternative to sutures, barbs, or fibrin glues for initial fixation. Unlike artificial materials, biological constructs do not possess the initial strength for press-fittin...

Cartilage repair and/or replacement is necessary for many orthopaedic conditions including fissures from blunt trauma, autograft or allograft transplantation, and replacement of focal defects with biological or synthetic constructs. In cartilage repair, initial integration between the host tissue and repair site is desirable to allow for nutrient t...