Valérie Martinez

Valérie Martinez
Assistance Publique – Hôpitaux de Paris | AP-HP

About

29
Publications
1,086
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1,166
Citations
Citations since 2017
0 Research Items
396 Citations
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2017201820192020202120222023020406080
2017201820192020202120222023020406080
2017201820192020202120222023020406080

Publications

Publications (29)
Article
Although the decline in cancer mortality rates with the advent of combination antiretroviral therapy (cART) in HIV-infected individuals can be mostly explained by a decrease in cancers incidence, we looked here if improved survival after cancer diagnosis could also contribute to this decline. Survival trends were analyzed for most frequent cancers...
Article
A recent consensus defines "late presentation" (LP) during the course of HIV infection as presentation with AIDS whatever the CD4 cell count or with CD4 <350 cells per cubic millimeter. Here, using this new definition, we examined the frequency and predictors of LP and its impact on mortality. In antiretroviral-naive patients enrolled in the French...
Article
Full-text available
Background: We examined trends in the incidence of the 3 AIDS-defining cancers (ADCs; Kaposi sarcoma [KS], non-Hodgkin lymphoma [NHL], and cervical cancer) among human immunodeficiency virus (HIV)-infected patients relative to the general population between 1992 and 2009 in France, focusing on age at ADC diagnosis and on patients with controlled v...
Article
Full-text available
Hodgkin lymphoma (HL) incidence with HIV infection may have increased with the introduction of combination antiretroviral therapy (cART), suggesting that immune reconstitution may contribute to some cases. We evaluated HL risk with cART during the first months of treatment. With 187 HL cases among 64 368 HIV patients in France, relative rates (RRs)...
Article
To describe features of reactive haemophagocytic syndrome (RHS) in HIV-1-infected adult patients. To compare characteristics of patients with malignancy-associated RHS and infection-associated RHS. Retrospective study in three departments of Infectious Diseases/Internal Medicine at three French tertiary centres. Medical charts of HIV-1-infected adu...
Article
HIV-specific CD8+ T cells from patients with primary HIV infection (PHI) and after antiretroviral therapy initiation were evaluated for CD127 expression and proliferative capacity and were compared with cells from chronically-infected patients, including long-term nonprogressors and HIV controllers. We studied 30 patients with PHI (from the Agence...
Article
Genital herpes is the leading cause of genital ulcer disease worldwide and is among the most common sexually transmitted diseases. Recurrent genital herpes is associated with major medical and psychosocial morbidities; therefore, suppressive therapy is required, especially in patients with frequent and/or severe episodes. A recent meta-analysis eva...
Article
To evaluate at 9 months and 24 months the safety and efficacy of intravenous immunoglobulins (IVIGs) administered for 6 months to treat relapses of Wegener's granulomatosis (WG) or microscopic polyangiitis (MPA) occurring either under treatment or during the year following discontinuation of corticosteroids and/or immunosuppressants. Patients recei...
Article
Full-text available
We report a fatal case of disseminated acanthamebiasis caused by Acanthamoeba lenticulata (genotype T5) in a 39-year-old heart transplant recipient. The diagnosis was based on skin histopathologic results and confirmed by isolation of the ameba from involved skin and molecular analysis of a partial 18S rRNA gene sequence (DF3).
Article
We describe the case of a 69-year-old man with systemic granulomatosis who presented with left-sided hemiplegia. Initial diagnosis concerning the neurological troubles was cerebral vasculitis. Corticosteroids associated with antituberculosis therapy showed a rapid but transient amelioration followed by neurological aggravation. Two weeks later, JC...
Article
Mitoxantrone is a DNA topoisomerase II poison commonly used for the treatment of hormone-refractory prostate cancer. The risk of secondary leukaemia is well described after mitoxantrone treatment in breast cancer and multiple sclerosis. Recent improvements of systemic chemotherapy increased the median survival in patients becoming resistant to andr...
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Full-text available
A 32-year-old HIV-infected man of African origin presented to our emergency department with a 3-day history of nausea, vomiting, abdominal pain and muscular pain. The patient was alert and oriented. He denied alcohol, tobacco and illicit drug use. His current medications were lopinavir, Epivir, stavudine and trimethoprim-sulfamethoxazole. In the em...
Article
Biotherapy now holds a specific place in the therapeutic armamentarium for systemic vasculitides. Such therapy includes cytokines, such as (pegylated) alpha-interferon for hepatitis B virus-related polyarteritis nodosa and hepatitis C virus-related cryoglobulinemic vasculitis, and polyvalent immunoglobulin (IVIg), with well-defined indications and...
Article
Full-text available
The identification of antigens able to differentiate tuberculosis (TB) disease from TB infection would be valuable. Cellular and humoral immune responses to Erp (Exported repetitive protein)--a recently identified M. tuberculosis protein--have not yet been investigated in humans and may contribute to this aim. We analyzed the cellular and humoral i...
Article
Paradoxical reactions during tuberculosis are defined by exacerbation of clinical symptoms or laboratory or radiologic abnormalities during antituberculosis treatment or when an antiretroviral treatment is added to it. This phenomenon does not involve relapse of the opportunistic infection but rather a reconstitution of an abnormal immune response....
Article
Les réactions paradoxales au cours de la tuberculose sont définies par l'exacerbation de symptômes cliniques, d'anomalies radiologiques ou biologiques lors d'un traitement antituberculeux seul ou lors de l'instauration d'un traitement antirétroviral. Ce phénomène ne correspond pas à une rechute de l'infection opportuniste mais à une reconstitution...
Article
To test the hypothesis that an acute exacerbation of mycobacteria-specific Th1 response after HIV infection control by HAART causes immune restoration syndrome (IRS) in HIV-tuberculosis (TB) coinfected patients. Prospective, multicenter study of 19 consecutive untreated HIV-TB coinfected patients included when initiating antimycobacterial therapy a...
Article
Full-text available
Strong T cell and antibody responses to human immunodeficiency virus (HIV), low virus production, and some genetic traits have been individually associated with nonprogression of HIV infection, but the best correlate with protection against disease progression remains unknown. We prospectively followed 66 untreated long-term nonprogressors and anal...
Article
The aim of this article is to review the potential ocular and renal disorders in infectious diseases to which humans are susceptible and to determine prevalence of these diseases. Published cases of oculo-renal disorders associated with various infectious diseases were collected from the international literature by searching the MEDLINE database (P...

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