Valerie Biran

Valerie Biran
Assistance Publique – Hôpitaux de Paris | AP-HP · Neonatal Intensive Care Unit

About

157
Publications
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Publications

Publications (157)
Article
Background and objectives: The current threshold used for oliguria in the definition of neonatal AKI has been empirically defined as 1 ml/kg per hour. Urine output criteria are generally poorly documented, resulting in uncertainty in the most accurate threshold to identify AKI in very preterm infants with known tubular immaturity. Design, setting...
Article
Purpose : KCNQ2-epileptic encephalopathy (EE) is a neonatal epilepsy syndrome characterized by a typical clinical presentation and EEG recording, but without any brain or cortical abnormal development on MRI. Most of the patients have a severe developmental impairment. The epileptogenic mechanisms are thought to be the result of the changes of the...
Article
To our knowledge, there are no studies recording the reading eye movements of children born prematurely. We examined the oculomotor patterns during reading of 23 children born prematurely ( M age = 7.8, SD = 0.2 years) to compare them with those from two groups of children born at full-term who were matched for chronological age or reading age, res...
Article
Background Patients in neonatal intensive care units (NICUs) are at high risk of adverse events. The effects of medical and paramedical education programmes to reduce these have not yet been assessed. Methods In this multicentre, stepped-wedge, cluster-randomised controlled trial done in France, we randomly assigned 12 NICUs to three clusters of f...
Article
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Importance An international expert committee recently revised its recommendations on amino acid intake for very preterm infants, suggesting that more than 3.50 g/kg/d should be administered only to preterm infants in clinical trials. However, the optimal amino acid intake during the first week after birth in these infants is unknown. Objective To...
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Aim Eye movements have rarely been explored in preterm born children. The aim of this study was to compare horizontal eye movements in children born preterm and full-term when they reached 8 years of age. Methods Eye movements were recorded in 24 preterm born children (18 boys) and 26 matched controls (19 boys), recruited by a French hospital, usi...
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Background Population pharmacokinetic evaluations have been widely used in neonatal pharmacokinetic studies, while machine learning has become a popular approach to solving complex problems in the current era of big data.Objective The aim of this proof-of-concept study was to evaluate whether combining population pharmacokinetic and machine learnin...
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To describe the frequency and nature of premedication practices for neonatal tracheal intubation (TI) in 2011; to identify independent risk factors for the absence of premedication; to compare data with those from 2005 and to confront observed practices with current recommendations. Data concerning TI performed in neonates during the first 14 days...
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Purpose: Serum creatinine (SCr) is used as a marker of kidney function to guide dosing of renally eliminated drugs. Serum Cystatin C (S-CysC) has been suggested as a more reliable kidney marker than SCr in adults and children. Purpose of this study was to investigate S-CysC as alternative renal marker to SCr for estimating vancomycin clearance in n...
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Clinicians have long been interested in functional brain monitoring, as reversible functional losses often precedes observable irreversible structural insults. By characterizing neonatal functional cerebral networks, resting-state functional connectivity is envisioned to provide early markers of cognitive impairments. Here we present a pioneering b...
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Objective To define a nomogram of serum cortisol values before 24 hours of postnatal life for extremely preterm infants and determine whether baseline cortisol values affect the benefit/risk ratio of prophylactic hydrocortisone to improve survival without bronchopulmonary dysplasia (BPD). Study design We performed a predefined secondary analysis o...
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Few data are available on invasive group A Streptococcus (GAS) infections (IGASIs) in infants. We described initial clinical and laboratory features and outcomes of <3-month-old infants hospitalized for an IGASI between 2007 and 2016 in France. Patients were identified from the French National Reference Centre for streptococci. IGASI was defined by...
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In-line filtration is increasingly used in critically-ill infants but its benefits, by preventing micro-particle infusion in very preterm neonates, remain to be demonstrated. We conducted a randomized controlled trial among very preterm infants allocated to receive either in-line filtration of all the intra-venous lines or standard care without fil...
Article
Contexte La filtration des lignes de perfusion est de plus en plus utilisée en unité de soins intensifs néonatals, mais ses avantages par la réduction de l’administration de microparticules chez les nouveau-nés très prématurés, restent à démontrer. Méthodes Essai clinique randomisé monocentrique ouvert, mené auprès de nouveau-nés nés au terme de 2...
Article
Objective To determine whether early low-dose hydrocortisone treatment in extremely preterm infants is associated with brain damage assessed by MRI at term equivalent of age (TEA). Patients and outcomes This is a predefined secondary analysis of brain abnormalities, observed by MRI at TEA, of patients randomly assigned to receive either placebo or...
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Early-onset neonatal sepsis (EOS) is observed in 1.7% of extremely preterm infants, with high morbidity and mortality rate. Cord blood procalcitonin (PCT) is a sensitive marker of EOS in full-term newborns, but it has been rarely studied in premature infants. The diagnostic value of cord blood PCT by immunofluorescence has been assessed as an early...
Conference Paper
Background Serum creatinine (SCr) is used as a surrogate marker of glomerular filtration rate to guide dosing of drugs eliminated by the kidney. Serum Cystatin C (S-CysC) has been suggested as a more reliable biomarker than SCr for monitoring kidney function in adults and children. Purpose of this study was to evaluate whether S-CysC is a more usef...
Conference Paper
Background In the absence of consensus, the present meta-analysis was performed to determine an optimal dosing regimen of vancomycin for neonates. Methods A ‘meta-model’ using NONMEM with 4894 concentrations from 1631 neonates was built and Monte Carlo simulations were performed to design an optimal intermittent infusion, aiming at reaching a targ...
Article
Objectives: In the absence of consensus, the present meta-analysis was performed to determine an optimal dosing regimen of vancomycin for neonates. Methods: A ‘meta-model’ with 4894 concentrations from 1631 neonates was built using NONMEM, and Monte Carlo simulations were performed to design an optimal intermittent infusion, aiming to reach a targe...
Article
Objectives: In the absence of consensus, the present meta-analysis was performed to determine an optimal dosing regimen of vancomycin for neonates. Methods: A 'meta-model' with 4894 concentrations from 1631 neonates was built using NONMEM, and Monte Carlo simulations were performed to design an optimal intermittent infusion, aiming to reach a ta...
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Full-text available
The prevention of perinatal brain damage following preterm birth remains a public health priority. Melatonin has been shown to be a promising neuroprotectant in neonatal preclinical models of brain damage, but few studies have investigated melatonin secretion in newborns. We hypothesized that melatonin circulating levels would be lower in preterm c...
Article
L’apport de l’électroencéphalogramme (EEG) dans l’encéphalopathie anoxo-ischémique (EAI) du nouveau-né à terme, a été largement rapporté en néonatologie [1], [2]. Dans les premiers jours de vie, il constitue, avec l’IRM cérébrale (IRMc), l’un des examens-clé, dans l’évaluation pronostique de l’asphyxie périnatale. Depuis 2010, l’hypothermie thérape...
Article
Background: Successive implementation of seven-valent then 13-valent pneumococcal conjugate vaccines (PCVs) led to a marked decrease in pneumococcal disease burden, including pneumococcal meningitis. We assessed the long-term effect of implementation of PCVs on incidence of pneumococcal meningitis in children in France over a 16-year period. Meth...
Article
Résumé La documentation des infections bactériennes chez le nouveau-né représente un défi pour le clinicien et le microbiologiste à plusieurs titres. La difficulté de la réalisation des prélèvements chez le nouveau-né augmente le risque de contamination des prélèvements. Certains examens comme les hémocultures ont une sensibilité particulièrement d...
Article
Objectives: To assess whether it is possible to identify the neonatal predictors of neonatal hyperthyroidism at the presymptomatic stage of the disease. Study design: This retrospective multicenter study in 10 maternity units was based on the medical records of all patients monitored for a pregnancy between January 1, 2007, and January 1, 2014....
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Mucosal-associated invariant T (MAIT) cells are semi-invariant Vα7.2 ⁺ CD161 high CD4 ⁻ T cells that recognize microbial riboflavin precursor derivatives such as 5-OP-RU presented by MR1. Human MAIT cells are abundant in adult blood, but there are very few in cord blood. We longitudinally studied Vα7.2 ⁺ CD161 high T cell and related subset levels...
Article
Objective To determine whether early hydrocortisone treatment in extremely preterm infants affects neurodevelopmental outcomes at 2 years of age according to gestational age at birth. Patients and methods This is an exploratory analysis of neurodevelopmental outcomes by gestational age strata from the PREMILOC trial, in which patients were randoml...
Article
Aims: Pharmacokinetics (PK) of fluconazole and micafungin differ in neonates compared with children and adults. Dosing instructions in product labels appear inconsistent with the emerging scientific evidence. Limited information is available on their safety profile in neonates. Our objective was to study population PK and safety of both drugs, ran...
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Functional neuroimaging modalities are crucial for understanding brain function, but their clinical use is challenging. Recently, the use of ultrasonic plane waves transmitted at ultrafast frame rates was shown to allow for the spatiotemporal identification of brain activation through neurovascular coupling in rodents. Using a customized flexible a...
Article
Infants born preterm have higher risks of developing linguistic deficits. Considering that the ability to segment words from fluent speech is crucial for lexical acquisition, Experiment 1 tested the ability of healthy extremely-to-late preterm infants to segment monosyllabic words at 6 months of postnatal age. Results establish basic segmentation s...
Article
Résumé En cas d’accident vasculaire cérébral (AVC), les convulsions néonatales sont un signe diagnostique fréquent. Leur traitement, bien qu’encore largement débattu, doit intervenir en cas d’état de mal épileptique, de crises cliniques durant plus de 5 minutes consécutives ou plus brèves (> 30 secondes) mais répétées (2 ou plus par heure). Ce trai...
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Context Neonatal hyperthyroidism was first described in 1912 and in 1964 was shown to be linked to transplacental passage of maternal antibodies. To this day there are few multicenter studies describing the perinatal factors leading to foetal and neonatal dysthyroidism. Objective To show how foetal dysthyroidism (FD) and neonatal dysthyroidism (ND...
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Importance Dexamethasone to prevent bronchopulmonary dysplasia in very preterm neonates was associated with adverse neurodevelopmental events. Early low-dose hydrocortisone treatment has been reported to improve survival without bronchopulmonary dysplasia but its safety with regard to neurodevelopment remains to be assessed. Objective To assess wh...
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Neonatal arterial ischemic stroke (NAIS) is a rare event that occurs in approximately one in 5000 term or close-to-term infants. Most affected infants will present with seizures. Although a well-reco- gnized clinical entity, many questions remain regarding diagnosis, risk factors, treatment, and follow-up modalities. In the absence of a known patho...
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Objective: Proton pump inhibitors are frequently administered on clinical symptoms in neonates but benefit remains controversial. Clinical trials validating omeprazole dosage in neonates are limited. The objective of this trial was to determine the minimum effective dose (MED) of omeprazole to treat pathological acid reflux in neonates using reflu...
Data
Protocol OMEPRAZOLE-1—Recherche de dose et Pharmacocinétique de population de l’Oméprazole chez le nouveau-né en traitement du reflux gastrooesophagien. (PDF)
Data
Pooled estimation of the minimum effective dose in the group of infants born after 32 weeks of gestational age. (DOCX)
Data
Sequential estimation of posterior probabilities of success after each cohort of three patients for the group of neonates born between 32 and 35 weeks of gestational age. Bold characters indicate the estimations of the minimum effective dose after the inclusion of each cohort. Data from the 12 neonates that participated in the first-stage analysis...
Data
Sequential estimation of posterior probabilities of success after each cohort of three patients for the group of neonates born after 35 weeks of gestational age. At the end of the recruitment, it was not possible to determine the minimum effective dose in the >35 weeks GA study group due to low inclusion rate. Thus, we decided to pool the data with...
Data
Mean posterior probability of success related to the minimum effective dose and its 95% credibility interval according to patients’ inclusions in the group of neonates born between 32 and 35 weeks of gestational age (n = 18). CI95%: 95% credibililty interval, MED: Minimum Efficient Dose. (DOCX)
Article
L’accident vasculaire cérébral ischémique artériel néonatal (AVCian) est une pathologie rare. Afin d’actualiser les connaissances sur ce sujet, un groupe de travail multidisciplinaire s’est constitué sous l’égide de la Société française de néonatologie et le Centre national de référence de l’AVC de l’enfant afin de proposer des recommandations sur...
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Objective: Diffusion-weighted magnetic resonance imaging (DWI) is a sensitive method for assessing brain maturation and detecting brain lesions, providing apparent diffusion coefficient (ADC) values as a measure of water diffusion. Abnormal ADC values are seen in ischemic brain lesions, such as those associated with acute or chronic hypoxia. The a...
Article
Brain injury related to preterm birth and neonatal asphyxia is a leading cause of childhood neuromotor and cognitive disabilities. Unfortunately, the strategies to prevent perinatal brain damages remain limited. Among the candidate molecules, melatonin appears to be one of the most promising agents for its antioxidant and neuromodulatory action. Ro...
Article
Presenter: Evelyne Jacqz-Aigrain (e-mail: evelyne.jacqzaigrain@gmail.com) Introduction: Neonatal Candida infection requires urgent treatment because of high risk disease with possible central nervous system infection. Fluconazole prophylaxis is recommended in NICUs with a high incidence in fungal infections. Both fluconazole and micafungin are used...
Article
Cefotaxime is one of the most frequently prescribed antibiotics in neonates for the treatment of Gram-negative neonatal sepsis. However, a considerable variation of dosing regimens exists in routine clinical practice. The objective of the present study was to conduct a population pharmacokinetic study of cefotaxime in neonates and young infants in...
Article
La prescription néonatale des antibiotiques pose le problème d’une grande variabilité de pratiques tant au niveau national qu’international. Ceci reflète un manque d’évaluation de cette classe thérapeutique, pourtant largement utilisée. Face à ce constat, un travail d’optimisation de la prescription s’impose pour assurer chez le nouveau-né l’effica...
Article
While the incidence of diabetes mellitus (DM) during pregnancy has been steadily increasing in recent years, the link between gestational DM and respiratory outcome in neonates has not been firmly established. To address this gap in understanding, we asked whether DM status and its treatment during pregnancy influence risk of neonatal respiratory d...
Article
Background and objective Pharmacokinetic modeling approach is often applied to evaluate antimicrobials in neonates. However, the clinical application of the model-based personalized antimicrobial therapy is still limited. Our objective is to evaluate the clinical utility and safety of the model-based patient-tailored dosing of vancomycin in neonate...
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Full-text available
BACKGROUND AND OBJECTIVE: Pharmacokinetic modeling was often applied to evaluate vancomycin pharmacokinetics in neonates. However, clinical application of the model-based personalized vancomycin therapy is still limited. The objective of the present study is to evaluate the clinical utility and safety of a model-based patient-tailored dose of vanco...
Article
Background Cefotaxime is one of the most frequently prescribed antibiotics for the treatment of Gram-negative bacterial sepsis in neonates. However, the dosing regi-mens routinely used in clinical practice vary considerably. The objective of the present study was to conduct a population pharmacokinetic study of cefotaxime in neonates and young infa...
Chapter
Les infections à Candida sont les plus fréquentes des infections fongiques en période néonatale. Comme les infections bactériennes, elles sont séparées en infections materno-fœtales (IMF) précoces et en infections tardives, primitives ou nosocomiales. L’incidence des IMF à Candida est, en France, inférieure à 1 %. Leur diagnostic n’est qu’inconstam...
Chapter
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The mechanisms for acquiring nosocomial infections are identical in newborn to those described in the adult population. Nosocomial infections are particularly common in premature infants who combine many risk factors : immature immune system, low level of antibodies against several pathogens, parenteral nutrition through central catheter, exposure...
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The feasibility and reproducibility of liver stiffness measurements using Supersonic Shear-wave Imaging (SSI) in preterm neonate have not been reported. Our aim was to determine if liver stiffness differs between intra-uterine growth restriction (IUGR) and appropriate for gestational age (AGA) preterm infants with/without cholestasis. We measured l...
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Previous studies have shown that preterm children are at a higher risk for cognitive and language delays than full-term children. Most of these studies have concentrated on the effects of prematurity during the preschool or school years, while the effect of preterm birth on the early development of language, much of which occurs during the first ye...
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Full-text available
While the incidence of diabetes mellitus (DM) during pregnancy has been steadily increasing in recent years, the link between gestational DM and respiratory outcome in neonates has not been definitely established. We asked the question whether DM status and its treatment during pregnancy could influence the risk of neonatal respiratory distress. We...
Article
Full-text available
Background: We aimed to describe features of Escherichia coli meningitis in a large population of children and the molecular characteristics of the involved strains to determine factors associated with severe disease or death. Methods: Between 2001 and 2013, a prospective national survey collected data for 325 children hospitalized with E. coli...
Article
Full-text available
Ultrafast ultrasonic imaging is a rapidly developing field based on the unfocused transmission of plane or diverging ultrasound waves. This recent approach to ultrasound imaging leads to a large increase in raw ultrasound data available per acquisition. Bigger synchronous ultrasound imaging datasets can be exploited in order to strongly improve the...
Article
Résumé Les infections néonatales précoces (INP) nécessitent une stratégie diagnostique et thérapeutique optimale en raison du taux élevé de mortalité, en particulier chez le prématuré et du risque de complications majeures notamment neurologiques. Le diagnostic précoce des INP est difficile du fait de signes cliniques non spécifiques chez le nouvea...