Valerie Attali

Valerie Attali
Assistance Publique – Hôpitaux de Paris | AP-HP

MD PhD

About

128
Publications
11,862
Reads
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1,867
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Introduction
Valerie Attali currently works at Service des Pathologies du Sommeil, Département R3S, Hôpital Pitié-Salpêtrière, AP-HP. Sorbonne Université, 75013 Paris, France AND Sorbonne Université, Inserm, UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique, 75005 Paris, France. Valerie does research in Sleep Medicine and Respiratory Medicine. Their current project is "Respiration and Posture"
Additional affiliations
September 2020 - present
French Institute of Health and Medical Research
Position
  • Researcher
November 2015 - present
Ecole Nationale Supérieure d'Arts et Métiers
Position
  • MD PhD
Description
  • poste d'accueil APHP/Arts et métiers paristech
September 2009 - present
Hôpital La Pitié Salpêtrière (Groupe Hospitalier "La Pitié Salpêtrière - Charles Foix")
Position
  • MD PhD
Education
December 2018 - December 2018
Sorbonne Université
Field of study
September 2015 - September 2015
Sorbonne Université
Field of study
  • Physiologie physiopathologie et thérapeutique
January 1996 - July 1996
Paris Descartes, CPSC
Field of study

Publications

Publications (128)
Article
Full-text available
Introduction This study analyzes anatomical variations of the thoracic cage (TC) according to spinopelvic alignment, age and gender using stereoradiography in erect position. Methods This retrospective multicentric study analyzed computed parameters collected from free-standing position bi-planar radiographs, among healthy subjects. Collected data...
Article
Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive diaphragm weakness and deteriorating lung function. Bulbar involvement and cough weakness contribute to respiratory morbidity and mortality. ALS-related respiratory failure significantly affects quality of life and is the leading cause of de...
Article
Pathologies of the respiratory system can by accompanied by alterations of the biomechanical function of the rib cage, as well as of its morphology and movement. The assessment of such pathologies could benefit from rib cage kinematic analysis during breathing, but this analysis is challenging because of the difficulties in observing and quantifyin...
Article
Full-text available
(1) Background: osteopathic manipulation of the sphenopalatine ganglia (SPG) blocks the action of postganglionic sensory fibres. This neuromodulation can reduce nasal obstruction and enhance upper airway stability. We investigated the manipulation of the SPG in 31 patients with obstructive sleep apnoea syndrome (OSAS); (2) Methods: Randomised, cont...
Article
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Background: The biplanar 2D/3D X-ray technology (BPXR) is a 2D/3D imaging system allowing simultaneous stereo-corresponding posteroanterior (PA) and lateral 2D views of the whole body. The aim of our study was to assess the feasibility of cephalometric analysis based on the BPXR lateral skull view to accurately characterize facial morphology. Met...
Article
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Rationale Adaptive servo ventilation (ASV) is contraindicated in patients with systolic heart failure (HF) who have a left ventricular ejection fraction (LVEF) below 45% and predominant central sleep apnoea (CSA). However, the effects of ASV in other HF subgroups have not been clearly defined. Objective The European, multicentre, prospective, obse...
Article
Maxillomandibular deformity (MMD) and body posture appear to be correlated. However, no systematic literature review of the available evidence to support this correlation has been performed to date. The aim of this study was to conduct a systematic literature review on posture and MMD. This systematic literature review was registered in the PROSPER...
Article
Study objectives: Mandibular advancement devices (MADs) are an alternative to continuous positive airway pressure (CPAP) for the management of obstructive sleep apnea (OSA). The ORCADES study is investigating the long-term effectiveness of MAD therapy in OSA patients who refused or were intolerant with CPAP. Five-year follow-up data are presented....
Article
Objectif Étude sur 1 an, évaluant efficacité sur Somnolence Diurne Excessive résiduelle (SDEr) et tolérance de Pitolisant (P), agent éveillant agoniste inverse des récepteurs H3 (histamine) versus placebo (pl) chez des patients avec syndrome d’apnées obstructives du sommeil (SAOS) observant sous PPC. Méthodes 2 parties : Double aveugle (DA) 12 sem...
Article
Objectif Pitolisant (P), agent éveillant agoniste inverse des récepteurs H3 (histamine) est un traitement de la somnolence diurne excessive (SDE) de la narcolepsie. La synthèse de son efficacité, sa tolérance à 20 mg versus placebo (pl) est démontrée via une méta-analyse des données individuelles patient à partir de 2 études chez des patients souff...
Article
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There are only few data concerning persistence of neutralizing antibodies (NAbs) among SARS-CoV-2-infected healthcare workers (HCW). These individuals are particularly exposed to SARS-CoV-2 infection and at potential risk of reinfection. We followed 26 HCW with mild COVID-19 three weeks (D21), two months (M2) and three months (M3) after the onset o...
Article
Introduction Les patients avec Syndrome d’Apnées Obstructives du Sommeil (SAOS) peuvent présenter une Somnolence Diurne Excessive résiduelle (SDEr) malgré un traitement par Pression Positive Continue (PPC) bien conduit. Le pitolisant (P), un agent éveillant agoniste inverse sélectif des récepteurs H3 (histamine) est évalué dans ce contexte. L’étude...
Article
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The objective of this study was to test the capacity of vibrotactile stimulation transmitted to the wrist bones by a vibrating wristband to awaken healthy individuals and patients requiring home mechanical ventilation during sleep. Healthy subjects (n = 20) and patients with central hypoventilation (CH) (Congenital Central Hypoventilation syndrome...
Article
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Background Excessive daytime sleepiness (EDS) in individuals with obstructive sleep apnea syndrome persisting despite good adherence to continuous positive airway pressure (CPAP) is a disabling condition. Pitolisant is a selective histamine H3-receptor antagonist with wake-promoting effects. Research Question Is pitolisant efficacious and safe in...
Article
Aim: Periodic breathing is frequent in patients with severe heart failure. Apart from being an indicator of severity, periodic breathing has its own deleterious consequences (sleep-related oxygen desaturations, sleep fragmentation), which justifies attempts to correct it irrespective of the underlying disease. Animal models and human data suggest...
Article
Introduction Hypoglossal Nerve Stimulation (HGNS) decreases obstructive sleep apnea (OSA) severity by contracting the tongue and decreasing upper airway collapsibility. This study assessed the safety and effectiveness of a new implantable device that delivers bilateral HGNS: the Genio™ system. Methods The BLAST OSA study (BiLAteral Hypoglossal Ner...
Article
Full-text available
PurposeIn healthy humans, postural and respiratory dynamics are intimately linked and a breathing-related postural perturbation is evident in joint kinematics. A cognitive dual-task paradigm that is known to induce both postural and ventilatory disturbances can be used to modulate this multijoint posturo-ventilatory (PV) interaction, particularly i...
Article
Objectif Évaluer l’innocuité et l’efficacité, à 6 mois post implantation, d’un nouveau dispositif implantable (Genio®, NYXOAH S.A.) délivrant une stimulation bilatérale du XII pour le traitement du SAHOS modéré à sévère. Méthodes Étude prospective, ouverte, multicentrique (8 centres, Australie, France et Royaume-Uni) chez des patients avec un IAH...
Article
Objectif ORCADES est une cohorte prospective multicentrique qui évalue en vie réelle les bénéfices à long terme (5 ans) d’une orthèse d’avancée mandibulaire (OAM) sur mesure (ResMed, Narval™) chez des patients SAHOS légers à sévères, refusant ou étant intolérant à la pression positive continue (PPC). Méthodes 331 pts SAHOS traités avec une OAM ont...
Article
Background and objective: Average volume-assured pressure support-automated expiratory positive airway pressure (AVAPS-AE) combines an automated positive expiratory pressure to maintain upper airway patency to an automated pressure support with a targeted tidal volume. The aim of this study was to compare the effects of 2-month AVAPS-AE ventilatio...
Article
Full-text available
Obstructive sleep apnea syndrome (OSAS) is associated with postural dysfunction characterized by abnormal spinal curvature and disturbance of balance and walking, whose pathophysiology is poorly understood. We hypothesized that it may be the result of a pathological interaction between postural and ventilatory functions. Twelve patients with OSAS (...
Article
Full-text available
Background: Excessive daytime sleepiness is a common disabling symptom in obstructive sleep apnea syndrome. We aimed to evaluate the efficacy and safety of pitolisant, a selective histamine H3-receptor antagonist with wake-promoting effects, for treatment of daytime sleepiness in patients with moderate to severe obstructive sleep apnea refusing co...
Article
New finding: What is the central question of this study? The transition to the supine posture induces an inspiratory load associated with cortical activation in awake healthy subjects. Some OSA patients exhibit this cortical activity in the sitting position contributing to the arousal-dependent compensation of their upper airway abnormalities. Doe...
Article
Full-text available
Background and Aim Hypoglossal Nerve Stimulation (HNS) decreases Obstructive Sleep Apnea (OSA) severity via genioglossus muscle activation and decreased upper airway collapsibility. This study assessed the safety and effectiveness at 6 months post-implantation of a novel device delivering bilateral HNS via a small implanted electrode activated by a...
Article
Full-text available
Purpose Mandibular repositioning devices (MRDs) are an effective treatment option for obstructive sleep apnea syndrome (OSAS), particularly in patients who refuse or cannot tolerate continuous positive airway pressure (CPAP). However, sex differences in the response to therapy and predictors of response are not clearly defined. This analysis of dat...
Article
Full-text available
Objective/background: Mandibular repositioning device (MRD) therapy is an alternative to continuous positive airway pressure (CPAP). The Orkney Complex Disease Study-ORCADES study is assessing the long-term efficacy and tolerability of MRD therapy in obstructive sleep apnoea syndrome (OSAS); two-year follow-up data are presented. Patients/methods...
Article
Full-text available
The maintenance of upright balance in healthy humans requires the preservation of a horizontal gaze, best achieved through dynamical adjustments of spinal curvatures and a pelvic tilt that keeps the head-to-pelvis alignment close to vertical. It is currently unknown whether the spinal and pelvic compensations of respiratory-related postural perturb...
Article
New findings: What is the central question of this study? Moving to supine induces upper airway modifications and fluid shift to the neck, which represent inspiratory load that predisposes to upper airway collapse. Is there cortical participation in the response to the load induced by moving to supine in awake healthy subjects? What is the main fi...
Article
Full-text available
Obstructive sleep apnoea syndrome (OSAS) patients do not report breathing discomfort in spite of abnormal upper airway mechanics. We studied respiratory sensations in OSAS patients without and with mandibular advancement device (MAD). Fifty-seven moderate to severe non obese OSAS patients were asked about breathing discomfort using visual analogue...
Article
Introduction: Continuous positive airways pressure, generally used to treat obstructive sleep apnea-hypopnea syndrome (OSAHS), is not tolerated well by many patients. An alternative is to treat OSAHS with mandibular advancement devices (MAD). This research assesses the long term (> 2 years) effectiveness and the side effects on dental and skeletal...
Article
Objectif ORCADES est une étude multicentrique prospective évaluant les bénéfices à long terme d’une OAM sur mesure chez les patients SAOS en échec de PPC ou ayant refusé le traitement. Les déplacements dentaires dans un sous-groupe de patients ont été étudiés grâce une méthode d’analyse 3D. Méthodes Soixante et un pts SAOS traités par OAM (NARVAL,...
Article
Objectif Nous avons fait l’hypothèse qu’il existait une dysfonction posturale d’origine centrale dans le syndrome d’apnées obstructives du sommeil (SAOS). Méthodes Une stabilométrie couplée à la ventilation a été réalisée, yeux ouverts (YO), yeux fermés (YF), en double tâche (DT) chez 8 patients SAOS (53 ans [42 ; 63] ; IMC 28,3 kg/m² [24,2 ; 34,1...
Article
Full-text available
Background: Osteopathic manipulative treatment (OMT) of the sphenopalatine ganglion (SPG) is used empirically for the treatment of rhinitis and snoring and is thought to increase pharyngeal stability. This trial was designed to study the effects of this treatment on pharyngeal stability evaluated by critical closing pressure in obstructive sleep a...
Article
Full-text available
Background The purpose of this study was to describe the sleep structure (especially slow wave sleep) in adults with congenital central hypoventilation syndrome (CCHS), a rare genetic disease due to mutations in the PHOX2B gene. Fourteen patients aged 23 (19.0; 24.8) years old (median [1rst-3rd quartiles]) with CCHS underwent a sleep interview and...
Article
Study Objectives Excessive sleepiness is a common symptom in Prader–Willi syndrome (PWS), and it negatively impacts the quality of life. Obstructive sleep apnea and narcolepsy phenotypes have been reported in PWS. We characterized sleep disorders in a large cohort of adults with PWS. Methods All consecutive patients with genetically confirmed PWS...
Article
Objectif Nous avons evalue le caractere predictif du niveau de variabilite de la pression (Pvar) et de la pression efficace (Peff) sur l’efficacite du mode constant ou autopilote de la PPC dans le traitement du Syndrome d’apnees hypopnees obstructives (SAHOS). Methodes Dans le cadre d’une etude nationale, prospective, randomisee, multicentrique, (P...
Article
Full-text available
Objectif ORCADES est une etude de cohorte prospective multicentrique qui evalue en vie reelle les benefices a long terme (5 ans) d’une OAM sur mesure chez les patients ayant un SAHOS refusant ou intolerant a la Pression Positive Continue (PPC). Methodes 315 pts SAHOS traites avec une orthese CAD/CAM (ResMed, Narval CC™) ont ete evalues a 2 ans de s...
Article
Introduction Afin d’optimiser l’efficacite du traitement par pression positive continue (PPC) du syndrome d’apnees hypopnees obstructives (SAHOS), nous avons evalue le caractere predictif du niveau de variabilite de la pression (Pvar) et de la pression efficace (Peff) sur l’efficacite du mode constant ou autopilote de la PPC. Methodes Dans le cadre...
Article
Introduction ORCADES est une etude de cohorte nationale prospective multicentrique qui evalue en vie reelle les benefices a long terme (5 ans) d’une OAM sur mesure CAD/CAM chez les patients ayant un SAHOS refusant ou intolerant a la pression positive continue (PPC). Methodes Au total, 315 patients SAHOS traites avec une orthese CAD/CAM (ResMed, Nar...