Valeria P. Novikova

Valeria P. Novikova
Saint Petersburg State Pediatric Medical Academy · Department of Pediatrics

Doctor of Medicine

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75
Publications
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72
Citations

Publications

Publications (75)
Article
The clinical guidelines for the diagnosis and treatment of the3 functional disorders of the digestive system in children were prepared by a Group of Experts, domestic leading specialists in the field of the pediatric gastroenterology, who generalized the foreign guidelines and domestic experience, suggesting the tactics for the pediatrician actions...
Article
Objective. To analyze clinical and laboratory parameters, as well as the dynamics of cytokine production in children of different ages with acute infectious mononucleosis caused by Epstein-Barr virus (EBV mononucleosis). Patients and methods. We examined two groups of patients: group I included 20 children aged 1 to 7 years, whereas group II includ...
Article
Aim : to compare physical development in children with celiac disease (CD), depending on adherence to a gluten-free diet (GFD), and in children without CD. Materials and methods : 176 children with gastrointestinal disease were examined. Group 1 consisted of 58 children with newly diagnosed CD and chronic gastritis (CG), before the appointment of a...
Article
Congenital sodium diarrhea (P78.3 according to ICD 10) is a rare autosomal recessive disease, clinically and genetically heterogeneous. The sodium absorption defect is caused by disruption of the intestinal sodium-proton pump in the non-syndromic form and in the epithelial sodium channels in the syndromic form. Mutations in 3 genes,SPINT2(localizat...
Article
The key to shaping the health of the future generation are the start timing of breastfeeding. In a single-center observational study in the Department of physiology of the newborn Perinatal Center, the nature of breastfeeding and problems in breast-feeding in mothers of healthy newborns in the first days after birth were evaluated. An analysis of t...
Article
Today, the microbiota is recognized as a new «extracorporeal body» maintaining homeostasis of our body. The value of some microorganisms has already been determined, but the role of most of them is not yet clear. The researchers believe that 81- 99% of all microorganisms in healthy adults have been already identified. The mechanism of interaction o...
Article
Full-text available
A group of experts, leading specialists in the field of pediatric gastroenterology have prepared clinical recommendations for the diagnosis and treatment of functional digestive disorders in children; they have summarized the international recommendations and domestic experience, suggesting the tactics of in everyday pediatrician’s practice. The se...
Article
Full-text available
A group of leading experts in the field of pediatric gastroenterology prepared clinical recommendations for the diagnosis and treatment of functional digestive disorders (FDD) in children; they have summarized international recommendations and domestic experience and suggested the tactics for a pediatrician in everyday practice. The first part of t...
Article
Full-text available
With oral intake, iron absorption in patients with celiac disease (CD) is reduced due to the decreased absorption surface of the atrophic small intestine mucous membrane. Besides, there are additional risk factors for anemia whose mechanisms are unclear.The aimof this study was to evaluate gastrointestinal risk factors for anemia in children. Mater...
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Mortality due to cancer of the rectal colon is currently increasing in all groups of the adult population. Various screening methods are used to identify the pre-tumor and early stages of the development of tumor pathology of the colon: occult blood tests in feces, computer colonography (virtual colonoscopy), colonoscopy, DNA testing, tumor marker...
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The diagnoses «functional nausea» and «functional vomiting» were for the first time described in the structure of paediatric functional digestive disorders in the 2016 Rome IV criteria. The prevalence of functional nausea approximates 0.1–0.5%, functional vomiting – 0.6–1.4%. Functional nausea and vomiting arise from complex interactions between th...
Article
The review is devoted to the study of the effects of leptin, as one of the most important hormones that regulate the body's vital processes. His participation in the regulation of carbohydrate metabolism and insulin levels in the blood was revealed; maintaining vascular tone; the formation of eating behavior (including newborns); sexual development...
Article
Study objective. To investigate the etiology of chronic gastritis in children with various forms of coeliac disease. Patients and methods. 176 children with various forms of coeliac disease and morphologically verified chronic gastritis (CG) were examined. The first group consisted of 58 children with CG and newly diagnosed CD who did not adhere to...
Article
Objective. To evaluate the efficacy of Zosterin-Ultra enterosorbent in comprehensive treatment of children with lambliasis. Patients and methods. This study included 60 children with lambliasis aged between 3 and 17 years. Patients were divided into 3 groups depending on their therapy. Group 1 included 20 children who received Zosterin-Ultra-30% pl...
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Insulin-like growth factor is one of the regulators of fetal growth in the intrauterine period, and is responsible for its further development. Purpose. To study postnatal growth in relation to insulin-like growth factor-1 and somatotropic hormonelevels in infants born to obese mothers. Materials and methods. The prospective study included 18 child...
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Adipose tissue is now recognized as an important endocrine organ that secretes numerous protein hormones, including leptin, adiponectin, and resistin. Adiponectin is a hormone that is produced by white adipose tissue. Adiponectin has been isolated independently by several groups of scientists. In humans, this protein is encoded by the ADIPOQ gene....
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One of non-IgE-mediated disorders that pediatricians and allergologists have to deal with is food protein-induced enterocolitis syndrome (Food Protein Induced Enterocolitis Syndrome, FPIES). Cow milk and soy proteins are the most common cause of FPIES. Other foods that can cause FPIES include a wide range of solid food stuffs, such as grains, veget...
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Anthropometric evaluation is an essential feature of pediatric evaluation. Different countries use different approaches in pediatric growth assessment. The article presents a comparative analysis of the body length (BL) indicators of modern school-age children in St. Petersburg with regional standards (1991) and international standards (WHO Growth...
Conference Paper
Full-text available
Introduction Cow’s milk protein allergy (CMPA) is one of the causes of secondary lactose intolerance (SLI) in infants. The aim To determine the possibility of faecal tests: calprotectin, ECP and hidden blood in the stool for the diagnosis of gastrointestinal manifestations of CMPA in infants with SLI. Patients and methods 30 children, aged from 1...
Conference Paper
Introduction Modern epidemiologic data reveal that the prevalence of celiac disease (CD) is approximately 1% in Europe population. Statistics varies considerably in different countries. The latest Russian clinical recommendations ‘Celiac disease in children’ published in 2016, suggest the screening for CD only among children with type 1 diabetes me...
Conference Paper
Introduction The Epstein-Barr virus has been recently considered as an etiological cause of chronic gastritis. Objectives To study the relationship between the morphological features of chronic gastritis and Epstein-Barr virus infection. Methods 50 children (mean age 12.4 ± 0.3 years) with morphologically verified chronic gastritis were examined....
Conference Paper
Introduction IgE-mediated as well as non-IgE-mediated inflammation to the mucous membranes of the gastrointestinal tract is possible in children with allergic diseases. Purpose of the study: We investigated the morphological features of chronic esophagitis in children with atopic dermatitis (AtD) and bronchial asthma (BA) taking in account the cyto...
Conference Paper
Introduction The upward steady trend in the prevalence of obesity in the pediatric population during the last decades is a significant medical and social problem. Objectives To study the prevalence of obesity among schoolchildren in St. Petersburg. Methods Totally 6449 schoolchildren aged 6–17 years old had been enrolled in the cross-sectional st...
Conference Paper
Introduction Chronic gastroduodenitis in adolescents is often accompanied by a decrease in bone density. The mechanisms of this relationship are not fully understood. Objective To study the level of 25 (OH)-vitamin D, vitamin D receptor gene polymorphisms and bone metabolism in adolescents with chronic gastroduodenitis in dependency of helicobacte...
Conference Paper
Introduction Increased level of angiogenic and adhesion molecules released from adipose tissue in pregnant women with obesity may affect the process of angiogenesis, metabolic state and inflammatory potential in both mother and her offspring. Objectives To determine the effect of maternal obesity on the level of sVCAM-1 and VEGF-A in mothers and t...
Conference Paper
Introduction Obesity in adolescents is associated with the development of metabolic disorders, chronic inflammation and endothelial dysfunction. Objectives To determine the peculiarities of metabolic status and presence of markers of endothelial cell dysfunction sVCAM-1 and VEGF-A in adolescents with obesity. Methods We examined 44 young people:...
Conference Paper
Introduction Infants with at least one biological parent who has allergic conditions are at risk for developing allergic disease. Caesarean born infants have a more slowly diversifying microbiota, with differences reported from normally born infants.This, in turn, can affect immunophysiological development with a heightened allergic disease risk. T...
Article
Objective: to assess the efficacy of liquid lactase for the treatment of secondary lactase deficiency (LD) in infants with cow's milk protein intolerance (CMPI). Patients and methods. We examined 30 breastfed and mixed-fed infants with LD and CMPI. The diagnosis of LD was confirmed by the assessment of stool osmotic gap (SOG). The mean fecal calpro...
Article
Full-text available
The aim of this study was to observe the features of chronic gastritis in children with celiac disease (СD). Materials and methods. 176 children with chronic gastritis (CG) aged from 3 to 16 years were examined. Group I consisted 58 child ren with CG and newly diagnosed CD not adherent to the gluten-free diet (GFD), group II consisted 49 children w...
Article
Full-text available
Comorbid pathology is one of the factors that adversely affect the course and prognosis of the underlying disease. Objective of the research - to identify the pathogenetic peculiarities of chronic gastroduodenitis (CGD) course in adolescents depending on the number of associated diseases (comorbidity index - CI). Materials and methods: 340 children...
Article
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Dysplasia of the main veins (DMV) is known by the names of authors had described this pathology as the Klippel-Trenone syndrome (KTS). Many authors consider the cause of the syndrome to be the impact of various teratogenic factors. These include drugs, infectious agents, radiation exposure, domestic and occupational hazards. Teratogenic factors can...
Article
The article presents the second part of the literature review of the evolutional aspects of neonatal gastroenterology dealing with the evolutional interrelationship between the development of the digestive system and the formation of the gut microbiome. General regularities of the formation of the gut microbiome are discussed including stage-by-sta...
Article
Taking into account social significance of reproductive health of young people, special attention is paid to the impact of coeliac disease on fertility of patients. Literature data are presented dealing with the effect of coeliac disease on male reproductive function. Its decrease is accounted for by tissue resistance to circulating plasma testoste...
Article
Objective: To study specificities of the spectrum of sensitisation in children suffering from moderate bronchial asthma. Patients and methods. The examination included 126 children aged 1 to 12 years, the levels of total IgE and allergen-specific sIgE to five groups of allegerne were tested: food, household, epidermal, pollen, fungal. Results: As h...
Article
Birth is the most important period in the development and formation of a child’s microbiota, since exposure to maternal bacteria (intestinal, skin, cervical canal, mouth cavity, uterus, amniotic fluid, etc.) during natural birth determines the creation of stable flora of the intestines, skin, respiratory and urogenital tract of the newborn child, t...
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Full-text available
Coeliac disease is one of the most common autoimmune diseases. This article highlights modern extra-laboratory rapid tests for diagnosing coeliac disease. Tests for determination of the antibody spectrum are discussed: to deamidated gliadin peptides, tissue transglutaminase and the endomysium. Summarised data of meta-analyses of screening tests are...
Article
Objective. To study morphological, morphometric and immunohistochemical features of the duodenal mucosa in children with atopic dermatitis (ATD).Patients and methods. 41 children with atopy aged 6 to 17 years with chronic gastroduodenitis (CGD) were examined. The main group consisted of 18 children suffering from ATD and CGD, the comparison group i...
Conference Paper
Introduction Obesity is common metabolic disorder in children, but little information is available about quality of life (QoL) and other aspects of their well being in overweight compare with obese children. Aims To study quality of life and range of psychological parameters in overweight and obese children. Methods For this purpose we assessed Q...
Conference Paper
Aim To evaluate the prevalence of autoimmune gastritis in children with celiac disease, according to enzyme-linked immunosorbent assay (ELISA) and indirect immunofluorescence reaction (IIFR). Methods 155 children of both sexes at the age of 3 to 17 years were examined. The study involved 78 children with different clinical forms of celiac disease...
Conference Paper
The aim of the research was the study of peculiarities of formation of atopic Phenotype in children the first months of life, babies born to mothers suffering bronchial asthma. Examined 56 pairs of mother-child (boys-44.6%, girls-55.4%). all children born from a single fetation, urgent delivery (96.5%) in satisfactory condition (98.3%), with the av...
Article
Environmental pollution occurring in many regions of Russia through impact of eco-pollutants on a child's respiratory tract results in the change of the trace element composition of the body due to accumulation of salts of heavy metals, which might be not only factors of BA development but also trigger exacerbation of disease or compromise its cour...
Article
The objective. To study the trace element status in children with chronic gastroduodenitis at different phases of disease and its interrelations with specific states of other homeostatic systems of the body. Patients and methods. The article evaluates the trace element homeostasis, parameters of oxidant and antioxidant status, intestinal microbiota...
Article
The objective. To determine the levels of 25-OH-Vitamin D (25(OH)D) in blood serum of children with chronic gastroduodenitis and its interrelation with inflammatory and dystrophic changes of the gastric and duodenal mucosa. Patients and methods. In 20 children aged 16.05 ± 1.6 years with chronic gastroduodenitis and 20 healthy children aged 15.85 ±...
Article
The article reviews literature dealing with specificities of intrauterine and extrauterine formation of the digestive system. Characteristics of the main stages of ontogenesis and directions of the evolution of the gastrointestinal tract are given as well as factors determining realization of the genetic programme of the growth and differentiation...
Article
The objective. To study the trace element status of children with moderate bronchial asthma living in St.Petersburg and to assess the detoxification effect of the drug «Zosterin-ultra-60». Patients and methods. We examined 32 children (age - 10.12 ± 3.79 years), suffering from moderate bronchial asthma (BA); all were in the state of drug-induced re...
Article
Changes in mental and emotional status such as subdepression and increased anxiety, both reactive and personal, are characteristic of adolescent children with chronic gastroduodenitis. These changes cannot be resolved with the traditional therapy of chronic gastroduodenitis and are maintained during remission, thereby worsening the quality of life,...
Article
Atopic dermatitis (AD) is a multifactorial disease. The implementation of blood pressure plays an important role genetic determinism, which leads to disruption of the skin barrier, defects of the immune system (stimulation of Th2-cells with subsequent overproduction of IgE), hypersensitivity to allergens and nonspecific stimuli, the colonization of...
Article
The objective. Determination of the incidence of bacterial overgrowth syndrome (BOS) diagnosed with the use of lactulose breath test in children with functional dyspepsia (FD) and chronic gastroduodenitis (CGD). Patients and methods. We examined 78 children aged 5 to 14 years. The first group included 50 patients with FD; the control group - 28 chi...
Article
To detect the clinical diagnostic criteria for non-invasive diagnosis of erosive gastritis in children with juvenile arthritis have been studied the 92 children aged 9 to 16 years (mean age-13,9 ± 2,3 years) with verified diagnosis of juvenile arthritis, of whom 10 had erosive gastritis (group 1) and 82 without erosions (group 2). A comparison of t...
Article
Using gas chromatography-mass spectrometer for studying and evaluating the intestinal microflora in humans with chronic gastroduodenitis compared to traditional methods of diagnosis and microbiological analysis can significantly extend the range of the defined microbiota and its possible changes at different phases of the disease, thus enabling suc...
Article
To examine the state of the biliary system, a study of properties of bile "case-control") 100 children and adolescents aged 8 to 18 years, held checkup in consultative and diagnostic center for chronic gastroduodenitis. BMI children were divided into 2 groups: group 1-60 children with obesity (BMI of 30 to 40) and group 2-40 children with normal an...
Article
Objectives: This study aimed to assess frequency of association between hepatic steatosis and pancreatic steatosis in obese children and find out common chains of pathogenesis. Methods: This study was conducted among 100 children aged 12-17 years, consisted 2 groups: 60 overweight children (BMI from 30,1 to 42,87-1st group) and 40 children with...
Article
The survey results are presented concerning 340 children with Chronic Gastroduodenitis (CGD) at the age of 13-15 years. It was revealed that a higher level of H. pylori infection corresponded to large values of Comorbidity Index (CI), the activity of lipid peroxidation processes and a more severe lymphoplasmacytic infiltration in the fundal and ant...
Article
According to the World Health Organization, it is recorded steady growth of the number of chronic liver diseases, including nonalcoholic fatty liver disease (NAFLD), in recent years. As an independent nosological entity, NAFLD is one of the risk factors for cardiovascular diseases, associated with abdominal-visceral obesity, peripheral insulin resi...
Article
Objective: Despite well-known evidence of association of caries with bone metabolic diseases, there are only a small number of studies about caries and bone mineral density (BMD) on pediatric population. We evaluated the possibility of bone mineralization and metabolism disturbances in children with caries and compared them with healthy individual...
Article
According to recommendations of the European Health Committee, noninvasive methods should be preferred for diagnosis of Helicobacter pylori (HP) infection in children. Equipment and reagents for respiration diagnostic tests available from foreign manufacturers have rather high cost, which hinders their use in domestic medical institutions. A new no...
Article
We examined 50 children at the age of 4-17 suffering from chronic gastritis. AntiH+/K+-ATPhase antibodies of gastric parietal cells, anti-EBV antibodies IgG EA and IgM VCA were determined with the help of immune-enzyme analysis methods. The first group comprised 28 children with a high level of antiparietal antibodies in the blood serum, and 22 chi...
Article
54 children at the age of 3-15 suffering from HP-associated CG were examined. Antibodies to H+/K(+)-ATPase of gastric parietal cells were determined with the help of the immune-enzyme analysis method. It was discovered that antibodies to H+/K(+)-ATPase are found in 27.7% of children. Concomitant autoimmune diseases, pangastritis, morphologic sympto...
Article
We examined: 1 group--16 children with chronic gastritis (CG) and autoimmune thyroiditis (AT); 2 group--41 children with functional thyroidal pathologies; 3 group--23 children with CG only. The average age in all groups was 11.17 +/- 2.98. HP (68%) was revealed equally frequently in all the groups. Antibodies to H+/K(+)-ATPase of parietal cells wer...

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