Valeria Caponnetto

University of L'Aquila | Università dell'Aquila · Department of Biotechnological and Applied Clinical Sciences

Rising costs and demands for improved quality of care present complex challenges for existing healthcare systems. The strain on healthcare resources is exacerbated by the increasing complexity of patient conditions. The Diagnosis-Related Group (DRG) system classifies inpatients according to clinical and treatment criteria, controls healthcare expen...

Background: The term 'Missed Nursing Care' (MNC) refers to any aspect of nursing care that is not delivered, partially delivered, or delayed. MNC has significant negative consequences, including adverse patient outcomes, safety risks, and decreased job satisfaction. While extensively studied in hospitals, MNC in community healthcare settings, rema...

Background Resistant and refractory migraine are commonly encountered in specialized headache centers. Several comorbidities, mostly psychiatric conditions, have been linked to migraine worsening; however, there is little knowledge of the comorbidity profile of individuals with resistant and refractory migraine. Methods REFINE is a prospective obs...

Background/Objectives: The limited and inconsistent adoption and regulation of nurse-led clinics (NLCs) and “See & Treat” (S&T) services in Italy needs to be explored considering their value towards patients’ outcomes acknowledged in the literature. This study aims to explore the phenomenon of hidden nursing activities (HNAs) in these settings, hyp...

Background Migraine with aura (MwA) is a debilitating disorder characterized by paroxysmal attacks of pain preceded or accompanied by reversible neurological symptoms. While the pathophysiology remains unclear, trigeminovascular system activation and cortical spreading depression have been implicated. This study aims to comprehensively investigate...

Background and aim Migraine is a common disabling conditions which, globally, affects 15.2% of the population. It is the second cause of health loss in terms of years lived with disability, the first among women. Despite being so common, it is poorly recognised and too often undertreated. Specialty centres and neurologists with specific expertise o...

Objective To develop and validate a questionnaire to evaluate missed nursing care (MNC) in a home care setting. Design A new instrument was developed and tested performing a preliminary analysis of a multicenter cross‐sectional study in Italy. Reporting was performed according to COnsensus‐based Standards for the selection of health status Measure...

Background To meet the population's needs, community care should be customized and continuous, adequately equipped, and monitored. Introduction Considering their fragmented and heterogeneous nature, a summary of community healthcare services described in European literature is needed. The aim of this study was to summarize their organizational mod...

Background Migraine lacks biomarkers that can trace the biological pathways of the disease and predict the effectiveness of treatments. Monoclonal antibodies targeting calcitonin gene-related peptide pathway – including erenumab – offer the opportunity of investigating potential migraine biomarkers due to their specific mechanism of action in preve...

One of the aims of migraine prevention is to improve response to acute migraine treatments. The aim of the present study was to assess whether monoclonal antibodies targeting the CGRP pathway (CGRP-mAbs) can improve the perceived efficacy of acute treatments. We included and followed up patients with chronic or episodic migraine from the Headache C...

Background: Heart failure (HF) is a cardiac clinical syndrome that involves complex pathological aetiologies. It represents a growing public health issue and affects a significant number of people worldwide. Objectives: To synthesize evidence related to the impact of telemonitoring strategies on mortality and hospital readmissions of heart failure...

Real-world studies on fremanezumab, an anti-calcitonin gene-related peptide monoclonal antibody for migraine prevention, are few and with limited follow-up. We aimed to evaluate the long-term (up to 52 weeks) effectiveness and tolerability of fremanezumab in high-frequency episodic migraine and chronic migraine. This s an independent, prospective,...

High-fidelity simulation (HFS) is a technology-based educational approach performed in a realistic and safe environment. It is a powerful tool for nursing education, especially in critical care. Literature results are heterogeneous but confirm the power of this teaching methodology in improving learning outcomes. However, little is known about the...

Computer-based technologies have been widely used in nursing education, although the best educational modality to improve documentation and nursing diagnostic accuracy using electronic health records is still under investigation. It is important to address this gap and seek an effective way to address increased accuracy around nursing diagnoses ide...

In migraine patients with a poor response to a calcitonin gene-related peptide monoclonal antibody against the receptor, switching to a calcitonin gene-related peptide monoclonal antibodies against the ligand may be beneficial. This was a long-term real-world prospective analysis conducted in treatment-refractory chronic migraine patients coming fr...

Primary headache patients, especially migraineurs, often present psychiatric comorbidities or cognitive impairment. Most frequent psychiatric comorbidities include major depression, anxiety, panic disorder, posttraumatic stress disorder (PTSD), or suicidal behaviour, while most dysfunctional cognitive domains usually are processing speed, memory, e...

The high-fidelity simulation is a teaching method based on the use of technologically enhanced manikins that faithfully reproduce real clinical conditions allowing students to learn by doing clinical activities in a controlled and safe learning environment. Currently, there is evidence that single exposures to high-fidelity simulation can improve t...

Prevention and monitoring are fundamental to improve migraine patterns, though evidence about the effectiveness of educational and e-educational interventions is poor and controversial. We aimed at describing the prototype of a mobile app aimed at educating and monitoring through a diary people with migraine. We considered quality standards describ...

Background: Controlled and real-world evidence have demonstrated the efficacy of calcitonin gene related peptide (CGRP) monoclonal antibodies (MABs) in migraine. However, data on the over-one-year sustained effectiveness of CGRP MABs in resistant chronic migraine (CM) is sparse. METHODS: This is a two-year real-world prospective analysis of an ong...

Objective Cranial autonomic symptoms (CAS), including conjunctival injection, tearing, nasal congestion or rhinorrhea, eyelid edema, miosis or ptosis, and forehead or facial sweating ipsilateral to headache, are often reported by patients with migraine during headache attacks. CAS is a consequence of the activation of the trigeminovascular system,...

Migraine is a complex condition in which genetic predisposition interacts with other biological and environmental factors determining its course. A hyperresponsive brain cortex, peripheral and central alterations in pain processing, and comorbidities play a role from an individual biological standpoint. Besides, dysfunctional psychological mechanis...

Background Migraine is a recurrent headache disorder that has a still unclear pathophysiology, involving several circuits of both the central and peripheral nervous system. Monoclonal antibodies acting on the calcitonin gene-related (CGRP) pathway (CGRP-MAbs) are the first drugs specifically designed for migraine; those drugs act peripherally on th...

Introduction Assessing the impact of migraine preventive treatments on acute medication consumption is important in clinical evaluation. The number of acute medication intakes per each monthly migraine day (MMD) could provide insights on migraine burden and represent a new proxy of treatment effectiveness in clinical trials and real-life studies. W...

Background: The best application modality of high-fidelity simulation in graduate critical care nursing courses is still rarely investigated in nursing research. This is an important issue since advanced nursing skills are necessary to effectively respond to critically ill patients’ care needs. The aim of the study was to examine the influence of a...

Current research experiences provide promising evidence about the positive impact of robotics in improving students’ learning outcomes. The growing interest in robotics for nursing education led to new evidence. This scoping review aimed to identify available evidence, to examine how research has been conducted, and to explore knowledge gaps in the...

Background Triptans and erenumab are both migraine-specific agents acting on the calcitonin gene-related peptide pathway. Therefore, response to triptans might be associated with response to erenumab. Main body In our study, consecutive patients referring to the Headache Centers of the Abruzzo region from January 2019 to March 2020 and treated wit...

Background New treatments are currently offering new opportunities and challenges in clinical management and research in the migraine field. There is the need of homogenous criteria to identify candidates for treatment escalation as well as of reliable criteria to identify refractoriness to treatment. To overcome those issues, the European Headache...

Background Primary headache disorders are common and burdensome conditions. They are associated to several comorbidities, such as cardiovascular or psychiatric ones, which, in turn, contribute to the global burden of headache. The aim of this study is to provide a comprehensive description of the pooled prevalence of comorbidities of primary headac...

Background Transcranial direct current stimulation (tDCS) could counteract the pathophysiological triggers of migraine attacks by modulating cortical excitability. Several pilot randomized controlled trials (RCTs) assessed the efficacy of tDCS for migraine prevention. We reviewed and summarized the state of the art of tDCS protocols for migraine pr...

Background: Due to coronavirus disease-19 (COVID-19) pandemic, Italian outpatient clinics were suspended in March-April 2020 and subsequently slowed down. Telemedicine was shown to be useful in headache clinics, despite absence of a detailed protocol for its development. Objective: To describe the implementation of a structured telemedicine protoco...

Aim: To assess the efficacy of remote ischemic conditioning (RIC) in patients with ischemic stroke within 9 h of onset, that are not candidates for recanalization therapies. Sample Size Estimates: A sample size of 80 patients (40 in each arm) should yield 80% power to detect a 20% difference in early neurological improvement at 72 h at p = 0.05, tw...

Background In postgraduate intensive care nursing courses, high-fidelity simulation is useful to prepare students to guarantee safe and quality care of critically ill patients. Surprisingly, this issue has not attracted sufficient attention in the literature, and it is not clear whether the linear application of the traditional high-fidelity simula...

Gradual replacement of the mercury thermometers with alternative devices is ongoing around the world in a bid to protect human health and the environment from the adverse effects of mercury. However, to reduce the risks of misdiagnosis, unnecessary treatments, and omission of care in pediatric populations, more evidence on the reliability of altern...

Data were extracted from observational studies describing undergraduate nursing students’ academic outcomes that were included in a systematic review and meta-analysis conducted in 2019 and updated in 2020 about nursing students’ academic outcomes [1]. Data were extracted by two researchers independently through a previously tested electronic sprea...

The study aims were to define the psychometric properties of the Albanian Jefferson Scale of Empathy–Health Professional Students’ version, compare empathy levels among Albanian Health Professional students, and explore any relationship among students’ characteristics and their empathy levels. To achieve these aims, a comparative cross-sectional st...

Migraine course is influenced by female reproductive milestones, including menstruation and perimenopause; menstrual migraine (MM) represents a distinct clinical entity. Increased susceptibility to migraine during menstruation and in perimenopause is probably due to fluctuations in estrogen levels. The present review provides suggestions for the tr...

Background: The restrictions taken to control the rapid spread of COVID-19 resulted in a sudden, unprecedented change in people's lifestyle, leading to negative consequences on general health. This study aimed to estimate the impact of such changes on migraine severity during 2020 March-May lockdown. Methods: Patients affected by migraine with o...

Introduction: OnabotulinumtoxinA (BT-A) is a preventive treatment for chronic migraine (CM), which needs to be administered regularly by a trained clinician every 3 months. The spread of the severe acute respiratory syndrome coronavirus-2 pandemic has forced many patients to momentarily stop the scheduled BT-A injections. The goal of this study was...

Objectives: The study aims to assess the impact of the second COVID-19 pandemic wave on migraine characteristics. Methods: This is an observational cross-sectional study conducted on migraine patients previously interviewed during the first Italian pandemic outbreak. A second structured telephone interview was conducted between 20 November 2020...

High-fidelity simulation provides nursing students with the opportunity to learn and achieve competence in a safe context. The aim of the study was to assess learning outcomes following multiple exposures to high-fidelity simulation sessions. The sample consisted of 18 graduate students enrolled in a critical care nursing course. A four-hour high-f...

Introduction Migraine prevalence is higher in fertile than in postmenopausal women. However, few literature data are available on the prevalence and characteristics of migraine after the menopause and on the effect of hormones in postmenopausal women with migraine. Methods We performed a systematic literature review of studies available on Scopus...

Background: We aimed to assess the differences between menstrual and non-menstrual headache in women with chronic migraine treated with erenumab. Methods: We included fertile women from a single center. Patients were defined as responders to erenumab if reporting a ≥50% decrease in monthly headache days, as compared to pre-treatment for more tha...

Introduction Cervicogenic headache (CGH) is a secondary headache disorder caused by cervical spine or neck soft tissues lesions. Despite few available evidence-based pharmacological treatments are available, greater occipital nerve blocks (GONBs) are considered as therapeutic option. Area covered In June 2020, the authors conducted a systematic re...

Background New treatments are currently offering new opportunities and challenges in clinical management and research in the migraine field. There is the need of homogenous criteria to identify candidates for treatment escalation as well as of reliable criteria to identify refractoriness to treatment. To overcome those issues, the European Headache...

Objectives To synthesize the definitions of nursing students' academic outcomes and provide a quantitative synthesis of their associated and predictive factors. Design Systematic review and meta-analysis. Data sources. Four scientific databases were searched until January 2020. Review methods. Observational studies describing undergraduate nursing...

Background Monoclonal antibodies targeting the calcitonin gene-related peptide, including erenumab, are migraine-specific preventive treatments, whose long-term effectiveness has still to be evaluated in real-life settings. We assessed early outcomes of erenumab discontinuation after a 52-week treatment in patients with a continuous positive respon...

High-Fidelity Simulation (HFS) is a tool used to expand nursing students’ opportunities to care for critically ill patients while also overcoming limitations often faced during clinical placements. HFS provides students with opportunity to interact within a realistic clinical environment with a patient simulator able to reproduce a wide range of cl...

High-fidelity simulation (HFS) is an educational method based on technological mannequins which faithfully reproduces both physiological or physiopathological human body responses to specific clinical conditions and nursing care. When the traditional education is integrated with HFS, improvements in nursing students’ knowledge, performance, self-ef...

Background and aim of the work: In the advanced stages of Parkinson's Disease, patients need complex care and support, especially at home, where they often receive assistance by familial caregivers. However, caregivers may be or feel unable to cope with their role and, despite the needs of caregivers are often assessed in the literature, their opi...

Background: Previous studies during SARS and Ebola pandemics have shown that quarantine is associated with several negative psychological effects, such as post-traumatic stress symptoms, confusion, and anger. These conditions may affect the course of many diseases, including migraine. Although it is possible that the quarantine measures for the cur...

Background. Triptans and erenumab are both migraine-specific agents acting on the calcitonin gene-related peptide pathway. Therefore, response to triptans might be associated with response to erenumab. Main body. In our study, consecutive patients referring to the Headache Centers of the Abruzzo region from January 2019 to March 2020 and treated wi...

A gradual replacement of the mercury thermometers with alternative devices is ongoing around the world as effect of the global strategies to reduce mercury pollution. However, to reduce the risks of misdiagnosis, unnecessary treatments, and omission of care in the pediatric population, more evidence on the reliability and validity of alternative th...

BACKGROUND: Previous studies during SARS and Ebola pandemics have shown that quarantine is associated with several negative psychological effects, such as post-traumatic stress symptoms, confusion and anger. These conditions may affect the course of many diseases, including migraine. Although it is possible that the quarantine measures for the curr...

Background: Most patients treated with erenumab in clinical practice have chronic migraine (CM). We assessed the rate and possible predictors of conversion from CM to episodic migraine (EM) in a real-life study. Main body: We performed a subgroup analysis of patients treated with erenumab from January 2019 to February 2020 in the Abruzzo region,...

Introduction . The treatment of cluster headache (CH) is challenging in view of the few evidence-based treatments. The authors aim to summarize the evidence of efficacy and safety of greater occipital nerve blocks (GONBs) in CH. Areas covered . The authors included papers indexed in PubMed and Web of Science from the beginning of indexing to May 5...

Background Most patients treated with erenumab in clinical practice have chronic migraine (CM). We assessed the rate and possible predictors of conversion from CM to episodic migraine (EM) in a real-life study.Main bodyWe performed a subgroup analysis of patients treated with erenumab from January 2019 to February 2020 in the Abruzzo region, centra...

Background. Most patients treated with erenumab in clinical practice have chronic migraine (CM). We assessed the rate and possible predictors of conversion from CM to episodic migraine (EM) in a real-life study. Main body. We performed a subgroup analysis of patients treated with erenumab from January 2019 to February 2020 in the Abruzzo region, ce...

BACKGROUND Previous studies during the SARS and Ebola pandemics have shown that quarantine is associated with several negative psychological effects. Although it is possible that quarantine for the current COVID-19 pandemic affects migraine burden, no information is currently available on this i AIM: In this study, we aimed: a) to explore the effec...

Background and aim of the work: Structured nursing care planning, patients' satisfaction with care, nurses' job satisfaction, and the characteristics of the work environment may influence each other and impact on the quality of hospital care. This study aimed at investigating the differences in nurses' perception of the work environment and patien...

Background: In daily clinical practice, healthcare workers face end-of-life issues, such as futility, which is generally defined as the provision of treatments that do not produce any meaningful benefit for patients. Study design: To investigate the end-of-life issues according to Italian nurses' and physicians' opinions and to detect any differ...

Migraine, and especially migraine with aura, is associated with an increased risk of stroke and vascular events; however, the reasons for this association are unclear. Several studies evaluated cerebral autoregulation and vasomotor reactivity in patients with migraine compared with non-migraineurs, with conflicting results. Our narrative review aim...

Introduzione: L’emorragia arteriosa è una delle principali cause di morte in ambito civile e militare. Nonostante la pressione manuale diretta del sito emorragico sia ancora lo standard di riferimento per il controllo del sanguinamento, l’applicazione precoce, in ambito extra-ospedaliero di tourniquet si è dimostrata capace di ridurre le mort...

The risk derived by the transmission of biological agents (especially blood-borne pathogens) responsible for infectious diseases in human beings is called biological risk (or hazard). Biological risk is the most diffused occupational hazard in the hospital, and it represents a threat to nursing students particularly. This project aims to provide ev...

High-Fidelity Simulation (HFS) founded on critical care scenarios requires nursing students to perform clinical interventions to effectively face life-threatening conditions. Since little evidence is available on the effectiveness of HFS on knowledge, self-confidence, self-efficacy, performance, and satisfaction of postgraduate nursing students att...

Objective The purpose was to analyse the effectiveness of high-fidelity patient simulation (HFPS) based on life-threatening clinical condition scenarios on undergraduate and postgraduate nursing students’ learning outcomes. Design A systematic review and meta-analysis were conducted based on the Cochrane Handbook for Systematic Reviews of Interven...

High-Fidelity Patient Simulation (HFPS) allows the nursing students’ immersion in a learning environment marked by complexity, dynamism, reality, and safety, connecting theory to practice. The increased use of the HFPS was also sustained by the beneficial impact that HFPS seems to produce on nursing students’ learning outcomes. However, available r...

High-Fidelity Patient Simulation is defined as a replicated clinical experience in a controlled learning environment that closely represents reality. This learning method creates the opportunity for students to gain specific and fundamental clinical skills in a controlled, safe, and forgiving environment. Even though the available evidence shows th...

Chronic diseases are mostly managed by family caregivers that often face the “caregiver burden”. This study aimed to understand whether a multidisciplinary theoretical-practical training course could influence the burden, health literacy and needs of caregivers. Seventy-six familial caregivers were asked to complete the Caregiver Burden Inventory-C...