Valère LounnasEuropean Molecular Biology Laboratory (Heidelberg) · Theoretical study of proteins and their function
Valère Lounnas
Doctor of Philosophy
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19
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Introduction
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Publications
Publications (19)
Despite a peer review process prior to being published in Biomedicine & Pharmacotherapy, Pradelle et al, "Deaths induced by compassionate use of hydroxychloroquine (HCQ) during the first COVID-19 wave: an estimate" is cluttered with several scientific integrity issues, one of them being the lack of validation against real life data. Mathematical mo...
A cohort of 30,423 Covid-19 patients treated between March 2020 and December 2021 at the IHU-Méditerranée Infection in Marseille (France) was retrospectively analyzed in terms of treatment attempted and disease worsening factors to quantify efficacy with respect to the composite endpoint of transfer to intensive care unit or death, within a couple...
A cohort of 30,423 Covid-19 patients treated between March 2020 and December 2021 at the IHU-Méditerranée Infection in Marseille (France) was retrospectively analyzed in terms of treatment attempted and disease worsening factors to quantify vaccination efficacy with respect to the composite endpoint of transfer to intensive care unit or death, with...
CONCLUSIONS
The objective was here to present a genome characteristic that may partly explain the sudden propagation of the monkeypox virus in the form we observe in May 2022 in quite a number of countries.
The role of the peculiar 30-T base long sequence right in the middle of the virus genome is still to be determined.
.The emergence of the Omicron variant of SARS-CoV2 identified first in South Africa was announced with anxiety in media following alarm and concern by many researchers in the scientific community and the WHO has declared it a variant of concern (VOC): “The discovery of a highly mutated coronavirus variant in South Africa has triggered a global scra...
We analyzed 15 genomes and Spikes of the new OMICRON variant, on the one hand 7 from the very first 21K lineage (South Africa, USA, Belgium, Canada), on the other hand 8 from the later second sister-clade 21L (USA , Switzerland, UK).
We applied, at the scale of the whole genome and the spike gene, the biomathematics method of Fibonacci meta-struct...
Summary for the hurried reader : in this part 3 of chapter 8, we have deepened the initial work of Li-Meng Yan to demonstrate that she is indisputably right on two crucial issues that demonstrate the artificiality of SARS-Cov2. Firstly, we show that the three viruses : SARS-Cov2 (human), RaTG13 (bat) and Pan-Cov-GD (Pangolin-Cov-2020), supposedly f...
TO THE EDITOR
We were surprised by the hydroxychloroquine dose chosen in the Randomized Evaluation of Covid-19 Therapy (RECOVERY) trial conducted by Horby et al. (Nov. 19 issue).1 In this trial, patients received a higher dose of hydroxychloroquine (4 g cumulated over the first 3 days) than that administered in the trial conducted by Lagier et al.2...
Several points of concern arise regarding the methodology and the presented results of Discovery, the large French multicenter, randomized, controlled trial which evaluated the efficacy and safety of lopinavir + ritonavir (L/r), lopinavir/ritonavir + Interferon β-1a (L/r + IFN), and hydroxychloroquine (HCQ) in adults hospitalized for COVID-19. Resu...
France Soir has already published two articles on hydoxychloroquine (HCQ) overdosing during the first day of treatment of patients with Covid-19 acute symptoms in the HCQ arm of the Recovery trial (1, 2). In that trial, a loading dose of 2.4 g was administered at day 1, in 4 separate intakes spread over 24h, followed by 800 mg/day the next 9 days....