Valentyn Mohylyuk

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• PhD
• Pharm Scientist - Group Leader at Riga Stradiņš University

The customisation of solid oral dosage forms is essential for maximising efficacy, minimising harm, and providing patient-centred care. Fused Deposition Modelling (FDM) 3D-printing (3DP) is current research of interest within the pharmaceutical industry to produce personalised 3D printed oral "tablets" (printlets) by utilising drug-loaded polymer f...

Dwell time is an important parameter responsible for the material deformation and the mechanical and biopharmaceutical properties of the tablet. Thus, it is widely used for scale-up purposes. The geometric dwell time (GDT) can be assumed based on the shape of the punch head and the diameter and speed of the turret. This research is aimed to compare...

Acceptor compartment media evaluation in ex vivo studies where poorly soluble drugs' permeability was investigated.

The deformulation stage of original drug products, which includes the quantification of critical excipients, is crucial for the successful development of generic drug products of solid dosage form. Sodium lauryl sulphate (SLS) belongs to the group of critical excipients due to its influence on the bioavailability of drugs, such as metformin. The pu...

Compaction pressure can induce an undesirable solid-state polymorphic transition in drugs, fragmentation, loss of coated pellet integrity, and the decreased viability and vitality of microorganisms. Thus, the excipients with increased plasticity can be considered as an option to decrease the undesirable effects of compaction pressure. This study ai...

The bitter drug, warfarin, has a narrow therapeutic index (NTI) and is used in paediatrics and geriatrics. The aim of this feasibility study was to formulate the taste-masked warfarin-containing pellets to be applicable for dose personalisation and to improve patient compliance, as well as to investigate the effect of the core type (PharSQ® Spheres...

AIM Amorphization of poor water-soluble crystalline drugs is one of the main current strategies for enhancing aqueous solubility. However, the amorphized state is unstable and subject to self-conversion into a more ordered crystals. To overcome this, a drug can be dispersed in a polymer(s) at temperatures above the glass transition and in such a wa...

Using microcrystalline cellulose (MCC) with plastic behaviour and calcium phosphate anhydrous (CaHPO4) with brittle behaviour under compaction is very popular in the pharmaceutical industry for achieving desirable structural–mechanical properties of tablet formulations. Thus, mixtures of specific grades of MCC and CaHPO4 were tested in volume propo...

Amorphization is fundamental to enhancing drug solubility using polymer-based solid dispersions (SDs). Apart from inherent drug properties (glass-forming ability, drug-polymer miscibility), amorphous behaviour can be affected by process parameters, such as after-melt cooling rate, which is relevant for downstream processing in pharmaceutical hot me...

Flavonoids are hydroxylated polyphenols that are widely distributed in plants with diverse health benefits. Despite their popularity, the bioavailability of flavonoids is often overlooked, impacting their efficacy and the comparison of products. The study discusses the bioavailability-related physicochemical properties of flavonoids, with a focus o...

Vat photopolymerisation (VP) three-dimensional printing (3DP) has attracted great attention in many different fields, such as electronics, pharmaceuticals, biomedical devices and tissue engineering. Due to the low availability of biocompatible photocurable resins, its application in the healthcare sector is still limited. In this work, we formulate...

The aim of this feasibility study was to investigate the possibility of producing industrial-scale relevant, robust, high drug-loaded (90.9%, w/w) 100 mg dose immediate-release tablets of isoniazid and simultaneously meet the biowaiver requirements. With an understanding of the real-life constrictions on formulation scientists during product develo...

Вступ. Параметри розчинності за Хансеном (δd, δp, δh) дозволяють спрогнозувати ймовірність розчинності фармацевтичних інгредієнтів один в одному, а відтак науково-обґрунтовано звузити коло об’єктів та загальний обсяг експериментальних досліджень. Одним із способів визначення δd, δp, δh є розрахунковий метод групових внесків: усі три параметри розра...

To achieve desirable oral absorption of poorly soluble drug the formulation should provide a fast dissolution rate, a high degree of supersaturation (DS) in biologically relevant dissolution media and maintain a reasonable DS during the drug transit through the gastrointestinal tract to ensure the intestinal absorption. Amorphous drug due to the ab...

Objective The aim of this study was to use an alternative granulation technique, solventless roll compaction, and to investigate the effect of the roll compaction pressure on the properties of granules and high-drug-loaded (80%, w/w) immediate release piracetam tablets. Significance. Piracetam commonly manufactured as high drug-loaded tablets by we...

The aim of this study was to prepare tablets that offer an immediate release (IR) of the loaded active ingredient using fused deposition modelling (FDM) 3D printing. Hydrochlorothiazide (HCTZ) was used as a model drug, with polyvinyl alcohol (PVA) as the primary polymeric carrier and sorbitol as a plasticizer. The impact of printer parameters, incl...

The pharmaceuticalindustry has a growing interest in continuous manufacturing, particularly forhigh-volume dosage forms such as solid oral tablets. This is driven by the obviousbenefits such as small footprint, batch size flexibility, the relative simplicityof scale-up and process control. Tablets are the most popular solid dosageform, while batch...

3D printing (3DP) by fused deposition modelling (FDM) is one of the most extensively developed methods in additive manufacturing. Optimizing printability by improving feedability, nozzle extrusion, and layer deposition is crucial for manufacturing solid oral dosage forms with desirable properties. This work aimed to use HPMCAS (AffinisolTM HPMCAS 7...

In recent years, probiotics have attracted public attention and transformed the social perception of microorganisms, convening a beneficial role/state on human health. With aging, the immune system, body physiology, and intestinal microbiota tend to change unfavorably, resulting in many chronic conditions. The immune-mediated disorders can be linke...

Purpose The purpose of this study was to correlate the gel strength of swollen matrix tablets with their in vitro robustness against agitation intensity and applied mechanical forces. Five commercial products, i.e. Glucophage®, Alfuzosin®, Tromphyllin®, Preductal® MR and Quetiapin® formulated as water-soluble/erodible matrix tablets were investigat...

Omeprazole is a widely used over-the-counter (20 mg) proton pump inhibitor, usually supplied as oral enteric-coated pellets intended to release at pH 5.5 and higher; however, it is sensitive to acidic pH. The likelihood of elevated gastric pH in practice is very high for patients; thus, the aim of this study was to investigate the effect of elevate...

Probiotics are living microbial strains, also considered functional foods, that improve the human intestine and mucosal sites' functionality and normalize the immune system balance. This symbiosis between the human body and microorganisms has attracted scientists and showed a notable role in maintaining human health. The microbiota composition with...

During pandemics and global crises, drug shortages become critical as a result of increased demand, shortages in personnel and lockdown restrictions that disrupt the supply chain. The pharmaceutical industry is therefore moving towards continuous manufacturing instead of conventional batch manufacturing involving numerous steps, that normally occur...

Silymarin is a mixture of flavonolignans obtained from the seeds of milk thistle (Silybum marianum L. Gaertner). Silymarin behaves as a weak acid and is categorised as a class IV drug substance in accordance with biopharmaceutics drug disposition classification system, possessing low solubility, as well as low bioavailability. The scope of this stu...

Purpose When establishing IVIVC, a special problem arises by interpretation of averaged in vivo profiles insight of considerable individual variations in term of time and number of mechanical stress events in GI-tract. The objective of the study was to investigate and forecast the effect of mechanical stress on in vivo behavior in human of hydrophi...

Dissolution media based on bicarbonate buffers closely mimic the environment of intestinal fluids and thus improve in vitro in vivo correlation compared to phosphate buffers. Purging gases into the medium is used as a method to stabilise bicarbonate buffers; however, this causes issues due to the disturbance of the hydrodynamics in the dissolution...

It is a challenge to safely administer sustained release medicines to patients with dysphagia. Sustained release tablets must not be crushed and multiparticulates with large particle sizes cause gritiness reducing patient acceptability. The aim of this study was to develop “instant” jellies as delivery vehicles incorporating sustained release micro...

Suspension of microparticles in an easy-to-swallow liquid is one approach to develop sustained-release formulations for children and patients with swallowing difficulties. However, to date production of sustained-release microparticles at the industrial scale has proven to be challenging. The aim of this investigation was to develop an innovative c...

The main objective of this study was to investigate the effect of microcrystalline cellulose (MCC) spheres (Cellets) size effect on the powder properties to assess the possible impact of the Cellets’ size on the powder behaviour in the down-flow bed and horizontal transport zone when a Wurster fluid-bed coater is used. The particle size distributio...

Мета роботи полягає у порівнянні існуючих підходів до підвищення пероральної біодоступності активних фармацевтичних інгредієнтів ІІ класу за біофармацевтичною класифікаційною системою та визначення серед них найбільш перспективних.Матеріали та методи. Матеріалом статті слугували дані наукових досліджень стосовно підходів до підвищення пероральної б...

The aim of this investigation was to apply a novel MicroCoatTM technology to improve coating process of small particles of less than 150 µm in size using aqueous sustained release polymer dispersions during Wurster fluid-bed coating.

A novel Microcoat technology was developed to eliminate particle agglomeration during coating of microparticles. The aim of this project was to investigate the effect of the MicroCoat technology on drug release from coated microparticles for the development of gliclazide oral sustained release liquid suspensions.

Fluid-bed coating of microparticles using aqueous polymer dispersions is a challenge due to particle agglomeration. Agglomeration is an undesirable phenomenon especially for modified release products resulting in inconsistent and unreliable coating thickness and drug release profile. Due to the small particle size and relatively high coating level,...

Most oral dosage forms such as tablets and capsules are not suitable for older people with swallowing difficulties. Capsule opening and tablet crushing are commonly used to overcome this problem. In addition to safety and legal concerns, this approach cannot be applied to sustained release products because of the loss of their functionality, conseq...

Most oral dosage forms such as tablets and capsules are unsuitable for older people with swallowing difficulties. Capsules opening and tablet crushing are commonly used to overcome this problem. In addition to safety and legal concerns, this approach cannot be applied to sustained products because of the loss of their functionality, consequently ca...

The objective of this study was to develop delivery systems for taste masking based on multiparticulates coated with Kollicoat(®) Smartseal 30 D formulated as liquid oral suspensions. Coating of particles containing bitter drugs with Kollicoat(®) Smartseal reduced drug leaching into aqueous medium, especially when increasing pH, therefore can be us...

Effect of different diluents types on the dissolution profile of trimetazidine dihydrochloride and caffeine from Kollidon SR matrix tablets was investigated using microcrystalline cellulose (Avicel PH-101), calcium hydrogen phosphate dihydrate (Emcompress) and sorbitol (Neosorb P100T). The decreasing of mentioned diluents possibility to slow down o...

Hydrophilic polymers using as matrix former in matrix tablets is a common approach and wellknown excipient Carbopol is widely used for this reason too. In common case polymer doesnit interact with drug but Carbopol is a weak polyacrylic acid and obviously can interact at physiological enteric conditions with weak base drugs like trimetazidine dihyd...

In case of soluble matrices, a hydrogel formed after contact of the matrix with the release medium anddrug release occurs either via drug diffusion through a network of capillaries formed between compacted matrix former or/and erosion of the matrix. Dependent on the aqueous drug solubility, one of the mechanisms could dominate or combination ofboth...