Valentina Petkova

Valentina Petkova
Medical University of Sofia · Faculty of Pharmacy

DSc, PhD, MSc., MPH, Professor (Full)

About

187
Publications
67,837
Reads
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440
Citations
Introduction
Professor, MSc, PhD, Pharmacy, MSc, Public Health, Vice Dean of International Integration at Faculty of Pharmacy, Medical University - Sofia
Additional affiliations
February 2012 - May 2016
Medical University of Sofia
Position
  • Head of Faculty
January 2006 - present
Faculty of Pharmacy, Sofia
January 2006 - present
Medical University of Sofia
Education
January 2015 - December 2015
Medical University of Sofia
Field of study
  • Pharmaceutical care
May 2012
Faculty of Pharmacy, Medical University - Sofia, Bulgaria
Field of study
  • Pharmacy

Publications

Publications (187)
Article
Extemporaneous dispensing is a manual process where a manufactured product may undergo modification or made from raw ingredients, performed by a dispenser or pharmacist, who has to incorporate all the necessary ingredients according to a physician’s prescription, a drug formula, or a recipe in which calculated amounts of ingredients are made into a...
Article
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The effective communication between the medical specialists and pharmacy industry representatives is very important. Essential parts of the published surveys in this area are related to the attitude of the physicians towards the medical sales representatives. Although there are lots of studies focused on the influence of pharmaceutical industry on...
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WHO statistics reports that more then 210 million people suffer from chronic obstructive pulmonary disease (COPD) and 3 million people died of COPD annually. The aim of this study is to assess the effect of education of patients with COPD on their quality of life. The study results show that engagement of community pharmacists for management o...
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The objective was to adapt and test an educational programme for type 2 diabetes patients. The sample consisted of 24 individuals with type 2 diabetes between 31 and 75 years of age that did not require insulin, without severe complications of diabetes. A patient satisfaction questionnaire was applied in the beginning and at the end of the survey....
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Asthma is a clinical problem with social, psychological, and economic burdens. To improve patient disease management and quality of life (QOL), different education programs have been developed. The purpose of this study is to adapt and implement a community-based educational program for patients with asthma. A prospective, randomized, controlled tr...
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Despite significant successes in the treatment of various human tumors with platinum derivatives and in particular with cisplatin, its clinical application is limited to a relatively narrow range of tumor types. Severe side effects such as nephrotoxicity, peripheral neuropathy, myelosuppression, etc. due to the ineffective accumulation of the drug...
Article
Aim: The objective is to study the availability and affordability of biosimilar medicinal products containing monoclonal antibodies, measure their drug utilization, and evaluate the rational drug use globally through analysis and systematic review of scientific articles published in the scientific literature. Materials and methods: The documentary...
Article
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Citation: Atanasov P, Ivanova S, Kobakova Y, Moneva-Sakelarieva M, Obreshkova D, Petkova V, Laleva-Jordanova P (2022) Immunogenesis in patients with medium and severe coronavirus infection-dynamics in different age groups. Pharmacia 69(1): 157-165. https://doi. Abstract The results of a one-year prospective study, during which the process of immuno...
Article
Aim: To analyze drug utilization and rational drug use in treatment of essential arterial hypertension in Bulgaria by using quantitative and qualitative parameters at national level. To assess generic penetration as a part of rational drug use. Materials and methods: Design: retrospective study of publicly accessible data from registries of Nationa...
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Clinical trials of medicinal products related to the prevention and treatment of osteoporosis cover all activities, operations, methods and means for obtaining summary data and their interpretation in order to reveal the nature of the procedures, as well as certain relationships and dependencies of interest imposed the relevant study. The main obje...
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The interest in the practical use of herbal substances for medical purposes is growing worldwide. The herbal medicines can be applied as a supplement not only to restore the physiological functions but also to treat specific conditions such as– dyspepsia; hepatic and biliary diseases; to prevent and modify cardiovascular diseases; and even to treat...
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The etiological cause of Coronavirus infection, which has captured the attention of almost the whole world at the moment, is SARS-CoV2. The clinical picture of coronavirus infection varies from asymptomatic to severe respiratory infection with manifestations of respiratory failure, the development of respiratory distress syndrome and even death. Al...
Preprint
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Background: Arterial hypertension is prevalent and remains one of the most significant causes of mortality worldwide. Over 1.7 million Bulgarians (24%) have a blood pressure (BP) value equal to or higher than 140/90 mmHg and therefore are at increased risk of complications. Adherence to antihypertensive medications is the cornerstone for achieving...
Article
The entry of the biological medicinal products (BMPs) in the clinical practice more than 10 years ago raised complex regulatory issues as well as significant pharmacoeconomic concerns, because the costs of treatment is higher than the costs of the conventional products. The “data exclusivity” of BMPs expired and biosimilar medicinal products (BSMPs...
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Herbal medicines have evolved through their traditional use in a specific or cultural context. The pharmacological effects of herbal medicines are not due to their “natural” origin, but to the complex character of biologically active substances. Pediatricians have begun to integrate the use of complementary / alternative medical therapies with conv...
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BACKGROUND: Overweight and obesity are serious health problems in most developed countries. The percentage of young women with excessive weight who get pregnant continues to grow every year. This raises a concern about the risks of the mother and the baby during pregnancy and after birth. AIM: This study aims to determine health risk for overweight...
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Ovarian endometriomas are benign ovarian lesions. Rupture of endometriomas is a rare condition which may cause serious damage both for the mother and for the fetus. Our patient was at 36 week of gestation with the complains of low abdominal pain. She has a history of severe endometriosis in the past. Urgent Cesarean section resulted in the birth of...
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Vitamin B12 is a macronutrient with a crucial role in embryogenesis. It is associated with obesity and overweight, anemia, and possible neurological damage over the mater and the fetus. The aim of this study is to determine health risk for pregnant women with vitamin B12 deficiency, as well as to determine the risk of preterm birth. This is a pros...
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Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia, which is caused by impaired insulin secretion, insulin action, or both. Four complications of DM have been identified – diabetes microangiopathy including nephropathy, retinopathy and polyneuropathy and diabetes macroangiopathy. DM is diagnosed on the basis of one of the...
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Болестта на Паркинсон е второто най-често срещано неврологично разстройство, засягащо хората с увреждания, след инсулта. Цел: да се оцени качеството на живот на пациенти, страдащи от болестта на Паркинсон в България, с помощта на специализирания въпросник PDQ-39, като се проведат директни анкети в лечебно заведение за специализирана доболнична помо...
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Aims To evaluate the expected life expectancy in patients with diabetes in Bulgaria and to compare it to the expected life expectancy of the non-diabetic population in the country. Methods It is a retrospective observational population study on individuals diagnosed with diabetes, compared to the non-diabetic population in Bulgaria for the period...
Article
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Peptide drugs have received a considerable amount of attention by various researchers over last years. Innovations in the health and pharmaceutical sectors are interpreted as a transformation of the potential scientific and technical progress into a real one, by creating new medical products and health services. The development of peptide products...
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The overproduction of reactive oxygen species and the weakening of the antioxidant defense mechanisms in human body are the main reason for the oxidative stress, which underlies the development of neurodegenerative Alzheimer's disease. The important strategy for treatment of Alzheimer's disease is with compounds such as natural product Galantamine...
Article
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Medicinal plants, their extracts and herbal medicinal products occupy a growing share of medicines in the pharmacy worldwide. Historically, the first medicines were products of plants, as well as some of the most important medicines still in use today. With the development of phytochemistry, as part of the pharmaceutical science, great progress has...
Article
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Background. In an attempt to stop the distribution of falsified medicinal products, the EU has adopted Directive 2011/62/EU. Since 9th February 2019, each package of medicinal product must be given a unique number in combination with a mandatory indicator of integrity. The Directive requires the creation of a system of serialization and verificatio...
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Background: The information for the impact of air pollutants on the severity of chronic obstructive pulmonary disease (COPD) and hospital admissions in Bulgaria is scarce. The aim of the study is to assess the relationship between some ambient air pollution and exacerbations levels as well as hospital admissions of patients with COPD in Bulgaria....
Article
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The aim of this study was to investigate the economic burden of Chronic Obstructive Pulmonary Disease (COPD)-related hospitalizations on a macro and micro level. Macro analysis was performed on the rate of DDD utilisation of COPD medicines, time of their inclusion in the reimbursement lists and the number of hospitalizations. On a micro level, a st...
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The study investigates the quality of diabetes control and its economic implications in Bulgaria for the years 2012–2016. It is a retrospective study of the national diabetes register. Patients were categorized according to type of diabetes, gender, newly diagnosed cases per year, body-mass index (BMI) and achieved disease control. The relative ris...
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Introduction: Depression is the most common form of mental disorder of great social significance. Antidepressant treatment is a standard approach to treat depressed patients, but in order to be effective, patients need to follow their strictly prescribed treatments. Bad compliances are mostly associated with side effects, poor patient awareness, co...
Article
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Biological products for treatment of rheumatoid arthritis usually are cost effective for healthcare systems in Europe, but they are huge financial burden due to the high number of patients and the significant budget impact. The expected saving from introduction on the market of biosimilars are significant and are linked to better access and afforda...
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Introduction. According to German scientists, arthrosis is the most common joint disease in adults. Frequency increases steeply with age. In the United States, it is estimated that arthrosis debilitates about 10% of the population over 60 years of age and is responsible for lowering the quality of life of over 20 million people. Objectives. The aim...
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An estimated 17.7 million people died from cardiovascular diseases (CVDs) in 2015, representing 31% of all global deaths. Of these deaths, an estimated 7.4 million were due to coronary heart disease and 6.7 million were due to stroke. The global market expanded from $18.8 billion in 2002 to $23.6 billion by 2007. The aim of this study is to analyze...
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ABSTRACT The aim of this study is to present the methods of medical rehabilitation and the results from methodical administration in cases of Duchenne-Erb palsy, with damaged C5 and C6 roots. From 2011 to 2016 we have administered complex medical rehabilitation (electrotherapy, kinesitherapy – passive, active, reflexive; medicinal massage – general...
Article
This study presents new epidemiological data for the demographic characteristics, patient groups with regards to age, gender, severity of the disease in Bulgaria. A multi-centre, prospective, one-year observational study was conducted in 17 population centres across the country including 426 patients. A tendency has been established which shows tha...
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Introduction: Glaucoma commonly refers not to a single disease, but to a group of disorders that have certain common features, in particular cupping and atrophy of the optic nerve head; characteristic visual field loss. Quality of life in glaucoma is affected earlier than previously thought. Aim of this study is to assess the social and economic bu...
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Purpose: The aim of this study is to assess the impact of Polycystic Ovary Syndrome (PCOS) on Bulgarian patients’ QoL through a Polycystic Ovary Syndrome Questionnaire (PCOSQ). Methods: A pilot survey was conducted in a sample of individuals aged 15 to 35 (n=24) from Sofia, Bulgaria. Data were collected via PCOSQ. The PCOSQ scale was translated int...
Article
Introduction: Quality of Life (QoL) of patients with rare diseases (RDs) is significantly worsened in all dimensions. Applying different general or specific life quality assessment questionnaires could help assessment of the individual rare diseases severity and the impact of available treatment options on the quality of life. Purpose: This pilot a...
Article
The introduction of antibacterial agents led to a revolution in the management of bacterial infections. Unfortunately, today we are facing an emerging and increasing resistance to antibiotics that become a threat to public health in Europe and globally. Infections in children are an important topic because children are highly susceptible to infecti...
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Background: Food additives are subject to certain regulatory requirements, as in some countries, the control is very strict, while in others there is almost no control. Some food supplements can affect existing diseases or interact with some medications, food and beverage, a fact that is not mentioned on the packaging or in product instructions. Me...
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Pharmacies in Bulgaria have a monopoly on the dispensing of medicinal products that are authorized in the Republic of Bulgaria, as well as medical devices, food additives, cosmetics, and sanitary/hygienic articles. Aptekari (pharmacists) act as responsible pharmacists, pharmacy owners, and managers. They follow a five year Masters of Science in Pha...
Article
Introduction: While the impact of COPD in Western-Europe is known, data from Eastern-Europe is scarce. We aimed to evaluate clinical characteristics, treatment patterns and the socio-economic burden of COPD in Eastern-Europe, taking Bulgaria as a reference case. Methods: A representative sample of Bulgarian patients with COPD was randomly chosen...
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AD is the most common form of dementia worldwide, accounting for approximately 60% of all dementia cases. The main pathological hallmarks of AD, including senile plaques, resulted from the extracellular accumulation of the amyloid beta (Aβ) protein, and the neurofibrillary tangles (NFTs), formed by hyperphosphorylated and aggregated Tau protein. Co...
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Endoprosthesis surgery of joints in traumatic injuries is emerging as one of the main directions of development of modern orthopedic surgery. It is one of the most successful operations in orthopedic surgery. The aim of the presented clinical case is to determine the effect of kinesitherapeutic methodology applied to patients with total endoprosthe...
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REVIEW The fat content of the human body is about 97% saturated and monounsaturated fat, with only 3 % polyunsaturated fats. Half of that three percent is Omega-3 fats, and that balance needs to be kept. Vegetable oils contain very high levels of polyunsaturated fats, and these oils have replaced many of the saturated fats in our diets since the 19...
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In this work are presented various chromatographic systems, TLC, HPLC, GC, designed to identify and accurately quantify the long-chain mono-and polyunsaturated fatty acids of different samples with a focus on literature that was published in the last decade.
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Consumption of fish, fish oil and lipids can be beneficial for the heart system because of the effect of omega fatty acids. There are evidences from controlled trials from the recent years about that. That is why the aim of this study is to make a documental review and to assess the evidences for the effect of omega fatty acids on the human health...
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The aim of this study is to evaluate the cost-effectiveness of continuous subcutaneous insulin infusion (CSII) to multiple daily insulin injection (MDI) either with analogues or with human insulin, based on the achieved therapeutic results such as changes in glycated hemoglobin level (HbA1c) in the various therapies. The study was performed with ch...