Valentina Mazzoli

Valentina Mazzoli
New York University | NYU · Department of Radiology

PhD

About

41
Publications
3,587
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397
Citations

Publications

Publications (41)
Article
Full-text available
This work presents a deep learning approach for rapid and accurate muscle water T2 with subject-specific fat T2 calibration using multi-spin-echo acquisitions. This method addresses the computational limitations of conventional bi-component Extended Phase Graph fitting methods (nonlinear-least-squares and dictionary-based) by leveraging fully conne...
Article
Diffusion‐weighted imaging (DWI) is an established MRI technique that can investigate tissue microstructure at the scale of a few micrometers. Musculoskeletal tissues typically have a highly ordered structure to fulfill their functions and therefore represent an optimal application of DWI. Even more since disruption of tissue organization affects i...
Article
Static quantitative magnetic resonance imaging (MRI) provides readouts of structural changes in diseased muscle, but current approaches lack the ability to fully explain the loss of contractile function. Muscle contractile function can be assessed using various techniques including phase‐contrast MRI (PC‐MRI), where strain rates are quantified. How...
Article
Full-text available
Chronic knee pain is a common condition. Causes of knee pain include trauma, inflammation, and degeneration, but in many patients the pathophysiology remains unknown. Recent developments in advanced magnetic resonance imaging (MRI) techniques and molecular imaging facilitate more in-depth research focused on the pathophysiology of chronic musculosk...
Article
Due to its exceptional sensitivity to soft tissues, MRI has been extensively utilized to assess anatomical muscle parameters such as muscle volume and cross‐sectional area. Quantitative Magnetic Resonance Imaging (qMRI) adds to the capabilities of MRI, by providing information on muscle composition such as fat content, water content, microstructure...
Article
The purpose of this article is to review steatosis and fibrosis of skeletal muscle, focusing on older adults. Although CT, MRI, and ultrasound are commonly used to image skeletal muscle and provide diagnoses for a variety of medical conditions, quantitative assessment of muscle steatosis and fibrosis is uncommon. This review provides radiologists w...
Article
Full-text available
Purpose\(T_2\) mapping is a powerful tool for studying osteoarthritis (OA) changes and bilateral imaging may be useful in investigating the role of between-knee asymmetry in OA onset and progression. The quantitative double-echo in steady-state (qDESS) can provide fast simultaneous bilateral knee \(T_2\) and high-resolution morphometry for cartilag...
Preprint
Full-text available
Semantic segmentation is a crucial step to extract quantitative information from medical (and, specifically, radiological) images to aid the diagnostic process, clinical follow-up. and to generate biomarkers for clinical research. In recent years, machine learning algorithms have become the primary tool for this task. However, its real-world perfor...
Article
Background: Diffusion-weighted imaging (DWI) may allow for breast cancer screening MRI without a contrast injection. Multishot methods improve prone DWI of the breasts but face different challenges in the supine position. Purpose: To establish a multishot DWI (msDWI) protocol for supine breast MRI and to evaluate the performance of supine vs. pr...
Article
Full-text available
Objective Altered joint function is a hallmark of osteoarthritis (OA). Imaging techniques for joint function are limited, but [¹⁸F]sodium fluoride (NaF) PET-MRI may assess the acute joint response to loading stresses. [¹⁸F]NaF PET-MRI was used to study the acute joint response to exercise in OA knees, and compare relationships between regions of in...
Article
Full-text available
Background: Deep learning (DL)-based automatic segmentation models can expedite manual segmentation yet require resource-intensive fine-tuning before deployment on new datasets. The generalizability of DL methods to new datasets without fine-tuning is not well characterized. Purpose: Evaluate the generalizability of DL-based models by deploying...
Preprint
Full-text available
Magnetic resonance imaging (MRI) is a cornerstone of modern medical imaging. However, long image acquisition times, the need for qualitative expert analysis, and the lack of (and difficulty extracting) quantitative indicators that are sensitive to tissue health have curtailed widespread clinical and research studies. While recent machine learning m...
Article
Full-text available
Background The purpose of this study was to develop a DTI-based method to quantitatively assess fiber angles and changes therein in leg muscles in order to facilitate longitudinal studies on muscle fiber architectural adaptations in healthy subjects. Methods The upper legs of five volunteers were scanned twice on the same day. The right lower legs...
Article
The dynamic contrast‐enhanced (DCE)‐MRI parameter K trans can quantify the intensity of synovial inflammation (synovitis) in knees with osteoarthritis (OA), but requires the use of gadolinium‐based contrast agent (GBCA). Diffusion tensor imaging (DTI) measures the diffusion of water molecules with parameters mean diffusivity (MD) and fractional ani...
Article
Full-text available
Background Injuries to the articular cartilage in the knee are common in jumping athletes, particularly high‐level basketball players. Unfortunately, these are often diagnosed at a late stage of the disease process, after tissue loss has already occurred. Purpose/Hypothesis To evaluate longitudinal changes in knee articular cartilage and knee func...
Article
Full-text available
Diffusion tensor imaging (DTI) measures water diffusion in skeletal muscle tissue and allows for muscle assessment in a broad range of neuromuscular diseases. However, current DTI measurements, typically performed using pulsed gradient spin echo (PGSE) diffusion encoding, are limited to the assessment of non-contracted musculature, therefore provid...
Article
Objective Molecular information derived from dynamic [ ¹⁸F]sodium fluoride ([ ¹⁸F]NaF) PET imaging holds promise as a quantitative marker of bone metabolism. The objective of this work was to evaluate physiological mechanisms of [ ¹⁸F]NaF uptake in subchondral bone of individuals with and without knee osteoarthritis (OA). Methods Eleven healthy vo...
Article
Cartilage transmits and redistributes biomechanical loads in the knee joint during exercise. Exercise‐induced loading alters cartilage hydration and is detectable using quantitative MRI, where T2 relaxation time (T2) is influenced by cartilage collagen composition, fiber orientation, and changes in extracellular matrix. This study characterized sho...
Article
Chemical exchange saturation transfer of glycosaminoglycans, gagCEST, is a quantitative MR technique that has potential for assessing cartilage proteoglycan content at field strengths of 7 T and higher. However, its utility at 3 T remains unclear. The objective of this work was to implement a rapid volumetric gagCEST sequence with higher gagCEST as...
Article
Background Diffusion-weighted imaging (DWI) can depict the inflamed synovial membrane in arthritis. Purpose To study the diagnostic accuracy of DWI for the detection of arthritis compared with the clinical reference standard and to compare DWI to contrast material-enhanced MRI for the detection of synovial inflammation. Materials and Methods In thi...
Article
Full-text available
Background Ongoing arthritis in children with juvenile idiopathic arthritis (JIA) can result in cartilage damage. Objective To study the feasibility and repeatability of T1ρ for assessing knee cartilage in JIA and also to describe T1ρ values and study correlation between T1ρ and conventional MRI scores for disease activity. Materials and methods...
Article
Full-text available
Purpose: To assess reliability and clinical utility of evaluating stress-related metaphyseal water distribution using a semi-quantitative Dixon MRI-based method for early diagnosis of physeal stress injuries in adolescent gymnasts. Methods: Twenty-four gymnasts with clinically suspected overuse injury of the distal radial physis, 18 asymptomatic...
Article
Characterization of the main tibiofemoral ligaments is an essential step in developing patient-specific computational models of the knee joint for personalized surgery pre-planning. Tensile tests are commonly performed in-vitro to characterize the mechanical stiffness and rupture force of the knee ligaments which makes the technique unsuitable for...
Article
Full-text available
Background Surgical resection of tongue cancer may impair swallowing and speech. Knowledge of tongue muscle architecture affected by the resection could aid in patient counseling. Diffusion tensor imaging (DTI) enables reconstructions of muscle architecture in vivo. Reconstructing crossing fibers in the tongue requires a higher‐order diffusion mode...
Conference Paper
Full-text available
Background Early detection of microstructural damage to cartilage of patients with juvenile idiopathic arthritis (JIA) might prevent irreversible cartilage damage by timely treatment and follow-up of cartilage microstructure. New, quantitative MRI sequences such as T1ρ are possibly able to detect pre-erosive cartilage damage by quantifying proteogl...
Article
Purpose: 3D time-resolved (4D) phase contrast MRI can be used to study muscle contraction. However, 3D coverage with sufficient spatiotemporal resolution can only be achieved by interleaved acquisitions during many repetitions of the motion task, resulting in long scan times. The aim of this study was to develop a compressed sensing accelerated 4D...
Article
Early diagnosis of deep tissue injury remains problematic due to the complicated and multi-factorial nature of damage induction, and the many processes involved in damage development and recovery. In this paper we present a comprehensive assessment of deep tissue injury development and remodeling in a rat model by multi-parametric magnetic resonanc...
Article
Anatomical (static) magnetic resonance imaging (MRI) is the most useful imaging technique for the evaluation and assessment of internal derangement of the knee, but does not provide dynamic information and does not allow the study of the interaction of the different tissues during motion. As knee pain is often only experienced during dynamic tasks,...
Data
Figure S1. Bland–Altman of fascicle length measured in two different sessions for all muscles of the calf. Figure S2. Mean muscle fascicle length in dorsiflexed, neutral, and plantarflexed foot position for all muscles of the calf. Table S1. Mean fascicle length and standard deviation (SD), coefficient of variation (CV) and minimal detectable dif...
Article
Full-text available
Musculoskeletal (dys-)function relies for a large part on muscle architecture which can be obtained using Diffusion-Tensor MRI (DT-MRI) and fiber trac-tography. However, reconstructed tracts often continue along the tendon or aponeurosis when using conventional methods, thus overestimating fascicle lengths. In this study, we propose a new method fo...
Article
In this study we investigated the changes in fiber length and diffusion parameters as a consequence of passive lengthening and stretching of the calf muscles. We hypothesized that changes in radial diffusivity (RD) are caused by changes in the muscle fiber cross sectional area (CSA) as a consequence of lengthening and shortening of the muscle. Diff...
Article
Purpose: To introduce a method for obtaining fat-suppressed images in real-time MRI of moving joints at 3 Tesla (T) using a bSSFP sequence with phase detection to enhance visualization of soft tissue structures during motion. Methods: The wrist and knee of nine volunteers were imaged with a real-time bSSFP sequence while performing dynamic tasks...
Article
To study diffusion-prepared neurography optimized for a large field-of-view (FOV) to include the neck and both shoulders. In a large FOV poor homogeneity of the magnetic field (B0 ) often leads to poor image quality and possibly to poor diagnostic accuracy. The aim was therefore to find an optimal (combination of) shimming method(s) for diffusion-p...

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