Valentina Borghesani

Valentina Borghesani
University of California, San Francisco | UCSF · Department of Neurology

PhD

About

52
Publications
6,749
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
325
Citations
Additional affiliations
April 2016 - June 2016
Università degli Studi di Trento
Position
  • Research Assistant
Description
  • Current debates in cognitive neuroscience (M. Piazza): module on Semantics
September 2014 - September 2016
Sorbonne Université
Position
  • Research Assistant
Description
  • Mission d’enseignement: English
September 2012 - September 2013
Atomic Energy and Alternative Energies Commission
Position
  • Research Internship as graduate student
Description
  • 1 year full time - Design and implementation of fMRI studies; uni- and multi- variate analysis of neuroimaging data.
Education
October 2013 - December 2016
Sorbonne Université
Field of study
  • Cognitive Neuroscience
September 2010 - September 2012
Università degli Studi di Trento
Field of study
  • Psycholgy
September 2007 - July 2010
University of Bologna
Field of study
  • Sciences of Behaviour and Social Relations

Publications

Publications (52)
Preprint
Full-text available
Developmental dyscalculia (DD) is an heterogenous neurodevelopmental learning disability that manifests as persistent difficulties in learning mathematics. DD can occur in isolation but is often diagnosed as a co-occurring difficulty in children with language-based learning disabilities. Basic cognitive and neuroimaging findings suggest different s...
Preprint
Primary Progressive Aphasia (PPA) is a clinical syndrome in which patients progressively lose speech and language abilities. The non-fluent variant of PPA (nfvPPA) is characterised by impaired motor speech and agrammatism. To date, no study in nfvPPA patients has either examined speech motor control behaviour or imaged the speech motor control netw...
Article
Focal anterior temporal lobe (ATL) degeneration often preferentially affects the left or right hemisphere. While patients with left-predominant ATL (lATL) atrophy show severe anomia and verbal semantic deficits and meet criteria for semantic variant primary progressive aphasia (svPPA) and semantic dementia, patients with early right ATL (rATL) atro...
Preprint
Climate change threatens the future of humanity. It will also significantly impede our ability toconduct science, by destabilising societies globally. Aviation, including travel to scientificconferences, generates a huge carbon footprint. This must be addressed if we are to limit globalwarming to the 1.5C mandated by the UN Intergovernmental Panel...
Article
Full-text available
Primary progressive aphasia (PPA) is a clinical syndrome in which patients progressively lose speech and language abilities. Three variants are recognized: logopenic (lvPPA), associated with phonology and/or short-term verbal memory deficits accompanied by left temporo-parietal atrophy; semantic (svPPA), associated with semantic deficits and anteri...
Article
Science and art have been intertwined for centuries, as both embody means for humans to represent, communicate, and interpret our external and internal worlds. The collective effort to gather and organize knowledge about the brain blends well with a wide array of human creative activities, from visual and performing arts to interactive media. It th...
Preprint
Primary Progressive Aphasia (PPA) is a clinical syndrome in which patients progressively lose speech and language abilities. Three variants are recognized: logopenic (lvPPA), associated with phonology and/or short-term verbal memory deficits accompanied by left temporo-parietal atrophy; semantic (svPPA), associated with semantic deficits and anteri...
Chapter
Frontotemporal dementia (FTD) is an umbrella term covering a plethora of progressive changes in executive functions, motor abilities, behavior, and/or language. Different clinical syndromes have been described in relation to localized atrophy, informing on the functional networks that underlie these specific cognitive, emotional, and behavioral pro...
Article
Full-text available
Decades of neuroscientific findings have elucidated the highly specialized brain areas involved in reading, especially along the ventral occipitotemporal stream where the critical step of recognizing words occurs. We report on a 14-year-old female with temporary dyslexia after a left ventral occipitotemporal ischemic stroke. Our longitudinal multim...
Preprint
Full-text available
Real-world generalization, e.g., deciding whether to approach or run away from a never-seen-before animal, relies on contextual information as well as previous experiences. Such a seemingly easy behavioral choice requires the interplay of multiple neural mechanisms, from integrative encoding to category-based inference, weighted differently accordi...
Preprint
Science and art have been intertwined for centuries, both representing means for humans to represent, communicate and interpret our external and internal worlds. Our collective effort to gather and organize knowledge about the brain blends well with a wide array of human creative activities, from visual and performing arts to interactive media. It...
Article
Full-text available
Semantic representations are processed along a posterior-to-anterior gradient reflecting a shift from perceptual (e.g., it has eight legs ) to conceptual (e.g., venomous spiders are rare ) information. One critical region is the anterior temporal lobe (ATL): patients with semantic variant primary progressive aphasia (svPPA), a clinical syndrome ass...
Preprint
Anterior temporal lobe (ATL) degeneration is caused by a pathological process that has a focal onset in the left or right hemisphere. Patients with left-lateralized ATL atrophy typically meet criteria for semantic variant primary progressive aphasia (PPA), a clinical syndrome characterized by loss of verbal semantic knowledge. There is less consens...
Article
Naming of nouns and verbs can be selectively impaired in neurological disorders, but the specificity of the neural and cognitive correlates of such dissociation remains unclear. Functional imaging and stroke research sought to identify cortical regions selectively recruited for nouns versus verbs, yet findings are inconsistent. The present study in...
Article
Background and Purpose The ventral occipitotemporal cortex (vOT) is a region crucial for reading acquisition through selective tuning to printed words. Developmental dyslexia is a disorder of reading with underlying neurobiological bases often associated with atypical neural responses to printed words. Previous studies have discovered anomalous str...
Article
Brainhack is an innovative meeting format that promotes scientific collaboration and education in an open, inclusive environment. This NeuroView describes the myriad benefits for participants and the research community and how Brainhacks complement conventional formats to augment scientific progress.
Article
When primates (both human and non-human) learn to categorize simple visual or acoustic stimuli by means of non-verbal matching tasks, two types of changes occur in their brain: early sensory cortices increase the precision with which they encode sensory information, and parietal and lateral prefrontal cortices develop a categorical response to the...
Preprint
Full-text available
Brainhack is an innovative meeting format that promotes scientific collaboration and education in an open and inclusive environment. Departing from the formats of typical scientific workshops, these events are based on grassroots projects and training, and foster open and reproducible scientific practices. We describe here the multifaceted, lasting...
Article
Full-text available
Having the means to share research data openly is essential to modern science. For human research, a key aspect in this endeavor is obtaining consent from participants, not just to take part in a study, which is a basic ethical principle, but also to share their data with the scientific community. To ensure that the participants' privacy is respect...
Article
Full-text available
Scientific research aims to bring forward innovative ideas and constantly challenges existing knowledge structures and stereotypes. However, women, ethnic and cultural minorities, as well as individuals with disabilities, are systematically discriminated against or even excluded from promotions, publications, and general visibility. A more diverse...
Preprint
Reading requires the sophisticated interplay of multiple neurocognitive systems. Decades of neuropsychological and neuroimaging findings have shed light onto the highly specialized brain areas along the ventral occipitotemporal stream that harbor the first critical step: the transition from grouping of lines to recognizable words.Here, we report on...
Preprint
Scientific research aims to bring forward innovative ideas and constantly challenges existing knowledge structures and stereotypes. However, women, ethnic and cultural minorities, as well as individuals with disabilities, are systematically discriminated against or even excluded from promotions, publications, and general visibility. A more diverse...
Preprint
Awake humans constantly extract conceptual information from a flow of perceptual inputs. Category membership (e.g., is it an animate or inanimate thing? ) is a critical semantic feature used to determine the appropriate response to a stimulus. Semantic representations are thought to be processed along a posterior-to-anterior gradient reflecting a s...
Article
Reading aloud requires mapping an orthographic form to a phonological one. The mapping process relies on sublexical statistical regularities (e.g. 'oo' to |uː|) or on learned lexical associations between a specific visual form and a series of sounds (e.g. yacht to/jɑt/). Computational, neuroimaging, and neuropsychological evidence suggest that subl...
Article
Full-text available
Post-mortem studies show that focal anterior temporal lobe (ATL) neurodegeneration is most often caused by frontotemporal lobar degeneration TDP-43 type C pathology. Clinically, these patients are described with different terms, such as semantic variant primary progressive aphasia (svPPA), semantic dementia (SD), or right temporal variant frontotem...
Article
The temporal variant of frontotemporal dementia (tv-FTD) is a progressive neurodegenerative disease with a complex clinical picture mainly characterized by behavioral and language disorders. In this work, we describe clinical, genetic, neuroanatomical and neuropathological (only in one case) features of two patients with tv-FTD carrying C9orf72 rep...
Article
Intrinsic connectivity networks (ICNs) identified through task-free fMRI (tf-fMRI) offer the opportunity to investigate human brain circuits involved in language processes without requiring participants to perform challenging cognitive tasks. In this study, we assessed the ability of tf-fMRI to isolate reproducible networks critical for specific la...
Article
Full-text available
The human anterior insula (aINS) is a topographically organized brain region, in which ventral portions contribute to socio-emotional function through limbic and autonomic connections, whereas the dorsal aINS contributes to cognitive processes through frontal and parietal connections. Open questions remain, however, regarding how aINS connectivity...
Preprint
Reading aloud requires mapping an orthographic form to a phonological one. The mapping process relies on sub-lexical statistical regularities (e.g., “oo” to |u□|) or on learned lexical associations between a specific visual form and a series of sounds (e.g., yacht to /j□t/). Computational, neuroimaging, and neuropsychological evidence suggest that...
Preprint
Post-mortem studies show that focal anterior temporal lobe (ATL) neurodegeneration is most often caused by frontotemporal lobar degeneration TDP-43 type C pathology. Clinically, these patients are described with different terms, such as semantic variant primary progressive aphasia (svPPA), semantic dementia (SD), or right temporal variant frontotem...
Article
Full-text available
Background: Semantic variant primary progressive aphasia (svPPA), a clinical syndrome characterized by loss of semantic knowledge, is associated with neurodegeneration that starts in the anterior temporal lobe (ATL) and gradually spreads towards posterior temporal and medial frontal areas. At the earliest stages, atrophy may be predominantly latera...
Preprint
Full-text available
The human anterior insula (aINS) is a topographically organized brain region, in which ventral portions contribute to socio-emotional function through limbic and autonomic connections, whereas the dorsal aINS contributes to cognitive processes through frontal and parietal connections. Open questions remain, however, regarding how aINS connectivity...
Article
Processing a famous face involves a cascade of steps including detecting the presence of a face, recognizing it as familiar, accessing semantic/biographical information about the person, and finally, if required, production of the proper name. Decades of neuropsychological and neuroimaging studies have identified a network of occipital and temporal...
Article
Reduplicative paramnesia for places (i.e., the delusional belief that a place has been duplicated or exists in two different locations) is a rare disorder observed in neurological patients. We review the existing literature on the topic, highlighting commonalities and differences among the 51 cases published since the first report in 1903. Our resu...
Article
Previous evidence from neuropsychological and neuroimaging studies suggests functional specialization for tools and related semantic knowledge in a left frontoparietal network. It is still debated whether these areas are involved in the representation of rudimentary movement-relevant knowledge regardless of semantic domains (animate vs. inanimate)...
Article
Full-text available
The semantic variant of primary progressive aphasia (svPPA) is a clinical syndrome characterized by semantic memory deficits with relatively preserved motor speech, syntax, and phonology. There is consistent evidence linking focal neurodegeneration of the anterior temporal lobes (ATL) to the semantic deficits observed in svPPA. Less is known about...
Article
Full-text available
A single word (the noun " elephant") encapsulates a complex multidimensional meaning, including both perceptual (" big," " gray," " trumpeting") and conceptual (" mammal," " can be found in India") features. Opposing theories make different predictions as to whether different features (also conceivable as dimensions of the semantic space) are store...
Article
A current intense discussion in numerical cognition concerns the relationship between the processing of numerosity and other non-numerical quantities. In particular, it is a matter of debate whether number and other quantities (e.g., size, length) are represented separately in the brain or whether they share a common generalized magnitude represent...
Article
We live our lives surrounded by symbols (e.g., road signs, logos, but especially words and numbers), and throughout our life we use them to evoke, communicate and reflect upon ideas and things that are not currently present to our senses. Symbols are represented in our brains at different levels of complexity: at the first and most simple level, as...
Thesis
One of the core human abilities is that of interpreting symbols. Notwithstanding decades of neuropsychological and neuroimaging work on the cognitive and neural substrate of semantic representations, many questions are left unanswered. The research in this dissertation attempts to unravel one of them: are the neural substrates of different componen...
Conference Paper
Full-text available
The application of multivariate approaches to neuroimaging data analysis is providing cognitive neuroscientists with a new perspective on the neural substrate of conceptual knowledge. In this paper we show how the combined use of decoding models and of representational similarity analysis (RSA) can enhance our ability to investigate the inter-categ...

Network

Cited By

Projects

Project (1)