Valentin Natarov- M.Sc (Chemistry)
- Researcher at Belarusian State University
Valentin Natarov
- M.Sc (Chemistry)
- Researcher at Belarusian State University
About
11
Publications
4,311
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277
Citations
Introduction
Industrial production of reagents for molecular biology. Synthesis, functionalization and biomedical applications of hybrid magnetic nanoparticles. Nucleic acids technologies. Medical PCR analysis.
Current institution
Additional affiliations
May 2016 - present
JSC "GenTerra"
Position
- Lead technologist
Description
- Production of magnetic particles for isolation and purification of nucleic acids. Production of enzymes and other reagents for molecular biology.
December 2015 - March 2016
Position
- Intern
Description
- Synthesis of magnetic nanocomposites.
August 2015 - November 2015
Position
- Intern
Description
- Reagents for molecular biology. Isolation and purification of nucleic acids. PCR analysis.
Education
September 2011 - July 2017
Publications
Publications (11)
Two facile methods for bulk preparation of γ-Fe2O3/SiO2 agglomerated magnetic nanocomposite (MNC) particles for magnetic separation of nucleic acids (NAs) are compared together. Different silica coating approaches were used for iron oxide silanization: Stöber method and sodium silicate dense-liquid process. Additional thermal treatment at 750 °C pr...
Structural characteristics and magnetic properties of ZnxFe3–xO4 (where х = 0; 0.09; 0.18; 0.45; 1) nanoparticles were studied with X-ray diffraction (XRD), transmission electron microscopy (TEM), infrared spectroscopy (IR) and vibrating sample magnetometry (VSM). Oxidation of Fe²⁺ ions, redistribution of Zn²⁺ and Fe³⁺ ions between octahedral and t...
The lightly doped BaFe12-xDxO19 (D = Al³⁺, In³⁺; x = 0.1 and 0.3) polycrystalline hexaferrite samples have been investigated by powder neutron diffractometry as well as by vibration sample magnetometry in a wide temperature range from 4 K up to 740 K and in magnetic field up to 14 T to establish the nature of Fe³⁺(Al³⁺, In³⁺) – O²⁻ - Fe³⁺(Al³⁺, In³...
M-type BaFe11.9Al0.1O19 hexaferrite was successfully synthesized by solid state reactions. Precision investigations of crystal and magnetic structures of BaFe11.9Al0.1O19 powder by neutron diffraction in the temperature range 4.2 – 730 К have been performed. Magnetic and electrical properties investigations were carried out in the wide temperature...
The results of proton nuclear magnetic resonance (NMR) relaxation measurements in aqueous solutions of MgxZnyFe3-x-yO4 magnetite-based composite magnetic nanoparticles (MNPs) are discussed. It is shown that their transverse relaxivity (relaxation efficiency) r2 is significantly higher than the longitudinal relaxivity r1 and depends on the magnetic...
The crystal structure features and the unit cell parameters were refined using the powder x-ray method for the solid solutions BaFe12−x Ga xO19 (x = 0.1–1.2) barium hexagonal ferrites of M-type at 300 K. With increase of substitution level the unit cell parameters monotonically decrease. The temperature and field dependences of the specific magneti...
NMR relaxation of protons in aqueous solutions of MgxZnyFe3-x-yO4 ferrite nanoparticles, on the surface of which poly(diallyldimethylammonium chloride) is adsorbed, was studied. The transverse relaxivity r2 is significantly higher than the longitudinal relaxivity r1 and depends on the composition and synthetic method of ferrites. Being of comparabl...
Superparamagnetic ferrite nanoparticles in the system of MgxZn1-xFe2O4 (х = 0,25; 0,5; 0,7) were prepared by coprecipitation, spray pyrolysis and nitrate-citrate approaches. The dependence of the phase composition, morphology and magnetic properties of the nanoparticles on their chemical composition and synthesis conditions were studied. The crysta...
Results of proton NMR relaxation measurements in
aqueous solutions of iron oxide composite magnetic nanoparticles
are discussed. It is shown that their r2 relaxation efficiency
coefficient is much higher than r1 relaxation efficiency coefficient
and depends on the composition, method of MNPs synthesis. It
allows to use this parameter to assess the...
Citric-stabilized colloidal solutions of Fe3O4 and Zn0.18Fe2.82O4 nanosized oxides were studied as potential contrasting agents for MRI. The samples were characterized by TEM, SEM, XRD, PMR- and IR-spectroscopy. The Zn-doped Fe3O4 was shown to have higher magnetization and T2-relaxivity as compared to pure Fe3O4. A low concentration threshold of th...
Questions
Questions (5)
Dear colleagues
I have a GeneRead QIACube station which is specified for no longer supported Qiagen NGS GeneReader workflow (emulsion technology). It looks pretty much the same as casual QIACube, but has other worktable and screen. I just can't put a standard reagent tray into the device.
Is it possible to convert GeneRead QIACube (NGS sample preparation) into a QIACube for NA isolation?
Dear colleagues
Recently, I decided to reproduce the approach for the synthesis of magnetite/polystyrene microparticles via emulsion polymerization developed by dr. Gu lab. I used this paper:
I've prepared magnetic fluid which is oleic acid coated magnetite nanoparticles in heptane 50 Wt% (the authors used octane, but I didn’t see significant difference) and tried to sonicate it (10 min, 600 W) in 0.4 mg/ml SDS (1/20 V/V).
Unfortunately, I faced the problem that during sonication there are some large clumps of magnetite formed. I can easily separate them but it causes some loses of the product. It's definitely agglomerated hydrophobic magnetite because I can dissolve them in hexane completely. Increasing of SDS conc. is undesirable because it's make droplets smaller than I need. Decreasing of magnetite content in magnetic fluid also undesirable because I want high magnetite content in the resulted hybrid beads.
I'll be glad any suggestions
Valentin
Dear colleagues
I'm an R&D lab head in a small chemical company. There are only 5 members in our lab. Our company produces synthetic oligonucleotides, enzymes and make custom organic synthesis. I'm interested to set up an electronic lab system to manage current research projects effectively.
We are currently trying free platforms such as Notion and Bitrix24. They have basic modules but I'm curious about something more specialized for researchers.
Could anyone suggest me free or paid platforms for scientific projects management (chemistry, biotech)?
Dear colleagues. What set of buffer solutions (components and concentrations) is better for general zeta porential measurement of nanoparticles at specific ph. In particular, I'm interested to make zeta potential vs ph (2-11) curve for mangetite nanoparticles and PS-PAA micropartucles. I'm using Malvern Zetasizer ZSP.
How to conduct measurement at ph near IEP when particles have a strong tendency to agglomerate?
Thank you for any advise
Valentin N.
Dear fellow scientists
I am studying the effect of electrolytes on the size of agglomerates of magnetite nanoparticles in water or EtOH/water. Malvern zetasizer ZS is probably the best device for that (the most available), but anyway the obtained results are not clear becouse of preciptation taking place during the measurements. I tried ultrasonication but I'm affraid It can affect to the size of agglomerates (my aim)
Could you advice me how to optimize the measuremt protocol using Zetasizer or what method to use for the measurement of the size of agglomerated magnetite nanoparticles (without their damage).
How to measure large microparticles (1-5 mkm) using Zetasizer (stable agglomerates, kind of solvent is not important) and be sure that precipitation do not affect to the results?
With best regards
