Valdes Bollela

Valdes Bollela
University of São Paulo | USP · Tropical & Infectious Diseases Division of Internal Medicine Department FMRP-USP (Ribeirão Preto)

MD. PhD.; Infectious Diseases and Health Professions Educator Specialist.

About

185
Publications
63,708
Reads
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2,298
Citations
Introduction
MD; PhD. Associate Professor at Tropical and Infectious Diseases Division of Internal Medicine Department at Ribeirão Preto School of Medicine, University of São Paulo (FMRP-USP), Brazil. Main research areas: drug-resistant tuberculosis; molecular diagnosis of TB, whole genome sequencing for TB diagnosis and epidemiologic studies; Nontuberculous Mycobacteria, HIV-aids. Co-founded Brazilian FAIMER Regional Institute (2007). Fellow (2006-2008) and Global Faculty at FAIMER Philadelphia (2009-2018). Expert in Health Professions Education (HPE) with the main focus on Medical Education (Assessment and curriculum design). Hospital Administration specialist (2010).
Additional affiliations
February 2011 - December 2026
University of São Paulo
Position
  • Professor (Associate)
June 2006 - February 2011
Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo
Position
  • Outpatient Clinic Manager
Description
  • I was the manager in the outpatient Clinic of the Hospital. A place where 2.000 patients has been seen every day, in more than 160 different specialties.
March 1996 - February 2011
Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo
Position
  • Research Assistant
Description
  • Worked in the special Unit for HIV and infectious diseases.

Publications

Publications (185)
Article
Full-text available
We correlated clinical, epidemiological, microbiological, and genomic data of an outbreak with polymyxin B (PB)- and carbapenem-resistant Klebsiella pneumoniae during the COVID-19 pandemic. Twenty-six PB- and carbapenem-resistant K. pneumoniae were isolated from patients in the COVID-19 ICU (Intensive Care Unit), non-COVID-19 ICU (Intensive Care Un...
Article
Aims: To investigate the influence of pharmacogenetic polymorphisms on efavirenz (EFV) exposure and metabolism in HIV-infected Brazilians under treatment with EFV-containing antiretroviral (ART) regimens. Methods: HIV-positive adults (n=82) on stable ART regimens containing 600 mg EFV once daily for at least 6 months were recruited at two univer...
Article
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We conducted a prospective cohort study in a population with diverse ethnic backgrounds from Brazil to assess clinically meaningful symptoms after surviving coronavirus disease. For most of the 175 patients in the study, clinically meaningful symptoms, including fatigue, dyspnea, cough, headache, and muscle weakness, persisted for >120 days after d...
Article
There are contrasting findings regarding the effect of HIV on the pharmacokinetics of first-line anti-tubercular drugs (FLATDs) due to a lack of prospective controlled clinical studies, including patients with tuberculosis (TB) and patients with TB living with HIV. This study aims to assess the effect of HIV coinfection and antiviral therapy on the...
Article
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Objective: To identify and synthesize the scientific knowledge produced regarding the effectiveness of the GeneXpert test in the diagnosis of pulmonary tuberculosis (TB) in people living with HIV/AIDS. Methods: Integrative literature review, which was searched on Embase, Scopus, PubMed, Cinahl, Academic Search Premier, Socindex, and LILACS platf...
Article
Some studies have demonstrated a high prevalence of Candida species in patients with tuberculosis (TB). This is most likely due to long-term antimicrobial therapy. To date, no longitudinal studies addressed the effects of anti-TB treatment on the fungal burden and virulence of Candida spp. This study investigated the prevalence and virulence of Can...
Article
Full-text available
There are contrasting findings regarding the effect of HIV on the pharmacokinetics of first-line anti-tubercular drugs (FLATDs) due to a lack of prospective controlled clinical studies, including patients with tuberculosis (TB) and patients with TB living with HIV. This study aims to assess the effect of HIV coinfection and antiviral therapy on the...
Article
A prática assistencial em saúde apresenta desafios crescentes, exigindo do médico o desenvolvimento de habilidades e competências diversificadas que facilitem a sua atuação qualificada. A reflexão crítica e a autonomia no gerenciamento da prática profissional exigem do médico domínio de fundamentos de metodologia científica, o que nem sempre é cont...
Article
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RESUMO Este artigo traz uma reflexão sobre transformações possíveis e necessárias, a partir das experiências vividas por docentes, estudantes e instituições de ensino ao longo do ano de 2020, na medida em que sobreviviam, aprendiam e se adaptavam à pandemia da COVID-19. Não resta dúvidas de que a maneira de ensinar deverá estar alicerçada em conhec...
Article
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RESUMO Todo o conhecimento acumulado sobre o processo de ensino e aprendizagem, considerando as melhores práticas docentes e os conceitos sobre aprendizado de adultos, aprendizagem significativa e aprendizado centrado no es-tudante devem ser continuamente exercitados e revisitados, independente do formato: presencial, ensino remoto (ER) ou ensino a...
Article
A pandemia da Covid-19 e as ações para seu enfrentamento resultaram, entre outras coisas, na suspensão das aulas presenciais nas instituições de ensino e em todos os níveis, da educação básica ao ensino superior. Seguindo as recomendações do Ministério da Saúde e da Secretaria Estadual da Saúde e sem poder manter as atividades de ensino presenciais...
Article
A pandemia da COVID-19 impactou a educação superior de diversas formas, demandando criatividade e resiliência no seu enfrentamento. Além dos novos desafios, o cenário induzido pela crise sanitária também agudizou problemas pré-existentes, principalmente no que se refere às relações humanas dentro da universidade, à equidade no acesso a recursos edu...
Article
Após a suspensão das aulas presenciais em 2020, devido à pandemia da Covid-19, foi necessário viabilizar educação remota emergencial para milhares de estudantes de todos os níveis do ensino no Brasil. Quase ninguém estava preparado para enfrentar um desafio desta grandeza. Por conta da falta de familiaridade com as estratégias de educação mediada p...
Article
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Introduction: Antimicrobial resistance has worsened since the onset of COVID-19. Methods: This study involved patients admitted to the adult intensive care unit (ICU) of a tertiary hospital. Pre- and post-COVID-19 data were analyzed. The healthcare-related infections (HCRIs) reported between January 2018 and January 2020 and during the pandemic...
Article
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Objective: to identify the prevalence of latent tuberculosis in patients with chronic kidney disease on hemodialysis and associated factors. Method: a cross-sectional study conducted with 176 patients with chronic kidney disease on hemodialysis. The tuberculin test was performed with the standardized antigen, distributed by the Brazilian Ministr...
Article
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Introduction: This epidemiological household survey aimed to estimate the prevalence of the current and past SARS-CoV-2 infections in Ribeirão Preto, a municipality of southeast Brazil. Methods: The survey was conducted in two phases using a clustered sampling scheme. The first phase spanned May 1-3 and involved 709 participants. The second phas...
Article
Full-text available
To describe the medium-term ophthalmological findings in patients recovering from COVID-19. Patients recovered from the acute phase of COVID-19 underwent a complete ophthalmological evaluation, including presenting and best-corrected visual acuity (BCVA), refractometry, biomicroscopy, tonometry, break-up time and Schirmer tests, indirect ophthalmos...
Article
Molecular-typing can help in unraveling epidemiological scenarios and improvement for disease control strategies. A literature review of Mycobacterium tuberculosis transmission in Brazil through genotyping on 56 studies published from 1996-2019 was performed. The clustering rate for mycobacterial interspersed repetitive units-variable tandem repeat...
Article
Full-text available
Molecular-typing can help in unraveling epidemiological scenarios and improvement for disease control strategies. A literature review of Mycobacterium tuberculosis transmission in Brazil through genotyping on 56 studies published from 1996-2019 was performed. The clustering rate for mycobacterial interspersed repetitive units - variable tandem repe...
Article
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Although ocular toxoplasmosis is a leading cause of posterior uveitis worldwide, there is scarce information about the real-life frequency of ocular lesions, visual outcomes, and risk factors for poor prognosis. We conducted a community-based cross-sectional study with 721 adults living in Cássia dos Coqueiros, Southeast Brazil, consisted of visual...
Article
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Objective To evaluate whether the addition of colchicine to standard treatment for COVID-19 results in better outcomes. Design We present the results of a randomised, double-blinded, placebo-controlled clinical trial of colchicine for the treatment of moderate to severe COVID-19, with 75 patients allocated 1:1 from 11 April to 30 August 2020. Colc...
Article
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Severe COVID-19 patients develop acute respiratory distress syndrome that may progress to cytokine storm syndrome, organ dysfunction, and death. Considering that neutrophil extracellular traps (NETs) have been described as important mediators of tissue damage in inflammatory diseases, we investigated whether NETs would be involved in COVID-19 patho...
Article
Candida albicans is the main causative agent of oral lesions in HIV-infected patients and its oral colonization is a potential source of systemic dissemination. Although the high prevalence of lesions in HIV patients can be explained by the immunosuppressive condition, several studies have reported that natural selection can make C. albicans more v...
Article
Histoplasmosis is a systemic infectious disease caused by the fungus Histoplasma capsulatum, which is present in contaminated soils. Infection occurs by inhaling microconidia from the filamentous phase of the fungus, and 1 of the variations of the clinical spectrum of this disease is to affect immunocompromised patients. A female patient, 41 years...
Preprint
Full-text available
Introduction Neutrophilia and high levels of proinflammatory cytokines and other mediators of inflammation are common finds in patients with severe acute respiratory syndrome due to COVID-19, a dramatic condition for which there is no specific treatment, but supportive care and attempts to control the systemic inflammation. By its action on leukocy...
Article
Tuberculosis (TB) is the leading cause of mortality among infectious diseases worldwide. The study of molecular targets for therapy and diagnosis suggested that Notch signaling is an important pathway for the maintenance of the immune response during Mycobacterium tuberculosis (Mtb) infection. We evaluated the participation of the Notch pathway in...
Preprint
Full-text available
Severe COVID-19 patients develop acute respiratory distress syndrome that may progress to respiratory failure. These patients also develop cytokine storm syndrome, and organ dysfunctions, which is a clinical picture that resembles sepsis. Considering that neutrophil extracellular traps (NETs) have been described as an important factors of tissue da...
Article
Roselino et al. (2001) reported the first link between salivary proteins from sand flies and pemphigus foliaceus (PF) pathogenesis on the basis that patients living in a Brazilian region where PF is endemic showed higher titers of IgG antibodies against maxadilan, one of the most immunogenic salivary proteins described in Lutzomyia longipalpis, as...
Article
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Over the years, various recommendations have been made in pursuit of controlling resistance to antituberculosis drugs, especially multidrug resistance, in Brazil. Given the importance of standardizing those recommendations, the aim of this study was to describe the main recommendations of the Brazilian guidelines, primarily those related to the tre...
Article
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Objective Multidrug‐resistant tuberculosis (MDR‐TB) remains a serious public health problem worldwide. Accordingly, this study sought to identify individual, community and access to health services risk factors for MDR‐TB. Methods Retrospective cohort of all TB cases diagnosed between 2006 and 2016 in the state of São Paulo. A Bayesian Spatial Hie...
Article
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The aim of the study was to compare the impact of 12-week resistance training with blood flow restriction (GRTBFR) versus, traditional resistance training (GTRT) and non-training on the muscle strength and body composition HIV/AIDS participants. Muscle strength was tested at baseline, and on the 6th, 21st and 36th training sessions, using maximal r...
Article
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In face of the current pandemic, universities are closing worldwide. In Brazil, as elsewhere, academic activities have been suspended in response to the Ministry of Health’s recommendations to socially distance. This created risk of suboptimally utilizing the great potential students have to contribute to the COVID‐19 response.
Article
Objective Tuberculosis (TB) transmission in healthcare facilities is still a concern in low-income countries, where airborne isolation rooms are scarce due to high costs. We evaluated the use of single GeneXpert MTB/RIF, the molecular Mycobacterium tuberculosis (MTB) DNA and resistance to rifampicin (RIF) test, as an accurate and faster alternative...
Article
Background: Mozambique is a high-burden tuberculosis (TB) country where TB/HIV co-infection and drug resistant TB (DR-TB) incidence is increasing. Whole genome sequencing (WGS) comprehensively describes the molecular epidemiology of TB, allows prediction of DR-TB phenotypes, lineages strains identification and better understanding of transmission...
Article
Background: Mozambique is a high-burden tuberculosis (TB) country where TB/HIV co-infection and drug resistant TB (DR-TB) incidence is increasing. Whole genome sequencing (WGS) comprehensively describes the molecular epidemiology of TB, allows prediction of DR-TB phenotypes, lineages strains identification and better understanding of transmission c...
Article
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Introduction: Delivering bad news is a difficult task for physicians, and medical schools do not always prepare future physicians for this inevitable task. Objective: To examine training in breaking bad news, to improve medical students' competence and confidence in dealing with this important aspect of clinical practice. Methods: An explorato...
Article
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Introduction: Mozambique is one of three countries with high prevalence of tuberculosis (TB), TB/human immunodeficiency virus coinfection, and multidrug-resistant TB. We aimed to describe Mycobacterium tuberculosis spoligotypes circulating among drug resistant (DR) strains from Beira, Mozambique comparing them with genotypes in the country. Metho...
Article
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Introduction: currently, there is no consensus regarding accurate and low-cost methods for diagnosing lipodystrophy in people living with HIV/AIDS (PLWHA). The aim of this study was to propose anthropometric cutoff points for the diagnosis of lipodystrophy among PLWHA. Methods: we included 106 PLWHA (men = 65, women = 41) who are under antiretro...
Article
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Objetivo Analisar os desafios relacionados à regularidade no uso da terapia antirretroviral pelas pessoas vivendo com HIV privadas de liberdade. Métodos Trata-se de um estudo exploratório, com abordagem quantitativa, realizado em seis unidades prisionais de dois municípios paulistas. A coleta de dados ocorreu no período de agosto a novembro de 201...
Article
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Objective: to analyze the temporal trend, identify the factors related and elaborate a predictive model for unfavorable treatment outcomes for multidrug-resistant tuberculosis (MDR-TB). Methods: Retrospective cohort study with all cases diagnosed with MDR-TB between the years 2006 and 2015 in the state of São Paulo. The data were collected from...
Article
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Effective treatment of tuberculosis (TB) remains a serious public health problem in many countries, including Brazil, especially when considering drug-resistant disease. Xpert MTB/RIF has been implemented in many countries to reduce the time to TB diagnosis and to rapidly detect rifampicin resistance. The study aimed to describe and evaluate Xpert...
Article
Lineage 1 (L1) is one of seven Mycobacterium tuberculosis complex (MTBC) lineages. The objective of this study was to improve the complex taxonomy of L1 using phylogenetic SNPs, and to look for the origin of the main L1 sublineage prevalent in Para, Brazil. We developed a high-throughput SNPs-typing assay based on 12-L1-specific SNPs. This assay al...
Chapter
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RESUMO Este estudo buscou conhecer as percepções sobre quais competências devem ser desenvolvidas no internato, do ponto de vista da comunidade e de gestores do SUS. Para tal, dois grupos focais (GF) foram organizados: GF1 - gestores municipais e estaduais e GF2 - usuários representantes dos Conselhos Estadual e Municipal de Saúde, com posterior an...
Article
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Background An outcome-based curriculum helps to communicate expectations of performance to students and clinical teachers. The Mini Clinical Evaluation Exercise (mini-CEX) is a useful tool for workplace-based formative assessment. The objective of this study was to use workplace-based assessment and student feedback to evaluate an Obstetrics and Gy...
Article
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Tuberculosis (TB) was responsible for approximately 1.6 million deaths in 2017 and it is the deadliest among the infectious diseases, killing more than Acquired Immunodeficiency Syndrome (AIDS) related diseases. One of the most lethal forms of this disease is the central nervous system TB. The clinical and microbiological diagnosis of tuberculous m...
Article
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INTRODUCTION: The prevalence of Toxoplasma gondii infection varies markedly among different populations, especially depending on factors related to socioeconomic development and eating habits. Cássia dos Coqueiros is a small city in Brazil with rural characteristics and increased risk factors traditionally associated with T. gondii infection. METH...
Article
ABSTRACT Introduction: In 2010, the Ottawa Conference produced a set of consensus criteria for good assessment. These were well received and since then the working group monitored their use. As part of the 2010 report, it was recommended that consideration be given in the future to preparing similar criteria for systems of assessment. Recent develo...
Article
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Following publication of the original article [1], one of the authors flagged that unfortunately their last name, Doltario, was incorrectly spelled as 'Dotrário'. This has since been corrected in the original article [1].
Article
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O presente artigo tem por objetivo apresentar três projetos de ensino desenvolvidos em cursos de graduação da Universidade Federal de Goiás – UFG, sendo eles: 1º) na Escola de Engenharia Elétrica, Mecânica e de Computação (EMC) o Prof. Dr. Getúlio Antero de Deus Júnior tem trabalhado com Aprendizagem Baseada em Problemas (PBL) e Aprendizagem Basead...
Article
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O objetivo deste estudo foi avaliar a sala de aula invertida como estratégia de ensino-aprendizagem para o conteúdo abertura coronária. O material didático para estudo prévio individual pelos estudantes foi disponibilizado online por meio de um software/aplicativo para desktop e dispositivos móveis contendo textos, imagens e vídeos demonstrativos....
Article
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Este artigo descreve a experiência do projeto Pró-Ensino na Saúde (Capes-Edital 024/2010) da Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo. Entre 2011 e 2016 o projeto formou quatro mestres e cinco doutores, além de criar disciplinas abordando tópicos de ensino-aprendizagem na saúde. Nesse período, consolidou-se grupo de pesqui...
Article
Background: Body fat redistribution and metabolic abnormalities found in HIV patients receiving highly active antiretroviral therapy (HAART) contribute to an atherogenic profile, increasing cardiovas-cular disease risk. Objective: We aimed to evaluate adiposity measures/indexes and propose cutoffs associated with predictors of cardiovascular diseas...
Article
Background: Body fat redistribution and metabolic abnormalities found in HIV patients receiving highly active antiretroviral therapy (HAART) contribute to an atherogenic profile, increasing cardiovascular disease risk. Objective: We aimed to evaluate adiposity measures/indexes and propose cutoffs associated with predictors of cardiovascular dise...
Article
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Interleukin (IL)-1β is a potential target for treatment of several inflammatory diseases, including envenomation by the scorpion Tityus serrulatus. In this context, bioactive lipids such as prostaglandin (PG)E2 and leukotriene (LT)B4 modulate the production of IL-1β by innate immune cells. Pattern recognition receptors (PRRs) that perceive T. serru...
Data
Shows the gene expression of Cd14 and Cd36 in C57BL/6 peritoneal macrophages stimulated with T. serrulatus venom (TsV), and tumor necrosis factor (TNF)-α and IL-6 quantification in C57BL/6, Cd14−/−, and Cd36obl/obl peritoneal macrophages stimulated with TsV.
Data
Shows gene expression of Ptgs2, and prostaglandin (PG)E2, IL-1β, TNF-α, and IL-6 quantification in Tlr2−/− and Tlr4−/− peritoneal macrophages stimulated with TsV.
Data
Shows hematological parameters of healthy human subjects.
Data
Shows soluble CD14 quantification in plasma of envenomed patients and controls; mean fluorescence intensity (MFI) of CD14 and CD36 cell membrane expression in healthy human whole blood stimulated or not with TsV; PGE2, IL-1β, TNF-α, and IL-6 quantification in healthy human peripheral blood mononuclear cells (PBMC) stimulated or not with TsV; and co...
Article
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Monocytes are key cells in the immune dysregulation observed during human immunodeficiency virus (HIV) infection. The events that take place specifically in monocytes may contribute to the systemic immune dysfunction characterized by excessive immune activation in infected individuals, which directly correlates with pathogenesis and progression of...