Vaishnavi Mallikarjun

Bannari Amman Institute of Technology | BIT · Department of Computer Science and Engineering

According to an FDA survey conducted between 1995 and 2002, only 9% of the new drug entities belonged to BCS class-I category, majority of new drug candidates (approximately more than 40%) have poor aqueous solubility because of their low bioavailability. Self emulsifying drug delivery systems (SEDDS) are a class of lipid based delivery systems con...

Oral delivery is not possible for 50% of currently marketed drug compounds due to low oral bioavailability. One of the most popular approaches to enhance the oral bioavailability of these molecules is the utilization of a lipid based drug delivery systems. Self emulsifying drug delivery systems (SEDDS) are a class of lipid based delivery systems. C...

Dendrimers are a new class of synthetic polymers which have the structure like a tree or star shape, with a central core, interior branches and terminal groups which decorate the surface. Cavities inside the core and the interior branches can be modified to carry hydrophobic and hydrophilic drugs. The terminal groups on the surface can also be adap...

Poorly water soluble compounds have solubility and dissolution related bioavailability problems. The dissolution rate is directly proportional to solubility of drugs. Drugs with low aqueous solubility have low dissolution rates and hence suffer from oral bioavailability problems. The poor solubility and poor dissolution rate of poorly water soluble...

The purpose of this investigation was to prepare a gastro retentive drug delivery system of Glipizide. Floating tablets of Glipizide were prepared employing two different grades of HPMCK4 and HPMC K15 polymers by effervescent technique; these grades of polymers were evaluated for their gel forming properties. Sodium bicarbonate was incorporated as...