Vaida Glatt

Vaida Glatt
The University of Texas Health Science Center at San Antonio | UT HSC · Department of Orthopaedics

PhD

About

133
Publications
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Publications

Publications (133)
Article
Full-text available
Orthopaedic surgeons routinely assess the biomechanical environment of a fracture to create a fixation construct that provides the appropriate amount of stability in efforts to optimize fracture healing. Emerging concepts and technologies including reverse dynamization, “smart plates” that measure construct strain, and FractSim software that models...
Article
The management of bone defects and nonunions creates unique clinical challenges. Current treatment alternatives are often insufficient and frequently require multiple surgeries. One promising option is bone morphogenetic protein-2 (BMP-2), which is the most potent inducer of osteogenesis. However, its use is associated with many side effects, relat...
Article
Background: The concept of reverse dynamization involves modifying the mechanical environment surrounding a fracture to influence the healing response. Initially, less rigid stabilization is performed to allow micromotion, encouraging cartilaginous callus formation. This is followed by a conversion to more rigid fixation to prevent the disruption...
Article
Full-text available
At the 2021 annual meeting of the Orthopaedic Trauma Association, the Basic Science Focus Forum hosted its first ever debate-style symposium focused on biomechanics and fracture repair. The 3 subjects of debate were "Mechanics versus Biology-Which is 'More Important' to Consider?" "Locked Plate versus Forward Dynamization versus Reverse Dynamizatio...
Article
Background: The purpose of this study was to perform a systematic review and meta-analysis of studies comparing local injections of either platelet-rich plasma (PRP) or corticosteroid for the treatment of lateral elbow epicondylitis. Methods: A systematic review of Medline, Embase, Scopus, and Google Scholar was performed, and all level 1 and 2...
Article
Our previous rat study demonstrated an ex vivo-created “Biomimetic Hematoma” (BH) that mimics the intrinsic structural properties of normal fracture hematoma, consistently and efficiently enhanced the healing of large bone defects at extremely low doses of rhBMP-2 (0.33 μg). The aim of this study was to determine if an extremely low dose of rhBMP-2...
Article
Successful repair of large bone defects remains a clinical challenge. Following fractures, a bridging hematoma immediately forms as a crucial step that initiates bone healing. In larger bone defects the micro-architecture and biological properties of this hematoma are compromised, and spontaneous union cannot occur. To address this need, we develop...
Article
Background: The purpose of this study was to perform a systematic review and meta-analysis of both randomized controlled and observational studies comparing conservative to surgical treatment of displaced proximal humerus fractures. Methods: Systematic review of Medline, Embase, Scopus, and Google Scholar, including all level 1-3 studies from 20...
Article
Tibial pilon fractures are typically the result of high-energy axial loads, with complex intra- articular fractures that are often difficult to reconstruct anatomically. Only nine simultaneous pilon and talus fractures have been published previously, but we hypothesised the chondral surface of the dome is affected more frequently. Data was acquired...
Article
This study investigated concurrent talar dome injuries associated with tibial pilon fractures, mapping their distribution across the proximal talar dome articular surface. It compared the two main mechanisms of injury (MOI), falling from a height and motor vehicle accident (MVA), and whether the fractures were open or closed. From a previously comp...
Article
Background: Surgical reconstruction of ACL injuries is a common strategy but superiority over conservative treatment has not been established. The aim was to perform a systematic review and meta-analysis comparing outcomes between operative and non-operative treatment of ACL injuries. Methods: Systematic review of Medline, Embase, Scopus, and Go...
Article
Full-text available
IntroductionThe purpose of this study was to perform a systematic review and meta-analysis of both randomized controlled and observational studies comparing surgical interventions for proximal humerus fractures.Methods Systematic review of Medline, Embase, Scopus, and Google Scholar, including all level 1–3 studies from 2000 to 2022 comparing surgi...
Article
The hematoma that forms between broken fragments of bone serves as a natural fibrin scaffold, and its removal from the defect site delays bone healing. The hypothesis of this study is that the microarchitectural and mechanical properties of the initially formed hematoma has a significant effect on the regulation of the biological process, which ult...
Article
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Introduction Managing critical-sized tibial defects is one of the most complex challenges orthopedic surgeons face. This is even more problematic in the presence of infection and soft-tissue loss. The purpose of this study is to describe a comprehensive three-stage surgical protocol for the reconstruction of infected tibial injuries with combined b...
Article
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Purpose The purpose of this study was to perform a Delphi consensus for the treatment of patients with shoulder impingement with intact rotator cuff tendons, comparing North American to European shoulder surgeon preferences. Methods Nineteen surgeons from North America [NAP] and 18 surgeons from Europe [EP] agreed to participate and answered 10 op...
Article
Purpose The purpose of this systematic review was to investigate variability in biomechanical testing protocols for laboratory-based studies using suture anchors for glenohumeral shoulder instability and SLAP lesion repair. Methods A systematic reviewing of Medline, Embase, Scopus and Google Scholar using Covidence software was performed for all b...
Article
Full-text available
Background Higher posterior tibial slope (PTS) is a risk factor for anterior cruciate ligament (ACL) injury in men and women. The individual contribution of the lateral (LPTS) and medial (MPTS) slope has not yet been investigated. Purpose To determine whether either the LPTS or the MPTS is an independent risk factor for ACL injury, and to determin...
Article
Osteal macrophages (osteomacs) support osteoblast function and promote bone anabolism, but their contribution to osteoporosis has not been explored. While mouse ovariectomy (OVX) models have been repeatedly used, variation in strain, experimental design and assessment modalities, have contributed to no single model being confirmed as comprehensivel...
Article
Full-text available
Purpose: The purpose of this study was to quantify the posterior horn meniscal slope and determine its contribution to the reduction in posterior tibial slope. Methods: Patients aged between 16 and 60 years and had intact menisci with no evidence of previous injury or surgery were included. Patients with radiological evidence of osteoarthritis G...
Article
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The present review acknowledges the tremendous impact of Stephan Perren’s strain theory, considered with respect to the earlier contributions of Roux and Pauwels. Then, it provides further insight by examining how the concept of reverse dynamisation extended Perren’s theory within a modern context. A key factor of this more contemporary theory is t...
Article
Macrophage-targeted therapies, including macrophage colony-stimulating factor 1 (CSF1), have been shown to have pro-repair impacts post-fracture. Preclinical/clinical applications of CSF1 have been expedited by development of chimeric CSF1-Fc which has extended circulating half-life. Here, we used mouse models to investigate the bone regenerative p...
Article
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Purpose The purpose of this study was to measure slope of both the medial and lateral posterior horn of the meniscus, and its contribution to the overall resulting posterior tibial slope (bone and meniscus combined slope) in ACL-intact (ACLI) and ACL-deficient (ACLD) knees. Methods MR images of patients with intact menisci aged between 16-60 years...
Article
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Aim and objective: The purpose of this study was to compare clinical results following complex proximal, midshaft, and distal tibial fractures and investigate whether there are differences in outcomes between these locations. Materials and methods: Patients between 18 years and 65 years of age and minimum follow-up of 12 months with complex tibi...
Article
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Clinical management of delayed healing or non-union of long bone fractures and segmental defects poses a substantial orthopaedic challenge. There are suggestions in the literature that bone healing may be enhanced by inhibiting the activities of T and B lymphocytes, but this remains controversial. To examine this matter in more detail, sub-critical...
Article
Full-text available
Purpose The common peroneal nerve (CPN) can be injured during fibular-based posterolateral reconstructions due to its close relationship to the neck of the fibula. Therefore, the purpose of this study was to observe the course of the CPN and its branches around the fibular head and neck and quantify the position in relation to relevant bony landmar...
Preprint
Full-text available
Osteal macrophages (osteomacs) support osteoblast function and promote bone anabolism, but their contribution to osteoporosis has not been explored. While mouse ovariectomy models have been repeatedly used, variation in strain, experimental design and assessment modalities, have contributed to no single model being confirmed as comprehensively repl...
Article
Background: Reverse dynamization is a mechanical manipulation regimen designed to accelerate bone-healing and remodeling. It is based on the hypothesis that a fracture that is initially stabilized less rigidly allows micromotion to encourage initial cartilaginous callus formation. Once substantial callus has formed, the stabilization should then be...
Article
Objective: Compare anterior minimally invasive plate osteosynthesis (MIPO) to open reduction/internal fixation (ORIF) for humeral shaft fractures, assessing complications and clinical outcomes. Design: Retrospective matched case-controlled cohort. Setting: Tertiary referral trauma centre. Patients/participants: Humeral shaft fractures identi...
Conference Paper
Purpose: Reverse dynamization (RD) is a method developed to accelerate bone healing and remodeling. Using RD, the fracture is initially fixed with a more flexible fixation, and is then followed by a rigid fixation. The hypothesis is that a fracture initially stabilized less rigidly will allow micromotion and encourage cartilaginous callus formation...
Article
Purpose To summarize the best available evidence with regards to timing of staged bone grafting for infected tibial non-union, and to extract evidence-based criteria indicating when bone grafting can be safely performed. Methods Medline, Embase, Scopus, and Google Scholar were searched, and publications of evidence Level I-IV from 2000 to 2020 wer...
Article
Background Plantar fasciitis is a common cause of heel pain. Corticosteroid injections are commonly used and proven to be effective, and lately platelet-rich plasma (PRP) has been used with mixed results. Purpose To perform a systematic review and meta-analysis comparing intralesional injections of PRP and steroid infiltration. Study Design Syste...
Article
Full-text available
Introduction The purpose of this study was to perform a systematic review and meta-analysis comparing intra-articular knee injection of PRP and hyaluronic acid and investigate clinical outcomes and pain at both 6 and 12 months. Methods A systematic review of Medline, Embase, Scopus, and Google Scholar was performed in the English and German litera...
Article
Objectives: To develop a post-traumatic bone defect classification scheme, and complete a preliminary assessment of its reliability. Design: Retrospective classification. Setting: Tertiary referral trauma center. Patients/participants: 20 open fractures with bone loss. Intervention: Assignment of a bone defect classification grade. Main o...
Article
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Purpose To determine whether femoral epicondylar width (FECW) obtained from either magnetic resonance imaging (MRI) or plain radiographs could be used to predict anterior cruciate ligament (ACL) length. A secondary purpose was to develop a formula to use maximum FECW on either MRI or plain radiographs to estimate ACL length preoperatively. Methods...
Article
Full-text available
Purpose: The purpose of this study was to perform an evidence-based, expert consensus survey using the Delphi panel methodology to develop recommendations for the treatment of degenerative meniscus tears. Methods: Twenty panel members were asked to respond to 10 open-ended questions in rounds 1 and 2. The results of the first 2 rounds served to...
Article
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Aim: The purpose of this study was to compare the functional and radiological outcomes of complex tibia fractures treated with two different hexapod fixators. Material and methods: This is a retrospective comparative study of patients treated for complex tibial fractures between 2010 and 2015. Inclusion criteria was patients between 18 years and...
Article
Full-text available
Introduction The purpose of this study was to perform a meta-analysis comparing open and arthroscopic surgical techniques for distal clavicle resection. Methods A systematic review of Medline, Embase, Scopus, and Google Scholar identified relevant publications in the English and German literature between 1997 and 2017. All included studies were le...
Article
» Deforming forces make it difficult to reduce and maintain reduction of Neer type-II distal clavicular fractures. » Contemporary surgical techniques are associated with high rates of union and good and excellent outcomes. » Plate fixation of distal clavicular fractures does not address horizontal and vertical instability. » Hook-plate fixation has...
Article
Conventional bone decalcification is a time-consuming process and is therefore unsuitable for clinical applications and time-limited research projects. Consequently, we compared the effect of four different decalcification solutions applied at three different temperatures, and assessed the rate of decalcification and the implications on tissue morp...
Article
Full-text available
INTRODUCTION: Traumatic femoral segmental bone loss is a complex clinical problem, one that often requires extreme solutions. This study examines a new treatment strategy for segmental bone loss using patient-specific 3D printed titanium cages in conjunction with the Masquelet technique. METHODS: The study was composed of a clinical observational c...
Article
Background Lower extremity fractures have a profound negative effect on a patient’s gait and outcomes. Correction of deformity, and with it normalization of objective gait parameters, may result in better subjective and objective functional outcomes in patients treated with circular external fixation for malunited tibial fractures. Aim The purpose...
Article
The purpose of this study was to determine whether differences in structural and material properties of bone between different mouse strains influence the fracture patterns produced under experimental fracture conditions. Femurs of C57BL/6 (B6), C3H/HeJ (C3H), and DBA/2 (DBA) strains were evaluated using micro-computed tomography (μCT), measurement...
Article
Full-text available
PurposeThe purpose of this study was to investigate the isokinetic, eccentric and isometric hamstring/quadriceps (HQ) ratios in patients before and after ACL reconstruction (ACLR) using bone–patellar tendon grafts and to establish the relationships between HQ ratio and knee function. Methods Forty-four patients (mean age of 26.6 years) underwent is...
Article
Regenerative rehabilitation is an emerging area of investigation that seeks to integrate regenerative medicine with rehabilitation medicine. It is based on the realization that combining these two areas of medicine at an early stage of treatment will produce a better clinical outcome than the traditional, linear approach of first administering the...
Article
Full-text available
Purpose The purpose of this study was to evaluate the clinical and functional outcomes of failed plate fixation in distal tibia fractures salvaged with hexapod circular fixators. Materials and methods The database of a specialized limb reconstruction center was searched for all patients with failed plate fixation undergoing limb reconstruction wit...
Article
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Background Swimming induced pulmonary oedema is an uncommon occurrence and usually presents during strenuous distance swimming in cold water. The prevalence is most likely underreported and the underlying mechanisms are controversial. The purpose of this study was to summarize the evidence with regards to prevalence, pathophysiology and treatment o...
Article
Background: Preoperative planning for circular external fixators is considered vital towards achieving the best results for complex post-traumatic tibial deformities, and patient-specific 3D printed (3DP) models were used here as a planning aid. The main goal was to investigate the fidelity of the preoperative planning process, by assessing the po...
Article
Most closed humeral shaft fractures can be successfully managed nonsurgically. However, fractures for which closed treatment is unsuccessful are stabilized using either plates or intramedullary nails. There are shortcomings associated with each technique, including the potential complications of nonunion, infection, shoulder pain, and radial nerve...
Article
Full-text available
Background The purpose of this study was to conduct a bibliometric analysis of orthopaedic academic output in the United States. Methods Publications based on city and state origin, corrected for population size, median household income, total number of surgeons, and the number of various subspecialties were evaluated. The 15 highest-ranked orthop...
Article
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PurposeThe purpose of this study was to perform a systematic review and meta-analysis comparing single- and double-row biomechanical studies to evaluate load to failure, mode of failure and gap formation. Materials and methodsA systematic review of MEDLINE, Embase, Scopus and Google Scholar was performed from 1990 through 2016. The inclusion criter...
Article
Purpose: The purpose of this systematic review was to investigate study quality and risk of bias for randomized trials comparing partial meniscectomy with physical therapy in middle-aged patients with degenerative meniscus tears. Methods: A systematic review of Medline, Embase, Scopus, and Google Scholar was performed from 1990 through 2017. The...
Article
Background: The purpose of this study was to evaluate the reliability and reproducibility of three commonly used radiographic measures for plantar surface angles. Methods: The calcaneal angle (CA), calcaneal pitch angle (CPA), and length-height index (LHI) was measured by three independent examiners on two occasions on lateral foot radiographs....
Article
Human cadaveric specimens commonly serve as mechanical models and as biological tissue donors in basic biomechanical research. Although these models are used to explain both in vitro and in vivo behavior, the question still remains whether the specimens employed reflect the normal in vivo situation. The mechanical properties of fresh-frozen or pres...
Article
Objectives: To develop and validate an unbiased, accurate, convenient and inexpensive means of determining when an osseous defect has healed and recovered sufficient strength to allow weight-bearing. Methods: A novel image processing software algorithm was created to analyze the radiographic images and produce a metric designed to reflect the bo...
Article
Full-text available
A new technique called osseointegration was introduced recently by intimately connecting the artificial limb prosthesis to the residual bone, eliminating the problematic socket-residuum interface. The objective here is to describe the two-stage strategy for the osseointegrated reconstruction of amputated limbs and discuss the clinical outcomes of t...
Article
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Blood clots (haematomas) that form immediately following a bone fracture have been shown to be vital for the subsequent healing process. During the clotting process, a number of factors can influence the fibrin clot structure, such as fibrin polymerization, growth factor binding, cellular infiltration (including platelet retraction), protein concen...
Article
Background The purpose of this study was to perform a meta-analysis comparing open and arthroscopic surgery for the treatment of anterior shoulder instability by analyzing comparative studies during 2 different time intervals during the last 20 years. Methods We conducted a systematic review of MEDLINE, Embase, Scopus, and Google Scholar. Two grou...
Article
Introduction: This study compared bone transport to acute shortening/lengthening in a series of infected tibial segmental defects for infected tibial non-union. Methods: In a retrospective comparative study 42 patients treated for infected tibial non-union with segmental bone loss measuring between 3 and 10cm were included. Group A was treated w...
Article
Background Whether early or delayed surgical intervention in patients with multi-ligament injuries results in better outcomes, is of current and controversial debate. Purpose The purpose of this study was to perform a meta-analysis comparing early versus late surgical treatment of multi-ligament knee injuries. Methods We performed a systematic re...
Article
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AIM To perform a bibliometric analysis of publications rates in orthopedics in the top 15 orthopaedic journals. METHODS Based on their 2015 impact factor, the fifteen highest ranked orthopaedic journals between January 2010 and December 2014 were used to establish the total number of publications; cumulative impact factor points (IF) per country w...
Article
Purpose: To use magnetic resonance imaging to determine the influence of the labrum on both the osseous version and effective diameter of the glenoid. Methods: This was a retrospective, cross-sectional study of patients with shoulder pain who underwent MRI between February 2014 and February 2015. The morphology of the glenoid labrum and glenoid...
Article
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3D printing technology has revolutionized and gradually transformed manufacturing across a broad spectrum of industries, including healthcare. Nowhere is this more apparent than in orthopaedics with many surgeons already incorporating aspects of 3D modelling and virtual procedures into their routine clinical practice. As a more extreme application,...
Article
Introduction: The purpose of this study was to survey the growth of Google Scholar public profiles in orthopedics over a 12-month period and to investigate global patterns. Methods: Data was prospectively acquired from June 2013 to June 2014. Google Scholar queries specific to orthopedic surgery were performed at 90-day intervals. Demographic as...
Article
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In order to achieve consistent and predictable fracture healing, a broad spectrum of growth factors are required to interact with one another in a highly organized response. Critically important, the mechanical environment around the fracture site will significantly influence the way bone heals, or if it heals at all. The role of the various biolog...
Article
Introduction Research is a major component of innovation and can contribute to health improvements through a knowledge-to-action-process. 1 In general, the total number of publications by a country is one of the indicators of research output and productivity and is an important aspect of clinical excellence. 2-4 While the developing world contains...
Article
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Background and purpose — Constant fixator stiffness for the duration of healing may not provide suitable mechanical conditions for all stages of bone repair. We therefore investigated the influence of stiffening fixation on callus stiffness and morphology in a rat diaphyseal osteotomy model to determine whether healing time was shortened and callus...
Article
3D computer modelling and 3D printing technology is approaching a commodity level in many areas, including medical applications. 3D computer models are used in a wide variety of these applications, such as pre-operative planning and patient specific customized implants in orthopaedics that treat complex fractures and correct pathological anatomy. T...
Article
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Three-dimensional (3D) printing has been used in complex spinal surgical planning since the 1990s and is now increasingly utilized to produce surgical guides, templates, and more recently customized implants. Surgeons report beneficial impacts using 3D-printed biomodels as a preoperative planning aid as it generally provides for a better representa...
Article
Hypothesis: The purpose of this study was to perform a meta-analysis comparing the clinical outcomes and complications between anterior humeral minimally invasive plate osteosynthesis (MIPO) and the 2 standard techniques, either open reduction and plating or humeral nailing. Methods: We performed a systematic review of Medline, Embase, Scopus, a...
Article
Abstract Aims This study describes the Osseointegration Group of Australia’s Accelerated Protocol two-stage strategy (OGAAP-1) for the osseointegrated reconstruction of amputated limbs. Patients and Methods We report clinical outcomes in 50 unilateral trans-femoral amputees with a mean age of 49.4 years (24 to 73), with a minimum one-year follow-...
Article
Background: Reverse dynamization is a technology for enhancing the healing of osseous defects. With use of an external fixator, the axial stiffness across the defect is initially set low and subsequently increased. The purpose of the study described in this paper was to explore the efficacy of reverse dynamization under different conditions. Meth...