Vad Pérez

Vad Pérez
CMN Siglo XXI - IMSS

Latest work: "The two roles of Ca2+ signaling" (2020). bit.ly/34F02oP

About

26
Publications
23,238
Reads
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307
Citations
Introduction
Currently I am working on comparative functional architectonics. Functional architectonics: how processes are organized in organisms. Comparative: how such organization and realization differs among organisms. Presumably, the organization of physiological processes itself can be inferred from such comparison. Works carried following this approach are presented in the Featured Research section, below (reading order: older to newer).
Skills and Expertise
Additional affiliations
November 2015 - present
Mexican Institute of Social Security
Position
  • Researcher

Publications

Publications (26)
Article
Full-text available
The central or lytic vacuole is the largest intracellular organelle in plant cells, but we know unacceptably little about the mechanisms regulating its function in vivo. The underlying reasons are related to difficulties in accessing this organelle without disrupting the cellular integrity and to the dynamic morphology of the vacuole, which lacks a...
Article
Full-text available
Unlike animals, plants possess a non-strict and sometimes very fuzzy morphology. Mutual proportions of plant parts can vary to a much greater extent than in animals, changing according to the environmental conditions and the plant needs of nutrients, water and light. Despite the existence of this fundamental difference between plants and animals, i...
Preprint
Full-text available
Genes are the determinants and limiting constraints of all the possible features a living organism can display. Genes, however, are largely lineage-specific, and a strict focus on them can lead to an overlook of functional analogies existing between organisms belonging to non-related lineages. In the present concept work we propose that: 1) Ca2+ si...
Article
We contribute with the design and synthesis of novel 2,3‐diphenyl‐2H‐indazole hybrids series (1–14). Compounds 4 and 6 had the highest antiproliferative activity against the cancer cell lines, HeLa, SK‐LU‐1, K‐562, PC‐3, SW620 and MCF‐7 (CC50 values from 3 to 5.4 μM). Their activity was also evaluated against a normal human cell line, showing their...
Book
Full-text available
"En este libro, nosotros explicaremos qué es la “electricidad animal”, cómo surge ésta y cómo es que la aprovechan los seres vivos. Éste es el tema central de nuestro libro. No obstante, aparte de la “electricidad animal” este libro tiene un segundo protagonista—la ciencia que lleva por nombre Electrobiología. Todos los resultados que presentamos e...
Preprint
Full-text available
Traducción del ruso al español de la entrada de blog https://ivanov-petrov.livejournal.com/2288083.html
Article
Full-text available
Desmoplastic stroma (DS) and the epithelial-to-mesenchymal transition (EMT) play a key role in pancreatic ductal adenocarcinoma (PDAC) progression. To date, however, the combined expression of DS and EMT markers, and their association with variations in survival within each clinical stage and degree of tumor differentiation is unknown. The purpose...
Article
Full-text available
Cancer is the second leading cause of death, after cardiovascular diseases. Different strategies have been developed to treat cancer; however, chemotherapy with cytotoxic agents is still the most widely used treatment approach. Nevertheless, drug resistance to available chemotherapeutic agents is still a serious problem, and the development of new...
Article
Full-text available
In cutaneous T cell lymphoma (CTCL), a dominant Th2 profile associated with disease progression has been proposed. Moreover, although the production and regulation of IL-4 expression during the early stages of the disease may have important implications in later stages, these processes are poorly understood. Here, we demonstrate the presence of TOX...
Article
Full-text available
We previously reported that triple-negative breast cancer (BRCA) cells overexpress the cytokines GM-CSF, G-CSF, MCP-1, and RANTES, and when monocytes were 3-D co-cultured with them, M1-like macrophages were generated with the ability to induce aggressive features in luminal BRCA cell lines. These include upregulation of mesenchymal and stemness mar...
Article
Full-text available
The Retinoblastoma protein (pRb) is a key cell cycle regulator conserved in a wide variety of organisms. Experimental analysis of pRb's functions in animals and plants has revealed that this protein participates in cell proliferation and differentiation processes. In addition, pRb in animals and its orthologs in plants (RBR), are part of highly con...
Chapter
Full-text available
* (en la opinión del traductor) Texto mínimo esencial para cualquier persona que posea el grado de Philosophy Doctor. * La Antigüedad: el primer sistema y el destino del legado de Aristóteles. Revisión general del legado de Aristóteles: la historia de la escuela de Aristóteles.
Chapter
Full-text available
The concepts of hierarchy and rank lay in the fundament of biological taxonomy. Some discoveries of the last years have opened the possibility of viewing the foundations of taxonomic theory from a new perspective. This book presents the history of the concepts of hierarchy and rank, from Aristotle's time and up to modern days. Their evolution is tr...
Article
Tuberculosis (TB) is the most prevalent infectious disease worldwide, with no fully effective vaccine yet available. Considering that BCG strains devoid of the BCG1416c or BCG1419c genes afforded protection in mice versus highly virulent M. tuberculosis challenge, or in chronic infection models compared to BCG, respectively, we hypothesized that a...
Chapter
Full-text available
microRNAs are noncoding RNAs of 20–24 nucleotides (nt) in length that act as repressors of genes and are important in key developmental processes in the entire life cycle of plants. To determine the function of a microRNA, the first step is to resolve its expression pattern; this can be achieved by in situ hybridization, RNA blot assays, or quantit...
Article
Full-text available
It has been widely described that chronic intake of fructose causes metabolic alterations which can be associated with brain function impairment. In this study, we evaluated the effects of fructose intake on the sleep–wake cycle, locomotion, and neurochemical parameters in Wistar rats. The experimental group was fed with 10% fructose in drinking wa...
Article
Full-text available
Recently, the presence of antibodies and dengue virus (DV) RNA in neotropical wild mammals, including Desmodus rotundus, was reported. In a previous study, DV was also found in a high percentage (39.6%) of ectoparasitic hematophagous dipters specifics of these hematophagous bats. In order to verify the susceptibility of these ectoparasites to DV, i...
Preprint
Full-text available
Autophagy is an evolutionary conserved pathway, by which eukaryotic cells degrade long-living cellular proteins and intracellular organelles, to maintain a pool of available nutrients. Impaired autophagy has been associated to important pathophysiological conditions, and this is the reason why several techniques have been developed for its correct...
Article
Full-text available
Pediatric oncology, notably childhood acute lymphoblastic leukemia (ALL), is currently one of the health leading concerns worldwide and a biomedical priority. Decreasing overall leukemia mortality in children requires a comprehensive understanding of its pathobiology. It is becoming clear that malignant cell-to-niche intercommunication and microenv...
Article
Full-text available
Intracellular Mg2+ roles are commensurate with its abundance in the cell cytoplasm. However, little is known about Mg2+ subcellular dynamics, primarily due to the lack of suitable Mg2+-selective tools to monitor this ion in intracellular compartments. To cope with this lack, we developed a Mg2+-sensitive indicator - MagIC (indicator for Magnesium I...
Article
Full-text available
Genetically encoded calcium ion (Ca(2+)) indicators have become very useful and widely used tools for Ca(2+) imaging, not only in cellular models, but also in living organisms. However, the in vivo and in situ characterization of these indicators is tedious and time consuming, and it does not provide information regarding the suitability of an indi...
Article
Full-text available
Hypersensitive cell death is known to involve dynamic remodeling of intracellular structures that uses energy released during ATP hydrolysis. However, the relationship between intracellular structural changes and ATP levels during hypersensitive cell death remains unclear. Here, to visualize ATP dynamics directly in real time in individual living p...
Preprint
Full-text available
In recent years the use of genetically encoded Ca 2+ indicators has expanded. New types of genetically encoded indicators are obtained, that combine better folding, improved signal-to-noise characteristics, faster kinetics and wide range of affinities for calcium. The last versions of GECI evolved in specialized and improved constructions, in compa...
Article
Full-text available
This article examines, on one hand, the intensive development of three renewable energy industries in Latin America: wind (in Brazil and Mexico), hydropower (in Brazil) and large scale soy growing (in Argentina and Brazil) and, on the other, social movements that emerge in response to the expansion of these industries. The text posits the existence...
Article
Full-text available
Ca2+, Mg2+, and K+ activities in red beet (Beta vulgaris L.) vacuoles were evaluated using conventional ion-selective microelectrodes and, in the case of Ca2+, by non-invasive ion flux measurements (MIFE) as well. The mean vacuolar Ca2+ activity was ∼0.2 mM. Modulation of the slow vacuolar (SV) channel voltage dependence by Ca2+ in the absence and...

Questions

Questions (14)
Question
Is there a comprehensible text on the history of epistemology of biology, since ancient times till nowadays?
Question
Modern science is increasingly speacializing.
We have more and more narrow disciplines and specialists, and all organization of science (institutions, journals, infrastructure and funding) follows this trend.
Is should mean we are confident in that "the main principles" of nature are already discovered: modern science has adapted its own structure to the available knowledge.
However, looking back, we can see paradigms have changed multiple times in the past, together with the organization of the social structures that generated knowledge.
So, has modern science the mechanism(s) that could provide the required flexibility for big new paradigms to appear? What are such mechanisms?
Or is modern organization of science the most effective one and no new paradigms are expected?
Question
Physics has a compendium of most important and intriguing open questions (e.g. https://www.preposterousuniverse.com/blog/2005/01/30/the-most-important-questions-in-physics/)
Why there is no such compendium in Biology?
Does it imply an average biologist is not aware of possible connections between her/his research and other fields in Biology; that there is no any common ground from which perspective different biological question can be analyzed? (here we take apart the Dobzhansky's famous quote)
Does it also imply Biology is advancing without any special route map?
Question
Recently I am receiving a lot of very kind invitations from journals, even outside of my field of knowledge, to publish "a short, two-page communication, review" or whatever.
Given this demand, I am seriously considering to set a price on my work.
So, my question is: what price would you suggest to start from?
Question
Just a thought: as the number of narrow specialists grows, so does decrease the number of peers who can “double-blindly” revise one's work, turning the review process into a fallacy.
So, will there be out there that beautiful and magical moment when joint work will become a realm, at least within such narrow fields?

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Cited By

Projects

Projects (5)
Project
Traducciones a mis posibilidades. Entre sus opciones de contribución Researchgate no tiene el papel de traductor; es necesario ser autor para poder cargar escritos. Mi contribución dentro de este proyecto es únicamente la traducción de las obras presentadas (del ruso al español).
Archived project
Unpublished works and plain lists of references to receive RG publication suggestions.
Project
Basically, similarities between functions and pathways are inferred by analyzing their roles within the structural organization of different organisms. It is proposed that roles for specific players can be reconstructed by analyzing the role of similar ("isomorphic") functional blocks in other organisms. The factors responsible for these convergent features may belong to completely different families (e.g., be proteins, non-proteic compounds, organelles), and so these effects are not necessarily discoverable by "big data" bioinformatics approaches.