V. Vadivel

V. Vadivel
SASTRA University · Biotechnology Division

Doctor of Philosophy

About

151
Publications
47,733
Reads
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3,558
Citations
Citations since 2016
72 Research Items
2414 Citations
20162017201820192020202120220100200300400500
20162017201820192020202120220100200300400500
20162017201820192020202120220100200300400500
20162017201820192020202120220100200300400500
Introduction
Dr. V. Vadivel working as Assistant Professor at the School of Chemical and Biotechnology (SCBT) of SASTRA Deemed University. Interested in bioprospecting plant resources to overcome ROS mediated cytotoxicity and microbial infections.

Publications

Publications (151)
Article
Methicillin resistant Staphylococcus aureus (MRSA) is a prime pathogen responsible for various infections in human beings. Expression of virulence factors is a biggest challenge in MRSA, which results in failure of conventional antibiotic therapy. In connection to the search for natural and safe anti-virulence compounds, the present study focused t...
Article
The anti-proliferative potential of vanillin isolated from an ethnomedicine Flacourtia indica bark was evaluated in an acute lymphoblastic leukemia cell line (Jurkat) in our previous study, but its molecular mechanisms of action are not yet revealed. The present work investigated the pharmacokinetic properties & cellular uptake of vanillin, in addi...
Article
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the prime pathogens responsible for surgical site infection (SSI). Treatment of SSI remains challenging because of resistant nature of MRSA, which is a major threat in recent years. Our previous work revealed the antibacterial potential of catechin isolated from cashewnut shell against MR...
Article
Myricitrin, a naturally occurring flavonoid in Madhuca longifolia, possesses several medicinal properties. Even though our earlier work revealed its role against the proliferation of acute myelogenous leukemia cells (HL-60), its molecular mechanisms have not yet been revealed. The current study aims to explore the molecular mechanisms of myricitrin...
Article
Objectives Leukemia is one of the severe cancer types all around the globe. Even though some chemotherapeutic drugs are available for treating leukemia, they have various side effects. As an alternative approach, herbal drugs are focused on current research to overcome leukemia. The present work was conducted to investigate the antileukemic mechani...
Article
The search for pioneering nutraceuticals from plants is genuine and crucial. Based on the literature review as per Ayurvedic texts, four common plants Capparis spinosa L. (flower buds), Caesalpinia bonducella L.(seeds), Luffa acutangula L.(fruits) and Cassia occidentalis L. (aerial parts) were selected to develop nutraceuticals and were standardize...
Article
Full-text available
Present study was undertaken to optimize the extraction conditions for the recovery of anthocyanins from an agricultural byproduct (banana bract) and also to study its utilization in green synthesize of silver nanoparticles (AgNPs) with anti-proliferative efficacy. Experiments were conducted to identify the suitable solvent, co-solvent and extracti...
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This work aimed to synthesize silver nanoparticles (AgNPs) using cashewnut shell extract (CNSE) and evaluate its antibacterial and anti-biofilm activities against Staphylococcus aureus. CNSE showed the presence of isorhamnetin as the major phytochemical compound. The size, shape, morphology and stability of synthesized CNSE-AgNPs were investigated...
Preprint
Background: Myricitrin, a naturally occurring flavonoid in Madhuca longifolia, possesses several medicinal properties. Even though our earlier work revealed its role against the proliferation of acute myelogenous leukemia cells (HL-60), its molecular mechanisms have not yet been revealed. The current study aims to explore the molecular mechanisms o...
Article
Full-text available
Ralstoniasolanacearum is a soil-borne plant pathogen which causes wilt disease in economically important crops of the Solanaceae family in tropical and temperate regions. As biofilm formation is the major virulence factor in R.solanacearum, research inputs are necessary to identify natural biofilm inhibitors to mitigate virulence of this bacterium....
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Wheat straw is an easily affordable, cost-effective and natural source of antioxidants and cellulose, but its full potential is not yet utilized. In the present investigation, an auto-hydrolytic process was applied to recover both antioxidant phenolic compounds and cellulose from wheat straw. Two three-step acid/alkaline fractionation processes wer...
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Staphylococcus aureus causes severe infections and among all methicillin-resistant S. aureus (MRSA) remains a great challenge in spite of decade research of antibacterial compounds. Even though some synthetic antibiotics have been developed, they are not effective against MRSA, and hence, there is a search for natural, alternative and plant-based a...
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In the present study, EOs of commonly used spices i.e. coriander, cumin, fennel, lemongrass and pepper and their major components (linalool, cuminaldehyde, anethole, citral and beta-caryophyllene) were nanoemulsified and investigated for their antibacterial and anti-biofilm activities against Salmonella enterica Typhimurium. The mean droplet size o...
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This research work explains the antioxidant and anti-atherogenic effects of selected Siddha polyherbal decoctionssuch as Nilavembukudineer, Kabasurakudineer, NotchikudineerandAdathodaikudineer. Even though all the above decoctions have been used for fever, cold, cough, bronchitis, dysphonea and body pain in Siddha system of medicine, their antioxid...
Article
Present work was carried out with the objectives to isolate polyphenol-rich fraction from Mangifera indica leaves and its analysis in LCÀMS/MS and also to investigate the antioxidant potential and cyto-protective activity of the active fraction against UV radiation-induced oxidative stress in PBMC model. M. indica leaf extracts were prepared using...
Article
Ethnopharmacological relevance: In search of safe and effective therapeutic agents as alternative to synthetic chemotherapeutics for the treatment of leukemia, the herbal drugs (Leaf of Madhuca longifolia, leaf of Prosopis cineraria and bark of Flacourtia indica) with long traditional use in West Bengal have received our attention. Aim of the stu...
Article
The present work explored the influence of individual and combinations of citral and linalool along with different Ostwald ripening inhibitors on the nanoemulsion stability and their antibacterial activity against Listeria monocytogenes. Nine different nanoemulsions (N1–N9) containing individual or combinations of citral, linalool with or without r...
Article
Citral is known as potent antibacterial agent, but its incorporation in food system is limited because of low water solubility and stability. Such limitations can be overcome by nano-emulsification of citral and its delivery on food surface through edible coating. In the present study, effect of sodium alginate based edible coating containing diffe...
Article
Present work carried out with the objectives to isolate active component of S. potatorum and also to evaluate its free radical scavenging activity and preventing capacity against heavy metal toxicity. Solvents of different polarity were used to prepare crude extracts of S. potatorum seeds and screened for antioxidant activity. Among the crude extra...
Article
Vibrio harveyi causes severe loss to the aquaculture industry due to its virulence, which is mediated by Quorum sensing (QS) and biofilm formation. In the current study, we have explored the anti-virulent properties and biofilm disruption ability of luteolin (extracted from coconut shell) and linalool against this important aquaculture pathogen. HP...
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Introduction: Flower buds of Sirunagapoo (Mesua ferrea) are used in Siddha system of medicine as carminative, astringent and anti-vatha. It is traditionally used to treat various diseases like cough, venerial, white discharge, diarrhea, over-bleeding and peripheral neuritis. It is one of the major ingredients in Amukkara choornam, Inji choornam and...
Article
In the present work, 16 different plant drugs used by traditional healers from West Bengal were screened through in vitro cell line model. Herbal drugs used by traditional tribal healers in Purulia, Birbhum and Bankura districts of West Bengal were collected and screening against acute myeloid leukemia (AML) cell line (HL-60). Among 16 plant extrac...
Article
The silver nanoparticles (AgNPs) synthesized by physical and chemical methods are not much desirable due to the use of high energy consumption, environmentally toxic and biological hazards chemicals. Therefore green synthesis of AgNPs using natural plant extract is more appropriate method. Hence, in the present work we have employed an anti-cancer...
Article
In India, agro-food by-products such as shell cake of cashew nut (Anacardium occidentale L.), shell of coconut (Cocos nucifera L.) and hull of groundnut (Arachis hypogaea L.) are cheaply available on a vast scale. Even though a small portion of these solid waste materials is being used, a large quantity is not being utilized. Based on literature da...
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Capparis spinosa L. (Capparaceae) is growing wild on walls or in rocky coastal areas all over India and normally known as Maratimokku in Tamil. The current study was aimed reveal the botanical and chemical pharmacognostic standards, and pharmacological and toxicity properties of aqueous extract of C. spinosa flower buds. Powder microscopy revealed...
Article
In this communication, we present the green synthesis of silver nanoparticles (AgNPs) using medicinally important Nardostachys jatamansi rhizome extract in the presence of sunlight. UV–vis spectroscopy, Fourier Transform Infrared spectroscopy (FTIR), Transmission electron microscope (TEM) and Energy dispersive X-ray analysis (EDX) were employed to...
Article
Aqueous extract of nut by-products (cashewnut shell, coconut shell, and peanut hull) were studied for their physicochemical properties, antibacterial activity and food preservation potential in an artificially inoculated fresh-cut fruit (papaya) model. Physicochemical characteristics revealed the colour, odor, nearly neutral pH (6.67–6.83), high wa...
Article
Green synthesis of silver nanoparticles (AgNPs) is environmentally satisfactory because of their low cost and safe to nature. In the present study, extract of an agricultural waste, coconut (Cocos nucifera) shell is used to synthesize AgNPs and their antibacterial effect was investigated against selected human pathogens Staphylococcus aureus, Liste...
Article
To overcome the problem of breast cancer, silver nanoparticles (AgNPs) synthesized using Indian medicinal plant Madhuca longifolia could be explored as an alternative anticancer medicine. Synthesized AgNPs were studied their characteristics and their anti-proliferative property was investigated in breast cancer cell line (4T1). Based on zeta sizer...
Article
Background: Radiotherapy is the most widely used treatment method for treating cancer with or without surgery and chemotherapy. In lung cancer, it is one of the important treatment steps in excising the tumor from the lung tissue; unfortunately, radiation can induce epithelial- mesenchymal transition (EMT), a typical physiological process in which...
Article
Due to the convenience and nutritional value, minimally processed fruits and vegetables (MPFV) are one of the rapid growing sectors in the food industry. However, their microbiological safety is a cause of great concern. Essential oils (EOs), known for potent antimicrobial efficacy have been shown to reduce microbial load in MPFV, but their low wat...
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Present work was carried out with a view to develop chemical fingerprints to differentiate the herbal drugs Taxus baccata L. and Abies webbiana (Wall ex D. Don) Lindl. Both the plants are commonly called as Talisapatra in India and having different medicinal applications. T. baccata is native to Europe and A. webbiana is found in India and also use...
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Objective: This study deals with the antioxidant and anti-inflammatory activities of selected Siddha polyherbal formulations such as Amukkara choornam, Thirikadugu choornam, Eladi choornam and Thiripala choornam. Amukkara choornam consist of seven herbals (withania, ginger, black pepper, long pepper, mesua, cardamom and clove). Thirikadugu choornam...
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In Siddha system of medicine, herbs, metals, minerals, hydrochemicals, arsenics and animal products are predominantly used for medicine preparations. Annabethi is a common hydrochemical drug, which is popularly known as green vitriol (chemical name is ferric sulphate). Naturally Annabethi is collected in hills and also synthesized, which is green i...
Article
In the present study Markhamia lutea (Benth) K. Schum., a Bignoniaceae member was evaluated for its physicochemical properties, phytochemical constituents and antioxidant activity with a view to develop a herbal drug for treating / preventing oxidative stress mediated diseases. Physicochemical properties (total ash, acid soluble ash, water soluble...
Article
Madhuca longifolia is a traditional medicinal plant used in the treatment of several diseases including cancer in Indian system of medicine. Even though the chemical composition, bioactive principles and medicinal value of M. longifolia leaf have investigated earlier, the extraction of phytochemical compounds is not yet optimized, because preparati...
Article
The present investigation was aimed to evaluate the release of both antioxidants and cellulosic fibre from different agro-food wastes. Cost-effective and easily available agro-food residues (brewers’ spent grains, hazelnut shells, orange peels and wheat straw) were selected and submitted to a double-step acid/alkaline fractionation process. The obt...
Article
Objectives: Different parts of jamun tree (Syzygium cumini L. skeels) which belongs to the family - Myrtaceae are well-known for their antidiabetic activity. Traditional practitioners in India are using the leaf, bark, and fruits of this medicinal plant over many centuries to manage the diabetic patients. Although several research works have been c...
Article
In the present study, three biologically active, substituted acyl thiourea compounds (1–3) have been synthesized from 2,4-dichlorobenzoyl chloride, potassium thiocyanate and the corresponding secondary amine in dry acetone. As analytical and spectral data of 1 and 3 have already been discussed in the literature, only the compound 2 was characterize...
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The number of diabetes mellitus cases is rapidly increasing worldwide and its complications are a major cause of disability and hospitalization,posing a significant financial burden. Diabetes mellitus is a complex and a fast growing medical problem throughout the globe,in both developed and developing countries. As per WHO report,diabetes is a mult...
Article
Aim: Dasamula is an Ayurvedic formulation, which is used for the management of pain, arthritis, and inflammatory disorders. Even though this formulation has been widely used in the Ayurvedic system of medicine to cure inflammation-mediated diseases, no deeper research studies have been conducted to prove its antioxidant and anti-inflammatory activi...
Article
Silver nanoparticles (AgNPs) were synthesized from aqueous extract of Clerodendrum phlomidis L. leaves and characterized by UV–visible spectroscopy, field emission scanning electron microscope (FESEM), transmission electron microscope (TEM), energy-dispersive X-ray spectroscopy (EDX) and Fourier transform infrared spectroscopy (FTIR) analysis. Prel...
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Objectives: To evaluate the therapeutic potential of Abies webbiana (Wall ex D. Don) Lindl, plants leaves belongs to Pinaceae family are grown in Northern India, Afghanistan, China (Tibet), Nepal, and Pakistan. It is a large tree grows up to 50 m height. Leaves of this plant are useful in Siddha and Ayurveda Systems of Medicine. It acts as an expec...
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In the present, work chemical composition and nutritional value of aerial parts of Cassia occidentalis L. was studied. The aerial parts of C. occidentalis possess favorable physicochemical properties with good nutritional value, such as high energy value, crude fibers, and vitamin levels. The X-ray fluorescence spectrophotometry data revealed that...
Article
In the present study, attempts are made to evaluate the in vitro cytotoxic potentials of aqueous extracts of Terminalia catappa L. bark, fruits and wood against Ehrlich Ascites Carcinoma (EAC) cell line and also to identify their phytochemical constituents using LC-ESI-MS/MS. Data of the results obtained from the present study revealed that the aqu...
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Herbal drugs such as cardamom (Elletaria cardamomum L.), ginger (Zingiber officinale Roscoe), arrow root (Maranta arundinacea L.), yew leaves (Abies webbiana (D. Don) Spach), Indian rose chestnut (Mesua ferrea L.), pepper (Piper nigrum L) and clove (Syzygium aromaticum (L.) Merrill & Perry) have been used in the preparation of various Siddha formul...
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Embelia ribes Burm. (Family: Myrsinaceae, Vidangam in Tamil) has been used as herbal drug for various diseases in Indian medicinal systems. Many research works have been focused on embelin (a high polar bioactive constituent), no study found on low polar compounds. Hence, in the present work we have analyzed the antioxidant and anticancer propertie...
Article
Modulation of immune response to cure various diseases has been a very interesting concept and becoming the field of intensive research worldwide. Widespread efforts have been made to identify immunomodulatory agents as prophylactic or therapeutic regimens to combat infections or to enhance the immunocompetence of the host. Immunomodulators have be...
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The nutraceuticals have many physiological effects on the health of consumers. The upper limit of the physiological effect dimension would be food that can cure or heal certain diseases. Nutraceuticals also have the benefits beyond to its basic nutritional functions. It is important to distinguish nutritional deficiency from other physiological eff...
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Luffa acutangula L. (Common name: Ridge gourd, Family: Cucurbitaceae) is a popular vegetable in India and other Asian countries. It is a healthy food and contains good amount of fiber, vitamins and minerals including Vitamin B2, Vitamin C, carotene, niacin, calcium, phosphorus, iron and small quantities of iodine and fluorine. It is reported to con...
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Cassia occidentalis L. is an important member of plant family Fabaceae. C. occidentalis is known as ‘kasamarda’ and it has been mentioned in various nighandus viz. Rajnighantu, Dhanwantari, Bhavaprakasa, Rajballaba. It has active ingredients such as anthraquinones derivatives and their glycosides. C. occidentalis extract is used to cure eye inflamm...
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Objective: Capparis spinosa L. (Caper) is a perennial spiny bush that bears rounded, fleshy leaves and big white to pinkish-white flowers. It is native to the Mediterranean region and growing wild on walls or in rocky coastal areas throughout India. Even though it has been used in traditional Indian system of medicines for various human diseases, t...
Article
Reactive oxygen species including include superoxide anion radical, hydrogen peroxide, hydroxyl radical, and singlet oxygen are capable of damaging DNA, proteins, carbohydrates and lipids in aerobic organisms. Inflammation is a bodily response to injury, infection or destruction characterized by heat, redness, pain, swelling and disturbed physiolog...
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Hypertension is the gift of modern life due to change in food habit and reduced physical activities. According to Siddha literatures hypertension is termed as ‘Kurithi azhal noi’. The causative factors, symptoms and medicinal remedies for hypertension were explained detail in the Siddha literature. Drugs for hypertension are many and usually the tr...
Article
In the present study, antioxidant and anticancer activities of different solvent extracts of an Indian medicinal plant, Spathodea campanulata P. Beauv. (leaf) were investigated. Among the different extracts studied, 70% ethanolic extract of S. campanulata leaf registered high antioxidant activity in terms of phosphomolybdate reducing power (955 FAE...
Article
Obesity is a significant risk factor for increased morbidity and mortality from cardiovascular disease and diabetes and it is also associated with many other medical conditions including cancer, liver and kidney diseases, sleep apnea, and depression. The inhibition of dietary fat absorption is a logical target for managing obesity and pancreatic li...