V. N. Postnov

Background. The use of nanotechnology achievements in medicine opens up prospects for the development and improvement of means and methods of prevention and treatment of diseases of various origins. Carbon nanotubes (CNTs) are a product of modern nanotechnologies, and in addition to their unique physical and chemical properties, they are promising...

Background : The relevance of the work lies in the search for new hemocontact drugs with hemocompatibility and a pronounced activation effect on the cellular and humoral blood systems for their possible use in clinical practice during low-volume hemoperfusion. The aim of this work was to assess the activation capabilities of three granular hemosorb...

The influence of nanostructure carbon additives (functionalized nanotubes, deaglomerated detonation nanodiamonds, nanocarbon) on the conductivity of the Aquivion perfluoropolymer membrane is studied. In the work the data are presented on the manufacturing of the composite materials and the investigation of their proton conductivity via the impedanc...

The glycidine spacer was synthesized from three different solvents. It is shown that the samples synthesized from benzene have the highest efficiency. Human albumin was immobilized onto a glycidine spacer. A mechanism for the interaction of albumin with a glycine spacer is proposed. An analysis of the determination of albumin adsorbed by magnetic n...

A method is proposed for immobilization of anti-ischemic drug phosphocreatine on the surface of aminated silica and magnetite nanoparticles of similar size and shape. The synthesis of spacer and the coordination-ionic drug immobilization technique are described. Magnetite nanoparticles demonstrated much more efficient chemisorption of phosphocreati...

A method for the synthesis of Aquivion composite membranes containing oxidized carbon nanotubes was developed, and the effect of these dopants on proton conductivity was investigated. A significant increase in the proton conductivity of doped membranes with reducing the relative air humidity was found.

Rationale: During hemosorption procedures, it is important to investigate not only the sorption and activation characteristics of hemocontact agents, but also to assess the effect of sorbents on the parameters of blood homeostasis. The intensity of hemolysis can be judged by the degree of changes in optical density of blood plasma at wavelengths cor...

The work is devoted to the evaluation of the effectiveness of the methods of modifying magnetic nanoparticles for the development of targeted drug delivery systems. Both chemisorption by aminated particles and adsorption by unaminated particles are considered. Various methods for the determination of albumin and the study of the kinetics of dissolu...

A formulation superior in absorption compared to any biological tissue, including bone one, has been obtained by immobilization of radiopaque substance iodixanol on the surface of magnetic nanoparticles.

A procedure for the preparation of nanodispersed silica (Aerosil) modified by tris-malonyl-C60-fullerene has been developed.

Purpose of the study. To assess the effect of contact between hyper-crosslinked polystyrene (HCP) MN-202 and two silica gels (coarse-grained silica gel large-pore (CSL-2) and Silochrom S-120) with human venous blood in vitro conditions to change its physico-chemical parameters. Material and methods. In bench conditions the contact interaction of he...

The research is devoted to the investigating of the possibility of using colloidal quantum dots, covered by various layers and nanoparticles of chitosan labelled with indocyanin green for fluorescence imaging in vitro and in vivo. Pure quantum dots and dots in the shell synthesized from 3-aminopropyltriethoxysilane and in the shell of albumin were...

In this work silica aminated nanoparticles were used to show capability for chemisorbing organic compound having a carboxyl group. Phosphocreatine (creatine phosphate) was used as an active ingredient. Since the method for determination of phosphocreatine with the sample analysis using Jaffe reaction didn't give a positive result, the definition of...

The comparative research of silica, the magnetite and magnetite-silica nanoparticles modified with fluorescent dyes using gas-phase and liquid-phase methods was conducted. At the content of fluorescent dye comparable in size a particular spectrophotometric method, nanoparticles with fluorescein have up to 1000 times larger overall luminous efficien...

Nafion- and Aquivion-based composite solid polyelectrolytes containing deagglomerated detonation nanodiamonds were studied by the impedance spectroscopy method. It was found that introduction of these dopants leads to a substantial increase in proton conductivity of hybrid membranes with low relative humidity.

Kinetics of isoleucine chemisorption on the modified silica surface involving an amide bond formation was studied. The grafted amino groups acting as chemisorption sites are uniformly distributed with respect to the activation energies. The reaction kinetics obeys the Roginsky–Zeldovich equation.

The paper describes the experimental data on physico-chemical study of the C60-l-lysine derivative water solutions. The data on temperature dependence of solubility in water, concentration dependence of density, specific conductivity, molar conductivity, dissociation constant as well as experimental data on dynamic light scattering are presented an...

Nafion-based composite solid electrolytes containing multiwalled carbon nanotubes have been studied by impedance spectroscopy. The effect of carbon nanotube morphology on the proton conductivity of the composites has been estimated at low relative humidity. Surface modification of carbon nanotubes with acidic groups increases the proton conductivit...

Nafion-based composite solid polyelectrolytes containing fullerene C60 and its water-soluble derivatives fullerenol-C60 and tris-malonate-C60 were studied by the impedance spectroscopy method. It was found that introduction of these dopants in Nafion leads to a substantial increase in proton conductivity of the composites in the region of low relat...

A procedure for the synthesis of carbon-encapsulated multilayer magnetite and zirconium oxide–magnetite nanoparticles that form porous nanostructures, for use as biocompatible sorbents, is proposed. The properties, composition, dimensions, particle shapes, surface morphology, and magnetic characteristics of the products are studied.

The paper presents experimental data on physico-chemical study of the C60-arginine derivative water solutions. The data on temperature dependence of solubility in water, concentration dependence of density, specific conductivity, molar conductivity, dissociation constant, and dynamic light scattering are presented and characterized.

Silicon-containing nanoparticles (NPs) are considered promising drug carriers for targeted drug delivery. In this study, we investigated the physical and chemical properties of silicon-containing NPs, including silica and organomodified silica NPs (SiO2NPs and OrSiO2NPs, respectively), with different surface modifications, with the aim of increasin...

Procedure for modifying the silica gel surface with pyrenyl groups, based on a chemical assembly of surface compounds, was developed. The procedure includes successive treatments of silica with (2-phenylethyl) trichlorosilane, water, chloromethyl methyl ether, and pyrene. The reaction conditions providing the maximum content of grafted pyrenyl grou...

This review is the first attempt to integrate the available data on all types of phase equilibria (solubility, extraction and sorption) in systems containing light fullerenes (C60 and C70). In the case of solubility diagrams, the following types of phase equilibria are considered: individual fullerene (C60 or C70) - solvent under polythermal and po...

Nafion - fullerene (C60, C70), Nafion - fellerenol (C60(OH)n (n=22-24), C70(OH)12) and Nafion - fullerene tris-malonate (C60[C(COOH)2]3) composite films were prepared by casting from alcohol-water Nafion solutions doped with these additives and then drying. Proton conductivity (σ) of the films was measured at different relative humidity (RH) levels...

Aerosilogel modified with hydroxylaluminum (=Al-OH) groups has been synthesized via the molecular layering procedure, and aerosilogel modified with aminopropylsilyl groups [=Si(CH2)(3)NH2] has been prepared via chemisorption of (3-aminopropyl)triethoxysilane. The modified aerosilogel have been further used to prepare composite Nafion-containing ele...

A procedure has been developed for the synthesis of silica-supported polymerization initiators, which includes chemisorption of (3-aminopropyl)triethoxysilane, hydrolysis of the alkoxy groups, and chemisorption of 4,4′-azobis(4-cyanopentanoic acid). It has been found that the reaction of 4,4′-azobis(4-cyanopentanoic acid) with immobilized amino gro...

The surface of aerosilogel and macroporous and microporous glasses was modified with aromatic sulfo groups (≡Si(CH2)2-C6H4-SO3H) by the chemical assembly method. Composite solid electrolytes containing Nafion were prepared from the silica matrices with a chemically modified surface. The proton conductivity of the materials was studied by impedance...

Synthesis of a porous carbon material using Aerosil as template is suggested. The material obtained has high specific surface area (2800 m2 g−1) and high limiting sorption volume (6.2 cm3 g−1). The porous carbon material prepared by this procedure can be used in solid-phase extraction of organic toxicants from aqueous solution.

Pharmacological agents suggested for infarct size limitation have serious side effects when used at cardioprotective doses which hinders their translation into clinical practice. The solution to the problem might be direct delivery of cardioprotective drugs into ischemic-reperfused myocardium. In this study, we explored the potential of silica nano...

Silica nanoparticles as carriers for targeted drug delivery to the heart were studied. Studies of hemodynamic parameters of rats after intravenous infusion of silica nanoparticles showed no acute toxicity. Intravenous infusion of silica nanoparticles to animals with ischemia-reperfusion of the myocardium led to accumulation of the nanoparticles in...

Investigation of extraction of fullerene mixture from the fullerene soot obtained by plasma erosion of graphite rod in helium atmosphere with different solvents such as α-chloronaphthalene, o-dichlorobenzene, o-xylene, toluene, benzene, carbon tetrachloride, and n-hexane at 25°C was carried out. Completeness and effectiveness of extraction as well...

Polythermal solubility of individual light fullerenes (C60, C70) and industrial fullerene mixture (60% С60, 39% С70, 1% С76–90) in some essential oils (e.g., essential oil of coriander, cypress, hazel, carnation, cade (leafage), cade (wood), cedar) is investigated. Temperature dependences of solubility are presented and characterized.

Method of isothermal saturation in ampules was used to study the solubility of fullerenol in distilled water in the temperature range 20–80°C and to determine the composition of its equilibrium crystal hydrates. The pycnometric technique was employed to examine how the density depends of the concentration of fullerenol solutions and the average mol...

Dependence of the pH value on the concentration of fullerenol solutions was studied by means of pH-potentiometry, and the apparent degree of dissociation and the dissociation constant of fullerenol were calculated. The dependence of the electrical conductivity of fullerenol solutions on their concentration was examined. The molar electrical conduct...

The clinical outcome in patients with ischemic heart disease can be significantly improved with the implementation of targeted drug delivery directly into the ischemic myocardium. In this study we describe the concept of heart-targeted drug delivery with the use of silica nannocarriers. The techniques of nanoparticle functionalization, as well as t...

A route was developed for synthesis of fullerenol, which was further identified by electron spectroscopy, infrared spectroscopy, optical microscopy, high-performance liquid chromatography, and mass spectrometry.

Available published data on isothermal solubility (at 20°C) of individual light fullerenes in a homologous series of n-alkanes, n-alkanols, n-alkylcarboxylic acids, and arenas were systematized. A correlation between the parameter of Hildebrand’s cohesion and the logarithm of the mole fraction of the fullerene in the saturated solution was revealed...

Purpose – Clinical outcome in patients with ischemic heart disease can be significantly improved with the implementation of targeted drug delivery into the ischemic myocardium. The purpose of this paper is to review the data of recent literature and present original findings relevant to the problem of therapeutic heart targeting with use of nanopar...

The clinical outcome of patients with ischemic heart disease can be significantly improved with the implementation of targeted drug delivery into the ischemic myocardium. In this paper, we present our original findings relevant to the problem of therapeutic heart targeting with use of nanoparticles. Experimental approaches included fabrication of c...

A new procedure is proposed for synthesis on silica of multilayer vanadium phosphorus oxide systems containing vanadium in oxidation state (+4). The procedure includes joint chemisorption of phosphorus and vanadium oxochlorides, hydrolysis of chlorine-containing surface compounds by water vapor, and reduction of vanadium with ammonia vapor. Investi...

Grafted imidazole-containing groups were obtained using successive chemical reactions on the surface of disperse silica containing layers of titanium, aluminum, and zirconium oxides. The influence exerted by the nature of silica surface on the catalytic activity of grafted imidazole in hydrolysis of p-nitrophenyl acetate was studied.

A method is developed for synthesizing on silica surface of anchor groups of various nature, which act as centers of amino acid chemisorption. A relation is established between the donor-acceptor properties of the substituents in the aromatic ring of the anchor groups and the kinetics of BOC-glycine chemisorption. The corresponding rate constants a...

Mineral carbon sorbents based on KSK-2 silica gel (460 m2 g-1 specific surface area, 12-15 nm pore size) were obtained by catalytic pyrolysis. Sorption properties of the sorbents were investigated with respect to organochlorine pesticides (e.g., Lindane) and phenol.

A model is proposed for the activation of O2 by methane monooxygenase using a supported binuclear iron complex as a catalytic centre in the presence of Zn as a reducing agent, methylviologen as a mediator, and acetic acid as an effector.

The purpose of this investigation was to synthesize grafted imidazole groups on a modified Silochrome surface and to use this system as a heterogeneous catalyst for hydrolysis of p-nitrophenyl acetate (substrate for serine proteases). The experimental results show that the surface concentration of imidazole has a significant influence on the rate o...

The authors examine the possibility of planned regulation of the activity of vanadium oxide catalysts in oxidation of benzene to maleic anhydride. It is shown that the catalytic properties of systems of oxide monolayers on the surface of a silica support in oxidation of benzene to maleic anhydride can be regulated by variation of the number of phos...

In this investigation the inorganic matrix was modified by the method of chemical assemblage - synthesis of polypeptide chains on the surface by alternation of reactions involving functional end groups. It is found that matrices of specified structure for immobilization of enzymes have been synthesized by chemical assemblage. With spacer molecules...