V. Motto-Ros

Claude Bernard University Lyon 1 | UCBL · Institut lumière matière

Phosphorite rocks are mined for the production of P fertilizers and contain rare earth elements (REEs, that include lanthanides and yttrium from ~200 to 20000 ppm) [1]. The latter are considered as critical metals essential for green technologies (magnets, catalysts, batteries) and their demand is growing exponentially. Consequently, phosphorite de...

With the development of micro-LIBS imaging, the ever-increasing size of data sets (sometimes >1 million spectra) makes the processing of spectral data difficult and time consuming. Advanced statistical methods have...

Nanoparticles are used in the clinic as contrast agents or theranostic agents gathering imaging and therapy purposes. The administration routes of nanoparticles are varied, including the conventional oral and systemic routes, but local and topical administrations also occur. Hence, their complete characterization is necessarily performed in animals...

Laser-induced breakdown spectroscopy (LIBS) imaging is a powerful and innovative technique with a constant increasing success and interest in many scientific fields. Using LIBS imaging, it is possible to highlight the presence of atoms in complex samples of different nature to achieve important spectral and spatial information. Simple preparation o...

Today, we acquire larger and larger spectroscopic imaging data sets on complex samples. Even before proceeding with a spectroscopic analysis, we often have information concerning for example the presence of major compounds. However, we are not in the same position regarding the presence and location of minor compounds and traces in the sample, whil...

Fluorapatite (FAp; Ca5(PO4)3F), mainly used for the production of agricultural fertilizers, contains significant amounts of rare earth elements [1] (REEs; from ~200 to 20000 ppm) including yttrium and lanthanides, which are considered as strategic metals for energy transition technologies (magnets, catalysis, batteries), and for which demand is gro...

Biological tissues contain various metals and metalloids ions with central role in the regulation of several pathophysiological functions. In parallel, the development and the evaluation of novel nanocompounds for biomedicine require the monitoring of their biodistribution in tissues of interest. Therefore, researchers need to use reliable and acce...

Mineralogical and petrographic studies require analytical methods capable to underline the repartition of major to trace elements within geological samples. The EPMA (Electron Probe Micro Analyzer) conventional method used for such investigation, but on restrictive zones, is on the verge to be reached by μLIBS (micro Laser-Induced Breakdown Spectro...

Lime mortar is a complex mixture resulting from hardening of lime, water, and aggregates. Lime mortar was used from the time of the Roman Empire until the Industrial Revolution. The recipes used differ according to the period, geographical area of preparation, craftsman, or function. This is why the study of archaeological mortars is of such great...

Coupling HSI and μ-LIBS for elemental and mineralogical imaging in rocks. Elemental and mineral distribution with micrometric spatial resolution. μ-LIBS was expanded to a new field of molecular imaging.

Laser-induced breakdown spectroscopy (LIBS) imaging is an innovative technique that associates the valuable atomic, ionic and molecular emission signals of the parent spectroscopy with spatial information. LIBS works using a powerful pulse laser as excitation source, to generate a plasma exhibiting emission lines of atoms, ions and molecules presen...

The preparation step of a catalyst is of primary importance as it may govern its performance. We report here the first direct multi-elemental imaging of an alumina-supported catalyst during the maturation process. Alumina extrudate support was impregnated with a nickel nitrate solution in the presence of citric acid as an organic additive. Wet extr...

Self-absorption of spectral lines is known to lower the performance of analytical measurements via calibration-free laser-induced breakdown spectroscopy. However, the error growth due to this effect is not clearly assessed. Here we propose a method to quantify the measurement error due to self-absorption based on the calculation of the spectral rad...

Anastomosing branching and wavy laminae in quartz-rich sandstones of the 3.22 Ga Moodies Group in the Barberton Greenstone Belt (BGB), South Africa, have been extensively described as fossilized microbial mats developed in terrestrial to marine transitional environments. Petrological and geochemical characteristics of a ~ 350 m thick Moodies succes...

Atmospheric aerosols (particulate matter – PM) affect the air quality and climate, even in remote areas, such as the Antarctic Region. Current techniques for continuous PM monitoring are usually complex, costly, time consuming and do not provide real-time measurements. In this work, based on micro laser-induced breakdown spectroscopy (LIBS), an inn...

Rare metals (Ge, Ga, In, Cd) are key resources for the development of green technologies and are commonly found as trace elements in base-metal mineral deposits. Many of these deposits are in orogenic belts and the impact of recrystallization on rare metal content and distribution in sphalerite needs to be evaluated. Based on laser ablation inducti...

Citation: Al-Kattan, A.; Grojo, D.; Drouet, C.; Mouskeftaras, A.; Delaporte, P.; Casanova, A.; Robin, J.D.; Magdinier, F.; Alloncle, P.; Constantinescu, C.; et al. Short-Pulse Lasers: A Versatile Tool in Creating Novel Nano-/Micro-Structures and Compositional Analysis for Healthcare and Wellbeing Challenges. Nanomaterials 2021, 11, 712. https://

We have all been confronted one day by saturated signals observed on acquired spectra, whatever the technique considered. A saturation, also known as clipping in signal processing, is a form of distortion that limits a signal once it exceeds a threshold. As a consequence, clipped or saturated bands with their characteristic plateau present numerica...

In the context of laser-induced breakdown spectroscopy (LIBS), plasma-induced luminescence (PIL) may be observed by tuning the temporal acquisition parameters (delay and gate). This approach provides useful information about minor elements in a sample. The broad range of excitation resulting from the laser-induced plasma enables the simultaneous ob...

To improve the prognosis of glioblastoma, innovative radiotherapy regimens are required to augment the effect of tolerable radiation doses while sparing surrounding tissues. In this context, nanoscintillators are emerging radiotherapeutics that down‐convert X‐rays into photons with energies ranging from UV to near‐infrared. During radiotherapy, the...

Contexte L’impact des expositions professionnelles ou environnementales sur les pathologies respiratoires est de plus en plus reconnu. Un consensus commun récent des sociétés savantes American Thoracic Society et European Respiratory Society [1], a estimé la fraction de risque attribuable au travail des pathologies respiratoires : 14 % des BPCO, 30...

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Boron neutron capture therapy (BNCT) is a radiotherapeutic modality based on the nuclear capture of slow neutrons by stable 10B atoms followed by charged particle emission that inducing extensive damage on a very localized level (<10 μm). To be efficient, a sufficient amount of 10B should accumulate in the tumor area while being almost cleared from...

L’étude de la dérégulation des métaux au sein des tissus biologiques intéresse de plus en plus le monde médical car une répartition anormale des métaux est une information importante qui peut contribuer au diagnostic clinique, et orienter le choix du traitement pour de nombreuses pathologies. En tant que méthode d’analyse élémentaire « tout optique...

Highly textured cm-sized (Ba1-xCax)TiO3 (x=0.05) polycrystals at off-eutectic composition were grown by the micro-pulling down freezing technique from the BaTiO3-CaTiO3 system at a high pulling velocity of about 48 mm.h-1. Textured polycrystals exhibiting submillimetre-sized dendrites along the (110)pc growth direction and geometrical grains with (...

We present results of the classification contest organized for the EMSLIBS 2019 conference. For this publication, we chose only the five best approaches and discussed their algorithm in detail. The main focus of the contest reflected both recent and long-term challenges of Laser-Induced Breakdown Spectroscopy (LIBS) data processing. The contest was...

Today, Laser-Induced Breakdown Spectroscopy (LIBS) imaging is in full change. Indeed, always more stable instrumentations are developed, which significantly increases the signal quality and naturally the analytical potential of the technique for the characterization of complex and heterogeneous samples at the micro-scale level. Obviously, other int...

Heterogeneous catalyst materials are the core of crude oil purification process performance. Catalyst deactivation, which is a result of crude impurity deposits into catalyst pores during this process, is therefore a major concern during refining. However, deactivation mechanisms are not easily investigated, as they involve carbon transport phenome...

Since the 2000s, the analytical potential of laser-induced breakdown spectroscopy (LIBS) has been growing steadily. This is explained by the many advantages it provides such as its sensitivity, its speed of acquisition, but also the possibility of analyzing most samples as they are without preparation. Like many spectroscopies in the framework of q...

Rare metals are essential to the development of the “green” technologies that are at the core of low-carbon societies. In nature, these metals are frequently present in trace amounts scattered in base metal ore deposits, but the physico-chemical processes that are responsible for their concentration into strategic minerals are still poorly understo...

Les dents sont l’un des matériaux les mieux préservés des assemblages archéologiques et paléoanthropologiques. Les tissus dentaires, tels que l'émail et la dentine, se forment par couches superposées qui seront préservées tout au long de la vie de l’individu. Cette séquence de couches contient l’enregistrement d'informations uniques sur de la traje...

In recent years, important developments have been achieved in the application of laser-induced breakdown spectroscopy (LIBS) for elemental imaging. The aim of this chapter is to report recent instrumental configurations and applications related to LIBS-based imaging. In the first section, different instrumental alternatives for LIBS imaging measure...

Effective drug delivery is restricted by pathophysiological barriers in solid tumors. In human pancreatic adenocarcinoma, poorly-permeable blood vessels limit the intratumoral permeation and penetration of chemo or nanotherapeutic drugs. New and clinically viable strategies are urgently sought to breach the neoplastic barriers that prevent effectiv...

While doping of semiconductors or oxides is crucial for numerous technological applications, its control remains difficult especially when the material is reduced down to the nanometric scale. Pulsed laser ablation in liquids (PLAL) of a solid target could offer a new way to synthesise doped-nanoparticles. This technique is already known as a clean...

Germanium (Ge) is often found as trace element in undeformed sphalerite (ZnS). However, the presence of Ge-minerals (oxides, chloritoids and/or sulphides with up to 70 wt% Ge) is remarkable in Pb-Zn deposits from the Variscan Pyrenean Axial Zone. Their abundance is controlled by the chemical and/or the mechanical processes that affect rare element...

Multi-elemental imaging of soft tissues using Laser-induced breakdown spectroscopy, also known as LIBS, allows for the direct visualization of the distribution of endogenous or exogenous elements within tissues. LIBS was used to image the kinetics of metal nanoparticles in elimination organs, but also the physiological distribution of biological el...

Elemental imaging using laser-induced breakdown spectroscopy: latest medical applications Multi-elemental imaging of soft tissues using Laser-induced breakdown spectroscopy, also known as LIBS, allows for the direct visualization of the distribution of endogenous or exogenous elements within tissues. LIBS was used to image the kinetics of metal nan...

Undoped sapphire rods crystals (ɸ = 3mm, length ≈170mm) along different crystallographic orientations (a [11 0], m [10 2 1 0], c [0001] and c [0001] shifted of 30° axis), were successfully grown by micro-pulling down (μ-PD) method. Bubbles defects distribution were investigated as a function of thermal gradient and pulling rates. It is observed tha...

BaTiO3-based crystal fibres with mm-sized grains were grown by the micro-pulling down technique from the BaTiO3-CaTiO3-BaZrO3 solid solution with pulling velocities about 6, 9 and 15 mm.h-1. Natural growth direction was identified as (001)pc. For pulling velocities about 15 mm.h-1 and 9 mm.h-1, effective partition coefficients have been calculated...

In general, bromine and iodine do not produce atomic or ionic emission lines of sufficient intensity to permit their sensitive detection by laser-induced breakdown spectroscopy in air. This situation is mainly due to both their high excitation levels and the position of their strongest emission lines being either in the VUV or NIR range. However, t...

Laser-induced breakdown spectroscopy (LIBS)-based imaging techniques have become well known among spatially resolved elemental approaches due to their mature instrumentation and outstanding advantages and applications. Data processing and in particular signal extraction are key in all LIBS-based imaging analyses to provide robust and reliable resul...

This paper reports studies on time-resolved laser induced breakdown spectroscopy (LIBS) of plasmas induced by Nd:YAG laser pulses on a sample lyophilized from swine muscle tissue. Samples were measured under vacuum conditions (0.1 Pa), and the laser was operated at 1064 nm, with 6-9 ns laser pulses. The behavior of specific neutral and ionized emis...

Laser-induced breakdown spectroscopy (LIBS) of atoms and ions of rare earth elements (REEs) appears to be an effective tool for REE detection and identification, specifically in imaging applications. We propose to combine this technique with the molecular emissions of LaO and YO and the plasma-induced luminescence (PIL) of REEs in luminescent matri...

Laser-Induced Breakdown Spectroscopy (LIBS) is in a stage of great vitality as an analytical technique. In the past few years, significant advances have been made in the area of LIBS applications to human and animal health. In this review, we have tried to capture their essence by describing briefly the methods used and highlight their key results....

During recent years, important developments have been achieved in the application of laser induced breakdown spectroscopy (LIBS) for elemental imaging. The aim of this review is to report recent instrumental configurations, data processing methodologies and applications related to LIBS-based imaging. In the first section, different instrumental alt...

We report in this study the in vivo biodistribution of ultra-small luminescent gold (Au) particles (∼1.5 nm core size; 17 kDa) so-called nanoclusters (NCs) stabilized by bidentate zwitterionic molecules in subcutaneous (s.c.) and orthotopic glioblastoma mice models. Particular investigations on renal clearance and tumor uptake were performed using...

Geological studies increasingly require highly sensitive elemental techniques able to image the distribution of elements in minerals with microscopic-scale resolution. In this paper, we present an evaluation of megapixel laser-induced breakdown spectroscopy (LIBS) imaging for the geological characterization of minerals. The study is conducted on a...

Imaging the distribution of reactive molecules in an internal diffusion-limited catalyst is of primary importance in the comprehension and modeling of these systems. Mesoporous alumina supports were impregnated with asphaltenes in a self-pressurized autoclave at high pressure (5 MPa) and high temperature (523 K). Extrudates were then analyzed by la...

Introduction L’exposition professionnelle et/ou environnementale à des poussières minérales inhalées peut favoriser des pathologies comme la sarcoïdose, les pneumopathies infiltratives associées à des connectivites et des fibroses. Ces pathologies sont cependant le plus souvent considérées comme idiopathiques, or parmi elles, un certain nombre sont...

Introduction There is a major health problem due to the occupational related exposures to mineral particles, metals, and dust. Pathologists never report the presence of a possible metal-related aetiology in a specimen by lack of available technology. Therefore, several respiratory diseases are considered idiopathic. We recently developed an all-opt...

Biological tissues contain various metal and metalloid ions that play different roles in the structure and function of proteins and are therefore indispensable to several vital biochemical processes. In this review, we discuss the broad capability of laser-induced breakdown spectroscopy (LIBS) for in situ elemental profiling and mapping of metals i...

Laser-Induced Breakdown Spectroscopy (LIBS) has achieved promising performance as an elemental imaging technology, and considerable progress has been achieved in the development of LIBS over the last several years, which has led to great interest in the use of LIBS in various fields of applications. LIBS is a highly attractive technology that is di...

We propose a methodology to compute the crust thickness of an element in an egg-shell catalyst from a two-dimensional elemental map. The methodology handles two important catalyst shapes: infinite extrudates of arbitrary section and spheres. The methodology is validated with synthetic analytical profiles on simple shapes (cylinder and sphere). Its...