Uwe Friese

Uwe Friese
Medical School Hamburg | MSH · Department of Psychology

PhD

About

30
Publications
7,184
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934
Citations

Publications

Publications (30)
Article
The integration of sensory signals from different modalities requires flexible interaction of remote brain areas. One candidate mechanism to establish communication in the brain is transient synchronization of oscillatory neural signals. Although there is abundant evidence for the involvement of cortical oscillations in brain functions based on the...
Article
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Propylene glycol, also denoted as 1.2 propanediol (C3H8O2), often serves as a solvent for dilution of olfactory stimuli. It is supposed to serve as a neutral substance and has been used in many behavioral and electrophysiological studies to dilute pure olfactory stimuli. However, the effect of propylene glycol on perception and on neuronal response...
Article
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Multisensory perception is shaped by both attentional selection of relevant sensory inputs and exploitation of stimulus-driven factors that promote cross-modal binding. Underlying mechanisms of both top-down and bottom-up modulations have been linked to changes in alpha/gamma dynamics in primary sensory cortices and temporoparietal cortex. Accordin...
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The classification of repeating stimuli as either old or new is a general mechanism of everyday perception. However, the cortical mechanisms underlying this process are not fully understood. In general, mnemonic processes are thought to rely on changes in oscillatory brain activity across several frequencies as well as their interaction. Lower freq...
Preprint
Multisensory perception is characterised by attentional selection of relevant sensory inputs and exploitation of cross-modal similarities that promote cross-modal binding. Underlying mechanisms of both top-down and bottom-up modulations have been linked to changes in alpha/gamma dynamics in primary sensory cortices. Accordingly, it has been propose...
Article
Full-text available
Working memory (WM) maintenance of sensory information has been associated with enhanced cross-frequency coupling between the phase of low frequencies and the amplitude of high frequencies, particularly in medial temporal lobe (MTL) regions. It has been suggested that these WM maintenance processes are controlled by areas of the prefrontal cortex (...
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Significance statement: Working memory maintenance, like other cognitive functions, requires the coordinated engagement of brain areas in local and large-scale networks. However, the mechanisms by which spatially distributed brain regions share and combine information remain largely unknown. We show that the combination of long-range low-frequency...
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In this study, we used a novel multisensory attention paradigm to investigate attention-modulated cortical oscillations over a wide range of frequencies using magnetencephalography in healthy human participants. By employing a task that required the evaluation of the congruence of audio-visual stimuli, we promoted the formation of widespread cortic...
Preprint
Full-text available
A novel crossmodal matching paradigm including vision, audition, and somatosensation was developed in order to investigate the interaction between attention and crossmodal congruence in multisensory integration. To that end, all three modalities were stimulated concurrently while a bimodal focus was defined blockwise. Congruence between stimulus in...
Article
Coherent percepts emerge from the accurate combination of inputs from the different sensory systems. There is an ongoing debate about the neurophysiological mechanisms of crossmodal interactions in the brain, and it has been proposed that transient synchronization of neurons might be of central importance. Oscillatory activity in lower frequency ra...
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Full-text available
Factors influencing crossmodal interactions are manifold and operate in a stimulus-driven, bottom-up fashion, as well as via top-down control. Here, we evaluate the interplay of stimulus congruence and attention in a visual-tactile task. To this end, we used a matching paradigm requiring the identification of spatial patterns that were concurrently...
Article
The role of induced gamma-band responses (iGBRs) in the human electroencephalogram (EEG) is a controversial topic. On the one hand, iGBRs have been associated with neuronal activity reflecting the (re-)activation of cortical object representations. On the other hand, it was shown that miniature saccades (MSs) lead to high-frequency artifacts in the...
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The present study investigated implicit and explicit recognition processes of rapidly perceptually learned objects by means of steady-state visual evoked potentials (SSVEP). Participants were initially exposed to object pictures within an incidental learning task (living/non-living categorization). Subsequently, degraded versions of some of these l...
Article
We used an identical repetition priming paradigm in functional MRI (fMRI) and magnetoencephalography (MEG) to investigate brain networks modulated by stimulus repetition and familiarity. In particular, pictures of familiar or unfamiliar objects were presented sequentially, with stimulus repetitions occurring within few trials. The results of both s...
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Diffusion tensor imaging (DTI) demonstrates decline of fractional anisotropy (FA) as a marker of fiber tract integrity in Alzheimer's disease (AD). We aimed to assess the longitudinal course of white matter microstructural changes in AD and healthy elderly control (HC) subjects and to evaluate the effects of treatment with the cholinesterase inhibi...
Article
We used a combined repetition/conceptual priming task to investigate attenuations of induced gamma-band activity (iGBA) due to prior experience. We hypothesized that distinguishable iGBA suppression effects can be related to the processing of (a) perceptual aspects, and (b) conceptual aspects of cortical object representations. Participants were as...
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The effect of cognitive intervention on brain metabolism in Alzheimer's disease (AD) is largely unexplored. Therefore, we aimed to investigate clinical cognitive parameters and 18FDG PET to test for effects of a cognitive intervention in patients with amnestic mild cognitive impairment (aMCI) or mild AD. Patients with aMCI (n = 24) or mild AD (n =...
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Recent studies have shown that patients with Alzheimer's disease (AD) and its possible prodromal stage mild cognitive impairment benefit from cognitive interventions. Few studies so far have used an active control condition and determined effects in different stages of disease. We evaluated a newly developed 6-month group-based multicomponent cogni...
Article
Novel MRI based acquisition and analysis techniques are increasingly used as biomarkers to discriminate between Alzheimer's disease and normal aging. Evaluating the diagnostic utility of the various approaches in use is difficult though because of significant methodological differences between studies. In this research we directly compare the diagn...
Article
Full-text available
The effect of cognitive intervention on brain metabolism in AD is largely unexplored. Therefore, we aimed to investigate cognitive parameters and 18FDG PET to test for effects of a cognitive intervention in patients with aMCI or mild AD. Patients with aMCI (N = 24) or mild AD (N = 15) were randomly assigned either to cognitive intervention groups (...
Article
Full-text available
We report evidence that multivariate analyses of deformation-based morphometry and diffusion tensor imaging (DTI) data can be used to discriminate between healthy participants and patients with Alzheimer's disease (AD) with comparable diagnostic accuracy. In contrast to other studies on MRI-based biomarkers which usually only focus on a single moda...
Article
Full-text available
During language comprehension, readers or listeners routinely infer information that has not been stated literally in a given text or utterance in order to construct a coherent mental representation (situation model). We used a verification task in a behavioral study and in an event-related functional magnetic resonance imaging (fMRI) experiment to...

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