Usama Ramadan Abdelmohsen

• Professor
• Professor at Deraya University

The prevalence of methicillin-resistant Staphylococcus aureus (MRSA) has been steadily increasing over the past few decades, prompting an urgent need to develop novel antibiotic classes to combat the growing threat of multidrug-resistant bacteria. In this context, a phytochemical investigation of Citrus australasica F. Muell. (finger lime, Rutaceae...

Tomato (Solanum lycopersicum L.) is one of the most common vegetable plants in the world. It is also named Lycopersicon esculentum. It serves as a model plant for the Solanaceae family, especially for plants that produce fleshy fruits. Various studies have shown that S. lycopersicum fruits, seeds, leaves, roots, in addition to tomato waste, constit...

Essential oils (EOs) have a long-standing tradition and remain widely used in therapeutic applications. Their biological activities are primarily driven by complex interactions among their diverse components which exhibit synergistic or antagonistic effects, resulting in a broad spectrum of pharmacological and biological properties. These component...

Peptic ulcer is a major health disease which could be defined as destruction in different parts of the gastrointestinal track mainly the lining mucosa of the stomach as well as the proximal duodenum. Additionally, the treatment of this illness emphases different challenges as the currently available medications have major side effects as well as li...

Chemical investigation of the ethyl acetate extract of the endophytic fungus Aspergillus terreus AArEF2 found in the fresh leaves of Artemisia arborescens L. led to isolation of five previously undescribed butenolides, asperterreunolides A-E (1-5), along with the known metabolite butyrolactone IV (6). The structure elucidation of these metabolites...

Our knowledge of the green macroalga Halimeda (Ulvophyceae, Chlorophyta) is still poor and underestimated from the phytochemical and pharmacological standpoints. Pharmacological and therapeutic potentials of chemically-diverse compounds derived from different species of the genus Halimeda are highly promising as antiviral, antimicrobial, cytotoxic,...

Corchorus olitorius L. Moench (Molokheia) is a common edible plant that is rich in terpenoids and flavonoids. Later, for the first time, this article was planned to study the potential of C. olitorius roots and their nanocrystals against breast cancer (MCF-7), hepatocellular carcinoma (HepG2) and colon cancer (Caco-2) cell lines. Generally, the tot...

Methicillin-resistant Staphylococcus aureus (MRSA) is a significant pathogen associated with healthcare-related infections that are often challenging to treat. Conditions such as, skin and soft tissue infections, bloodstream infections, and pneumonia highlight the critical need for effective therapeutic strategies. Careful use of antibiotics under...

The current study investigated the effects of Olea europaea L. cv. Nepal (OEN) leaf extract on obesity‐related disorders in rabbits. OEN extract, in dose 100 mg/kg body weight, significantly reduced cholesterol (TC), triglycerides (TAG), and inflammatory markers (MCP‐1, VCAM‐1, IL‐6, IL‐1β, TNFα, NF‐κB) in both preventative and treatment groups. Ad...

Gold nanoparticles (Au) have attracted considerable attention in the field of biomedicine in recent years. The present work was designed to investigate gold nanoparticles obtained using a soil-associated actinomycetes, Streptomyces sp. ASM19. This microorganism was isolated and identified using DNA sequencing. The chemical profile of the Streptomyc...

Yellow fever (YF) is a mosquito‐borne virus with high mortality rates, affecting regions in South America and Africa. Despite the effectiveness of YF vaccines, increased global demand and reports of rare, severe side effects have spurred the search for safer therapeutic alternatives. Current treatments lack specific antiviral drugs approved for YF,...

Objectives Hepatocellular carcinoma (HCC) represents the third-most prevalent cancer in humans worldwide. The current study’s objective is to search for the potentiality of Washingtonia robusta H. Wendl (W. robusta) leaf extract in a nanoemulsion (NE) form in enhancing radiotherapy against HCC induced in rats using diethylnitrosamine (DEN). Materi...

Retraction of ‘The anti-Alzheimer potential of Tamarindus indica: an in vivo investigation supported by in vitro and in silico approaches’ by Abeer H. Elmaidomy et al., RSC Adv., 2022, 12, 11769–11785, https://doi.org/10.1039/D2RA01340A.

Mucormycosis, a life‐threatening fungal infection caused by Mucorales, affects immunocompromised patients, especially SARS‐CoV‐2 ones. Existing antifungal therapies, like amphotericin B, have serious health risks. The current study reviews the literature regarding an overview of SARS‐CoV‐2‐associated mucormycosis, along with different terpenes from...

This study explores the metabolic profile and wound-healing capabilities of Ficus trijuja, a species within the Moraceae family, for the first time. Ficus plants contain a variety of secondary metabolites such as flavonoids, triterpenoids, and alkaloids, known for their antioxidant, anti-inflammatory, and cytotoxic properties. Previous studies demo...

Retraction of ‘Antiulcer secondary metabolites from Elaeocarpus grandis, family Elaeocarpaceae, supported by in silico studies’ by Radwa Taher Mohie El-Dien et al., RSC Adv., 2020, 10, 34788–34799, https://doi.org/10.1039/D0RA06104B.

Egyptian seaweeds contain diverse bioactive compounds, but our understanding of their antimicrobial potential, particularly against multidrug-resistant (MDR) human pathogens, is still limited and underestimated. This study screened the antimicrobial potential of ethanolic extracts of Caulerpa racemosa, Dictyopteris polypodioides, and Padina pavonic...

Metabolic profiling of the ethyl acetate extract of Corchorus olitorius seeds associated with Penicillium sp. resulted in the dereplication of sixteen compounds (1-16). The present work investigated the combined wound-healing potential of BMMSCs and Penicillium sp. extract in immunocompromised rats. The BMMSCs/Penicillium sp. extract combination co...

Methotrexate (MTX) is commonly employed in cancer treatment, but its clinical use is restricted due to the MTX‐associated renal injury. This study investigates the combined potential of Rhus coriaria (sumac) and bone marrow mesenchymal stem cells (BMMSCs) against MTX‐induced nephrotoxicity in rats. The high‐resolution‐liquid chromatography‐mass spe...

Background Sponge-associated microorganisms are promising resources for the production of bioactive compounds with cytotoxic potential. The main goal of our study is to isolate the fungal endophytes from the Red Sea sponge Hyrtios sp. followed by investigating their cytotoxicity against number of cell lines. Results The fungal strain UR3 was isola...

Bioassay-guided fractionation approach led to identification of two novel compounds; (4-(hydroxymethyl)-3-methoxy-1H-pyrazol (1) and mycalene (2), alongside with four known metabolites; octadecane (3), hexatriacontane (4), 1-heneicosanol (5) and heptatriacontanoic acid (6) from the Red Sea marine sponge Hemimycale sp. The ethyl acetate fraction sho...

Endophytes are an appealing source of natural products with unique structures that can aid in the treatment of life-altering disorders because of the complexity and structural variety of the secondary metabolites they produce. The genus Cladosporium, which belongs to family Cladosporiaceae, class Dothideomycetes has received more attention due to t...

Endophytes are an appealing source of natural products with unique structures that can aid in the treatment of life-altering disorders because of the complexity and structural variety of the secondary metabolites they produce. The genus Cladosporium, which belongs to family Cladosporiaceae, class Dothideomycetes has received more attention due to t...

Gladiolus segetum Ker‐Gawl corms total extract exhibited remarkable in vitro anti‐proliferative effects against panel of cancer cell lines; including human colon carcinoma (Caco‐2), human breast cancer (MCF7) and hepatocellular carcinoma (HepG2) cell lines with IC50 values of 7.4, 9.1 and 11.2 μg/ml, respectively. The total ethanolic extract of G....

The chemical profiling of ethyl acetate extract of the endophytic fungus Pleosporales sp. using liquid chromatography–electrospray ionization–mass spectrometry (LC-ESI-MS) revealed the presence of 12 metabolites of different chemical classes such as steroids, α-pyrones, asterric acid derivatives, and quinones. Additionally, the gas chromatography–m...

The total ethanol extract of Dypsis decaryi aerial parts (TEEDDAP) was investigated the preliminary phytochemical screening, metabolomic analysis (28 compounds) in addition to of 7 isolated compounds. Five of them were isolated for the first time from the genus. It screened against 4 different cell lines. It showed strong cytotoxic effect against H...

Brain tumors are tenacious cancers with poor prognosis and disappointing survival rates. The most prevalent, deadly, and aggressive form of brain cancer in adults is called glioblastoma (GBM). The biology of brain cancer cells can be studied with the help of glioma cell lines such as, SNB-75. Fortunately, a variety of naturally occurring substances...

The methanolic extract of the marine sponge Hemimycale sp. yielded two new compounds; 1-(2'-methyl heptadecyl) phenol (1) and a new pyrazole derivative; 4-(hydroxymethyl)-1H-pyrazol-3-ol (2), together with previously isolated (2'R)-2'-hydroxy-N-((2S,3S,4R)-1,3,4-trihydroxy-16-methylpentadecan-2-yl)docosanamide (3), cholesterol (4), 5, 8-epi-dioxych...

The emergence of antibiotic-resistant Streptococcus pneumoniae necessitates the discovery of novel therapeutic agents. This study investigated the antimicrobial potential of green-synthesized gold nanoparticles (AuNPs) fabricated using Arthrospira platensis extract. Characterization using Fourier transform infrared spectroscopy revealed the presenc...

A main feature of neurodegenerative diseases is the loss of neurons. One of the most prevalent neurodegenerative illnesses is Parkinson disease (PD). Although several medications are already approved to treat neurodegenerative disorders, most of them only address associated symptoms. The main aim of the current study was to examine the neuroprotect...

Background Breast cancer is the most diagnosed cancer in women. Its pathogenesis includes several pathways in cancer proliferation, apoptosis, and metastasis. Some clinical data have indicated the association between coffee consumption and decreased cancer risk. However, little data is available on the effect of coffee on breast cancer cells in vit...

Seaweeds or marine algae with their three main taxa are recognized as a potential pot for numerous products. This has been imperative to valorize their components at an industrial scale in the context of the sustainability goals of the United Nations (UN). Biorefinery approaches have been attempted for several decades to produce bioactive, biofuels...

Simple Summary Cancer is the second leading cause of death worldwide, warranting the development of safer, more effective therapies. Liposomes and niosomes can be considered excellent drug delivery systems due to their ability to load all compounds and reduce the toxicity of the loaded drug without reducing its effectiveness. Synechocystis sp. is a...

Green seaweed (Ulva sp.) is frequently used as a food component and nutraceutical agent because of its high polysaccharide and natural fiber content in Asian countries. This study investigates both metabolomic profiling of Ulva sp. and the neuroprotective efficacy of its ethanol extract and its underlying mechanisms in a rotenone‐induced rat model...

Sarcoptic mange, also referred to as scabies in humans, is a highly contagious skin condition caused by the burrowing mite Sarcoptes scabiei (Astigmata: Sarcoptinae). This parasitic disease significantly affects livestock production and poses a substantial threat to both animal and human health. The current treatment methods primarily involve synth...

Environmentally friendly biosynthesis of silver nanoparticles (AgNPs) from Aeonium arboreum (L.) Webb & Berthel is reported for the first time. The synthesized AgNPs were characterized using UV-Vis, FTIR, TEM, Zeta potential, and XRD analysis, revealing high stability (−29.1 mV), spherical shape, and an average size of 100 nm. The antimicrobial act...

Delayed healing of chronic wounds results in amputation and mortality rates in serious cases. The present study examines the merged wound‐restorative efficacy of injectable bone marrow‐derived mesenchymal stem cells (BMMSCs) and topical Callyspongia sp. extract in immunocompromised rats. HR‐LC–MS analysis of Callyspongia sp. extract tentatively ide...

The red seaweed Hypnea J.V. Lamouroux is a cosmopolitan genus of the family Cystocloniaceae. It has been used in folk medicine, especially in eastern Asian countries. However, little literature highlighted the phytochemical and pharmaceutical values of its different species. In the past centuries, and until now, different Hypnea species have also b...

In the current study, we evaluated the in vitro antibacterial efficacy of the roots’ extracts of Jasminum officinale, Rosa damascene and Paeonia officinalis against MRSA (methicillin-resistant Staphylococcus aureus) by well diffusion technique. The root extract of P. officinalis exerted a potent anti-MRSA with MIC 0.4673 µg/ml, while both J. offici...

Osteoarthritis (OA) is a degenerative joint disease, characterized by infiltration of monocytes into the synovial joint which promotes inflammation, stiffness, joint swelling, cartilage degradation and further bone destruction. The leaves of Ocimum forskolei have been used for inflammation-related disease management in traditional medicine. Additio...

The aim of this study is to evaluate the anti-HPV potential of a Moringa olifera Lam seed, Nigella sativa L. seed, and Musa Acuminata peel herbal mixture in the form of polymer film-forming systems. A clinical trial conducted in outpatient clinics showed that the most significant outcome was wart size and quantity. Compared to the placebo group, th...

Nature has proven to be a treasure resource of bioactive metabolites. In this regard, Tamarix aphylla (F. Tamaricaceae) leaves crude extract was investigated for its gastroprotective effect against indomethacin-induced damage to the gastric mucosa. Additionally, phytochemical investigation of the methanolic extract afforded eight flavonoids’ deriva...

This study aimed to discover the potential of Medicago sativa-derived fungal endophytes as a prospective source of bioactive metabolites. In the present study, three different strains of fungal endophyte Aspergillus terreus were isolated from leaves L, roots T and stems St of Medicago sativa to explore their biological and chemical diversity. These...

A total of 20 endophytic fungi were isolated (ZSEFL1-ZSEFL20) from Ziziphus spina-christi (L.) Desf. (Nabq) leaves. Four isolates A2/ZSEFL2, Alternaria alternata, D/ZSEFL14, Aspergillus niger, E/ZSEFL15, Epicoccum nigrum, and S/ZSEFL19, Penicillium crustosum were found to show the most promising antimicrobial activities either in plug or disc diffu...

Caroxylon volkensii is a wild desert plant of the family Amaranthaceae. This study represents the first report of the metabolomic profiling of C. volkensii by liquid chromatography quadrupole-time-of-flight tandem mass spectrometry (LC-QTOF-MS/MS). The dereplication study of its secondary metabolites led to the characterization of 66 known compound...

Wound healing, one of the most intricate and dynamic processes of the body, maintains skin integrity following trauma. One of the main issues that still exists is impaired wound healing, particularly for immunosuppressed patients. Recently, natural products from marine environments have been employed in wound-repairing activities. This work investi...

Phytochemical investigation of Key lime ( Citrus aurantifolia L., F. Rutaceae) peels afforded six metabolites, known as methyl isolimonate acetate (1), limonin (2), luteolin (3), 3ˋ-hydroxygenkwanin (4), myricetin (5), and europetin (6). The structures of the isolated compounds were assigned by 1D NMR. In the case of limonin (2), further 1- and 2D...

Cancer stands as a prominent global cause of death. One of the key reasons why clinical tumor chemotherapy fails is multidrug resistance (MDR). In recent decades, accumulated studies have shown how Natural Product-Derived Compounds can reverse tumor MDR. Discovering novel potential modulators to reduce tumor MDR by Natural Product-Derived Compounds...

Background Gastric ulcers represent a worldwide health problem, characterized by erosions that affect the mucous membrane of the stomach and may even reach the muscular layer, leading to serious complications. Numerous natural products have been assessed as anti-ulcerogenic agents, and have been considered as new approaches for treatment or prevent...

Ethanol extracts of Caulerpa racemose (Forsskål) J.Agardh, 1873, Dictyopteris acrostichoides (J.Agardh) Bornet, 1885, Halimeda opuntia (Linnaeus) J.V.Lamouroux, 1816, and Polycladia myrica (S.G.Gmelin) Draima, Ballesteros, F.Rousseau & T.Thibaut, 2010, were tested for their cytotoxicity against human hepatoma, human breast adenocarcinoma, and human...

The in-vitro anti-proliferative evaluation of Sinularia levi total extract against three cell lines revealed its potent effect against Caco-2 cell line with IC50 3.3 μg/mL, followed by MCF-7 and HepG-2 with IC50 6.4 μg/mL and 8.5 μg/mL, respectively, in comparison to doxorubicin. Metabolic profiling of S. levi total extract using liquid chromatogra...

The crude extract of Hemimycale sp. marine sponge was evaluated as a cytotoxic drug against different cell lines; whereas it exhibited promising selective activity toward the breast cancer cell line only with IC50 value 199.6 ± 0.00512 µg/ml. Moreover, its cytotoxic activity against the breast cancer cell line was reevaluated upon forming total ext...

Expression of concern for ‘The anti-Alzheimer potential of Tamarindus indica: an in vivo investigation supported by in vitro and in silico approaches’ by Abeer H. Elmaidomy et al., RSC Adv., 2022, 12, 11769–11785, https://doi.org/10.1039/D2RA01340A.

In the current study, the actinomycetes associated with the red sea‐derived soft coral Sarcophyton glaucum were investigated in terms of biological and chemical diversity. Four different media, M1, ISP2, Marine Agar (MA), and Actinomycete isolation agar (AIA) were used for the isolation of three strains of actinomycetes that were identified as Stre...

Background Solanum lycopersicum Linn. (Tomato, Family Solanaceae) is one of the fruits that are most consumed worldwide. The current research intends to emphasise the possibility of positive and therapeutic effects of S. lycopersicum seed extract (SLSE) on Alzheimer's disease's neurodegeneration effects being reversed in a study utilising rats expo...

Malaria is a persistent illness that is still a public health issue. On the other hand, marine organisms are considered a rich source of anti‑infective drugs and other medically significant compounds. Herein, we reported the isolation of the actinomycete associated with the Red Sea sponge Callyspongia siphonella. Using "one strain many compounds" (...

Cancer is the world's second-leading cause of death. Drug development efforts frequently focus on medicinal plants since they are a valuable source of anticancer medications. A phytochemical investigation of the edible Ziziphus spina-christi (F. Rhamnaceae) leaf extract afforded two new dammarane type saponins identified as christinin E and F ( 1,...

Background Endophytic fungi are very rich sources of natural antibacterial and antifungal compounds. The main aim of this study is to isolate the fungal endophytes from the medicinal plant Corchorus olitorius seeds (F. Malvaceae), followed by antimicrobial screening against various bacterial and fungal strains. Results Seven endophytic fungal stra...

Endophytic fungi, particularly from higher plants have proven to be a rich source of antimicrobial secondary metabolites. The purpose of this study is to examine the antimicrobial potential of three endophytic fungi Aspergillus sp. SA1, Aspergillus sp. SA2, and Aspergillus sp. SA3, cultivated from Nigella sativa seeds against Staphylococcus aureus...

Background Cancer continues to be one of the biggest causes of death that affects human health. Chemical resistance is still a problem in conventional cancer treatments. Fortunately, numerous natural compounds originating from different microbes, including fungi, possess cytotoxic characteristics that are now well known. This study aims to investig...

Natural products continue to provide potential pharmacological activities treating life-threatening illnesses. Among them is hyperlipidemia, which is a critical issue affecting approx. one-third of the world population and considered a risk factor for numerous life-threatening diseases, including myocardial infarction and stroke. The current review...

The study of all chemical processes involving metabolites is known as metabolomics.

Nutritional deficits in one’s diet have been established as the key risk factor for T2DM in recent years. Nutritional therapy has been demonstrated to be useful in treating T2DM. The current study was carried out to assess the nutritional composition of bovine (12 months), chicken (4 months), sheep (13 months), and goat (9 months) femur bone extrac...

Malaria as an infectious disease is one of the world's most dangerous parasitic diseases. There is an urgent need for the development of new antimalarial drugs. Natural products are a very rich source of new bioactive compounds. Our research aims to shed light on the recent studies which demonstrated the antimalarial potential of phenylpropanoids a...

Cancer, which is characterized by uncontrolled cell growth and division with loss of physiological functions. It is one of the most fatal diseases in the world. For thousands of years, natural treatments, particularly those made from natural products, have been used to cure a variety of diseases, including cancer. Several Arecaceae species have bee...

The current study investigated the scabicidal potential of Egyptian mandarin peel oil (Citrus reticulata Blanco, F. Rutaceae) against sarcoptic mange-in-rabbits. Analysis of the oil's GC–MS identified a total of 20 compounds, accounting for 98.91% of all compounds found. Mandarin peel oil topical application improved all signs of infection, causing...

Endophytic fungi are known to be a rich source for anti-infective drugs. In this study, Aptenia cordifolia associated endophytic fungi were explored for the first time. Seven isolates were identified morphologically followed by screening of these fungi by plug diffusion assay which revealed their potential activity against Staphylococcus aureus (AT...

Aims: This study aims to prioritize fungal strains recovered from under-explored habitats that produce new metabolites. HRMS dereplication is used to avoid structure redundancy and molecular modelling is used to assign absolute configuration. Methods and results: MBC15-11F was isolated from an amphipod and identified using ITS, 28S, and β-tubuli...

Vitis vinifera Egyptian edible leaf extract loaded on a soybean lecithin, cholesterol, and Carbopol gel preparation (VVL-liposomal gel) was prepared to maximize the in vivo wound healing and anti-MRSA activities for the crude extract, using an excision wound model and focusing on TLR-2, MCP-1, CXCL-1, CXCL-2, IL-6 and IL-1β, and MRSA (wound infecti...

This study shed light for the first time on the in vivo diabetic wound healing potential activity of natural marine soft coral polymeric nanoparticle in situ gel using an excision wound model. A Nephthea sp. methanol–methylene chloride extract loaded with pectin nanoparticles (LPNs) was created. For the preparation of in situ gel, ion-gelation tech...

Aim This study aimed to use one strain many compounds approach (OSMAC) to investigate the cytotoxic potential of Aspergillus terreus associated with soybean versus several cancer cell lines, by means of in-silico and in vitro approaches. Methods and results Fermentation of the isolated strain was done on five media. The derived extracts were inves...

Abelmoschus esculentus Linn. (okra, F. Malvaceae) is a fruit widely consumed all over the world. In our study, the anti-Alzheimer’s potential of A. esculentus was evaluated. An in vitro DPPH free radical assay on A. esculentus seed’s total extract and AChE inhibition potential screening indicated a significant anti-Alzheimer’s activity of the extra...

Khella (Ammi visnaga (L.) Lam.) and celery (Apium graveolens L.) are two valuable medicinal plant species with a wide-ranging health and therapeutic benefits, including hepatoprotective and antiviral properties. Thus, in this work, the total ethanolic extracts of the roots of the aforementioned species were studied for their antiviral potential aga...

Aim: Metabolomics analysis using LC-HRESIMS of twelve extracts of Spongia irregularis associated actinomycetes for dereplication purposes in addition to evaluation of cytotoxic and antiviral activities of the extracts. Methods and results: In the present study, three actinomycetes belonging to the genera Micromonospora, Streptomyces, and Rhodoco...