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Ursula Bentin-Ley

Ursula Bentin-Ley
Dansk Fertilitetsklinik · Fertility Unit

MD, PhD

About

25
Publications
6,760
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1,144
Citations

Publications

Publications (25)
Article
The number of treatments with donated oocytes has risen markedly in Denmark during the latest decade due to changes in legislation and because female age is increasingly advanced when fertility treatment is warranted. Today, oocyte donation is a standard procedure offering the otherwise untreatable a high chance of achieving a pregnancy. Live birth...
Article
Objective To study if the age of women undergoing assisted reproductive technology treatment associates with stage, morphology, and implantation of the competent blastocyst. Design Multicenter historical cohort study based on exposure (age) and outcome data (blastocyst stage and morphology and initial human chorionic gonadotrophin [hCG] rise) from...
Article
Full-text available
Bemfola (follitropin alfa) (Finox AG, Switzerland), a new recombinant FSH, has a comparable pharmacological profile to that of Gonal-f (Merck Serono, Germany), the current standard for ovarian stimulation. A randomized, multi-centre, Phase 3 study in women undergoing IVF or intracytoplasmic sperm injection (n = 372) showed Bemfola yielding similar...
Article
Full-text available
The goal of embryo selection models is to select embryos with the highest reproductive potential, whilst minimizing the rejection of viable embryos. Ultimately, any embryo selection model must be tested on clinical outcome. We therefore retrospectively tested a published blastocyst prediction model on a large combined set of transferred embryos wit...
Article
To investigate in the natural cycle just before IVF, whether glycodelin levels in endometrial flushing fluid obtained days LH+1 and LH+7 can be used in predicting pregnancy in the following IVF cycle, and whether there are differences in women with tubal factor infertility compared to women with unexplained infertility and fertile controls. A prosp...
Article
To investigate the effect of levonorgestrel and mifepristone on the expression of endometrial receptivity markers in a three-dimensional endometrial construct. In vitro study. University hospital and research laboratory. Twelve fertile donors. Timed endometrial biopsy. Examine the effect of levonorgestrel along with another well-studied fertility-r...
Article
Full-text available
The use of fertility regulating drugs is limited among various socio-ethnic groups due to limited knowledge about their mechanism of action. This study investigates the effect of levonorgestrel and mifepristone on attachment of human embryos to an in vitro endometrial construct. Three-dimensional endometrial constructs were established by co-cultur...
Article
To compare endometrial dating and ultrasound texture in a natural cycle before IVF and relate these to outcome and to fertile references. Prospective study with a fertile reference group. Four university IVF clinics. Seventy-five IVF patients and 21 fertile women. Ultrasound, biopsy, blood sampling. In vitro fertilization-ET in the following cycle....
Article
Full-text available
Infertility is an increasing problem all over the world, and it has been estimated that 10-15% of couples in fertile age have fertility problems. Likewise induced unsafe abortion is a serious threat to women's health. Despite advances made in assisted reproduction techniques, little progress has been made in increasing the success rate during ferti...
Article
To investigate the effect of the anti-P Org 31710 on human blastocyst attachment to cultured endometrial epithelial cells. Experimental in vitro study. University hospital. Eleven fertile endometrial donors. Timed endometrial biopsy for cell cultures. Blastocyst attachment rate on endometrial cell cultures; secretion of glycodelin and leukemia inhi...
Article
To review the literature on various endometrial factors assumed to be of importance to implantation and to evaluate their potential clinical value in the assessment of endometrial function at the time of implantation in infertile women in natural and stimulated cycles. Literature review. Cytokines such as leukemia inhibitory factor, colony-stimulat...
Article
Endometrial pinopodes, hormone-dependent protrusions of the endometrial apical plasma membrane, have been suggested as indicators of endometrial receptivity. The lifespan of endometrial pinopodes appears to be tightly regulated. Interestingly, considerable interpatient variations according to the onset of pinopode formation have been observed. In n...
Article
Morphologic information on the earliest stages of human implantation in vitro is still missing. In this article, results of human blastocyst implantation in vitro are presented and discussed. The significance of endometrial pinopodes and the assumption that the blastocyst attaches to the apical endometrium before penetrations begins are discussed a...
Chapter
Implantation failure after assisted reproductive technology (ART) is still a major problem. Even after blastocyst transfer, implantation rates do not exceed 50% (1,2), most likely due to suboptimal endometrial preparation for implantation (3,4).
Article
Full-text available
The interactions of seven human blastocysts with cultured endometrial cells were investigated by light microscopy and transmission electron microscopy. Trophoblastic-endometrial contact was observed at the lateral border of endometrial epithelial cells where trophoblast and endometrial epithelial cells shared apical junctional complexes and desmoso...
Article
This paper reviews different in vitro models used for the study of blastocyst implantation in animals and the human. Furthermore, results from human blastocyst-endometrial interactions in vitro, investigated by scanning electron microscopy (SEM), light microscopy (LM) and transmission electron microscopy (TEM), are presented. SEM demonstrates the p...
Article
The interactions of seven human blastocysts with cultured endometrial cells were investigated by light microscopy and transmission electron microscopy. Trophoblastic-endometrial contact was observed at the lateral border of endometrial epithelial cells where trophoblast and endometrial epithelial cells shared apical junctional complexes and desmoso...
Article
Full-text available
In order to study changes occurring on the surfaces of human endometrial epithelial cells in the presence of an implanted blastocyst, we used scanning electron microscopy for investigation of five endometrial biopsies and three human implantation sites obtained in vitro. All specimens showed areas with endometrial pinopodes, separated by cells disp...
Article
Full-text available
Several retrospectively designed studies have shown an association between the presence of hydrosalpinx and impaired implantation and pregnancy rates among in-vitro fertilization (IVF) patients. In the present study we have evaluated the influence of hydrosalpinx fluid on normal human embryo development and implantation. Surplus, donated frozen emb...
Article
A three-dimensional cell culture system imitating normal uterine endometrium has previously been established. To what degree do cultured epithelial cells retain their morphological characteristics as compared to in vivo material obtained simultaneously from the same tissue donor. We found a high degree of similarity between the in vivo and in vitro...
Article
Full-text available
A cell culture system was established in which endometrial stromal cells were embedded in a collagen matrix and separated from the endometrial epithelium by basement membrane material (Matrigel). The epithelium, seeded on top of the collagen matrix, grew in a monolayer. The cultures were evaluated by light microscopy and transmission and scanning e...

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