Uros Marusic

Uros Marusic
Science and Research Centre Koper · Institute for Kinesiology Research

PhD
Exploring muscle-brain crosstalk using Mobile Brain/Body Imaging (MoBI).

About

75
Publications
20,838
Reads
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709
Citations
Additional affiliations
September 2018 - February 2019
University of Michigan
Position
  • Research Associate
October 2017 - present
Science and Research Centre Koper
Position
  • Senior Researcher
October 2017 - present
Alma Mater Europaea ECM
Position
  • Professor (Assistant)
Education
November 2011 - April 2015

Publications

Publications (75)
Article
Full-text available
Prosthetic devices that replace a lost limb have become increasingly performant in recent years. Recent advances in both software and hardware allow for the decoding of electroencephalogram (EEG) signals to improve the control of active prostheses with brain-computer interfaces (BCI). Most BCI research is focused on the upper body. Although BCI res...
Article
Full-text available
Parkinson’s disease (PD) is generally associated with abnormally increased beta band oscillations in the cortico-basal ganglia loop during walking. PD patients with freezing of gait (FOG) exhibit a more distinct, prolonged narrow band of beta oscillations that are locked to the initiation of movement at ∼18 Hz. Upon initiation of cycling movements,...
Article
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Background Efficient performance of most daily activities requires intact and simultaneous execution of motor and cognitive tasks. To mitigate age-related functional decline, various combinations of motor and cognitive training have shown promising results. The aim of this systematic review and meta-analysis of randomized controlled trials (RCTs) w...
Article
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A close inter-relationship between mobility and cognition is reported in older adults, with improvements in gait performance noticeable after cognitive remediation in frail individuals. The aim of this study was to evaluate the efficacy of computerized cognitive training (CCT) on mobility in healthy, independently living older adults, and to determ...
Article
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With advanced age, there is a loss of reaction speed that may contribute to an increased risk of tripping and falling. Avoiding falls and injuries requires awareness of the threat, followed by selection and execution of the appropriate motor response. Using event-related potentials (ERPs) and a simple visual reaction task (RT), the goal of our stud...
Article
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A major concern of public health authorities is to also encourage adults to be exposed to enriched environments (sensory and cognitive-motor activity) during the pandemic lockdown, as was recently the case worldwide during the COVID-19 outbreak. Games for adults that require physical activity, known as exergames, offer opportunities here. In partic...
Article
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Electroencephalography (EEG) is a non-invasive technique used to record cortical neurons' electrical activity using electrodes placed on the scalp. It has become a promising avenue for research beyond state-of-the-art EEG research that is conducted under static conditions. EEG signals are always contaminated by artifacts and other physiological sig...
Article
Electroencephalography (EEG) is a non-invasive technique used to record cortical neurons' electrical activity using electrodes placed on the scalp. It has become a promising avenue for research beyond state-of-the-art EEG research that is conducted under static conditions. EEG signals are always contaminated by artifacts and other physiological sig...
Article
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We examined activation patterns of the gastrocnemius medialis (GM), gastrocnemius lateralis (GL), soleus (SO), and tibialis anterior (TA) muscles in eight older (58.4 ± 3.3 years) and seven young (23.1 ± 2.9 years) participants, before and after 14 days of horizontal bed rest. Visual feedback on the exerted muscle torque was provided to the partici...
Article
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Biosignal control is an interaction modality that allows users to interact with electronic devices by decoding the biological signals emanating from the movements or thoughts of the user. This manner of interaction with devices can enhance the sense of agency for users and enable persons suffering from a paralyzing condition to interact with everyd...
Article
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The present study examined the effects of the lockdown period on basic anthropometric measures, countermovement jumping performance, skeletal muscle contractile properties derived from tensiomyography (TMG), injury incidence, and self-assessed general well-being in elite soccer players. A total of 266 players were assessed before (PRE) and 32 playe...
Article
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Motor imagery (MI) for health and performance strategies has gained interest in recent decades. Nevertheless, there are still no studies that have comprehensively investigated the physiological responses during MI, and no one questions the influence of low-level contraction on these responses. Thus, the aim of the present study was to investigate t...
Article
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Background: Hearing impairments are associated with reduced walking performance under Dual-task (DT) conditions. Little is known about the neural representation of DT performance while walking in this target group compared to healthy controls or younger adults. Therefore, utilizing the Mobile Brain/Body Imaging approach (MoBI), we aim at gaining de...
Article
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Although autonomic nervous system (ANS) dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) has been proposed, conflicting evidence makes it difficult to draw firm conclusions regarding ANS activity at rest in ME/CFS patients. Although severe exercise intolerance is one of the core features of ME/CFS, little attempts have bee...
Article
Space analogues, such as bed rest, are used to reproduce microgravity-induced morphological and physiological changes and can be used as clinical models of prolonged inactivity. Nevertheless, non-uniform decreases in muscle mass and function have been frequently reported, and peripheral nerve adaptations have been poorly studied, although some of t...
Article
Full-text available
Ohranjanje in krepitev fizičnega in kognitivnega zdravja je pri starejših osebah izziv, še posebej pri tistih, ki so podvržene pospešenim starostnim ali nevrodegenerativnim spremembam. Obstoječe nefarmakološke intervencije lahko stabilizirajo ali upočasnijo kognitivni upad, vendar se učinkovite preventivne tretmaje, ki bi zakasnili pojavnost simpto...
Article
Full-text available
Prolonged periods of complete physical inactivity or bed rest trigger various alterations in the functional and metabolic levels of the human body. However, bed rest-related adaptations of the central nervous system are less known and thoroughly studied. The aim of this study was to investigate brain electrophysiological changes using event-related...
Article
Full-text available
This study evaluated the effects of an exergame program (TennisVirtua-4, Playstation Kinect) combined with traditional tennis training on autonomic regulation, tennis technique, gross motor skills, clinical reaction time, and cognitive inhibitory control in children. Sixty-three children were randomized into four groups (1st-two exergame and two re...
Article
Muscle atrophy and decline in muscle strength appear very rapidly with prolonged disuse or mechanical unloading after actual hospitalization or after experimental bed rest periods. The current study analyzed data from short-, medium- and long-term bed rest (5-120 days) in a pooled sample of 326 healthy adults and modeled the mathematical relationsh...
Article
Full-text available
Shoulder exoskeletons potentially reduce overuse injuries in industrial settings including overhead work or lifting tasks. Previous studies evaluated these devices primarily in laboratory setting, but evidence of their effectiveness outside the lab is lacking. The present study aimed to evaluate the effectiveness of two passive shoulder exoskeleton...
Article
Background and Objective The input data distributions of EEG-based BCI systems can change during intra-session transitions, due to nonstationarity caused by features covariate shifts, thus compromising BCI performance. We aimed to identify the most robust spatial filtering approach, among most used methods, testing them on calibration dataset, and...
Article
Full-text available
Background: Physical inactivity is prevalent in older adults with type 2 diabetes mellitus (T2DM) and may exacerbate their clinical symptoms. The aim of this study was to examine the feasibility of 4-h regular versus more dynamic standing sessions while performing routine desktop activities as a non-exercise physical activity intervention in older...
Article
Full-text available
The study reports the performance of stroke patients to operate Motor-Imagery based Brain-Computer Interface (MI-BCI) in early post-stroke neurorehabilitation and compares three different BCI spatial filtering techniques. The experiment was conducted on five stroke patients who performed a total of 15 MI-BCI sessions targeting paretic limbs. The EE...
Preprint
Background: Physical inactivity is prevalent in older adults with type 2 diabetes mellitus (T2DM) and may exacerbate their clinical symptoms. The aim of this study was to examine the feasibility of 4-hour regular versus more dynamic standing sessions while performing routine desktop activities as a non-exercise physical activity intervention in old...
Article
Full-text available
Background The aging process alters upright posture and locomotion control from an automatically processed to a more cortically controlled one. The present study investigated a postural-cognitive dual-task paradigm in young and older adults using functional Near-Infrared Spectroscopy (fNIRS). Methods Twenty healthy participants (10 older adults 72...
Preprint
Full-text available
Background: Physical inactivity is prevalent in older adults with type 2 diabetes mellitus (T2DM) and may exacerbate their clinical symptoms. The aim of this study was to examine the feasibility of 4-hour regular versus more dynamic standing sessions while performing routine desktop activities as a non-exercise physical activity intervention in old...
Article
Introduction: Gait and balance disorders in Parkinson’s disease (PD) represent a major therapeutic challenge as frequent falls and freezing of gait impair quality of life and predict mortality. Limited dopaminergic therapy responses implicate non-dopaminergic mechanisms calling for alternative therapies. Areas covered: The authors provide a review...
Article
Full-text available
Background Motor imagery (MI) has been a widely used strategy in the past two decades to enhance physical capabilities among orthopaedic patients. However, its effectiveness is still questioned, since the demonstrated effects were likely task-dependent, with little evidence of transfer to tasks not specifically trained with MI. Objective The aim of...
Article
Purpose: Oxidative stress has been proposed as a contributor to pain in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). During incremental exercise in patients with ME/CFS, oxidative stress enhances sooner and antioxidant response is delayed. We explored whether oxidative stress is associated with pain symptoms or pain c...
Article
Objectives To investigates the short- and long-term effects of elastic resistance training (ERT) on physical performance, inflammatory markers, and myokines in older women living in a nursing home. Design A randomized controlled trial, with 12 weeks of ERT intervention. Setting and participants Nursing home. Twenty female nursing home residents (me...
Article
Full-text available
Prolonged periods of physical inactivity or bed rest can lead to a significant decline of functional and cognitive functions. Different kinds of countermeasures (e.g., centrifugation, nutritional, and aerobic interventions) have been developed to attempt to mitigate negative effects related to bed rest confinement. The aim of this report is to prov...
Article
Aim: The purpose of this pilot study was to quantify the effect of a continued active video games (AVG) playing on the tennis forehand and backhand technique development. Methods: Altogether 24 tennis players (7 – 9 year olds) were randomly divided in two different groups, both involved in a 12-week tennis training program (twice a week for an hour...
Article
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Recent literature suggests that alterations in both neural and structural components of the neuromuscular system are major determinants of knee extensor muscle weakness after total knee arthroplasty (TKA). Therefore, the goal of this study was to investigate the maximal voluntary strength (MVS), voluntary muscle activation (VMA), and the cross-sect...
Article
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Electroencephalographic neurofeedback (EEG-NFB) represents a broadly used method that involves a real-time EEG signal measurement, immediate data processing with the extraction of the parameter(s) of interest, and feedback to the individual in a real-time. Using such a feedback loop, the individual may gain better control over the neurophysiologica...
Chapter
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In this study, we examined the effect of neurofeedback on EEG changes due to immobilization of the dominant hand. Desynchronization of the sensorimotor rhythms during motor imagery was used as a tool to investigate brain activity. The study is based on 8 healthy subjects who underwent immobilization of the dominant hand for 24 hours. The electrical...
Article
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The purpose of this study was to create a valid and reliable assessment scale for the evaluation of three basic tennis strokes (forehand, backhand, serve) for 6–12-year-old tennis players, named the Tennis Rating Score for Children (TRSC). Altogether 60 players (21: forehand, 22: backhand, 17: serve) were video recorded (30 frames per second) while...
Article
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Background: Motor imagery (MI), a mental simulation of a movement without overt muscle contraction, has been largely used to improve general motor tasks. However, the effects of MI practice on maximal voluntary strength (MVS) remain equivocal. Objectives: The aims of this meta-analysis were to (1) estimate whether MI practice intervention can me...
Article
Full-text available
Objective: A strong relation between cognition and mobility has been identified in aging, supporting a role for enhancement mobility through cognitive-based interventions. However, a critical evaluation of the consistency of treatment effects of cognitive-based interventions is currently lacking. The objective of this study was 2-fold: (1) to revi...
Article
Normal and pathological ageing are associated with several motor impairments that reduce quality of life and represent a general challenge for public healthcare systems. Consequently, over the past decades, many scientists and physiotherapists dedicated their research to the development and improvement of safe and costless methods to counteract the...
Article
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This study aimed to determine whether the combination of action observation and motor imagery (AO+MI) of locomotor tasks could positively affect rehabilitation outcome after hip replacement surgery. Of initially 405 screened participants, 21 were randomly split into Intervention (N=10, mean age=64y, AO+MI of locomotor tasks: 30min/day in the hospit...
Article
Full-text available
Physical activity in the form of aerobic and resistance exercise, leading to a high level of cardio-respiratory fitness, represents a strong non-pharmacological preventive tool against cognitive decline and thus the occurrence of neuro-degenerative diseases in the third age. However, the effects are even greater if such exercise is performed on reg...
Article
Purpose: The aim of the present study was to determine the reliability and diagnostic accuracy of non-invasive urinary dehydration markers, in field-based settings on a day-to-day basis in elite adolescent amateur boxers. Methods: Sixty-nine urine samples were collected on a day-to-day basis, from twenty-three athletes (17.3±1.9 y), during their...
Conference Paper
During acute stress (such as 14 days of horizontal bed rest, BR) plasma level of the neurotrophin brain-derived neurotrophic factor (pBDNF) was demonstrated to increase in older, but not younger adults. We hypothesized that this increase might represent a mechanism of brain protection, and that performing computerized cognitive training (CCT) would...
Article
Full-text available
Background: Patients with myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) are unable to activate brain-orchestrated endogenous analgesia (or descending inhibition) in response to exercise. This physiological impairment is currently regarded as one factor explaining post-exertional malaise in these patients. Autonomic dysfunction is a...
Article
Full-text available
Acute stress, as bed rest, was shown to increase plasma level of the neurotrophin brain-derived neurotrophic factor (BDNF) in older, but not in young adults. This increase might represent a protective mechanism towards acute insults in aging subjects. Since computerized cognitive training (CCT) is known to protect brain, herein we evaluated the eff...
Article
Full-text available
Objective: A direct link between the mouth cavity and the brain for glucose (GLUC) and caffeine (CAF) has been established. The aim of this study is to determine whether a direct link for both substrates also exist between the nasal cavity and the brain. Methods: Ten healthy male subjects (age 22 ± 1 years) performed three experimental trials, s...
Article
Full-text available
Ageing is a multifactorial process associated with several irreversible functional and cognitive alterations of human body and determined by genetic and environmental factors. We aimed to investigate the effects of three physical activity interventions of 40 independently living older adults before and after a 3-month training period. Thirty female...
Article
Full-text available
The hippocampus is closely tied to spatial navigation, a central component in cognitive functioning, and critically involved in age-associated cognitive decline and dementia. This study evaluated a novel, cognitive computerized spatial navigation training (CSNT) program targeting the hippocampus, with expectation of mitigating possible cognitive de...
Article
Full-text available
IT IS GENERALLY ACCEPTED THAT VOLUNTARY WEIGHT CUTTING BEFORE ENTERING A COMPETITION HAS BECOME A HABITUAL PRACTICE AMONG COMBAT SPORTS ATHLETES. APART FROM ANTIDOPING REGULATIONS BANNING THE USE OF DIURETICS, THE OLYMPIC GOVERNING BODY HAS NOT ESTABLISHED POLICIES AIMED TO MONITOR AGGRESSIVE WEIGHT CUTTING. IT IS EXTREMELY IMPORTANT FOR COMBAT SPO...
Article
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Brain derived neurotrophic factor (BDNF) is a member of neurotrophin family implied in brain resistance to insults. Murine studies demonstrated increased hippocampal concentration after acute, and decreased after chronic immobilization. In humans, chronic stress and sedentary lifestyle decreased plasmatic BDNF, while there is no data regarding acut...
Article
Full-text available
This investigation aimed to compare the response of older adult and young men to bed-rest and subsequent rehabilitation. Sixteen older (OM: 55-65 years) and seven young men (YM: 18-30 years) were exposed to 14-day bed rest (BR) followed by 14-day rehabilitation (R). Quadriceps muscle volume (QVOL), force (QF) and explosive power (QP) of leg extenso...
Article
Full-text available
Prolonged physical inactivity or bed rest (BR) due to illness or other factors can result in significant declines in physical health and even cognitive functions. Based on random selection, 7 healthy older adult men received computerized spatial navigation training, while 8 served as active controls during 14-day BR. Greater post-BR declines were s...
Article
Full-text available
We investigated the effects of bed rest (BR) immobilization, with and without computerized cognitive training with virtual spatial navigation task (CCT), on vascular endothelium on older subjects. The effects of 14-day BR immobilization in healthy older males (n=16) of ages 53-65 years on endothelial function were studied using EndoPAT(®), a noninv...