Upasana Shyamsunder Singh

The University of Manchester · School of Earth, Atmospheric and Environmental Sciences

Malaria in India is declining, in part due to the use of long-lasting insecticide-treated nets (LLINs) and vector control. Historically, the north-eastern region of India has contributed ~10%-12% of the nation's malaria burden. The important mosquito vectors in northeast India have long been considered to be Anopheles baimaii and An. minimus, both...

Background: Despite declining incidence over the past decade, malaria remains an important health burden in India. This study aimed to assess the village-level temporal patterns of Plasmodium infection in two districts of the north-eastern state of Meghalaya and evaluate risk factors that might explain these patterns. Methods: Primary Health Cen...

Considering that VBDs are highly dependent on eco-climatic conditions of a particular location, the net holobiont (mosquito and its community of associated microorganisms) of these medically-important mosquitoes possibly form an “evolutionarily adapted microbial ecosystem”. Such an adapted microbial ecosystem in the mosquito’s salivary gland and mi...

Background: Malaria in sub-Saharan Africa (sSA) is thought to be mostly caused by Plasmodium falciparum. Recently, growing reports of cases due to Plasmodium ovale, Plasmodium malariae, and Plasmodium vivax have been increas-ingly observed to play a role in malaria epidemiology in sSA. This in fact is due to the usage of very sensitive diag-nostic...

Background Malaria in sub-Saharan Africa (sSA) is thought to be hugely caused by Plasmodium falciparum . Recently, growing reports of cases due to P. ovale , P. malariae , and P. vivax have been significantly reported to play a role in malaria epidemiology in sSA. This in fact is due to the usage of very sensitive diagnostic tools (e.g. PCR) which...

Host genetic factors are frequently ascribed to differential malaria outcomes as a by-product of evolutionary adaptation. To this respect, Tumor Necrosis factor alpha (TNF-α), a human cytokine, is known to be associated with malaria through its differential regulation in diverse malaria manifestations. Since diversity in differential malaria outcom...

Background & objectives: With the development of technological know-how, in recent years, malaria research in India has advanced to a great extent and the corresponding research is being translated into the form of publications, which has started to pile in thousands over the years. The purpose of the present study was to perform a bibliometric an...

Evolution and spread of malaria parasite Plasmodium falciparum capable of evading antimalarials are the prime concern to malaria control. The currently effective drug, artemisinin (ART), is under threat due to detection of ART-resistant P. falciparum parasites in the Southeast Asian countries. It has been shown that amino acid (AA) mutations at the...

Malaria is a vector-borne infectious disease, caused by five different species of the genus Plasmodium, and is endemic to many tropical and sub-tropical countries of the globe. At present, malaria diagnosis at the primary health care level in India is conducted by either microscopy or rapid diagnostic test (RDT). In recent years, molecular diagnosi...

The present study was carried out from January to June 2016 in Rajasthan that aimed to sequence the 16S rRNA gene of S. hardwickii to trace genetic variation. Non-invasive molecular techniques were used to isolate DNA from fecal matter. The sequences were edited and assembled using SeqMan computer program, aligned with six global sequences followin...

India is highly endemic to malaria with prevalence of all five species of human malaria parasites of Plasmodium genus. India is set for malaria elimination by 2030. Since cases of mixed Plasmodium species infections remain usually undetected but cause huge disease burden, in order to understand the distributional prevalence of both mono- and mixed...

The vector borne diseases (VBDs), alone constitutes to around 17% of the estimated global burden of all human infectious diseases. Some of the major VBDs include Malaria, Dengue, Chikungunya, Schistosomiasis, Human African trypanosomiasis, Leishmaniasis, Chagas disease, Yellow fever, Japanese encephalitis, Tick-borne rickettsial diseases and Onchoc...

Infectious diseases transmitted by insect vectors, otherwise known as Vector Borne Disease (VBDs) are causing havoc in the tropical and sub-tropical regions of the globe. Diseases like malaria, dengue, chikungunya, and zika are endemic to many of the countries. These VBDs not only cause mortalities, but some of them also cause high morbidity. Under...

With advancement in instrumentation, computation and under standing of disease etiology, proteomics has been expanded to harness the knowledge of change in protein folding and misfolding, protein-protein interaction, protein modification, etc. during progression of disease which is a source of discovery for various biomarkers including predictive b...