Umukoro Solomon

Umukoro Solomon
University of Ibadan · Department of Pharmacology & Therapeutics

Ph.D

About

133
Publications
20,662
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1,236
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Introduction
Umukoro Solomon currently works at the Department of Pharmacology & Therapeutics, University of Ibadan. Umukoro does research in biomedical Sciences. His current project includes evaluation of the molecular mechanism (s) involved in the protective effect of a compound against rotenone-induced parkinsonian-like behaviours and elucidation of the molecular pathways by which it attenuates behavoural and biochemical derangements induced by chronic stress and hypoxia in rats.
Additional affiliations
May 2002 - present
University of Ibadan
Position
  • I am a Senior Lecturer in the department of Pharmacology and Therapeutics, University of Ibadan, Nigeria. I am involved in the teaching and supervision of both undergraduate and postgraduate students, as well as in running of the department as a coordinator of postgraduate programmes.
Description
  • My major areas of specialization include behavioral pharmacology /basic neuroscience and biochemical pharmacology.

Publications

Publications (133)
Article
Full-text available
Jobelyn® (JB), a dietary supplement, derived from polyphenol-rich leaf sheath of Sorghum bicolor, has been reported to attenuate sensorimotor deficits and oxidative stress evoked by complete Freund-adjuvant in mice. This present study evaluated its effects on the life span, motor function and changes in oxidative stress parameters as well as acetyl...
Article
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A substantial number of epileptic patients are resistant to the current medication thus necessitating the search for alternative therapies for intractable forms of the disease. Previous studies demonstrated the acute anticonvulsant properties of the methanol extract of the stem bark of Psychotria camptopus (MEPC) in rats. This study investigated th...
Article
Full-text available
The unpredictable chronic mild stress (UCMS) mouse model of depression causes a variety of neuronal structural alterations ranging from dendritic spines loss and dendrite arbor retraction to spine proliferation in brain regions involved in the control of mood. Based on data showing that the plant stress hormone methyl jasmonate (MJ: methyl acetate-...
Article
Cymbopogon citratus aqueous leaf extract (CYC) otherwise known as lemongrass tea is used for achy joints (rheumatism) and central nervous system disorders in ethnomedicine. This study was designed to investigate the effects of CYC on neurobehavioral, oxidative, and inflammatory changes produced by complete Freund adjuvant (CFA) in male Swiss mice....
Article
Treatment-resistance depression and memory impairment disease, burdened with high levels of serious adverse effects of currently existing antidepressants and memory enhancers, have necessitated the search for alternative agents. Although previous preclinical studies have revealed the antidepressant-like and memory-enhancing potentials of morin, a c...
Article
Full-text available
Methyl jasmonate (MJ) is a derivative of the jasmonate family which is found in most tropical regions of the world and present in many fruits and vegetables such as grapevines, tomato, rice, and sugarcane. MJ is a cyclopentanone phytohormone that plays a vital role in defense against stress and pathogens in plants. This has led to its isolation fro...
Article
Oxidative and inflammatory signaling pathways have been identified as important targets for mitigating hypoxic stress-induced neurological complications. Thus, the effects of naringenin, a potent antioxidant, anti-inflammatory and neuroprotective bioflavonoid on hypoxic stress-induced depressive-like and anxiety-related behaviors in mice, and the u...
Article
Full-text available
Ocimum gratissimum L. has attracted substantial consideration from researchers because of its anti-inflammatory uses in ethnomedicine in Sub-Saharan Africa and Asia. This study investigated the effect of flavonoid-rich ethylacetate fraction of O. gratissimum (EAFOg) in apoptosis induction of activated macrophages and inflammatory response in LPS-in...
Article
Ocimum gratissimum L. has attracted substantial consideration from researchers because of its anti-inflammatory uses in ethnomedicine in Sub-Saharan Africa and Asia. This study investigated the effect of flavonoid-rich ethylacetate fraction of O. gratissimum (EAFOg) in apoptosis induction of activated macrophages and inflammatory response in LPS-in...
Article
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Mounting evidences have shown that nicotinamide adenine dinucleotide phosphate oxidase-2 (Nox-2) pathway modifies glutamic-acid decarboxylase-67 (GAD67) (GABAergic enzyme) and cholinergic systems via oxidative-nitrergic mechanisms in schizophrenia pathology. Rutin, a neuroactive antioxidant compound, with proven neuroprotective property has been sh...
Article
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Unpredictable chronic mild stress (UCMS) has been shown to cause memory loss via increased oxidative stress and deregulation of monoaminergic and cholinergic neurotransmissions. Although the benefits of methyl jasmonate (MJ), a well-known anti-stress plant hormone against chronic stress-induced psychopathologies, have been earlier reported, its eff...
Article
Fruit-based supplement has an important role in protecting the brain against oxido-inflammatory stress. Chrysophyllum albidum fruit contained several phytonutrients that possess antioxidants and anti-inflammatory properties. Hence, this study investigated the effect of C. albidum fruit supplemented diet (CAFD) on cognitive functions and lipopolysac...
Article
This study investigated the effect of high doses of monosodium glutamate (MSG), a known food additive on hepatic, memory and locomotor functions in mice, and the ameliorative potentials of Jobelyn® (JB), a unique dietary supplement. Twenty four male Swiss mice divided into 4 groups (n = 6) were given MSG (2, 4 and 8 g/kg) or normal saline (10 mL/kg...
Article
Objectives The contribution of anesthetic procedure to surgical stress and postoperative complications has been attributed to increased oxidative stress and release of inflammatory cytokines. Thus, the levels of oxidative stress biomarkers and inflammatory cytokines in patients with general anesthesia (GA) and spinal anesthesia (SA) that underwent...
Article
Objectives The contribution of anesthetic procedure to surgical stress and postoperative complications has been attributed to increased oxidative stress and release of inflammatory cytokines. Thus, the levels of oxidative stress biomarkers and inflammatory cytokines in patients with general anesthesia (GA) and spinal anesthesia (SA) that underwent...
Article
Full-text available
Morin hydrate (MH) is the major flavonoid constituent of Morus alba acclaimed to have antioxidant, anti-inflammatory, anti-stress and neuroprotective properties. However, report on the effect of MH on memory performance and the underlying mechanism following chronic stress exposure is lacking. The current study aimed at investigating the neuroprote...
Article
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Adaptogens are substances that act nonspecifically to combat stress by regulating the key elements involved in stress-induced pathologies. D-Ribose-L-cysteine (DRLC), a potent glutathione (GSH) booster, has been recommended for relief of stress. Hence, we investigated its adaptogenic-like effect in mice subjugated to unpredictable chronic mild stre...
Article
Objectives Repeated exposure to anoxic stress damages the brain through cortisol-mediated increases in oxidative stress and cellular-antioxidants depletion. Thus, compounds with antioxidant property might confer protection against anoxic stress-induced brain injuries. In this study, we further examined the protective effect of methyl jasmonate (MJ)...
Article
Objectives The juice extract of Cyperus esculentus commonly known as tiger nuts (TINUT) is widely used for its numerous health promoting effects including alleviation of symptoms associated with neurological disorders. Herein, we investigated the influence of the aqueous extract of C. esculentus on cognitive disorder and the underlying changes in a...
Article
Objectives Blend of seeds and leaves of Picralima nitida herein referred to as West African Durand powder (WDP) was investigated for antinociceptive and anti-inflammatory properties. Methods Acute toxic effect of the aqueous extract was evaluated in mice of both sexes. Antinociceptive effect of WDP (100–400 mg/kg) was evaluated in models of acetic...
Article
Objectives Purinergic signaling pathway has been implicated in maladaptation of animals subjected to chronic stress. Previous studies have shown that methyl jasmonate (MJ) exhibited adaptogenic properties in mice exposed to unpredictable chronic mild stress (UCMS) via antioxidant and neuroprotective-related mechanisms. Methods This study evaluated...
Article
Objectives Purinergic signaling pathway has been implicated in maladaptation of animals subjected to chronic stress. Previous studies have shown that methyl jasmonate (MJ) exhibited adaptogenic properties in mice exposed to unpredictable chronic mild stress (UCMS) via antioxidant and neuroprotective-related mechanisms. Methods This study evaluated...
Article
Full-text available
Objective Psychosocial stress has been implicated in the genesis of psychiatric disorders such as memory deficits, depression, anxiety and addiction. Aqueous leaf extract of Cymbopogon citratus (CYC) otherwise known as lemongrass tea has antidepressant, anxiolytic and anti-amnesic effects in rodents. This study was designed to evaluate if C. citrat...
Article
The effect of ethanol fruit extract of Spondias mombin (FESM) against scopolamine-induced memory impairment was evaluated in mice. Swiss mice were injected with scopolamine (3 mg kg⁻¹, i.p) and treated with FESM (25, 100, and 400 mg kg⁻¹) or vitamin C (100 mg kg⁻¹) for 7 d. FESM treatment prevented scopolamine-induced memory impairment on the Y-maz...
Article
Psychosocial stress and biological predispositions are linked to mood and personality disorders related to psychiatric behaviors. Targeting neuroinflammation and oxidative stress has been recognized as a potential strategy for the prevention of psychosocial stress-induced psychiatric disorders. Morin, a bioactive compound isolated from mulberry lea...
Article
Full-text available
Neuroinflammation observed during prenatal or early adolescent life plays a prominent role in the neuroprogression of schizophrenia. Thus, it has been hypothesized that suppressing neuroinflammation may retard the progression of the disease. Previous studies have shown that morin, a naturally bioactive compound, possesses antipsychotic-like and inf...
Article
Full-text available
Abstract The West-African variety of Sorghum bicolor leaf sheath (SBLS) Jobelyn® is a natural remedy, which has gained international recognition for its anti-anaemic effect and energy boosting qualities in debilitating diseases. The widespread use of traditional medicine in the region usually confirms its safety, but not its efficacy or deep assess...
Article
Full-text available
Abstract The West-African variety of Sorghum bicolor leaf sheath (SBLS) Jobelyn® is a natural remedy, which has gained international recognition for its anti-anaemic effect and energy boosting qualities in debilitating diseases. The widespread use of traditional medicine in the region usually confirms its safety, but not its efficacy or deep assess...
Article
Full-text available
d-Ribose-l-cysteine (DRLC), an analog of cysteine that boosts glutathione (GSH) content, has been reported to mitigate oxidative stress–mediated diseases. This study seeks to evaluate the effects of DRLC on memory deficits and the biochemical and histo-morphological changes induced by lipopolysaccharide (LPS) in mice. Male Swiss mice (n = 10) were...
Article
d‐Ribose‐l‐cysteine (DRLC) is an analogue of cysteine that has been shown to boost cellular antioxidant capacity by enhancing intracellular biosynthesis of glutathione (GSH). Deficiency of GSH has been implicated in the pathogenesis of Alzheimer's disease (AD), a neurodegenerative disorder associated with loss of memory. Thus, the use of antioxidan...
Article
Full-text available
Decreased tyrosine hydroxylase (TH) activity, due to degeneration of dopaminergic neurons contributes to the low dopamine content and the motor deficits that characterized Parkinson’s disease (PD). This study examines the effect of methyl jasmonate (MJ), a neuroprotective bioactive compound isolated from jasminum grandiflorum, on motor functions, i...
Article
The study evaluated the role of cytochrome C and pro-inflammatory cytokines in memory deficit produced by a commercial solid air freshener (SAF) in male Swiss mice. The animals were culled into 6 groups (n = 7): group 2-6 were exposed to SAF (10, 25, 50, 100 and 200 g) for 28 consecutive days through whole body exposure. Mice in group 1(control) we...
Article
Full-text available
Every individual experience stress as it is an imperative component of our daily life and a common life experience, and it is believed to be any situation that may lead to disconcertion of normal physiologic state. Morphological changes such as retraction of neuronal dendrites and spine loss have been identified as a common consequence of chronic s...
Article
Background Anxiety is a common ailment of high co-morbidity with epilepsy, a chronic neurologic disease characterized by recurrent seizures. Current drugs used for these conditions have several limitations such as disabling side effects, relapse, and ineffectiveness in certain population necessitating the search for alternative options. The aqueous...
Article
Full-text available
Background To investigate the antinociceptive and anti-inflammatory activities of aqueous extract of a blended mixture of dried leaves of Ocimum gratissimum and Psidium guajava, a traditional analgesic drug polyherbal (TADP) used as a remedy for pain-related conditions. Methods Antinociceptive activity of TADP (100, 200 and 400 mg/kg) was evaluate...
Article
l‐Arginine‐nitric oxide pathway has been reported to be involved in the mediation of the psychopharmacological effects of many psychotropic drugs. Previous studies have shown that morin, a psychotropic compound isolated from mulberry leaf produces functional psychopharmacological effects indicative of antidepressant, antipsychotic, anxiolytic and n...
Article
Background: Air fresheners are products with fragrances used to mask unpleasant odor in the environment. However, air fresheners contain diverse chemical substances that pose health challenges to the users; hence are of public health significance. Although previous studies have shown that air fresheners affect the lungs, liver and reproductive orga...
Article
Full-text available
Background: Air fresheners are products with fragrances used to mask unpleasant odor in the environment. However, air fresheners contain diverse chemical substances that pose health challenges to the users; hence are of public health significance. Although previous studies have shown that air fresheners affect the lungs, liver and reproductive orga...
Article
Full-text available
Ackee (Blighia sapida) is a commonly eaten fruit that is indigenous to West Africa and Jamaica. Ackee poisoning in young children have been reported in parts of Nigeria due to consumption of the unripe fruits. This study was designed to identify potential mechanisms of acute and sub-acute toxicity of unripe B. sapida fruit extract (BSE). Acute toxi...
Article
Oxidative stress and neuroinflammation play key roles in the initiation and progression of Parkinson's disease (PD), a neurodegenerative disorder, associated with the loss of nigrostriatal dopaminergic pathway. Thus, compounds that can mitigate oxidative stress and neuroinflammation are being investigated as promising agents for the treatment of PD...
Article
ETHNOPHARMACOLOGY RELEVANCE: the root decoction of Cnestis ferruginea Vahl ex DC (Connaraceae) is widely used in traditional African medicine for the treatment of various ailments including pain, inflammation and epilepsy. We have earlier reported anticonvulsant effect of Cnestis ferruginea root extract in mice. Aim of the study: to evaluate the...
Article
Flavonoids are naturally occurring bioactive phytochemical metabolites widely known to prevent and suppress several human diseases, and are important sources of therapeutic compounds from plants. Evidence derived from previous studies suggests that naringin, a neuroactive flavonoid possess functional beneficial neurobehavioral effects including anx...
Conference Paper
Full-text available
Every individual experience stress as it is an imperative component of our daily life and a common life experience, and it is believed to be any situation that may lead to disconcertion of normal physiologic state. Morphological changes such as retraction of neuronal dendrites and spine loss have been identified as a common consequence of chronic s...
Article
Full-text available
Introduction: Isoniazid-induced seizure, often described as Status Epilepticus (SE), is an emergency condition characterized by repeated convulsive episodes that responds poorly to the currently available anticonvulsant drugs. The current study aimed at ascertaining the effect of Jobelyn® (JB), an African dietary supplement, on seizures, altered ox...
Article
The effects of Jobelyn® (JB) on neurological deficits and biochemical alterations associated with ischemic stroke induced by bilateral common carotid artery occlusion (BCCAO) in rats were investigated in this study. Male Wistar rats were divided into five groups (n = 8): group 1 served as Sham control; group 2, which served as negative control rece...
Article
The aqueous leaf extract of Cymbopogon citratus (CYC) was evaluated for memory functions on scopolamine (SCO)-induced amnesia in mice. Male mice received CYC (25, 50, or 100 mg kg⁻¹) or saline (10 mL kg⁻¹) orally for 7 consecutive days. In the interaction studies, the mice were given CYC (25, 50, or 100 mg kg⁻¹, p.o) 30 min before SCO (3 mg kg⁻¹, i...
Article
Full-text available
Background: Gossypium barbadense L. (GB) is used in the treatment of various diseases such as convulsions, jaundice, gastrointestinal disorders, and rheumatism in African traditional medicine. Objectives: This study aimed at evaluating the antioxidant and in vitro membrane stabilization activities of leaf extracts of GB. Methods: Gossypium barbaden...
Article
Full-text available
Previous studies have revealed that morin (MOR), a neuroactive bioflavonoid, with proven psychotropic and neuroprotective properties reduced schizophrenic-like behaviors in mice. This study further evaluated the ability of MOR to prevent and reverse ketamine-induced schizophrenic-like behaviors and the underlying neurochemical changes and increased...
Article
Theeffectsofnaringenin; adietary flavonoid,withpotentanti-oxidant andanti-inflammatoryactivitiesonsocial defeat stress (SDS)-induced neurobehavioral and biochemical changes were evaluated in mice using residentintruder paradigm. The intruder male mice were distributed into 6 groups (n=6). Mice in group 1 (control) received vehicle (3% DMSO, i.p), grou...
Article
The effects of naringenin; a dietary flavonoid, with potent anti-oxidant and anti-inflammatory activities on social defeat stress (SDS)-induced neurobehavioral and biochemical changes were evaluated in mice using resident-intruder paradigm. The intruder male mice were distributed into 6 groups (n = 6). Mice in group 1 (control) received vehicle (3%...
Article
Ethnopharmacological relevance: The stem bark of Theobroma cacao L. have been used for the treatment of inflammation, toothache, measles and malaria in ethnomedicine. However, the anti-inflammatory activity of Theobroma cacao stem bark has not been fully elucidated. Aim: The anti-inflammatory activity of Theobroma cacao stem bark ethanol extract...
Conference Paper
Full-text available
Methyl jasmonate is a naturally-occurring anti-stress plant hormone and has been shown to ameliorate the effects of acute and chronic stress in mice. The present study aimed to study the behavioral and biochemical mechanisms underlying the adaptogenic-like properties of methyl jasmonate. Male Wistar albino rats were subjected to stressors of the un...
Article
Objectives This study was carried out to investigate the neurobehavioral properties of naringin, a flavonoid compound formed from naringenin on behavioral models in mice. Method The neurobehavioral property of naringin (2.5, 5 and 10 mg/kg) administered intraperitoneally (i.p.) was assessed on novelty-induced rearing, locomotor behavior using open...
Article
Purpose: The efficacy of current antidepressant drugs has been compromised by adverse effects, low remission and delay onset of action necessitating the search for alternative agents. Methyl jasmonate (MJ), a bioactive compound isolated from Jasminum grandiflorum has been shown to demonstrate antidepressant activity but its mechanism of action rem...
Article
GABAergic (Gamma-aminobutyric acid) and neurotrophic derangements have important implication in schizophrenia, a neuropsychiatric disease. Previous studies have shown that nicotinamide adenine dinucleotide phosphate oxidase (NADPH-oxidase) alters GABAergic and neurotrophic activities via inflammatory and oxidative pathways. Thus, it has been propos...
Article
Full-text available
The antidepressant-like activity of ethanol seed extract of Aframomum melegueta (AM) in mice was evaluated in this study. The duration of immobility was measured 30 min after oral administration of AM (25–400 mg/kg) in forced swim test. In the unpredictable chronic mild stress (UCMS) paradigm, mice were treated with AM (25–100 mg/kg) 30 min before...
Article
The involvement of oxidative/nitrosative stress, cholinergic and inflammatory pathways have been reported to contribute to the pathophysiology of schizophrenia, a debilitating neuropsychiatric disorder. Our previous studies have shown that doxycycline (DOX), a notable member of tetracyclines with proven antioxidant and anti-inflammatory properties,...
Article
Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects the physical and psychosocial wellbeing of the patients and a major cause of work disability. Current drugs for its treatment only provide palliative effect, as cure for the disease still remains elusive. Jobelyn® (JB), a potent anti-oxidant and anti-inflammatory dietary suppl...